Description / Table of Contents:
Anatomy and physiology of the blood-brain barriers -- Recent Progress in Blood-Brain Barrier and Blood-CSF Barrier Transport Research: Pharmaceutical Relevance for Drug Delivery to the Brain -- Blood-Brain Barrier (BBB) Pharmacoproteomics: A New Research Field Opened up by Quantitative Targeted Absolute Proteomics (QTAP) -- Drug Metabolism at the Blood-Brain and Blood-CSF Barriers -- Pharmacokinetic Concepts in Brain Drug Delivery -- In vitro models of blood-brain barriers -- In situ and in vivo animal models -- Principles of PET and its Role in Understanding Drug Delivery to the Brain -- PKPD Aspects of Brain Drug Delivery in a Translational Perspective -- Drug Discovery Methods for Studying Brain Drug Delivery and Distribution -- Prediction of Drug Exposure in the Brain from the Chemical Structure -- Integrated Approach to Optimizing CNS Penetration in Drug Discovery: From the old to the new Paradigm and Assessment of Drug-Transporter Interactions -- Pharmacoeconomic Considerations in CNS Drug Development -- Intranasal Drug Delivery to the Brain -- Blood-To-Brain Drug Delivery using Nanocarriers -- Development of new Protein Vectors for the Physiologic Delivery of Large Therapeutic Compounds to the CNS- CNS Gene Therapy Utilizing Intravenously Administered Viral Vectors -- Neurosurgical Approaches: Drug Infusion Directly into the Parenchyma or Cerebrospinal Fluid -- Osmotic Opening of the BBB for Drug Treatment of Brain Tumors (Focus on Methodological Issues) -- Emerging Engineering Technologies for Opening the BBB -- Disease Influence on BBB Transport in Inflammatory Disorders -- Disease Influence on BBB Transport in Neurodegenerative Disorders -- Drug Delivery in the Context of Stroke and Brain Trauma -- Which Drug or Drug Delivery Method can change Clinical Practice for Brain Tumor Therapy?
This book describes the different approaches for drug delivery to the brain with an emphasis on the physiology of the blood-brain barrier (BBB) and the governing principles and concepts for drug delivery across the BBB. It contains cutting-edge methods for studying drug delivery and administering drugs into the brain. The book also explores different approaches for predicting human brain concentrations as well as the influence of disease and drug industry perspectives. In addition to wide-ranging coverage of physiological concepts relevant to central nervous system (CNS) drug delivery, a detailed review of brain structure, function, blood supply and fluids is also provided. In each chapter, descriptions of future challenges and unresolved questions are combined with points for discussion. This unique combination of material makes this book a valuable resource for students and for established academic and industry scientists looking to learn about state-of-the-art drug delivery research. It is also a source for stimulating new ideas among experts already performing CNS drug delivery research or working in related areas. ℗ Margareta Hammarlund-Udenaes (Ph.D.) is a Professor in Pharmacokinetics and Pharmacodynamics (PK/PD) at Uppsala University and the Head of the Translational PK/PD Group. Her research is focused on studying pharmacokinetic aspects of BBB transport of drugs in relation to CNS effects, and it has led to the development of new concepts and methods within the BBB transport area, focusing on unbound drug relationships. ℗ Elizabeth C.M. de Lange (Ph.D.) is Head of the Target Site Equilibration Group at the Division of Pharmacology of the Leiden Academic Center for Drug Research (LACDR).℗ Her research program focuses on the development of generally applicable predictive PK/PD models on CNS drugs using advanced in vivo animal models and mathematical modeling techniques, with a number of recent successes. ℗ Robert G. Thorne (Ph.D.) is an Assistant Professor in Pharmaceutical Sciences at the University of Wisconsin-Madison School of Pharmacy. He was previously a research scientist and faculty member in the Department of Physiology & Neuroscience at the New York University School of Medicine. His research focuses on diffusive and convective transport within the CNS and the development, refinement and optimization of strategies for delivering biologics into the brain
XX, 731 p. 150 illus., 126 illus. in color. : online resource.