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  • 1
    Unknown
    Hershey PA : Idea Group Pub
    Keywords: ASDA (Group) ; Electronic commerce, Great Britain. ; Grocery trade, Technological innovations, Great Britain. ; Grocery trade, Great Britain, Management. ; Internet marketing, Great Britain.
    ISBN: 1-417-58264-2
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  • 2
    Unknown
    Burlington, Mass : Elsevier Butterworth-Heinemann
    Keywords: Materials, Fatigue, Testing. ; Strains and stresses, Testing.
    Pages: xiv, 402 p.
    ISBN: 1-417-54444-9
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  • 3
    Unknown
    Hershey PA : Idea Group Pub
    Keywords: Electronic commerce. ; Electronic data interchange.
    ISBN: 1-591-40383-9
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  • 4
    Keywords: Cognitive styles. ; Human information processing. ; Learning, Psychology of. ; Thought and thinking.
    Pages: x, 276 p.
    ISBN: 0-585-36394-3
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  • 5
    Unknown
    East Lansing, Mich : Michigan State University
    Keywords: Rural development, Sociological aspects, Cross-cultural studies. ; Rural population, Cross-cultural studies. ; Rural population, United States. ; Sociology, Rural. ; Sociology, Rural, Research.
    Notes: The poor in nonmetropolitan America / William P. O'Hare -- Mechanization in the western Upper Peninsula pulp-logging industry / Jon H. Rieger -- Development, women's work, and economic inequality in rural Taiwan / Rita S. Gallin -- Inequality and the emergence of nonfarm employment in Rwanda / Daniel C. Clay, Theobald Kampayana, and Jean Kayitsinga -- Social and economic transformation in a Greek farming village / George A. Daoutopoulos -- Recent population change in Michigan's metropolitan and nonmetropolitan areas / Ching-li Wang -- The transmission of information regarding population change in a rural county / Richard W. Rathge -- Fatal farm accidents in Michigan : implications for research and policy / Nan E. Johnson -- Irish rural-urban migration: post-1960 changes / Damian F. Hannan -- Changing rural communities : reconstructing the local economy of a nonmetropolitan community / Marilyn W. Aronoff -- Social change and dress among the Kalabari of Nigeria / Joanne Bubolz Eicher -- The call of the sugar cane : agricultural change, cooperative-capitalism, and migrants in northwestern Uruguay / Gaston J. Labadie
    Pages: x, 255 p.
    ISBN: 0-585-20090-4
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  • 6
    Keywords: Medicine ; Medical records / Data processing ; Medicine & Public Health ; Medicine/Public Health, general ; Health Promotion and Disease Prevention ; Health Informatics ; Springer eBooks
    ISBN: 9781461415992
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  • 7
    Keywords: Medicine ; Nephrology ; Biochemistry ; Cytology ; Molecular Medicine ; Nephrology ; Biochemistry, general ; Cell Biology ; Springer eBooks
    Description / Table of Contents: Prevalence and burden of chronic kidney disease -- Pathomorphism and evaluation of renal fibrosis -- Endothelial cells and renal fibrosis -- Mesangial cells and renal fibrosis -- Podocyte injury and glomerular sclerosis -- Tubular epithelial cell injury and renal fibrosis -- Monocyte-macrophages and renal fibrosis -- Pericytes and renal fibrosis -- Myofibroblast: Origin and regulation in renal fibrosis -- Mitochondrial lesion and renal fibrosis -- Metabolic nuclear receptors and renal fibrosis -- Role of renin angiotensin system in renal fibrosis -- Role of aldosterone in renal fibrosis -- TGF-β1 and renal fibrosis -- Connective tissue growth factor and renal fibrosis -- Lipid metabolism disorder and renal fibrosis -- Renal interstitial lymphangiogenesis in renal fibrosis -- Cell apoptosis and autophagy in renal fibrosis -- Pyroptosis and renal fibrosis -- Cell cycle arrest and renal fibrosis -- Inflammatory mediators and renal fibrosis -- Role of inflammasome in chronic kidney disease -- Oxidative stress and renal fibrosis -- Hypoxia and renal tubulointerstitial fibrosis -- Proteinuria and progression of chronic kidney disease -- Hypertension and renal fibrosis -- Diabetic Kidney disease and renal fibrosis -- Chronic allograft nephropathy and renal fibrosis -- Polycystic kidney disease and renal fibrosis -- Acute kidney injury and renal fibrosis -- Senescence and renal fibrosis -- Urinary biomarkers of renal fibrosis -- New therapies for the treatment of renal fibrosis
    Abstract: This book systemically presents the latest research on renal fibrosis, covering all the major topics in the field, including the possible mechanisms, biomarkers, and strategies for prevention and treatment of chronic kidney disease (CKD). Due to its high prevalence, CKD represents a huge global economic and social burden. Irrespective of the initial causes, CKD progresses to end stage kidney disease (ESKD) due to renal fibrosis, which is characterized by glomerulosclerosis, tubule atrophy and atresia, and the excessive accumulation of extracellular matrix (ECM) in the kidney. Unfortunately, an estimated 1%-2% of the adult population living with CKD will need renal replacement therapy at some point as a result of ESKD. As such, strategies for preventing or slowing CKD progression to ESKD are of utmost importance, and studies aiming to understand the mechanisms of renal fibrosis have been the focus of intensive research. Recently, novel insights into the pathophysiological processes have furthered our understanding of the pathogenesis of renal fibrosis, and more importantly, promoted studies on the early diagnosis and treatment of CKD. This book draws lessons from the extensive, state-of-the-art research in this field, elaborating the new theories and new techniques to offer readers a detailed and comprehensive understanding of renal fibrosis and as well as inspiration for future research directions
    Pages: XVI, 709 p. 63 illus., 55 illus. in color. : online resource.
