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  • 1
    Publication Date: 2020-07-01
    Print ISSN: 0195-6701
    Electronic ISSN: 1532-2939
    Topics: Medicine
    Published by Elsevier
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  • 2
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    German Medical Science GMS Publishing House; Düsseldorf
    In:  45. Jahrestagung der Deutschen Gesellschaft der Plastischen, Rekonstruktiven und Ästhetischen Chirurgen (DGPRÄC), 19. Jahrestagung der Vereinigung der Deutschen Ästhetisch-Plastischen Chirurgen (VDÄPC), 52. Jahrestagung der Österreichischen Gesellschaft für Plastische, Ästhetische und Rekonstruktive Chirurgie (ÖGPRÄC); 20140911-20140913; München; DOC316 /20140903/
    Publication Date: 2014-09-04
    Keywords: ddc: 610
    Language: German
    Type: conferenceObject
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  • 3
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    German Medical Science GMS Publishing House; Düsseldorf
    In:  64. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC); 20130526-20130529; Düsseldorf; DOCP 015 /20130521/
    Publication Date: 2013-05-22
    Keywords: Antibiotic prophylaxis ; Surgical site infection ; Third-generation cephalosporin ; ddc: 610
    Language: English
    Type: conferenceObject
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  • 4
    Keywords: DISEASE ; DISEASES ; GENE ; GENES ; PROTEIN ; PROTEINS ; RNA ; DNA ; recombination ; tumour ; BIOLOGY ; SEQUENCE ; chromosome ; NUMBER ; MUTATION ; inactivation ; REGION ; MUTATIONS ; EVOLUTION ; DEGRADATION ; CHROMOSOMES ; GENE FAMILY ; AID ; HUMAN GENOME SEQUENCE ; INACTIVATION CENTER ; LINKED MENTAL-RETARDATION ; MAMMALIAN Y-CHROMOSOME ; REPEAT HYPOTHESIS
    Abstract: The human X chromosome has a unique biology that was shaped by its evolution as the sex chromosome shared by males and females. We have determined 99.3% of the euchromatic sequence of the X chromosome. Our analysis illustrates the autosomal origin of the mammalian sex chromosomes, the stepwise process that led to the progressive loss of recombination between X and Y, and the extent of subsequent degradation of the Y chromosome. LINE1 repeat elements cover one-third of the X chromosome, with a distribution that is consistent with their proposed role as way stations in the process of X-chromosome inactivation. We found 1,098 genes in the sequence, of which 99 encode proteins expressed in testis and in various tumour types. A disproportionately high number of mendelian diseases are documented for the X chromosome. Of this number, 168 have been explained by mutations in 113 X-linked genes, which in many cases were characterized with the aid of the DNA sequence
    Type of Publication: Journal article published
    PubMed ID: 15772651
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  • 5
    Keywords: OPTIMIZATION ; APOPTOSIS ; CELLS ; proliferation ; INHIBITION ; VOLUME ; INDUCTION ; FLOW ; PARAMETERS ; CAPACITY ; PH ; FLAVONOIDS ; RECOVERY ; SEPARATION ; adsorption ; PEOPLE ; DESORPTION ; ANTHOCYANINS ; luteolin ; macroporous resins ; pigeonpea ; POLYMERIC ADSORBENTS
    Abstract: In the present study, the performance and separation characteristics of eight macroporous resins for the separation of luteolin (LU) from pigeonpea leaves extracts have been evaluated. The adsorption and desorption properties of LU on macroporous resins including AB-8, NKA-9, NKA-2, D3520, D101, H 1020, H103 and AL-2 have been compared. AL-2 resin offers the best adsorption and desorption capacity for LU than other resins based on the research results, and its adsorption data at 25 degrees C fit best to the Freundlich isotherm. Dynamic adsorption and desorption experiments have been carried out with the column packed by AL-2 resin to optimize the separation process of LU from pigeonpea leaves extracts. The optimum parameters for adsorption were sample solution LU concentration 65.5 mu g/ml, pH 5, processing volume 3 BV, flow rate 1.5 BV/h, temperature 25 degrees C; for desorption were elution solvent ethanol-water (50:50, v/v) 2 BV and followed by ethanol-water (60:40, v/v) 2 BV, and flow rate I BV/h. After treated with AL-2 resin, the LU content in the product was increased 19.8-fold from 0.129% to 2.55%, with a recovery yield of 78.54%. The results showed that AL-2 resin revealed a good ability to separate LU. Therefore, we conclude that results in this study may provide scientific references for the large-scale LU production from pigeonpea or other plants extracts. (c) 2006 Elsevier B.V. All rights reserved
    Type of Publication: Journal article published
    PubMed ID: 17126843
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  • 6
