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  • 1
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    German Medical Science GMS Publishing House; Düsseldorf
    In:  GMS Medizin - Bibliothek - Information; VOL: 16; DOC07 /20160923/
    Publication Date: 2016-09-23
    Description: To update the ordering process for interlibrary loan we want to reach the following: short and easy ways from research to literature for our users professional tool for order processing with research options and administration of suppliers for the library team The poster illustrates the ordering process, the implementation, the result and the benefits of the new system.
    Description: Mit der Überarbeitung der Bestellprozesse für die Aus- und Fernleihe wollten wir Folgendes erreichen: einen kurzen und direkten Weg von der Recherche bis zur Literatur für unsere Nutzer ein professionelles Tool zur Bestellabwicklung mit erweiterten Recherchemöglichkeiten und Lieferantenverwaltung für das Bibliotheksteam Im Poster werden der Bestellprozess, die Umsetzung, das Ergebnis und die Vorteile des entstandenen Systems dargestellt.
    Keywords: interlibrary loan ; ordering of literature ; ordering process ; medical library ; optimized workflow ; annual meeting of AGMB 2015 ; Aus- und Fernleihe ; Literaturbestellung ; Bestellprozess ; optimierte Arbeitsabläufe ; Medizinbibliothek ; AGMB-Jahrestagung 2015 ; ddc: 610
    Language: German
    Type: article
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  • 2
    ISSN: 1432-5233
    Keywords: Non-obese-diabetic (NOD) mouse ; High protein diet ; Insulin secretion ; Perfusion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Diet modifies the development of insulin-dependent diabetes mellitus in animals and in humans. We examined female non-obese-diabetic (NOD) mice, a diabetes-prone mouse strain with 70% spontaneous diabetes incidence and metabolic abnormalities in non-overtly diabetic litters. They were fed a diet containing 55% (n=27) or 15% (n=26) protein, respectively, after weaning. At an age of 30 weeks, non-diabetic NOD mice were submitted to an intravenous glucose tolerance test (0.5 g/kg body weight; blood samples were taken after 2, 4, 8, 10, 15, 20 and 30 min) and to perfusion of the pancreas (stimulation media were Krebs-Ringer-Hepes buffer with 5 mmol/l glucose, 30 mmol/l glucose and 5 mmol/l glucose plus 19 mmol/l arginine). Diabetic mice were removed from the experiment. Serum glucose concentration and body weight were monitored weekly. Food ingestion was checked at an age of 11 weeks. On average, the onset of diabetes was diagnosed in mice on a high-protein diet (19.7±1.3 weeks) 4 weeks earlier than in mice on a low-protein diet (23.5±1.1 weeks;P〈0.05). Non-diabetic NOD mice on a high-protein diet showed significantly better glucose tolerance (as determined by the glucose disappearance rate) and mean insulin secretion (at 30 mmol/l glucose). No difference in the serum glucose concentration between non-diabetic mice on the low-protein diet or high-protein diet could be proved. In non-diabetic mice on the high-protein diet the body weight and food ingestion exceeded those of mice on the low-protein diet (P〈0.05). High insulin secretion and glucose tolerance in non-diabetic mice may reflect the capacity of beta-cells to adapt; however, beta-cells tend to be destroyed under such circumstances. Thus, a high-protein diet promoted the onset of diabetes, but it did not increase significantly the incidence of the disease.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1432-5233
    Keywords: Key words Non-obese-diabetic (NOD) mouse ; High protein diet ; Insulin secretion ; Perfusion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Diet modifies the development of insulin-dependent diabetes mellitus in animals and in humans. We examined female non-obese-diabetic (NOD) mice, a diabetes-prone mouse strain with 70% spontaneous diabetes incidence and metabolic abnormalities in non-overtly diabetic litters. They were fed a diet containing 55% (n=27) or 15% (n=26) protein, respectively, after weaning. At an age of 30 weeks, non-diabetic NOD mice were submitted to an intravenous glucose tolerance test (0.5 g/kg body weight; blood samples were taken after 2, 4, 8, 10, 15, 20 and 30 min) and to perfusion of the pancreas (stimulation media were Krebs-Ringer-Hepes buffer with 5 mmol/l glucose, 30 mmol/l glucose and 5 mmol/l glucose plus 19 mmol/l arginine). Diabetic mice were removed from the experiment. Serum glucose concentration and body weight were monitored weekly. Food ingestion was checked at an age of 11 weeks. On average, the onset of diabetes was diagnosed in mice on a high-protein diet (19.7±1.3 weeks) 4 weeks earlier than in