Key words Follow-up study, glycated Hb, HbA1 c, IGT, Pima Indians.
Springer Online Journal Archives 1860-2000
Summary Glycated haemoglobin could offer several practical advantages over the OGTT for assessing glucose metabolism. Initial cross-sectional studies (1983–1985) on 381 subjects (mostly Pima Indians) described the relationship between HbA1 c (a specific glycated Hb) and the OGTT. We performed follow-up OGTTs and HbA1 c measurements on 257 of these same subjects 1.6–6.1 years later. Subjects were again grouped according to both the result of the OGTT (normal, IGT or diabetes, by WHO criteria) and HbA1 c result (normal or elevated based on mean ±1.96 SD of normal). Of 66 subjects with IGT at baseline, 47 (71 %) had normal HbA1 c and 19 (29 %) had elevated HbA1 c. Twenty-six (39 %) of these subjects had diabetes at follow-up. Of these subjects with IGT, a significantly greater percentage of subjects with elevated HbA1 c at baseline (68 %) showed worsening to diabetes than those with a normal HbA1 c (28 %); (chi-square =7.8, df =1, p〈0.01). Thus, in subjects with IGT, glycated Hb may be a useful predictor of progression to diabetes. [Diabetologia (1994) 37: 252–256]
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