Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    ISSN: 1524-475X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Aim: This study was aimed to confirm the usefulness of allogeneic cultured dermal substitute (CDS) in the treatment of skin defects after excision of skin cancer. Methods: Eleven elderly patients (mean age of 76.3 year old) with skin cancer were included in this study. Most of the patients had basic disease such as diabetes or ASO. Allogeneic CDS used in the study were produced at Kitasato University. The CDS were applied to skin defects with exposing bone or tendon after oncological surgery, and changed once or twice a week until the open wound became suitable for autologous skin grafting or healed completely. Results: Healthy granulation tissue was formed to cover the exposed bone or tendon in all cases. Only in one case, the treatment with allogeneic CDS was abandoned owing to undesirable infection. In eight cases, appropriate wound beds acceptable for autologous skin graft were prepared. In other two cases, the skin defect became smaller and eventually closed without skin graft. In ten cases with or without skin graft, undesirable scar contracture was not observed over prolonged follow-up. Conclusions: Elderly patients with skin cancer provide reconstructive surgeons with challenging problems when bone or bare tendon is exposed after oncological surgery. Flap transfer might be complicated especially when the patients suffered from a basic disease such as diabetes or ASO. This study has confirmed that the use of allogeneic CDS is a safe and reliable method to achieve wound healing in those high-risk patients.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 2
    ISSN: 0141-8130
    Keywords: Proteins ; collagen ; graft polypeptide ; pepleomycin derivative ; poly(α-amino acid) ; polymeric drug
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 3
    ISSN: 0141-8130
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 4
    ISSN: 0141-8130
    Keywords: Amino acids ; N^5-β-d-glucopyranosyl-l-glutamine ; copoly(α-amino acid) ; fibroblast cell ; γ-benzyl-l-glutamate
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 5
    ISSN: 1435-1536
    Keywords: Anioneneinfluß ; Konformation ; Copoly-(L-Leu-L-Orn) zwischenmolekulare Wechselwirkungen
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Description / Table of Contents: Abstract The conformation of the alternating copoly-(L.-leucyl-L-ornithine) was studied in solutions of various salts and in salt-free water as well by CD technique. This copolymer is shown to undergo a conformational transition from a disordered to aβ-structure by adding salts or with increasing the pH to a alkaline region. Such a tendency to form aβ-structure is enhanced by neutral salts like KF, NaF, and NaCl and remarkably enhanced by water structure breaking anions like LiClO4 and NaClO4. Theβ-structure induced by perchlorate ions is stable up to 90 °C. This finding can be interpreted in terms of the shielding effect resulted from a specific binding of perchlorate ions with positively charged side chains. Aβ-I-structure is also induced by water structure making anions like Li2SO4 and Na2SO4, but theβ-structure inducing molecular mechanism is probably different from the case of water structure breaking anions, due to its electrochemical bivalency. This becomes obvious from the fact that above 0.005 mole/l precipition occurs and from model considerations.
    Notes: Zusammenfassung Es wurde die Konformation von alternierendem (L-Leu-L-Orn) n in den Lösungen verschiedener Salze (NaCl, NaF, KF, LiClO4, NaClO4, Li2SO4, Na2SO4) sowie in salzfreiem Wasser durch CD-Messungen in Abhängigkeit von Konzentration, Temperatur und pH-Wert untersucht. Dabei ergab sich, daß dieses Copolymere, das in salzfreiem Wasser in ungeordneter Konformation vorliegt, bei Salzzugabe oder bei pH ≈ 8 in eineβ-Konformation übergeht. Diese Tendenz zum Übergang in eineβ-Konformation ist besonders ausgeprägt in den Lösungen von Salzen mit stark wasserstrukturbrechendem Anion wie LiClO4 und NaClO4. In diesen Lösungen ist dieβ-Konformation bis 2≥ 90 °C stabil. Dieser Befund wird auf einen elektrostatischen Abschirmeffekt der von den positiv geladenen Seitengruppen spezifisch adsorbierten Perchlorationen zurückgeführt. Zwar werden auch von Salzen mit stark wasserstrukturbildenden Anionen wie Li2SO4 β-Strukturen induziert, jedoch ist wahrscheinlich infolge seiner doppeltnegativen Ladung der molekulare Mechanismus ein etwas anderer als im Fall der Perchlorationen. Hierauf deutet die Tatsache hin, daß in Sulfatlösungen bereits 〉 0.005 Mol/l Ausfällung eintritt.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 6
    ISSN: 1435-1536
