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  • 1
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    Totowa, NJ : Humana Press, a part of Springer Science+Business Media, LLC
    Keywords: Medicine ; Critical care medicine ; Nephrology ; Personal health and hygiene ; Pediatrics ; Emergency Medicine ; Surgery ; Medicine & Public Health ; Clinical Nutrition ; Pediatrics ; Primary Care Medicine ; Intensive / Critical Care Medicine ; Pediatric Surgery ; Nephrology ; Springer eBooks
    Pages: : digital
    ISBN: 9781603272254
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  • 2
    Call number: 08-Biol
    Keywords: Molecular Biology / methods
    Pages: xi, 388 p. : ill.
    ISBN: 0444010823
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    08-Biol departmental collection or stack – please contact the library
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  • 3
    ISSN: 1573-6903
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The cerebral cortex from adult rats was separated into several subcellular fractions by using established methods of differential and sucrose density gradient centrifugation. Aliquots from each fraction were incubated with γ-32P-ATP, in the presence and absence of adenosine 3′,5′-monophosphate (cyclic AMP), and its protein constituents were separated by means of SDS-slab gel electrophoresis. Fractions containing nuclei, synaptosomes, myelin, microsomes, and soluble proteins each showed a characteristic pattern of protein staining and of endogenously phosphorylated proteins detected by autoradiography of the gels. Cyclic AMP-stimulated phosphorylation of proteins with MW 78K and 84K can serve as markers for membranes of synaptic origin, while cyclic AMP-independent phosphorylation of low-molecular-weight proteins (15K–20K) is characteristic of myelin. The finding of different phosphoproteins in various subcellular fractions may be related to the diversity of cellular functions known to be regulated by phosphorylative activity.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1617-4623
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary mei-S51 is a meiotic mutant of Drosophila melanogaster having the following properties: 1. mei-S51 consists of two recessive genes, located near the centromere regions of the second and third chromosomes, which are both required for the expression of the mutant phenotype. Salivary analysis reveals normal structures for both the second and third chromosomes. 2. mei-S51 has no effect in males but in females it causes a uniform decrease in X chromosome exchange, second chromosome exchange between c and bw, and increased nondisjunction of all chromosomes. Both of these effects appear to result from a defect prior to both exchange and disjunction, rather than one being the cause of the other. 3. Nondisjunction in mei-S51 females having a normal sex chromosome complement is the result of nonhomologous pairing as is the greatly increased nondisjunction found for XXY; mei-S51 females. This nondisjunction is not competitive with exchange; that is, exchange occurs as frequently between the X chromosomes of XXY females as those of XX females in spite of a greatly increased frequency of X chromosome nondisjunction in the former. 4. There is a pronounced increase in the frequency of nondisjunction in both XX and XXY; mei-S51 females if the X chromosomes are heterozygous for the inversion, In(1)dl49, although heterozygosity for In(1)dl49 causes-only a slight increase in nondisjunction in mei-S51 + (normal) XX females. 5. It appears unlikely that, in all instances of nonhomologous pairing, both chromosomes of each bivalent pair nonhomologously. Rather, in many instances one chromosome pairs with a nonhomolog and the other two elements are distributed at random and without loss to the poles. 6. In XX; mei-S51 females, nonhomologous pairing of the fourth chromosomes occurs exclusively with the X chromosomes, implying that the specificity of nonhomologous pairing (perhaps the size recognition mechanism demonstrated by Grell) is not affected by mei-S51. An hypothesis explaining these observations and a discussion of its implications with regard to the normal course of meiosis and the mechanism of nonhomologous pairing are presented.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Journal of automated reasoning 4 (1988), S. 445-462 
    ISSN: 1573-0670
    Keywords: Rules ; contexts ; ordered connectives
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science
    Notes: Abstract We construct equivalent “localized” versions of a formula, adding assumptions simultaneously to various locations, where the particular location determines what is added. Inference rules that take advantage of localized formulas are presented for sequent calculi in which the left hand side of sequents can be used to accumulate the background assumptions (or “contexts”) of assertions. The intended application is to the automatic generation of tractable justifying lemmas for substitution operations for interactive proof development systems, especially those concerned with mathematical topics where manipulation of deeply embedded terms is desirable.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1573-2568
