Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    ISSN: 1432-5233
    Keywords: Key words Goto-Kakizaki (GK) rats ; Fetal development ; Pregnancy ; Insulin secretion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Fetal development was investigated in Goto-Kakizaki (GK) rats. Between days 15 and 20 after identification of a positive sperm plug, the GK rats gained less weight than control animals. The number of conceptuses in each litter was not significantly different in control and GK rats. The incidence of abortive fetal development, however, averaged 39.7%±9.1% in GK rats, compared with only 5.6%±0.2% in control animals. The placental weight in living fetuses was slightly lower in GK rats than control rats. The crown-rump length was identical in the fetuses of control and diabetic mothers. The number of ossification points in the lumbosacral spine, pelvic girdle and anterior and posterior limbs was significantly lower in fetuses of GK rats than control animals. These anomalies could not be blamed on a lower plasma insulin concentration in GK than control animals, whether before or during (days 15–20) pregnancy. Moreover, in both control and GK rats, the insulinogenic index was raised during pregnancy. These findings indicate that GK rats represent a new model for the study of diabetes-related fetal anomalies, their pathogenesis and prevention.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Surgical and radiologic anatomy 15 (1993), S. 207-208 
    ISSN: 1279-8517
    Keywords: Inner ear ; Labyrinth ; Endolymphatic duct
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé Un cas de dédoublement unilatéral de l'aqueduc du vestibule est présenté. Tout porte à croire qu'il s'agit d'une anomalie extrêmement rare. Elle pourrait s'expliquer par une induction excessive du canal endolymphatique par le rhombencéphale, ou par une division complète de ce canal en ses parties utriculaire et sacculaire.
    Notes: Summary A case of unilateral duplication of the vestibular aqueduct is presented. This very rare abnormality can be explained either by an excessive induction by the rhombencephalon or by an abnormal complete division of the endolymphatic duct into utricular and saccular parts.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 3
    ISSN: 1279-8517
    Keywords: Mouse ; Embryo ; Retinoic acid ; Triazene ; Facial abnormalities
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé En vue d'apporter une meilleure compréhension des modèles tératogènes de la dysostose mandibulo-faciale et de la microsomie hémicrâniofaciale humaine, les auteurs ont entrepris une étude histologique au bleu de toluidine et une étude morphologique au microscope électronique à balayage des malformations faciales induites chez les embryons de souris par l'acide rétinoïque ou par le méthyl-triazène. L'administration d'une dose de 400 mg/kg d'acide 13-cis rétinoïque (AR) à 14 souris C57BL gravides, au 9e jour de gestation, engendre chez les embryons des anomalies de l'extrémité céphalique simulant la dysostose mandibulo-faciale humaine. Les 64 embryons récoltés présentaient dans 79 % des cas une hypoplasie des arcs branchiaux ou du museau, des anomalies auriculaires (47 %) et ophtalmiques (12,5 %). Quatorze souris NMRI ont reçu, au jour 10,5 de gestation, une dose de 1,5 mg (0,5 mg/kg) de méthyl-triazène (Méthyl). Les 126 embryons récoltés ont développé un pourcentage très élevé de micromandibulies et d'anomalies symétriques des ébauches auriculaires (94,6 à 100 %). En conclusion, les anomalies faciales engendrées par l'acide rétinoïque évoquent le syndrome humain de la dysostose mandibulo-faciale. En revanche, contrairement à l'hypothèse émise par Poswillo, aucune homologie ne peut être faite entre la microsomie hémicrâniofaciale et l'administration de méthyl-triazène.