    Keywords: CELLS ; AGENTS ; CELL ; Germany ; MICROSCOPY ; THERAPY ; DEATH ; TIME ; MECHANISM ; mechanisms ; treatment ; DAMAGE ; SURFACE ; MORPHOLOGY ; BODY ; AGENT ; BODIES ; CHEMISTRY ; HEIGHT ; LEVEL ; SIZE ; technique ; pharmacology ; ANTIBACTERIAL ; Atomic force microscopy ; SHAPE ; antibacterial activity ; CYTOPLASM ; essential oil ; GRAM-POSITIVE BACTERIA ; labiatae ; Propionibacterium acnes ; rosemary ; rosmarinus officinalis L ; VULGARIS
    Abstract: In the present study, the antibacterial activity of rosemary (Rosmarinus officinalis L. Labiatae) essential oil against Propionibacterium acnes (P. acnes) was observed with atomic force microscopy (AFM). The MIC (minimal inhibitory concentration) value of rosemary essential oil against Racnes was 0.56 mg/mL. Significant changes in morphology and size of P. acnes were observed by atomic force microscopy (AFM) in response to essential oil treatment. The essential oil first attached to the surface of A acnes at low concentration, the width and height of the bacterial body became larger, whereas the length did not change considerably. With increasing concentration of the essential oil, the bacterial bodies were severely damaged. The length, width and height were all reduced, when the concentration was increased up to 64 x MIC, the length, width and height were reduced by 42.56%, 92.00% and 41.58%, respectively. Furthermore, treated bacteria lost their native shape, the cell wall desquamated, and the cytoplasm leaked out of the bacterial body, finally leading to bacterial death. With the increasing time at MIC, the bacteria length was reduced at 8 h, the width and height gradually became smaller, the shape of the cell became distorted, and finally led to cell wall damage and bacterial death at 8 h. In conclusion, the AFM investigation of morphology and size of A acnes treated with rosemary essential oil represents a powerful technique, which can generally be applied to reveal the biological changing mechanisms of bacteria induced by antibacterial agents at the nanometer level
    Type of Publication: Journal article published
    PubMed ID: 17893831
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  • 7
    Keywords: ENVIRONMENT ; CANCER ; carcinoma ; CELL ; neoplasms ; COMMON ; incidence ; POPULATION ; GENE ; GENES ; ASSOCIATION ; polymorphism ; POLYMORPHISMS ; single nucleotide polymorphism ; SUSCEPTIBILITY ; FREQUENCIES ; cytokines ; DISTRIBUTIONS ; DIFFERENCE ; PROMOTER ; AGE ; SWEDEN ; LENGTH ; POPULATIONS ; HEALTHY ; basal cell carcinoma ; CYCLIN D1 ; CELL CARCINOMA ; WORLDWIDE ; ALLELE ; SINGLE NUCLEOTIDE POLYMORPHISMS ; SNPs ; RHEUMATOID-ARTHRITIS ; REDUCTASE ; INTERLEUKIN-6 ; BCC ; interleukin gene ; METHYLENETETRAHYDROFOLATE REDUCTASE ; MTHFR ; SINGLE-NUCLEOTIDE POLYMORPHISMS
    Abstract: Background: Pyrosequencing is a new method to detect single nucleotide polymorphisms (SNPs). Basal cell carcinoma (BCC) is one of the most common neoplasms in the world, and its incidence has been increasing worldwide in recent years. BCC is caused by an interplay between genetic and environment factors. Methods: Pyrosequencing and restrict fragment length polymorphism (RFLP) were used in the study. We conducted a case-control association study in BCC cases and controls from Sweden. For SNPs in IL-6, IL-10 andIL-1beta, 241 cases were at the age of 27-70 years (mean 50 years) and 260 healthy controls were 26-71 years (mean 48 years), 241 cases were 27-70 years (mean 50 years) and 574 healthy controls were 22-74 years (mean 52 years) for cyclin D1 G870A, 197 cases were 29-69 years (mean 47 years) and 574 healthy controls were 22-74 years (mean 52 years) for MTHFR C677T and A1298C. Nine SNPs for IL-6-174G/C, -634G/C and -597G/A; IL-10-1082G/A and -592C/A; IL-1beta-511CIT; cyclin D1 G870A; MTHFR C677T and A1298C were analyzed. Results: Most genotype distributions were in accordance with Hardy-Weinberg equilibrium (HWE), except IL-10-1082G/A, which had a significantly deviation from HWE in BCC cases (P〈0.05). Linkage disequilibrium was observed between the -174 and -597 alleles in the IL6 gene in the studied populations. The differences for cyclin D1 G870A and methylenetetrahydrofolate reductase (MTHFR) C677T were found between BCC cases group and control group (P〈0.05, OR=1.34, 95% CI, 1.00-1.74; P〈0.05, OR=1.67, 95% CI, 1.13-2.47, respectively). Conclusions: Cyclin DI G870A and MTHFR C677T were associated with BC cases from Sweden, the other SNPs studied here were not associated with BCC, but chance cannot be excluded. (C) 2004 Elsevier B.V All rights reserved
    Type of Publication: Journal article published
    PubMed ID: 15026274
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  • 8
    Keywords: DRUG ; HPLC ; ASSAY ; CARCINOMA CELLS ; TANDEM MASS-SPECTROMETRY ; PURIFICATION ; LIQUID-CHROMATOGRAPHY ; 10-deacetylbaccatin III ; CULTURES ; HIMALAYAN YEW ; PACLITAXEL TAXOL ; PFP column ; taxoids ; Taxus ; WALLICHIANA