mice on a low-protein diet (23.5±1.1 weeks; P〈0.05). Non-diabetic NOD mice on a high-protein diet showed significantly better glucose tolerance (as determined by the glucose disappearance rate) and mean insulin secretion (at 30 mmol/l glucose). No difference in the serum glucose concentration between non-diabetic mice on the low-protein diet or high-protein diet could be proved. In non-diabetic mice on the high-protein diet the body weight and food ingestion exceeded those of mice on the low-protein diet (P〈0.05). High insulin secretion and glucose tolerance in non-diabetic mice may reflect the capacity of beta-cells to adapt; however, beta-cells tend to be destroyed under such circumstances. Thus, a high-protein diet promoted the onset of diabetes, but it did not increase significantly the incidence of the disease.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1433-8580
    Keywords: Insulin ; Intestinal hormones ; Atropine ; Vagus ; Insulin ; Intestinale Hormone ; Atropin ; Vagus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung und Schluβfolgerung Bei 35 stoffwechselgesunden freiwilligen Probanden wurde vor sowie nach Atropingabe die Wirkung der intestinalen Hormone Sekretin und Cholecystokinin-Pankreozymin (CCK-PZ) auf die endokrine und exokrine Pankreasfunktion untersucht. Außerdem wurde die Wirkung von intravenös und oral bzw. intraduodenal verabreichter Glucose und Aminosäuren auf die Insulinsekretion, den Blutzucker und die freien Fettsäuren ebenfalls vor und nach Atropinmedikation geprüft. Intravenös verabreichtes Sekretin konnte weder in seiner exokrinen noch endokrinen Pankreasfunktion durch Atropin beeinflußt werden. Intravenös injiziertes CCK-PZ konnte mittels Atropin sowohl in seiner ekbolischen wie auch endokrinen Pankreasfunktion gehemmt werden. Die Wirkung von CCK-PZ ist somit an ein cholinerges System gebunden, so daß es erlaubt erscheint, bezüglich der Pankreozyminwirkung von einem synergistisch bzw. additiv wirksam werdenden „neurohormonalen“ Mechanismus zu sprechen. Die durch parenteral verabreichte Glucose oder Aminosäuren induzierte Insulinsekretion wurde durch Atropin nicht beeinflußt; hingegen hemmte Atropin dieβ-cytotrope Wirkung von oral bzw. intraduodenal verabreichter Glucose oder Aminosäuren. Dies läßt auf eine Abhängigkeit von einem cholinergen oder parasympathischen System in der Freisetzung dieser intestinalen Hormone schließen.
    Notes: Summary and Conclusions In 35 metabolically normal subjects the effect of i.v. secretin and cholecystokinin-pancreozymin (CCK/PZ) on the endocrine and exocrine pancreatic function was investigated, before and after atropine. In addition, the effect of oral, intravenous and intraduodenal administration of glucose and amino acids on blood sugar and free fatty acids before and after the injection of atropine was studied. The secretin stimulated endocrine and exocrine pancreas was not affected by atropine. However, atropine inhibited the ecbolic and endocrine pancreatic function after stimulation with CCK/PZ. Therefore, the effect of i.v. CCK/PZ seems to be mediated by the cholinergic system, or even a “neuro-hormonal” system which acts synergically or additively. No influence of atropine on the insulin secretion induced by i.v. glucose or amino acids was observed. On the other hand, atropine inhibited the beta-cytotropic effect of glucose and amino acids after oral or intraduodenal administration. These findings indicate that the release of these intestinal hormones is dependent on the cholinergic or parasympathetic system.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1432-0428
    Keywords: Sucrose ; increased body fat ; isolated perfused pancreas ; dynamics of insulin secretion ; hyperinsulinism ; insulin biosynthesis ; isolated islets of Langerhans
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Long term feeding of a sucrose rich diet to rats is accompanied by a decreased glucose assimilation rate, despite high plasma insulin levels. Hyperinsulinism is at least partially based on a relative obesity, with increased amounts of abdominal- and retroperitoneal fat tissue, but unchanged total body weight compared to starch fed controls. The secretory pattern of insulin release was studied following glucose, arginine, fructose and sulfonylurea administration in the isolated perfused pancreas of sucrose and isocaloric starch fed rats. In addition, isolated islets of Langerhans were used to demonstrate the effects of glucose on insulin secretion and the incorporation of H-3 leucine into the proinsulin and insulin fraction of islet proteins. Following 11 mM glucose, the dynamics of insulin release in the isolated perfused pancreas of sucrose fed rats is characterized by a markedly elevated, late