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  • 1
    Electronic Resource
    Electronic Resource
    [s.l.] : Macmillan Magazines Ltd.
    Nature 389 (1997), S. 706-709 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The preparation of synthetic molecules showing the remarkable efficiencies characteristic of natural biopolymer catalysts remains a formidable challenge for chemical biology. Although significant advances have been made in the understanding of protein structure and function, the de novo ...
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    [s.l.] : Macmillan Magazines Ltd.
    Nature 390 (1997), S. 591-594 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Symbiosis is an association between different organisms that leads to a reciprocal enhancement of their ability to survive. Similar mutually beneficial relationships can operate at the molecular level in the form of a hypercycle, a collective of two or more self-replicating species interlinked ...
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 382 (1996), S. 525-528 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] An autocatalytic process in which the reaction product serves as the specific catalyst for its own synthesis by recognizing and promoting coupling of reactant(s) is the most basic form of molecular self-replication (Fig. 1). A few examples of non-enzymatic template-directed autocatalytic systems ...
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  • 4
    ISSN: 0947-6539
    Keywords: autocatalysis ; coiled coil ; kinetics ; peptides ; self-replication ; Chemistry ; General Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: A 32-residue α-helical peptide with a sequence similiar to that of the GCN4 leucine zipper region is shown to catalyze its own formation by accelerating the amide bond formation of a 17-residue peptide, preactivated as a thiobenzyl ester, and a 15-residue peptide with a N-terminal cysteine. The self-replication process displays parabolic growth characteristics as revealed by a detailed kinetic analysis. Control reactions with single-mutant peptides strongly support a mechanism in which a ternary and/or quaternary complex of the product with both peptide fragments act(s) as the catalytically active intermediate(s). Furthermore, these experiments reveal a remarkable sequence selectivity, as evidenced by the loss of autocatalytic activity as a result of a single replacement of leucine or valine residues with an alanine at the recognition interface.
    Additional Material: 11 Ill.
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  • 5
    ISSN: 1573-2568
    Keywords: HEPATITIS C ; MORBIDITY
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We studied the morbidity of chronic hepatitis Cin patients referred to a tertiary care medicalfacility. The medical records of 500 consecutive casesof chronic hepatitis C were examined for the following: (1) source and time of exposure, (2) signs andsymptoms of liver disease, (3) degree of alcohol intake,(4) liver biopsy findings, (5) extrahepatic diseasemanifestations, and (6) coexisting illnesses that could have an impact on morbidity. Morbidityand histologic findings were evaluated in relation tothe duration of hepatitis C. The onset of infectioncould be determined in 376 patients (75%). A close relationship between the length of infectionand disease features was not observed. Fatigue wascommon at all stages of infection. Whereas cirrhosisoccurred more frequently in patients with disease of long duration, 15-24% of patients had signs ofadvanced liver disease (ascites, encephalopathy,thrombocytopenia) within six years of exposure. Overtextrahepatic manifestations of chronic hepatitis Coccurred infrequently, and depression was reported in24% of untreated patients. In conclusion, in patientsreferred to a tertiary care setting, chronic hepatitisC is often associated with significantmorbidity.
    Type of Medium: Electronic Resource
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