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Parenteral administration of amino acids has been utilized for the nutritional support of patients with a variety of gastrointestinal disorders including protracted pancreatitis and pancreatic fistulae. However, the effect of parenteral amino acid administration alone on human pancreatic secretion has not been studied. We have studied the short-term effect of parenteral administration of amino acids on pancreatic exocrine secretion in seven healthy men. A double-lumen tube was placed in the duodenum and polyethylene glycol was perfused into the proximal duodenum at the rate of 10 ml/min. A second double-lumen tube was placed in the stomach and bromsulfthalein was perfused into the cardia. Samples of duodenal contents were aspirated and gastric contents recovered during one hour of intravenous saline infusion followed by two hours of an amino acid mixture infusion. Hourly outputs of protein and pancreatic enzymes were determined, correcting for duodenogastric reflux based on concentrations of both markers in the samples. Despite an average increase of 72% in the plasma concentration of the infused amino acids, the outputs of protein, trypsin and amylase did not change significantly during amino acid infusion; the output of lipase decreased significantly during amino acid infusion. Two subjects were given intravenous secretin and cholecystokinin following amino acids; this resulted in increased outputs of protein, trypsin, and amylase in both. We conclude that the parenteral administration of amino acids to healthy young men does not stimulate pancreatic enzyme secretion as measured by the method using duodenal marker perfusion at the rate of 10 ml/min.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1435-4373
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The specificity of three HIV EIAs using synthetic peptides was evaluated and compared with that of four commercial EIAs using recombinant proteins or whole virus lysates of HIV-1 or of HIV-1 and HIV-2, and of two tests based on agglutination of sensitized particles. A total of 734 West African sera were screened. The best results were obtained with tests using recombinant proteins. HIV tests using synthetic peptides able to distinguish between HIV-1 and HIV-2 antibodies showed comparable specificity, but some false negative results represent a major handicap of these peptide EIAs in screening for HIV antibodies.
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1572-8854
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences , Physics
    Notes: Abstract A single crystal X-ray investigation of the purple nickel (II) complex Ni[L(en)](NO3)2, produced by condensation of 1,2-diaminoethane (en) with the thiodiketone S(CH2COCH3)2 in the presence of nickel (II) nitrate (L is NH2(CH2)2N=C(CH3)CH2SCH2COCH3), shows that the metal ions are six coordinate. The new ligand L is tetradentate, with the N,N and S donor atoms arranged meridionally, and the coordination shell completed by the carbonyl oxygen atom of L and the nitrogen atoms of 1,2-diaminoethane. Metal-ligand bond distances are Ni-N: 2.08 av. (en), 2.10 and 2.05 (NH2 and N=C respectively of L); Ni-O, 2.16; Ni-S, 2.45 Å. There is considerable angular distortion from regular octahedral values of the bond angles at nickel. The crystals are monoclinic,P21/c (No. 14),a=12.433(2),b=11.709(1),c=13.150(2) Å,β=103.93(1)°,V c=1858.2(4) Å3. The structure was solved by the heavy-atom method and refined by full-matrix least squares to anR value of 0.055 for 3633 reflections.
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 1573-6903
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Glycoproteins that contain phosphohexosyl groups were found to be present in the myelin- and synaptosomal-enriched fractions as well as in the microsomes of rat brain. The kinetics of flow of intraperitoneally injected [32P]phosphate suggests that the phosphate is enzymatically added in structures found in the microsomal fraction. The newly synthesized phosphoglycoproteins then appear in the soluble fraction of the synaptosomes and in the cytosol, prior to incorporation into the membranes of the synaptosomes and myelin. Phosphoglycopeptides recovered from the phosphoglycoprotein contain 3 Mannose units per N-acetylglucosamine residue; one of the mannose residues is phosphorylated. [13C]NMR studies indicate that the phosphoglycopeptides contain a chitobiose group and more than four sugar residues. Thus, the phosphomannoglycopeptides from rat brain contain an average of 2 N-acetylglucosamine, 6 mannose, and two phosphate moieties per oligosaccharide chain. Enzymatic treatment with α-mannosidase failed to remove the phosphomannose, although some mannose residues were released. Thus, the phosphorylated mannose is not removed by the glycosidase and terminal nonphosphorylated mannose residues are present in the oligosaccharide. The phosphate residues are removed by treatment with alkaline phosphatase.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Journal of the American Chemical Society 55 (1933), S. 4468-4474 
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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