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  • 1
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    STUTTGART U. A.: G. FISCHER
    Call number: QP501Z:5/16,2
    Pages: 84 S.
    ISBN: 3-437-11003-9
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  • 2
  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Cell & tissue research 238 (1984), S. 635-642 
    ISSN: 1432-0878
    Keywords: Liver ; Endothelium ; Kupffer cells ; Peroxidase ; Cytochemistry ; Ultrastructure ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Rat liver fixed by perfusion with low glutaraldehyde concentrations was incubated in diaminobenzidine-containing medium to stain for peroxidase. Endogenous peroxidatic activity was found not only in Kupffer cells but also in the endothelial cells lining the sinusoids and central veins. The reaction product was localized in the nuclear envelope and endoplasmic reticulum. The peroxidatic activity in endothelial cells showed a concentration-dependent sensitivity to glutaraldehyde: in liver samples fixed with 0.25% glutaraldehyde, approx. 23% of the sinusoidal endothelial cells and 65% of central vein endothelium were peroxidase-positive; with 0.5% glutaraldehyde, only approx. 8% of the sinusoidal endothelial cells contained detectable amounts of the reaction product; with 1.5% glutaraldehyde all endothelial cells were consistently peroxidase-negative. No peroxidatic activity could be found in liver endothelial cells following isolation by centrifugal elutriation. Endothelial cell peroxidase may possibly be involved in defense responses of liver and/or, as a part of prostaglandin synthase system, in prostanoid production.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 0949-877X
    Keywords: Key words: Databases - Distributed systems - Economic site - Autonomy - Wide-area network - Name service
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science
    Notes: Abstract. The requirements of wide-area distributed database systems differ dramatically from those of local-area network systems. In a wide-area network (WAN) configuration, individual sites usually report to different system administrators, have different access and charging algorithms, install site-specific data type extensions, and have different constraints on servicing remote requests. Typical of the last point are production transaction environments, which are fully engaged during normal business hours, and cannot take on additional load. Finally, there may be many sites participating in a WAN distributed DBMS. In this world, a single program performing global query optimization using a cost-based optimizer will not work well. Cost-based optimization does not respond well to site-specific type extension, access constraints, charging algorithms, and time-of-day constraints. Furthermore, traditional cost-based distributed optimizers do not scale well to a large number of possible processing sites. Since traditional distributed DBMSs have all used cost-based optimizers, they are not appropriate in a WAN environment, and a new architecture is required. We have proposed and implemented an economic paradigm as the solution to these issues in a new distributed DBMS called Mariposa. In this paper, we present the architecture and implementation of Mariposa and discuss early feedback on its operating characteristics.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 0949-877X
    Keywords: Transaction ordering ; synchronization ; execution correctness ; concurrent succession ; partial rollbacks
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science
    Notes: Abstract Database applications often impose temporal dependencies between transactions that must be satisfied to preserve data consistency. The extant correctness criteria used to schedule the execution of concurrent transactions are either time independent or use strict, difficult to satisfy real-time constraints. On one end of the spectrum, serializability completely ignores time. On the other end, deadline scheduling approaches consider the outcome of each transaction execution correct only if the transaction meets its real-time deadline. In this article, we explore new correctness criteria and scheduling methods that capture temporal transaction dependencies and belong to, the broad area between these two extreme approaches. We introduce the concepts ofsuccession dependency andchronological dependency and define correctness criteria under which temporal dependencies between transactions are preserved even if the dependent transactions execute concurrently. We also propose achronological scheduler that can guarantee that transaction executions satisfy their chronological constraints. The advantages of chronological scheduling over traditional scheduling methods, as well as the main issues in the implementation and performance of the proposed scheduler, are discussed.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1573-2592
    Keywords: IgD ; delta heavy chain ; immune deficiency ; Ig allelic variations ; human lambda light chains
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract IgD production by short-term human peripheral blood mononuclear cell (PBM) cultures was studied to establish thein vitro correlates of low serum IgD expression. Cells of persons with 〈3 µg/ml IgD in the serum, referred to as the low-serum IgD phenotype (LISP), were analyzed. Advantage was taken of recently developed data on spontaneous IgD biosynthesis by human B cells and the observation that lambda light chains are preferentially expressed by IgD-secreting cellsin vitro. Initial analysis of an IgD serum distribution showed that all LISP sera contained low but detectable amounts of IgD, with a mean value of 0.85 µg/ml; this figure was 30- to 35-fold lower than the mean of the majority of the population. LISP PBM contained normal numbers of IgD-positive B cells which displayed a normal intensity of IgD per cell using comparative analysis of mean channel fluorescence by cell flow cytometry. Several lines of evidence suggested that IgD-secreting cells could not be generated from LISP lymphocytesin vitro. Namely, it was found that (1) no IgD immunoglobulin-containing cells were found among PBM of LISP persons; (2) cell lysates enriched for the intracellular fraction by Triton X-114 phase separation showed low IgD in LISP cells despite “normal” amounts of IgD in membrane-enriched fraction preparations; (3) there was no spontaneous IgD secretion by any LISP PBM cultures; and (4) neither LISP sera nor cellular IgD preparations showed IgD lambda/kappa ratios 〉1.0, indicative of the absence of the preferential lambda light-chain expression associated with secretion of IgD. It was concluded that LISP IgD-positive B cells lacked both active secretion of IgD and the preferential delta heavy-lambda light-chain expression associated with secreted IgD. The issue of whether the underlying immunophysiologic “defect” was best characterized as an immune deficiency or a genetic variation is discussed.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1435-604X
    Keywords: Nd-YAG laser ; Sapphire tips ; Stomach seromyotomy ; Chronic duodenal ulcers
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Physics , Technology
    Notes: Abstract A new technique for performing a lesser-curve superficial myotomy of the stomach for the treatment of chronic duodenal ulceration has been proposed, using Nd-YAG laser energy delivered to the target via sapphire tips. A total of 12 patients have been operated on with only one haemorrhagic complication.
