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  • 1
    ISSN: 1432-1211
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Bovine genes encoding T-cell receptor, CD3, and CD8 molecules have been mapped to syntetic groups using bovine × rodent hybrid somatic cells. T-cell receptor α and δ chains were assigned to bovine syntenic group U5, and the β and γ genes were syntenic with each other and with markers on U13. CD3E and CD3D genes were syntenic with each other and located to bovine syntenic group U19. CD8 was most concordant with markers of syntenic group U16, although the concordancy was only 85% and the assignment must be regarded as tentative. The comparative gene maps of human chromosome 7, bovine syntenic group U13, and mouse chromosomes 6 and 13 suggest extensive evolutionary conservation.
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  • 2
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Nephrology 3 (1997), S. 0 
    ISSN: 1440-1797
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary: IgA nephropathy (IgAN) is polyphormic in its clinical manifestation, course and prognosis. Patients with isolated IgA deposit in glomeruli tend to have a high incidence of macroscopic haematuria and carry a better prognosis. In contrast, patients with deposits of IgA and IgG and IgM have a higher incidence of nephrotic syndrome and hypertension. In parallel, patients with IgA and IgG and IgM tend to have more glomerulosclerosis and tubulointestitial lesions. Recently, the angiotensin converting enzyme (ACE) gene polymorphism and its association in disease risk provided interesting exploration leading us to speculate about a possible mechanism to explain the variation in the rate of progression of IgAN; although, the results are still controversial. The variability of plasma ACE concentration has been shown to be associated with an insertion/deletion polymorphism. The frequencies of ACE genotype in 177 Chinese patients with IgAN has been observed. We found that patients with IgAN showed a higher frequency of DD genotype than normal population. In contrast to the previous reports, we did not find any association between ACE genotype and the rate of progression of IgAN. As different genotypes of IL-1 receptor antagonist (IL-1 ra) are also responsible for the circulating levels of IL-1 ra, the polymorphism of IL-1 ra gene has been analyzed in 100 IgAN patients. There was no significant difference in the frequency of IL1RN*2 allele between normal subjects and IgAN. However, patients with recurrent macroscopic haematuria showed a higher carriage rate of IL1RN*2. Hereditable factors, in combination with a number of recognized environmental risk factors, are important determinants of the pathogenesis and natural history of IgAN. The notion that the gene polymorphism might be responsible for the clinical features and progression of IgAN is both intriguing and provocative. The lessons from previous multiple small size studies have produced conflicting results illustrating the need for observation of large numbers of cases in further studies to verify these observed associations.
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  • 3
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Nephrology 2 (1996), S. 0 
    ISSN: 1440-1797
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary: Rhubarb (Rheum Officinale), a chinese herb that had been used as a laxative for many years during ancient times is now found to be of value in preventing progression of chronic renal disease. In animal experimentation it suppresses the hypermetabolic states of the severely damaged kidney and retards the progression of chronic renal failure. Controlled clinical trials also have proved that the extract of Rhubarb is effective in preventing the progression of chronic renal disease and the therapeutic results seemed to be better than that with an angioconvertirig-enzyme (ACE) inhibitor.
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  • 4
    ISSN: 1440-1797
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: SUMMARY In the present study, we investigated pauci-immune crescentic glomerulonephritis (PICGN) in Chinese patients. During 13 years (1985–98), 6400 patients underwent non-transplanting renal biopsy in the Nanjing Jinling Hospital. Twenty-four patients were diagnosed as having PICGN. They were 16 women and eight men with a median age of 33 (range 10–76 years). Microscopic polyarteritis (33.3%) and polyarteritis nodosa (8.3%) were the secondary diseases. The incidence of PICGN was 0.37% in renal biopsies and 22.9% in crescentic glomerulonephritis. Clinically, most patients (75.0%) showed rapidly progressive nephritis with enlarged kidneys. Onset gross haematuria was noted in 58.3% of the patients, hypertension 45.8%, nephrotic syndrome 41.7%, and oliguria 25.0%. However, systemic symptoms were rare except anaemia. Pathologically, we observed necrosis of glomerular capillaries (62.5%), infiltration of monocytes and neutrophil cells in glomeruli (66.7%), and vasculitis in interstitium (53.3%), in addition to glomerulosclerosis more than 50% (45.8%), severe tubular atrophy (83.3%) and interstitial fibrosis (75.0%). Antineutrophil cytoplasmic antibodies were positive in 52.2%. All patients except two received intensively immunosuppressive therapy. Sixteen patients were subjected to long-term follow up (median 29.8, range 8–92 months), 12 of them had life-sustaining renal function, four had normal range of serum creatinine (〈 124 μmol/L), only four patients were dialysis dependent.
