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  • 1
    Keywords: IN-VIVO ; TUMORS ; SUPPRESSION ; SPECTROSCOPY ; Coherence ; SEL-MQC ; SINGLE-SCAN ; RESONANCES
    Abstract: Selective detection of lactate signals in in vivo MR spectroscopy with spectral editing techniques is necessary in situations where strong lipid or signals from other molecules overlap the desired lactate resonance in the spectrum. Several pulse sequences have been proposed for this task. The double-quantum filter SSel-MQC provides very good lipid and water signal suppression in a single scan. As a major drawback, it suffers from significant signal loss due to incomplete refocussing in situations where long evolution periods are required. Here we present a refocused version of the SSel-MQC technique that uses only one additional refocussing pulse and regains the full refocused lactate signal at the end of the sequence.
    Type of Publication: Journal article published
    PubMed ID: 25909643
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  • 2
    ISSN: 0305-0491
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1432-1130
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Structural and elemental investigations of aquatic humic substances (HS) by means of X-ray photoelectron spectroscopy (XPS) are described. For that purpose small amounts (10–50 μg) of dissolved reference HS, which were characterized within the German research program DFG-ROSIG, were dried as thin films on small pieces of a high-purity silicon wafer. The photoelectrons from such HS layers exhibited characteristic signals of carbon C1s, nitrogen N1s, oxygen O1s and sulfur S2s, which could be fitted by Gaussian curves and used for the quantification of various moieties of HS: carbon (C-C, C-O, C=O, O=C-O), oxygen (C-O, C=O), nitrogen (C-N, C-N+) and sulfur. Moreover, by adding up the element signals of the HS samples their elemental composition of C, O, N and S was assessed. A comparison of the data based on solution state NMR and conventional elementary analysis revealed a satisfactory accuracy with those obtained by XPS.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    ISSN: 1432-1068
    Keywords: Infection ; Knee-hip ; Avascular necrosis ; Infection ; Genou ; Hanche ; Ostéonécrose ; aseptique
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé Dans un monde idéal, la plupart des jeunes gens devraient pouvoir vivre heureux, faire le métier qu'ils aiment, avoir une vie de couple et des enfants s'ils le désirent, mais certains n'ont pas cette chance et passent une bonne partie de leur existence dans les hôpitaux pour y subir des traitements pénibles. L'auteur raconte le cas malheureux, qu'il a personnellement vécu, d'un homme jeune chez qui la maladie s'est acharnée et qui présente de multiples complications dues à sa pathologie ou aux différents traitements médicaux. Mots-dès: Infection - Genou - Hanche - Ostéonécrose aseptique
    Notes: Summary In a perfect world, most young people should be able to be happy, do a job they love and have a spouse and kids if they so desire but some are denied that chance and spend a large part of their live in hospitals going through very difficult treatments. The author personally recalls the unhappy story of a young man relentlessly attacked by illness and who presents numerous complications due to his pathology and its different medical treatments
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1432-1130
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Two-dimensional heteronuclear multiple quantum coherence (HMQC) 1H-NMR was successfully applied to structural investigations of aquatic humic substance (HS) fractions obtained from multistage ultrafiltration (MST-UF) of a selected bog water HS (HO13-XAD8, German Research Program DFG-ROSIG). Details of the HMQC 1H-NMR novel in HS characterization are presented. The results of the combined procedure point out that structural units in isolated HS can be enriched in different mass fractions, for instance fatty acids in the fraction 〈1kDa, amino acids in the 10–50 kDa fraction and methyl groups attached to quaternary carbon atoms in the high molecular mass fraction 〉50 kDa.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary A case of 18q- syndrome due to a de novo tdic(14p;18q) is presented. The interest of this observation lies in the rarity of stable dicentric chromosomes arising from reciprocal translocations between autosomes.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1432-1106