    Abstract: A simple and accurate RP-HPLC method with pentafluorophenyl (PFP) column was developed for the simultaneous determination of six taxoids, i.e. paclitaxel, 10-deacetylbaccatin III (10-DAB III), 7-xylosyl-10-deacetyltaxol (7-xyl-10-DAT), 10-deacetyltaxol (10-DAT), cephalomannine and 7-epi-10-deacetyltaxol (7-epi-10-DAT), In the extracts from the needles of three Taxus species. The mobile phase consisted of acetonitrile (A) and water (B), and the extracts were separated using gradient elution program: 30% A at the first 7 min, and then ramped to 42% A at 8 min, held until 38 min. The developed method was validated with satisfactory precision (RSD 〈 2.61%), repeatability (RSD 〈 2.92%) and recovery (95.19-104.47%). The above taxoids in the extracts of Tamus cuspidata, T. chinensis and T. media were analyzed with the developed RP-HPLC method, and the results showed that the contents of different taxoids in three mentioned species were distinct. Maximal amounts of 10-DAB III, 7-xyl-10-DAT and 7-epi-10-DAT appeared in T. chinensis, while T. media possessed the highest content of 10-DAT, cephalomannine and paclitaxel. The developed method is accurate and efficient. It can be reliably used in the improved determination of taxoids for the quality control of Taxus species. Copyright (c) 2008 John Wiley & Sons, Ltd
    Type of Publication: Journal article published
    PubMed ID: 18816506
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  • 9
    Abstract: Previously we showed that sulfaphenazole (SUL), an antimicrobial agent that is a potent inhibitor of cytochrome P4502C9, is protective against ischemia/reperfusion (I/R) injury. The mechanism, however, underlying this cardioprotection, is largely unknown. With evidence that activation of autophagy is protective against simulated I/R in HL-1 cells, and evidence that autophagy is upregulated in preconditioned hearts, we hypothesized that SUL-mediated cardioprotection might resemble ischemic preconditioning with respect to activation of protein kinase C and autophagy. We used the Langendorff model of global ischemia to assess the role of autophagy and protein kinase C in myocardial protection by SUL during I/R. We show that SUL enhanced recovery of function, reduced creatine kinase release, decreased infarct size, and induced autophagy. SUL also triggered PKC translocation, whereas inhibition of PKC with chelerythrine blocked the activation of autophagy in adult rat cardiomyocytes. In the Langendorff model, chelerythrine suppressed autophagy and abolished the protection mediated by SUL. SUL increased autophagy in adult rat cardiomyocytes infected with GFP-LC3 adenovirus, in isolated perfused rat hearts, and in mCherry-LC3 transgenic mice. To establish the role of autophagy in cardioprotection, we used the cell-permeable dominant negative inhibitor of autophagy, Tat-Atg5K130R. Autophagy and cardioprotection were abolished in rat hearts perfused with recombinant Tat-Atg5K130R. Taken together, these studies indicate that cardioprotection mediated by SUL involves a PKC-dependent induction of autophagy. The findings suggest that autophagy may be a fundamental process that enhances the heart's tolerance to ischemia.
    Type of Publication: Journal article published
    PubMed ID: 20008275
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  • 10
    Keywords: RETROVIRAL VECTORS ; IMMUNODEFICIENCY-VIRUS ; BET FUSION PROTEIN ; INTERNAL PROMOTER ; FUNCTIONAL-CHARACTERIZATION ; LEUKOCYTE ADHESION DEFICIENCY ; CIS-ACTING SEQUENCES ; CALICIVIRUS INFECTION ; POTENT NEUTRALIZATION ; PRIMATE SPUMAVIRUSES
    Abstract: New-generation retroviral vectors have potential applications in vaccination and gene therapy. Foamy viruses are particularly interesting as vectors, because they are not associated to any disease. Vector research is mainly based on primate foamy viruses (PFV), but cats are an alternative animal model, due to their smaller size and the existence of a cognate feline foamy virus (FFV). The potential of replication-competent (RC) FFV vectors for vaccination and replication-deficient (RD) FFV-based vectors for gene delivery purposes has been studied over the past years. In this review, the key achievements and functional evaluation of the existing vectors from in vitro cell culture systems to out-bred cats will be described. The data presented here demonstrate the broad application spectrum of FFV-based vectors, especially in pathogen-specific prophylactic and therapeutic vaccination using RD vectors in cats and in classical gene delivery. In the cat-based system, FFV-based vectors provide an advantageous platform to evaluate and optimize the applicability, efficacy and safety of foamy virus (FV) vectors, especially the understudied aspect of FV cell and organ tropism.
    Type of Publication: Journal article published
    PubMed ID: 23857307
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