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  • 5
    ISSN: 1432-1777
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
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  • 6
    ISSN: 1546-170X
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] The widespread distribution of the tumor suppressor PTEN (phosphatase and tensin homolog deleted on chromosome 10) in the adult brain suggests its role in a broad range of brain functions. Here we show evidence supporting a physical interaction of PTEN with a region in the third intracellular loop ...
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  • 7
    ISSN: 1546-1718
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Xeroderma pigmentosum (XP) is a rare autosomal recessive disease of humans characterized by an accelerated chronic degeneration of sun–exposed areas of the body, including an elevated risk of developing cancers of the skin. We recently reported the isolation of a gene XPCC that complements ...
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  • 8
    ISSN: 1520-5118
    Source: ACS Legacy Archives
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Process Engineering, Biotechnology, Nutrition Technology
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  • 9
    Electronic Resource
    Electronic Resource
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 89 (2001), S. 942-950 
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: A refined model of a glass laser texturing process used on computer disk substrates is presented. Field equations for fictive temperature and elasto-viscoplastic strain in the glass are numerically integrated over the thermal cycle created with a microsecond CO2 laser pulse. Calculating the fictive temperature change as part of the solution provides for a consistent treatment of glass properties that depend on fictive temperature. The short time scale of the thermal cycle causes the final altered state of fictive temperature in the heat affected zone to be relatively constant over the depth of change, and higher than the initial value by more than 300 K. Plastic strain resulting from thermomechanical stresses and the fictive temperature rise are considered in this description. The model illustrates the rise in the compressive stress caused by initial heating, the relaxation process that occurs in the molten region above the transition temperature, and the subsequent introduction of tensile stress during cooling. At the end of the thermal cycle, the region of glass with altered fictive temperature is left in a state of high tensile stress. The time evolution of surface topography is studied with the model, and shows good agreement with measured dimensions of the final bump geometry over a range of laser pulse energies. © 2001 American Institute of Physics.
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  • 10
    Electronic Resource
    Electronic Resource
    s.l. ; Stafa-Zurich, Switzerland
    Solid state phenomena Vol. 116-117 (Oct. 2006), p. 583-586 
    ISSN: 1662-9779
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Physics
    Notes: It is significative to link the semi-solid process and continuous roll-casting process (CRP),through which we can get high quality magnesium alloy strips with non-dendritic structure andimprove the overall properties of the products. Furthermore, because CRP of semi-solid metalcombines casting and forming, it shortens the period of technological process. In general, severaltechnical parameters such as the inlet temperature of semi-solid slurry, the heat transfer betweenroll and molten alloy, the roll-casting speed, the position of solidification final point influence onthe strip quality in continuous roll-casting process. Therefore, the effects of the parameter tocontinuous roll-casting process should be investigated. In this paper, the finite volume method isused in the analysis of the CRP, a two-dimensional incompressible non-Newtonian flow with heattransfer is considered. Based on the simulated results, the optimizational technical parameters areobtained and the experiment of CRP was carried out. An ideal AZ91D strip with non-dendriticstructure has been obtained and also has been tested by cold rolling and hot rolling. The resultsshow that microstructure and mechanical properties of the strip are fine
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