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  • 1
    Keywords: Medicine ; Cancer Research ; Biomedicine ; Cancer Research ; Springer eBooks
    Description / Table of Contents: Molecular Detection of BCR-ABL in Chronic Myeloid Leukemia -- Induction of Chronic Myeloid Leukemia in Mice -- CML Mouse Model Generated from Leukemia Stem Cells -- Immunological Analyses of Leukemia Stem Cells -- Cell Cycle Analysis of CML Stem Cells using Hoechst33342 and Propidium Iodide -- Histological and In Vivo Microscopic Analysis of the Bone Marrow Microenvironment in a Murine Model of Chronic Myelogenous Leukemia -- The Culture Repopulation Ability (CRA) Assay and Incubation in Low Oxygen to Test Anti-Leukemic Drugs on Imatinib-resistant CML Stem-like Cells -- Tumor Suppressor Analysis in CML -- Detecting Autophagy and Autophagy Flux in Chronic Myeloid Leukemia Cells Using a Cyto ID Fluorescence Spectrophotometric Assay -- DREAM, A Simple Method for DNA Methylation Profiling by High Throughput Sequencing -- ChIP-seq Analysis of Human Chronic Myeloid Leukemia Cells -- Quantitative Proteomics Analysis of Leukemia Cells -- A Convenient Cell Culture Model for CML Acquired Resistance through BCR-ABL Mutations -- High Throughput Screening of Tyrosine Kinase Inhibitor Resistant Genes in CML -- Biological Analysis of Human CML Stem Cells; Xenograft Model of Chronic Phase Human Chronic Myeloid Leukemia -- New Mouse Models to Investigate the Efficacy of Drug Combinations in Human Chronic Myeloid Leukemia -- miRNome Analysis of CML Cells -- An Integrative Analysis of microRNA and mRNA Profiling in CML Stem Cells -- Single Cell Cytokine Profiling to Investigate Cellular Functional Diversity in Hematopoietic Malignancies
    Abstract: This volume highlights the molecular and cellular methods used in studying Chronic Myeloid Leukimia (CML) pathogenesis and stem cell biology. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Chronic Myeloid Leukemia: Methods and Protocols aims to ensure successful results in the further study of this vital field
    Pages: XI, 257 p. 63 illus., 43 illus. in color. : online resource.
    ISBN: 9781493940110
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  • 2
    Keywords: Oncology ; Stem Cells ; Cancer Research ; Stem Cells ; Springer eBooks
    Description / Table of Contents: Role of leukemia stem cells in pathogenesis of hematologic malignancies -- Leukemia stem cells in chronic myeloid leukemia -- Leukmeia stem cells in MLL-rearranged acute myeloid leukemia -- Interaction between leukmeia stem cells and bone marrow environment -- Molecular signatures of leukemia stem cells -- Metabolic regulation of leukemia stem cell function -- Epigenetic regulation of leukmeia stem cell function -- DNA instability and leukemia stem cell function -- Tumor suppressor genes in leukemia stem cells -- Targeting leukemia stem cells -- Leukemia stem cells and drug resistance -- Hypoxia and leukemia
    Abstract: This book introduces readers to the biology of leukemia stem cells (LSCs) and emphasizes the necessity and importance of targeting LSCs in the treatment of hematopoietic malignancies. It addresses the role of leukemia stem cells in different leukemia diseases and molecular signatures, as well as the metabolic and epigenetic regulation of leukemia stem cell function. With regard to solid tumors, a significant number of blood cancers are believed to be derived from leukemia stem cells (LSCs), which are responsible for disease progression, relapse and drug resistance. Consequently, new therapeutic strategies need to be developed by focusing on the complete eradication of LSCs. Given its scope, the book offers a valuable asset for graduate students and scientists in the fields of cell biology and cancer research etc
    Pages: VIII, 229 p. 40 illus., 37 illus. in color. : online resource.
    Edition: 1st ed. 2019.
    ISBN: 9789811373428
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  • 3
    ISSN: 1546-1718
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] The Abl kinase inhibitor imatinib mesylate is the preferred treatment for Philadelphia chromosome–positive (Ph+) chronic myeloid leukemia (CML) in chronic phase but is much less effective in CML blast crisis or Ph+ B-cell acute lymphoblastic leukemia (B-ALL). Here, we show that Bcr-Abl ...
    Type of Medium: Electronic Resource
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