Polymer and Materials Science
Wiley InterScience Backfile Collection 1832-2000
Chemistry and Pharmacology
We report the assignment of the backbone 1H- and 31P-nmr lines in the synthetic hexadeoxyribonucleotide pentaphosphate duplex d(GCATGC)2, using double quantum filtered 1H-1H correlation spectroscopy, 1H observed 1H-31P heteronuclear correlation spectroscopy, and 31P relayed 1H-1H correlation spectroscopy. The strategy used enables one to make sequence-specific resonance assignments without reference to a known or assumed conformation of the DNA fragment.
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