plateau-like response, usually seen only at higher glucose concentrations. Hyperinsulinism, as compared to starch fed controls, can also be demonstrated following arginine and the sulfonylurea HB-419, whereas fructose has no effect in the presence of low glucose concentrations. During incubation of the pancreatic islets, the hyperinsulinism in sucrose-, compared to starch fed rats, is more pronounced at 11 mM glucose than at 5.5 mM glucose. The incorporation of H-3 leucine into the proinsulin-insulin fraction of islet proteins in sucrose compared to starch fed rats, however, is significantly greater with glucose 5.5 mM than at high glucose level. In sucrose fed rats, secretion and biosynthesis of insulin thus appear to be elevated but closely linked only at physiological glucose concentration.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1432-0428
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1432-0428
    Keywords: Diabetic mice ; isolated perfused pancreas ; high insulin levels ; hyperglucagonemia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Diabetes mellitus is held to be accompanied by inappropriately high levels of plasma glucagon relative to blood glucose concentrations. This has been interpreted as indicating lack of insulin. To establish glucagon release in presence of high levels of endogenous insulin, the effects of both glucose and arginine were studied in the isolated perfused pancreas of genetically diabetic mice (db/db). Stimulation with glucose 2.75 mM or glucose plus arginine 8.25 mM exhibited a pronounced hyperglucagonemia. Following glucose 8.25 mM, however, there was no depression of glucagon secretion. Despite excessive high levels of endogenous insulin, there was a pattern of rather non-suppressible glucagon release. Lack of insulin per se, therefore, is unlikely to be the sole cause of hyperglucagonemia in this type of genetic animal diabetes mellitus.
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 0014-5793
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 1432-1440
    Keywords: Sucrose ; hyperinsulinemia ; glucose tolerance ; gastrointestinal factor ; Rohrzucker ; Hyperinsulinismus ; Glucoseassimilation ; gastrointestinale Faktoren
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Widersprüchliche Befunde in der Literatur ließen bisher keine Klarheit zu, inwieweit verschiedene Kohlenhydratformen einen unterschiedlichen Einfluß auf die Glucoseassimilation und Insulinsekretion haben. Bei Anwendung einer standardisierten isocalorischen Rohrzucker- bzw. Reisstärkediät wurden deshalb bei Ratten Glucosebelastungen durchgeführt und Blutzucker sowie Seruminsulin gemessen. Nach Rohrzuckerfütterung entsteht ein Hyperinsulinismus, der postprandial, besonders aber bei i.v. und peroraler Glucosegabe deutlich wird. Die Glucoseassimilation ist jedoch nur nach i.v. Belastung beschleunigt. Nach peroraler Glucosegabe besteht trotz Hyperinsulinismus ein verzögerter Schwund der Blutglucose. Dies tritt besonders deutlich bei einer Glucosebelastung des abgebundenen Duodenums hervor. Aus den vorliegenden Befunden muß eine gesteigerte insulinotrope Wirkung, eine beschleunigte Resorption aus dem Duodenum sowie ein durch Rohrzucker induzierbarer Duodenalfaktor als Ursache de gesteigerten Insulinsekretion nach Rohrzucker angenommen werden. Die verminderte Glucoseassimilation nach peroraler Belastung ist wahrscheinlich durch eine gesteigerte Glucagonsekretion bedingt.
    Notes: Summary Increase of diabetes mellitus and obesity following high caloric intake has shown to be an alarming symptom of our affluent society. Similar effects, however, can be mimicked by a dietary change from starch to sucrose-rich food without increasing caloric intake. Yet studies regarding this phenomenon have resulted in conflicting conclusions. The present experiments were therefore designed to gather more data on this subject, by applying an isocaloric starch or sucrose-rich diet in rats. Their effects on blood sugar and serum insulin should be examined in fasting and postprandial state and following I.V.G.T.T. In addition, separate parts of the upper gastro-intestinal tract were loaded with glucose. After sucrose feeding there is marked hyperinsulinemia following oral or intravenous tolerance tests. The glucose disappearance rate is only increased following I.V.G.T.T. Peroral and duodenal glucose load, however, decrease the disappearance rate. There seems to be good evidence that prolonged sucrose feeding in rats has a direct insulinotropic effect. In addition, some as yet unknown factor in the duodenal mucosa might be activated, contributing efficiently to hyperinsulinemia and possibly hyperglucagonemia.
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