    Edition: 1st ed. 2019.
    ISBN: 9789811388712
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  • 8
    Keywords: Medicine ; Immunology ; Microbiology ; Vaccines ; Biomedicine ; Medical Microbiology ; Immunology ; Vaccine ; Springer eBooks
    Description / Table of Contents: Overview on Lasso Peptide Research -- From the Producer Microorganisms to the Lasso Scaffold -- Biological Activities of Lasso Peptides and Structure-Activity Relationships -- Biosynthesis, Regulation and Export of Lasso Peptides -- Lasso Peptide Bioengineering and Bioprospecting
    Abstract: Lasso peptides form a growing family of fascinating ribosomally-synthesized and post-translationally modified peptides produced by bacteria. They contain 15 to 24 residues and share a unique interlocked topology that involves an N-terminal 7 to 9-residue macrolactam ring where the C-terminal tail is threaded and irreversibly trapped. The ring results from the condensation of the N-terminal amino group with a side-chain carboxylate of a glutamate at position 8 or 9, or an aspartate at position 7, 8 or 9. The trapping of the tail involves bulky amino acids located in the tail below and above the ring and/or disulfide bridges connecting the ring and the tail. Lasso peptides are subdivided into three subtypes depending on the absence (class II) or presence of one (class III) or two (class I) disulfide bridges. The lasso topology results in highly compact structures that give to lasso peptides an extraordinary stability towards both protease degradation and denaturing conditions. Lasso peptides are generally receptor antagonists, enzyme inhibitors and/or antibacterial or antiviral (anti-HIV) agents. The lasso scaffold and the associated biological activities shown by lasso peptides on different key targets make them promising molecules with high therapeutic potential. Their application in drug design has been exemplified by the development of an integrin antagonist based on a lasso peptide scaffold. The biosynthesis machinery of lasso peptides is therefore of high biotechnological interest, especially since such highly compact and stable structures have to date revealed inaccessible by peptide synthesis. Lasso peptides are produced from a linear precursor LasA, which undergoes a maturation process involving several steps, in particular cleavage of the leader peptide and cyclization. The post-translational modifications are ensured by a dedicated enzymatic machinery, which is composed of an ATP-dependent cysteine protease (LasB) and a lactam synthetase (LasC) that form an enzymatic complex called lasso synthetase. Microcin J25, produced by Escherichia coli AY25, is the archetype of lasso peptides and the most extensively studied. To date only around forty lasso peptides have been isolated, but genome mining approaches have revealed that they are widely distributed among Proteobacteria and Actinobacteria, particularly in Streptomyces, making available a rich resource of novel lasso peptides and enzyme machineries towards lasso topologies
    Pages: XIII, 103 p. 22 illus., 9 illus. in color. : online resource.
    ISBN: 9781493910106
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  • 9
    Keywords: Medicine ; Human Physiology ; Cytology ; Biomedicine ; Molecular Medicine ; Cell Biology ; Human Physiology ; Springer eBooks
    Description / Table of Contents: Key Characteristics of T-type calcium channels (E. Perez-Reyes, author) -- Novel T-type calcium channel blockers (M Li, author) -- Promotion of cell proliferation by T-type calcium channels (N. Prevarskaya, author) -- Role of T-type calcium channels in neuronal differentiation (P. Lory, author) -- T-type calcium channel and nociception (H.S. Shin, author) -- Activation of endothelial cells by T-type calcium channels (S. Wu, author) -- Link between seizures and T-type calcium channels (Y. Chen, author) -- Regulation of renal function by T-type calcium channels (P.B. Hansen, author) -- Effect of T-type calcium channel activation on smooth muscle cell function (L Cribbs, author) -- Does the T-type calcium channel have a function in the heart? (S. Schaffer, author) -- Calcium entry via the T-type calcium channel modulates retinal function (E. Carbone, author).-℗ T-type calcium channel and intestines -- Role of T-type calcium channel in bone development (M.C. Farach-Carson, author) -- Regulation of pancreatic secretary function by T-type calcium channel (P.O. Berggren, author) -- Role of T-type calcium channel in reproduction (T.W. Soong, author)
    Abstract: T-type calcium channels are prevalent in every organ of the body, and are believed to play a part in a variety of physiological processes, including contraction, shape change, secretion, endo- and exocytosis, cell proliferation and differentiation, modulation of enzyme function, and cell cycle progression. As such, research on the roles of these channels in a wide range of diseases has attracted increasing attention in recent years. The purpose of this book is to present a series of unique and comprehensive reviews of our current understanding of T-type calcium channels at the level of the basic sciences as well as the clinical sciences. For key organ systems, information is provided on the correlation between the molecular, biophysical and pharmacological properties of the channels, their cellular mechanisms, and their potential roles in the pathogenesis of various diseases. The compilation presents both commonplace and less well-known findings on these channels in a format designed to appeal to both casual readers and specialists in basic and clinical research on these transporters
    Pages: X, 154 p. 17 illus., 6 illus. in color. : online resource.