    Keywords: Multichain copoly(α-amino acid) ; Conformational transition ; Helix conformation ; Optical Rotatory Dispersion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract The conformational transition of multichain copoly(α-amino acid)s consisting of copoly(γ-methyl-L-glutamyl-L-lysine) as backbone molecule and poly(γ-benzyl-L-glutamate) as branch molecules was studied in chloroform and DCA mixtures. The helix stability of backbone molecule is strongly affected by the length of branch molecules. In the case of the multichain copolymer having short branch molecular chains, i.e.,DP br 〈10, the helix conformation of the backbone molecule is strictly affected by some interferences among the randomly coiled molecular chains. In the case of water-soluble multichain copolymer having poly(L-glutamic acid) or poly(L-lysine) as branch molecules, the transitional process from coil to helix is observed by depressing hydrostatic repulsion among the ionized side chain of branch molecules. However, such conformational transition is depressed to a considerable extent by interferences among the branch molecules.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 7
    ISSN: 1435-1536
    Keywords: Reversed micelle ; Basic poly(α-amino acid)s ; Circular dichroism measurement ; Conformational transition
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract The conformation of various basic poly (α-amino acid)s was investigated by CD measurements in aqueous solutions containing bis (2-ethylhexyl)sodium sulfosuccinate (AOT) as well as in the AOT reversed micelles. The addition of AOT into an aqueous solution of poly(L-lysine) induces the conformational transition from coil to ordered structure, followed by aggregation. On the other hand, poly(L-lysine) assumesΒ-structure in the reversed micelles at low wovalue (wo=[H2O]/[AOT]). Similarly to poly(L-lysine), poly(L-ornithine) takes an ordered structure in the aqueous solution containing AOT andΒ-structure in the reversed micelles. In this case, however, these ordered structures are not so stable, compared with that of poly(L-lysine). Poly(L-arginine) undergoes the conformational transition from coil to helix by addition of AOT into the aqueous solution. Further addition of AOT allows transformation intoΒ-structure. Copoly(L-lysyl-L-leucine) with 63% leucine residue was shown to take a stable helical conformation even in pure water. In the reversed micelles, however, this ordered structure is significantly changed probably because the hydrophobic interaction among the leucyl residues is lowered in the reversed micelles.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 8
    ISSN: 1435-1536
    Keywords: Controlled release of drug ; capsule ; poly(α amino acid)s ; membrane
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract The release behavior of a water-soluble drug through membranes made of poly(L-leucine) and its copolymer with different hydrophilic properties was studied. The effect of casting methods on the release rate was also investigated. It was found that the membrane with a higher hydrophilic property resulted in a higher permeation rate. The capsule was prepared as a composite sheet from a poly(L-leucine)-prednisolone 21-sodium succinate sponge and a poly(L-leucine) membrane. Release of the water-soluble drug from the capsule was found to be effectively governed by the hydrophilic character and thickness of the outer membrane. Biocompatibility studies carried out by implanting the poly(L-leucine) sponge subcutaneously in the dorsal surface of the rat showed that the sponge had a good biocompatibility and slow biodegradation. It was concluded from these results that poly(L-leucine) should be a suitable material for preparing a controlledrelease drug device for long-term dosage.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Colloid & polymer science 260 (1982), S. 460-460 
    ISSN: 1435-1536
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 10
    ISSN: 1435-1536
    Keywords: Copoly (N 5-ω-hydroxyalkyl-L-glutamine-L-glutamic acid) ; Solvent-induced conformational change ; pH-induced conformational change
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract Copoly (α-amino acid)s consisting ofL-glutamic acid residue andN 5-ω hydroxyalkyl-L-glutamine residue, i.e., 2-hydroxyethyl, 3-hydroxypropyl, and di-2-hydroxyethyl derivatives were prepared by the reactions of copoly (L-glutamic acid) containing succinimide ester with corresponding amino alcohols. The conformation of these copolymers was examined by the CD and infrared measurements. These three copolymers containing about 20–30% hydroxyalkyl groups undergo a methanol-induced and a pH-induced conformational transitions. The copolymer containing about 50% 3-hydroxypropyl group assumes the α-helical conformation in the pH region from 2.5 to 11.6, and in a methanol-water mixture (9∶1). On the other hand, the copolymer containing about 60% di-2-hydroxyethyl groups does not allow any helical conformation even at lower pH and also even in a trifluoroethanol-water mixture (9∶1), suggesting that the branched hydroxyalkyl group is unfavorable for the formation of α-helix. Furthermore, the poly(N 5-di-2-hydroxyethyl-L-glutamine) is shown to have a rather disordered structure in the solid state.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...