    Notes: Summary To obtain a better understanding of mandibulo-facial dysostosis and hemicraniofacial microsomia in man, the authors carried out a histologic and scanning electron microscope study of the facial malformations produced in mouse embryos by retinoic acid and methyl-triazene. The administration of 400 mg/kg 13 cis-retinoic acid (RA) to pregnant C57BL mice on day 9 of gestation produced anomalies of the cephalic extremity in the embryos resembling human mandibulo-facial dysostosis. The 64 embryos collected presented hypoplasia of the branchial arches or the snout in 79% of cases, auricular anomalies in 47% and ophthalmic anomalies in 12.5%. Fourteen NMRI mice on day 10.5 of gestation were treated with 1.5 mg (0.5 mg/kg) methyl-triazene (Methyl). The 126 embryos collected had developed a very high percentage of micromandibles and anomalies of both embryonic ears (94.6% to 100%). Finally, although the facial anomalies produced by retinoic acid resemble the human mandibulo-facial dysostosis syndrome, no correlation was found between hemicraniofacial microsomia and the administration of methyltriazene.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 4
    ISSN: 1279-8517
    Keywords: Mouse ; Embryo ; Retinoic acid ; Triazene ; Facial abnormalities
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract To obtain a better understanding of mandibulo-facial dysostosis and hemicraniofacial microsomia in man, the authors carried out a histologic and scanning electron microscope study of the facial malformations produced in mouse embryos by retinoic acid and methyl-triazene. The administration of 400 mg/kg 13 cis-retinoic acid (RA) to pregnant C57BL mice on day 9 of gestation produced anomalies of the cephalic extremity in the embryos resembling human mandibulo-facial dysostosis. The 64 embryos collected presented hypoplasia of the branchial arches or the snout in 79% of cases, auricular anomalies in 47% and ophthalmic anomalies in 12.5%. Fourteen NMRI mice on day 10.5 of gestation were treated with 1.5 mg (0.5 mg/kg) methyl-triazene (Methyl). The 126 embryos collected had developed a very high percentage of micromandibles and anomalies of both embryonic ears (94.6% to 100%). Finally, although the facial anomalies produced by retinoic acid resemble the human mandibulo-facial dysostosis syndrome, no correlation was found between hemicraniofacial microsomia and the administration of methyl-triazene.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 5
    ISSN: 1279-8517
    Keywords: Mouse ; Middle ear ; Ossicles ; Retinoic acid
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé L'administration orale d'acide rétinoïque (AR) à des souris gravides à 9 jours de gestation est responsable d'importantes malformations des osselets de l'oreille moyenne, associées à une dysmorphose d'ensemble de la sphère maxillo-faciale évoquant la dysostose mandibulo-faciale humaine. Le malleus, l'incus et le stapes sont affectés. Le malleus présente un manche séparé de sa tête et conservant un rapport constant avec le récessus tubo-tympanique. Le stapes peut ne présenter aucun contact avec la capsule otique. L'atteinte malformative est précocement visible par l'apparition d'un cartilage de Meckel anormalement arciforme au douxième jour, suivie du développement d'ébauches ossiculaires présentant d'emblée une forme anormale. L'administration d'AR à des souris gravides et la comparaison des résultats obtenus avec un modèle génétique (la mutation “far”) est source d'informations très intéressantes relatives aux mécanismes supposés caractériser les dysmorphoses de l'oreille moyenne dans l'espèce humaine. Cette méthodes nous fournit en outre de précieux renseignements relatifs aux caractéristiques de l'ontogenèse ossiculaire normale.
    Notes: Summary Oral administration of 13-cis retinoic acid (RA) to pregnant mice on the 9th gestation day provokes important malformations of the middle ear ossicles, associated with a general kind of craniofacial dysmorphogenesis evoking the human mandibulofacial dysostosis. The malleus, incus and stapes are affected. The malleus exhibits a handle separated from its head and keeping a persistant relationship with the tubotympanic recess. The stapes makes no contact with the otic capsule. The malformation pattern is visible early as shown by the appearance of an abnormally curved Meckel's cartilage at day 12, followed by the development of atypically shaped ossicular anlagen. The mouse “far” (first arch malformation) mutation is responsible for minor ossicular abnormalities which disrupts the normal relationships between the stapes, Reichert's cartilage and stapedial muscle. The administration of RA to pregnant mice and the comparison with a genetically induced malformation (the mutation far) provides some interesting information about the postulated mechanisms of human middle ear dysmorphogenesis, as well as precious data about the features of normal ossicular primordia formation. The comparison of these features with human middle ear abnormalities as revealed by medical imaging sheds light on human malformation patterns and provides a better understanding of normal and abnormal radiologic ossicular aspects.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 6
    ISSN: 1279-8517
    Keywords: Carpus ; 3D imaging ; Bone motion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé Une étude tomodensitométrique des poignets droits de 15 volontaires et de 5 préparations anatomiques réalisée en position neutre, en inclinaison radiale (15°) et ulnaire (30°) permet d'aborder l'analyse qualitative des mouvements des os du carpe. Les coupes tomodensitométriques ont été analysées et des reconstructions tridimensionnelles ont été effectuées à l'aide du programme CAMRA S100 de Philips. Les résultats montrent que le capitatum, les métacarpiens II et III et, dans une moindre mesure, le trapèze et le trapézoïde sont peu mobiles. Notre étude souligne l'importance du rôle des muscles fléchisseur et extenseur ulnaires du carpe sur la stabilité de la partie interne du carpe confirmant que le pisiforme doit être considéré comme os sésamoïde du tendon du fléchisseur ulnaire du carpe. Un modèle de structure fonctionnelle longitudinale du carpe lors des inclinaisons latérales, intermédiaire à ceux de Navarro et Taleisnik, est proposé.