    Keywords: Organotypic slice culture ; 5,7-Dihydroxytryptamine ; Dopaminergic neurones ; Ventral mesencephalon ; Substantia nigra ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The aim of the present study was to characterize electrophysiologically neurones in organotypic cultures of the rat ventral mesencephalon and to compare these results with results published for the same neurones in other types of preparation. Intracellular recordings were obtained in 3- to 8-week-old organotypic slice cultures of the ventral mesencephalon prepared from newborn rats. Dopaminergic neurones were distinguished from non-dopaminergic neurones by staining with the autofluorescent serotonin analogue 5,7-dihydroxytryptamine and briefly viewing the preparation with short exposures to ultraviolet (UV) light (365 nm). Short exposures to UV light did not affect the electrophysiological properties. There were no significant differences between dopaminergic and non-dopaminergic neurones with regard to resting membrane potential or action potential threshold and amplitude, and in both types of neurone spontaneous burst activity and glutamatergic excitatory postsynaptic potentials were seen. There were differences in the following parameters, which can be used to distinguish between the two types of neurone. Dopaminergic neurones had broad action potentials (2–9 ms), high input resistance (mean 81 MΩ), were silent or fired spontaneously at a low frequency (0–9 Hz), and no spontaneous GABAA-ergic inhibitory postsynaptic potentials or inward rectification were present. In contrast, non-dopaminergic neurones had fast action potentials (0.6–3.2 ms), low input resistance (mean 32 MΩ), were silent or fired spontaneously at relatively high firing frequency (0–28 Hz), and sometimes inhibitory postsynaptic potentials and inward rectification were seen. In the presence of 1 μM tetrodotoxin and 10 mM tetraethylammonium, Ca2+ spikes could be evoked in both dopaminergic and non-dopaminergic neurones. Dopaminergic neurones in 3- to 8-week-old organotypic slice cultures have a number of distinguishing electrophysiological characteristics similar to those recorded in other types of acute or cultured preparations. However, some intrinsic regulatory mechanisms, namely the slow oscillatory potentials, inward rectification and the K+ current, I A, seem to be missing in the cultured neurones.
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Two cases of newborn male infants afflicted with trisomy 18 and with signs of arthrogryposis multiplex congenita (AMC) are described. Anomalies occurring in most cases of trisomy 18 such as polyhydramnios, reduced foetal activity, and skeletal muscle hypoplasia decrease articular movements and, thus, might cause AMC. Since AMC is rarely associated with trisomy 18, chromosomal aberration is not the only factor involved in these cases.
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 1432-1254
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geography , Physics
    Notes: Abstract The investigation showed that positive and negative air ions have opposite general effects on the structure of sleep in rats. When submitted to positive air ions, the animals consecutively exhibited during sleep an EEG with increased amplitude and lowered frequency. This decrease in vigilance level is nevertheless accompanied by obvious signs of a disturbed sleep, that is: more polyphasic sleep and decrease of slow wave sleep which is the most efficient for physical restoration. The generally opposite action of negative air ions is consistent with their effects described by other authors who have studied human sleep after aeroionotherapy. The general paradigm of air ion action on sleep is in agreement with implications of recent sleep theories.
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 1432-1106
    Keywords: Entorhinal cortex ; Dentate gyrus ; Excitatory amino acids ; Epileptiform activity ; Simultaneous intra-cellular recording ; Rats
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The relationship between epileptiform events in the medial entorhinal cortex (MEC) and the dentate gyrus was investigated using a slice preparation from rat brain. Simultaneous intracellular recordings were made from neurones in layer II of the MEC and neurones in the granule cell layer of the dentate gyrus (DGC). Epileptiform activity was induced by perfusion with Mg++-free medium or GABAA-receptor blockers. Epileptiform discharges in MEC cells were reflected on a one-to-one basis and at a latency of 1–3 ms by depolarizing events in DGC. The latter rarely gave rise to action potentials. Bath perfusion of the N-methyl-D-aspartate (NMDA) receptor blocker, 2-aminophosphonovalerate (2-AP5) abolished the Mg++-free induced events in MEC cells and the corresponding depolarizations in the DGC but local application of 2-AP5 to the dentate gyrus only reduced the depolarizations. The non-NMDA-receptor antagonist 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX), whether bath applied or applied locally to the DG, had little effect on the cortical events but strongly reduced the depolarizations of the DGC. The discharges induced in MEC cells by GABA-blockers were reduced by bath applied 2-AP5 but abolished by CNQX. These effects were mirrored in the dentate gyrus by a reduction in the depolarizing events by 2-AP5 and their abolition by CNQX. Local application of either antagonist to the dentate gyrus reduced but did not abolish the depolarizations. Thus, Mg++-free induced events in MEC depend mainly on enhanced NMDA-receptor activity, while events induced by bicuculline are primarily dependant on non-NMDA receptors. The depolarizing events in the DGC which reflect the activity in the EC are mediated by both types of receptor, although non-NMDA receptors play a much greater role.
    Type of Medium: Electronic Resource
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