Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Abstract: BACKGROUND: Clock genes govern circadian rhythms and shape the effect of alcohol use on the physiological system. Exposure to severe negative life events is related to both heavy drinking and disturbed circadian rhythmicity. The aim of this study was 1) to extend previous findings suggesting an association of a haplotype tagging single nucleotide polymorphism of PER2 gene with drinking patterns, and 2) to examine a possible role for an interaction of this gene with life stress in hazardous drinking. METHODS: Data were collected as part of an epidemiological cohort study on the outcome of early risk factors followed since birth. At age 19 years, 268 young adults (126 males, 142 females) were genotyped for PER2 rs56013859 and were administered a 45-day alcohol timeline follow-back interview and the Alcohol Use Disorders Identification Test (AUDIT). Life stress was assessed as the number of severe negative life events during the past four years reported in a questionnaire and validated by interview. RESULTS: Individuals with the minor G allele of rs56013859 were found to be less engaged in alcohol use, drinking at only 72% of the days compared to homozygotes for the major A allele. Moreover, among regular drinkers, a gene x environment interaction emerged (p = .020). While no effects of genotype appeared under conditions of low stress, carriers of the G allele exhibited less hazardous drinking than those homozygous for the A allele when exposed to high stress. CONCLUSIONS: These findings may suggest a role of the circadian rhythm gene PER2 in both the drinking patterns of young adults and in moderating the impact of severe life stress on hazardous drinking in experienced alcohol users. However, in light of the likely burden of multiple tests, the nature of the measures used and the nominal evidence of interaction, replication is needed before drawing firm conclusions.
    Type of Publication: Journal article published
    PubMed ID: 23533602
    Signatur Availability
    BibTip Others were also interested in ...
  • 2
    Keywords: RECEPTOR ; human ; MODEL ; MODELS ; EXPOSURE ; RISK ; GENE ; TIME ; PATIENT ; ASSOCIATION ; FREQUENCY ; polymorphism ; POLYMORPHISMS ; single nucleotide polymorphism ; PATTERNS ; STRESS-RESPONSE ; DNA-BINDING ; ethanol ; INDIVIDUALS ; ALCOHOL ; CHILDREN ; PREVALENCE ; ALCOHOL-CONSUMPTION ; CONSUMPTION ; ENHANCER ; DISORDERS ; ADULTS ; DEPENDENCE ; MICE LACKING ; haplotype-tagging ; alcohol consumption ; animal model ; HORMONE-RECEPTOR ; TRANSCRIPTION FACTOR SP1 ; ADOLESCENTS ; AFFECTIVE-DISORDERS ; CORTICOTROPIN-RELEASING-FACTOR ; EARLY ADULTHOOD ; HPA-axis
    Abstract: To investigate the role of the corticotropin releasing hormone receptor 1 (CRHR1) in patterns of human alcohol drinking and its potential contribution to alcohol dependence, we analysed two independent samples: a sample of adolescents, which consisted of individuals from the 'Mannheim Study of Risk Children' (MARC), who had little previous exposure to alcohol, and a sample of alcohol-dependent adults, who met DSM-IV criteria of alcohol dependence. Following determination of allelic frequencies of 14 polymorphisms of the CRHR1 gene, two haplotype tagging (ht)SNPs discriminating between haplotypes with a frequency of 〉= 0.7% were identified. Both samples were genotyped and systematically examined for association with the htSNPs of CRHR1. In the adolescent sample, significant group differences between genotypes were observed in binge drinking, lifetime prevalence of alcohol intake and lifetime prevalence of drunkenness. The sample of adult alcohol-dependent patients showed association of CRHR1 with high amount of drinking. This is the first time that an association of CRHR1 with specific patterns of alcohol consumption has been reported. Our findings support results from animal models, suggesting an importance of CRHR1 in integrating gene environment effects in alcohol use disorders
    Type of Publication: Journal article published
    PubMed ID: 16550213
    Signatur Availability
    BibTip Others were also interested in ...
  • 3
    ISSN: 1435-165X
    Keywords: Key words Specific speech articulation disorder – expressive language disorder – receptive language disorder – specific reading disorder – specific spelling disorder
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Data from a prospective longitudinal study on the development of children born at biological and psychosocial risk were utilised to examine language and learning abilities of 320 children at ages 4.5 and 8 years. Following the research criteria of the ICD-10, specific developmental disorders of speech and language and specific developmental disorders of scholastic skills were diagnosed. Data were also provided for a clinical and general low achievement group according to less stringent criteria. Frequencies in the risk population were low for specific disorders (ICD-10) (0.6%–3.7% depending on age and type of disorder). Higher frequencies were found when a clinical definition (0.6%–13.6%) or overall low achievement score (0.6%–18.6%) was chosen. The impact of well-documented organic and psychosocial risks was analysed. Organic risk affected language abilities at 4.5 years of age but neither language nor learning abilities at 8 years of age. Psychosocial aspects of a child's environment proved to be associated with both specific language and learning abilities. Stability of language disorders, association between language and reading/spelling disorders as well as gender effects were investigated.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 4
    Publication Date: 2018-10-31
    Description: Integrated silicon qubit platform with single-spin addressability, exchange control and single-shot singlet-triplet readout Integrated silicon qubit platform with single-spin addressability, exchange control and single-shot singlet-triplet readout, Published online: 30 October 2018; doi:10.1038/s41467-018-06039-x Significant progress has been made developing the different methods needed for a spin-based quantum computer but the challenge of integrating them remains. Fogarty et al. present a system with single-spin addressability, spin-spin interactions and high-fidelity readout that provides a scalable foundation for error-corrected devices.
    Electronic ISSN: 2041-1723
    Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics
    Signatur Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...