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  • 1
    ISSN: 0173-0835
    Keywords: DNA sequencing ; Capillary electrophoresis ; Energy transfer primers ; Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Capillary electrophoresis DNA sequencing has been accomplished by using four different energy transfer primers and three fluorescence detection channels. Methods have also been developed to deconvolve the three-color data into the four base concentrations. The nonnegative least squares and model selection method resulted in the best accuracy. The three-color data were compared to sequencing data obtained using four detection channels and four energy transfer primers. The average accuracy rates obtained over three 500 base M13mp18 runs using three-color coding were 96% including 18 uncallable compressions and 99.6% if these compressions are excluded. The average accuracy rate obtained using four-color coding was 96.3% including 18 uncallable compressions and 99.9% if these compressions are excluded. Although it is unlikely that three-color schemes will replace four-color sequencing, these methods have exposed basic concepts that will be useful in the development of higher-order multiplex coding methods for DNA analysis.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1520-5118
    Source: ACS Legacy Archives
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1546-170X
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] The widespread distribution of the tumor suppressor PTEN (phosphatase and tensin homolog deleted on chromosome 10) in the adult brain suggests its role in a broad range of brain functions. Here we show evidence supporting a physical interaction of PTEN with a region in the third intracellular loop ...
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  • 4
    Electronic Resource
    Electronic Resource
    s.l. ; Stafa-Zurich, Switzerland
    Solid state phenomena Vol. 116-117 (Oct. 2006), p. 583-586 
    ISSN: 1662-9779
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Physics
    Notes: It is significative to link the semi-solid process and continuous roll-casting process (CRP),through which we can get high quality magnesium alloy strips with non-dendritic structure andimprove the overall properties of the products. Furthermore, because CRP of semi-solid metalcombines casting and forming, it shortens the period of technological process. In general, severaltechnical parameters such as the inlet temperature of semi-solid slurry, the heat transfer betweenroll and molten alloy, the roll-casting speed, the position of solidification final point influence onthe strip quality in continuous roll-casting process. Therefore, the effects of the parameter tocontinuous roll-casting process should be investigated. In this paper, the finite volume method isused in the analysis of the CRP, a two-dimensional incompressible non-Newtonian flow with heattransfer is considered. Based on the simulated results, the optimizational technical parameters areobtained and the experiment of CRP was carried out. An ideal AZ91D strip with non-dendriticstructure has been obtained and also has been tested by cold rolling and hot rolling. The resultsshow that microstructure and mechanical properties of the strip are fine
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1435-1528
    Keywords: Key words Birefringence ; Bead-spring model ; Extensional flow ; Polystyrene
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: Abstract An algorithm is derived for calculating flow-induced birefringence using a bead-spring model with and without excluded volume effects. The simulation results for the bead-spring model compare well with experimental results for stress and birefringence in extensional flows of dilute solutions of polystyrene molecular weight 2 million in a filament-stretching device in both “theta” and “good” solvents (Orr and Sridhar 1999; Sridhar et al. 2000). In a “good” solvent, both stress and birefringence rise much more rapidly with strain than in a “theta” solvent, making extensional rheology a very sensitive indicator of solvent quality.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    BIT 40 (2000), S. 410-414 
    ISSN: 1572-9125
    Keywords: P-matrix ; principal minor ; Schur complement ; complexity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics
    Notes: Abstract The time complexity for testing whether an n-by-n real matrix is a P-matrix is reduced from O(2n n 3) to O(2 n ) by applying recursively a criterion for P-matrices based on Schur complementation. A Matlab program implementing the associated algorithm is provided.
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  • 7
    ISSN: 1546-1718
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Xeroderma pigmentosum (XP) is a rare autosomal recessive disease of humans characterized by an accelerated chronic degeneration of sun–exposed areas of the body, including an elevated risk of developing cancers of the skin. We recently reported the isolation of a gene XPCC that complements ...
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  • 8
    ISSN: 1546-1718
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Sequencing and computational annotation revealed several features, including high gene numbers, unusual composition of the predicted genes and a large number of genes lacking homology to known genes, that distinguish the rice (Oryza sativa) genome from that of other fully sequenced model species. ...
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  • 9
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Nephrology 3 (1997), S. 0 
    ISSN: 1440-1797
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary: IgA nephropathy (IgAN) is polyphormic in its clinical manifestation, course and prognosis. Patients with isolated IgA deposit in glomeruli tend to have a high incidence of macroscopic haematuria and carry a better prognosis. In contrast, patients with deposits of IgA and IgG and IgM have a higher incidence of nephrotic syndrome and hypertension. In parallel, patients with IgA and IgG and IgM tend to have more glomerulosclerosis and tubulointestitial lesions. Recently, the angiotensin converting enzyme (ACE) gene polymorphism and its association in disease risk provided interesting exploration leading us to speculate about a possible mechanism to explain the variation in the rate of progression of IgAN; although, the results are still controversial. The variability of plasma ACE concentration has been shown to be associated with an insertion/deletion polymorphism. The frequencies of ACE genotype in 177 Chinese patients with IgAN has been observed. We found that patients with IgAN showed a higher frequency of DD genotype than normal population. In contrast to the previous reports, we did not find any association between ACE genotype and the rate of progression of IgAN. As different genotypes of IL-1 receptor antagonist (IL-1 ra) are also responsible for the circulating levels of IL-1 ra, the polymorphism of IL-1 ra gene has been analyzed in 100 IgAN patients. There was no significant difference in the frequency of IL1RN*2 allele between normal subjects and IgAN. However, patients with recurrent macroscopic haematuria showed a higher carriage rate of IL1RN*2. Hereditable factors, in combination with a number of recognized environmental risk factors, are important determinants of the pathogenesis and natural history of IgAN. The notion that the gene polymorphism might be responsible for the clinical features and progression of IgAN is both intriguing and provocative. The lessons from previous multiple small size studies have produced conflicting results illustrating the need for observation of large numbers of cases in further studies to verify these observed associations.
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  • 10
    Electronic Resource
    Electronic Resource
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 89 (2001), S. 942-950 
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: A refined model of a glass laser texturing process used on computer disk substrates is presented. Field equations for fictive temperature and elasto-viscoplastic strain in the glass are numerically integrated over the thermal cycle created with a microsecond CO2 laser pulse. Calculating the fictive temperature change as part of the solution provides for a consistent treatment of glass properties that depend on fictive temperature. The short time scale of the thermal cycle causes the final altered state of fictive temperature in the heat affected zone to be relatively constant over the depth of change, and higher than the initial value by more than 300 K. Plastic strain resulting from thermomechanical stresses and the fictive temperature rise are considered in this description. The model illustrates the rise in the compressive stress caused by initial heating, the relaxation process that occurs in the molten region above the transition temperature, and the subsequent introduction of tensile stress during cooling. At the end of the thermal cycle, the region of glass with altered fictive temperature is left in a state of high tensile stress. The time evolution of surface topography is studied with the model, and shows good agreement with measured dimensions of the final bump geometry over a range of laser pulse energies. © 2001 American Institute of Physics.
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