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1573-5001
    Keywords: Stereospecific assignments ; Floating prochirality ; Structure refinement ; Distance geometry ; Simulated annealing
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Summary We examine the statistical and other considerations which determine the validity and reproducibility of stereospecific hydrogen NMR assignments obtained by the floating prochirality method. In this method, the assignment of a prochiral configuration of hydrogens at selected centers is allowed to ‘float’ during the structure refinement, and the distribution of prochiral orientations in highly refined structures is subjected to statistical analysis. The underlying statistical basis for this approach is examined and potential limitations of current approaches are identified. As an example, approximately 1300 distance constraints obtained from NOESY spectra of oxidized horse cytochrome c have been used to examine several computational strategies. Repeated calculations were done by several different methods on both the whole molecule (104 residues plus heme) and on a 23-residue fragment containing two helices, a turn, and flanking residues. The results show that, even with NOE constraints alone, one third of the centers may be reproducibly assigned, provided appropriate precautions are taken. These precautions include adjustments for multiple statistical comparisons and characterization of statistical interactions between prochiral centers. The analysis demonstrates that inadequately constrained systems, such as fragments from a larger molecule, may produce misleading results, raising concerns about methods which rely solely on intraresidue and sequential interresidue contraints. A mathematical model describing interactions among prochiral centers is described and validated, and protocols for assignment and statistical validation are presented.
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 1573-2592
    Keywords: Immunodeficiency ; corticosteroids ; Ig synthesisin vitro
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Coculture experiments between lymphocytes of a 17-year-old immunodeficient male, DL, and a group of normal subjects, assaying pokeweed mitogen (PWM)-stimulated Ig secretion as a measure of B-cell function, revealed immunoregulatory abnormalities. Initial studies disclosed that DL had corticosteroid-sensitive T suppressor (Ts) cells capable of blocking Ig secretion by both HLA-identical and HLA-nonidentical cells in coculture. Cocultures of DL's peripheral blood mononuclear cells could be induced to secrete Ig in large amounts after certain maneuvers—the most informative of which involved mixing prednisolone-treated DL mononuclear cells with any normal T lymphocytes except those from DL himself. When these same experimental manipulations were performed individually, i.e., prednisolone treatment of cultured DL cells to remove Ts activity, or mixing equal numbers of normal T cells with untreated DL mononuclear cells, Ig was not produced. The data indicated that the T-cell abnormalities in DL included an excess of Ts cells and a deficiency of T helper (Th) cells. When repeat studies were performed later in the clinical course, during which interval a number of clinical interventions were attempted, it was found that the patient's cells were no longer corticosteroid sensitive and, further, they suppressed only HLA-identical cells.
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 1573-2649
    Keywords: Prostate cancer ; quality of life ; observational databases.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract This paper reviews the reliability and validity of an instrument for assessing health-related quality of life (HRQOL) in CaPSURE(tm) (Cancer of the Prostate Strategic Urologic Research Endeavor), an observational database of men with biopsy-confirmed prostate cancer. The questionnaire includes the RAND 36 item Health Survey 1.0, the UCLA Prostate Cancer Index and items measuring self-esteem and the impact of prostate cancer in general and on the family. The reliability and validity of this instrument are reported for a group of 2,382 men enrolled in CaPSURE(tm). Individuals complete HRQOL questionnaires at enrolment and quarterly thereafter. The subscales of the instrument resulted in a high internal-consistency reliability across all subscales (range=0.75-0.94). The test-retest reliability was good with the exception of the comparative health item (intraclass correlation coefficient (ICC)=0.55). The concurrent validity data included moderately strong associations with subscales of similar concepts and the ability to distinguish between patients who are known to be different - newly diagnosed (within 6 months) and patients diagnosed and treated an average of 3 years ago. Overall, this instrument demonstrated good reliability and validity and supported the need for incorporating HRQOL as a component of outcomes assessment in the management of patients with prostate cancer.
    Type of Medium: Electronic Resource
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