    Notes: Summary A computed tomography (CT) study of the right wrists of 15 volunteers and of 5 anatomical preparations in neutral position, radial (15°) and ulnar (30°) deviation enables to tackle the qualitative analysis of carpal bone motion. The CT Scans were analyzed and reconstructed in three dimensions by means of the Philips CAMRA S100 computer program. The results show that the capitate, the metacarpals II and III and, to a lesser extent, the trapezium and the trapezoid are poorly mobile. Our study points to the role of the flexor and extensor carpi ulnaris muscles in the stability of the internal carpus, confirming that the pisiform is a sesamoid bone in the flexor carpi ulnaris tendon. A model of longitudinal functional structure of the carpus during lateral deviation, intermediate between those of Navarro and Taleisnik, is proposed.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 7
    ISSN: 1279-8517
    Keywords: Mouse ; Embryo ; Folic acid ; Ear ; Ossicles
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé L'administration de triazène à des souris gestantes au 10ème jour donne lieu à de sévères anomalies de l'oreille, incluant des malformations des osselets du cavum tympanique. La tête du malleus et le corps de l'incus sont souvent absents. Dans un certain nombre de cas, le stapes apparaît anormal. Dans la majorité de cas, l'a, stapédienne, qualitativement normale, apparaît dilatée au même titre que la plupart des autres vaisseaux céphaliques. De sévères anomalies de l'oreille interne sont observées, ainsi que des ruptures du n. vestibulo-cochléaire associées à d'importantes lésions du système nerveux central. De multiples hématomes sont présents dans la face, mais les malformations de l'oreille peuvent apparaître en l'absence des hémorragies. Nous pensons que l'agent tératogène exerce un effet direct sur le mésenchyme branchial. Ce modèle apparaît utile pour la compréhension des anomalies de l'oreille rencontrées dans l'espèce humaine, mais ne constitue nullement un modèle de la microsomie hémicrâniofaciale.
    Notes: Abstract Triazene administration to 10-day pregnant mice gave rise to severe ear abnormalities, including middle ear ossicle malformations. The head of the malleus and the body of the incus were sometimes absent. In some instances, the stapes appeared dysplastic. The stapedial artery was often quite dilated, as well as other cephalic vessels, but qualitatively normal. Severe inner ear abnormalities were observed, as well as auditory nerve disruption, which was associated with central nervous system lesions. Multiple haematomas were present in the embryonic face, but ear abnormalities occurred even in the absence of local hemorhages. We postulate a direct effect of the teratogen on the branchial mesenchyme. This model seems to be useful for the comprehension of human middle ear abnormalities, but does not constitute a phenocopy of hemicranial microsomia.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 8
    ISSN: 1365-2559
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Aims:  To investigate whether epidermoid cysts, branchial cysts, craniopharyngiomas and cholesteatomas express S100 proteins differentially by immunohistochemical assaying the presence of S100A1, S100A2, S100A3, S100A4, S100A5, S100A6 and S100B.Methods and results:  Immunopositivity/negativity was recorded for each S100 protein in a series of 52 cases consisting of 12 epidermoid cysts, 12 branchial cysts, 15 adamantinomatous craniopharyngiomas and 13 acquired cholesteatomas. Except in the case of the craniopharyngiomas, immunoreactivity was assessed independently in the basal membrane and the basal, the internal and the keratin layers. Our data show that in contrast to S100B, which was rarely expressed, S100A1, S100A2, S100A4 and S100A5 were often present in these four types of epithelial lesions. S100A3 and S100A6 and, to a lesser extent, S100A5 were the most differentially expressed proteins across the different histopathological groups analysed. These three proteins are expressed more often in craniopharyngiomas and cholesteatomas, the two more aggressive types of lesions.Conclusions:  This is the first study to report data on the expression of seven S100 proteins in different histopathological groups of epithelial head and neck lesions, whose precise embryological origins are still a matter of debate. S100 proteins could possibly be used as markers to target this embryonic origin, since our results show that S100A3 and S100A6 (and, to a lesser extent, S100A5) are expressed differentially across these different groups of epithelial lesions.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 9
    ISSN: 1432-1920
    Keywords: Carotid arteries, abnormalities ; Cavernous sinus ; Meninges, neoplasms ; Anatomy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We report a cavernous sinus meningioma encasing the cavernous internal carotid artery in a patient with congenital agenesis of the contralateral internal carotid artery and cavernous sinus hypoplasia.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...