    ISBN: 9783709114131
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  • 10
    Keywords: Life sciences ; Biochemistry ; Cell Membranes ; Life sciences ; Biochemistry, general ; Membrane Biology ; Springer eBooks
    Description / Table of Contents: Rab Family of GTPases -- Bioinformatic Approaches to Identifying and Classifying Rab Proteins -- Rab-NANOPS: FRET-Biosensors for Rab Membrane Nano clustering and Prenylation Detection in Mammalian Cells -- High Throughput Assay for Profiling the Substrate Specificity of Rab GTPase-Activating Proteins -- Measuring Rab GTPase-Activating Protein (GAP) Activity in Live Cells and Extracts -- Analysis of the Interactions Between Rab GTPases and Class V Myosins -- Assaying the Interaction of the Rab Guanine Nucleotide Exchange Protein Sec2 with the Upstream Rab, a Downstream Effector and a Phosphoinositide -- Kinetic Activation of Rab8 Guanine Nucleotide Exchange Factor Rabin8 by Rab11 -- Ypt1 and TRAPP Interactions: Optimization of Multi-Color Bimolecular Fluorescence Complementation in Yeast -- Identifying a Rab Effector on the Macro autophagy Pathway -- Functional Analysis of Rab27 and its Effector Slp-2a in Renal Epithelial Cells -- Small GTPases in Acrosomal Exocytosis -- Rab Antibody Characterization: Comparison of Rab14 Antibodies -- Selective Visualization of GLUT4 Storage Vesicles and Associated Rab Proteins Using IRAP-pHluorin -- 3D Time-Lapse Analysis of Rab11/FIP5 Complex: Spatiotemporal Dynamics During Apical Lumen Formation -- In Vitro and In Vivo Characterization of the Rab11-GAP Activity of Drosophila Evi5 -- Characterization of the Role Rab25 in Energy Metabolism and Cancer Using Extracellular Flux Analysis and Material Balance -- Measurement of Rab35 Activity by the GTP-Rab35 Trapper RBD35 -- Analysis of Connecdenn 1-3 (DENN1A-C) GEF Activity for Rab35 -- Assay of Rab17 and its Guanine Nucleotide Exchange Factor Rabex-5 in Dendrites of Hippocampal Neurons -- Methods for Analysis of AP-3/Rabin4’ in Regulation of Lysosome Distribution -- Determination of Rab5 Activity in the Cell by Effector Pull-Down Assay -- Identification of the Rab5 Binding Site in p110b - Assays for PI3Kb Binding to Rab5 -- Role of the Rab5 Guanine Nucleotide Exchange Factor, Rme-6, in the Regulation of Clathrin-Coated Vesicle Uncoating -- Differential Effects of Overexpression of Rab5 and Rab22 on Autophagy in PC12 Cells With or Without NGF -- Determining the Role of Rab7 in Constitutive and Ligand-Mediated Epidermal Growth Factor Receptor Endocytic Trafficking Using Single Cell Assays -- Visualizing Directional Rab7 and TrkA Co-Trafficking in Axons by pTIRF Microscopy -- Quantitative Bead-Based Flow Cytometry for Assaying Rab7 GTPase Interaction with the Rab-Interacting Lysosomal Protein (RILP) Effector Protein
    Abstract: This volume covers the latest technological advances in the characterization of the biosynthesis and functions of Rab GTPases and their regulation by guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs). The book consists of 28 chapters, and starts with an overview of the Rab GTPase family. The next few chapters describe systematic approaches to the identification and classification of Rabs and Rab GAPs, as well as the detection of Rab isoprenylation and membrane distribution. The last few chapters examine the biochemical and functional properties of individual Rabs in the order of exocytic, recycling, and endocytic Rabs. Written in the highly successful℗ Methods of Molecular Biology℗ series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Instructive and practical,℗ Rab GTPases: Methods and Protocols℗ approaches each topic with great detail and is a valuable resource for researchers and students interested in the field of Rab GTPases
    Pages: XIV, 358 p. 82 illus., 54 illus. in color. : online resource.
    ISBN: 9781493925698
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