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  • 1
    Keywords: COMBINATION ; MODEL ; MODELS ; FOLLOW-UP ; INFORMATION ; DISEASE ; DISEASES ; RISK ; HEART ; TIME ; MARKER ; ASSOCIATION ; ASSAY ; DESIGN ; PLASMA ; NUMBER ; AGE ; meta-analysis ; smoking ; DATABASE ; C-REACTIVE PROTEIN ; MYOCARDIAL-INFARCTION ; HEART-DISEASE ; vascular disease ; REGRESSION ; ASSOCIATIONS ; ISCHEMIC-STROKE ; CORONARY-HEART-DISEASE ; METAANALYSIS ; LEVEL ; methods ; EXTENT ; ARTERY-DISEASE ; MIDDLE-AGED MEN ; ACTIVATING-FACTOR-ACETYLHYDROLASE ; ATHEROSCLEROSIS RISK ; lipoprotein-associated phospholipase A(2) ; LIPOPROTEIN-ASSOCIATED PHOSPHOLIPASE-A2 ; REPEAT
    Abstract: Background A large number of observational epidemiological studies have reported generally positive associations' between circulating mass and activity levels of lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) and the risk of cardiovascular diseases. Few studies have been large enough to provide reliable estimates in different circumstances, such as in different subgroups (e.g., by age group, sex, or smoking status) or at different Lp-PLA2 levels. Moreover, most published studies have related disease risk only to baseline values of Lp-PLA(2) markers (which can lead to substantial underestimation of any risk relationships because of within-person variability over time) and have used different approaches to adjustment for possible confounding factors. Objectives By combination of data from individual participants from all relevant observational studies in a systematic,meta-analysis, with correction for regression dilution (using available data on serial measurements of Lp-PLA(2)), the Lp-PLA(2) Studies Collaboration will aim to characterize more precisely than has previously been possible the strength and shape of the age and sex-specific associations of plasma Lp-PLA(2) with coronary heart disease (and, where data are sufficient with other vascular diseases, such as ischaemic stroke). It will also help to determine to what extent such associations are independent of possible confounding factors and to explore potential sources of heterogeneity among studies, such as those related to assay methods and study design. It is anticipated that the present collaboration will serve as a framework to investigate related questions on Lp-PLA(2) and cardiovascular outcomes. Methods A central database is being established containing data on circulating Lp-PLA(2) values, sex and other potential confounding factors, age at baseline Lp-PLA(2) Measurement, age at event or at last follow-up, major vascular morbidity and cause-specific mortality. Information about any repeat measurements of Lp-PLA2 and potential confounding factors has been sought to allow adjustment for possible confounding and correction for regression dilution. The analyses will involve age-specific regression models. Synthesis of the available observational studies of Lp-PLA(2) will yield information on a total of about 15 000 cardiovascular disease endpoints
    Type of Publication: Journal article published
    PubMed ID: 17301621
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Cluster computing 3 (2000), S. 215-230 
    ISSN: 1573-7543
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science
    Notes: Abstract Ring networks are enjoying renewed interest as Storage Area Networks (SANs), i.e., networks for interconnecting storage devices (e.g., disk, disk arrays and tape drives) and storage data clients. This paper addresses the problem of fairness in ring networks with spatial reuse operating under dynamic traffic scenarios. To this end, in the first part of the paper the Max-Min fairness definition is extended to dynamic traffic scenarios and an algorithm for computing Max-Min fair rates in a dynamic environment is introduced. In the second part of the paper the extended Max-Min fairness definition is used as a measure to compare the performance in dynamic conditions of three fairness algorithms proposed for ring-based SANs. These algorithms are characterized by different fairness cycle sizes (number of links involved in each instance of the fairness algorithm), i.e., different complexity. The results show that the performance increases as the fairness cycle size decreases. In particular, the Global-cycle algorithm (implemented in the Serial Storage Architecture - SSA), whose cycle size is equal to the number N of links in the ring, exhibits the lowest performance, while the One-cycle algorithm, so called because of its cycle size equal to 1, has the best performance. The Variable-cycle algorithm, whose cycle size changes between 1 and N links, performs in between and provides the best tradeoff between performance and complexity.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1572-8196
    Source: Springer Online Journal Archives 1860-2000
    Topics: Electrical Engineering, Measurement and Control Technology , Computer Science
    Notes: Abstract IEEE 802.11 is a Media Access Control (MAC) protocol which has been standardized by IEEE for Wireless Local Area Networks (WLANs). The IEEE 802.11 MAC protocol offers two types of services to its users: synchronous and asynchronous. This paper presents an in‐depth analysis, by simulation, of the asynchronous part alone. The analysis is performed by considering station data traffic patterns (hereafter advanced data traffic) which have a very similar shape to traffic generated by WWW applications. We carried out the simulation by taking into consideration two classes of scenarios: balanced and unbalanced. In the former class each station has the same offered load while in the latter class a specific station is more loaded than the others. Our conclusion is that the IEEE 802.11 MAC protocol performs satisfactorily for both classes of scenarios, although performance measures with advanced traffic are worse than the corresponding performance measures with Poissonian traffic. Furthermore, we broadened our analysis to include higher medium capacities than those planned (i.e., 1 and 2 Mbit/sec) up to 10 Mbit/sec. This part of the analysis shows that the IEEE 802.11 MAC protocol is not adequate to work at speeds planned for the forthcoming ATM Wireless LAN.
    Type of Medium: Electronic Resource
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