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1 streaming video file (25 min.) :
digital, mono., SWF file, sd., col.
Innate immunity : host recognition and response in health and disease
Contents: Plasmacytoid dendritic cells (pDCs) are important mediators of antiviral immunity through their ability to produce large amounts of type I interferons (IFNs) on viral infection -- This function of pDCs is linked to their expression of Toll-like receptor 7 (TLR7) and TLR9, which sense viral nucleic acids within the early endosomes -- Exclusion of self nucleic acids from TLR-containing early endosomes normally prevents pDC responses to them -- In some autoimmune diseases, self nucleic acids can be modified by host factors and gain entrance to pDC endosomes, where they activate TLR signaling -- Several pDC receptors negatively regulate type I IFN responses by pDCs during viral infection and for normal homeostasis.
Mode of access: World Wide Web.