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  • 1
    Keywords: Cytology ; Neurosciences ; Cell Biology ; Neurosciences ; Springer eBooks
    Description / Table of Contents: Single-Cell RNA Sequencing of Oligodendrocyte Lineage Cells from the Mouse Central Nervous System -- Isolation and Preparation of Cells from Focal Remyelinating Central Nervous System Lesion sfor RNA Sequencing -- Myelin: Methods for Purification and Proteome Analysis -- In Vitro Generation and Electrophysiological Characterization of OPCc and Oligodendrocytes from Human Pluripotent Stem Cells -- Isolation and Culture of Oligodendrocytes -- A Neuron-Free Microfiber Assay to Assess Myelin Sheath Formation -- Oligodendrocyte-Neuron Myelinating Co-Culture -- Teasing of Ventral Spinal Cord White Matter Fibres for the Analysis of Central Nervous System Nodes of Ranvier -- Whole-Cell Patch Clamp Recordings from Oligodendrocyte Lineage Cells in Brain Slices -- Ex Vivo Slice Cultures to Study Myelination, Demyelination, and Remyelination in Mouse Brain and Spinal Cord -- Forward Genetic Screen using Zebrafish to Identify New Genes Involved in Myelination -- Manipulating Neuronal Activity in the Developing Zebrafish Spinal Cord to Investigate Adaptive Myelination -- A Drug Inducible Transgenic Zebrafish Model for Myelinating Glial Cell Ablation -- Conditional Demyelination and Remyelination in a Transgenic Xenopus laevis -- Conditional Mutagenesis in Oligodendrocyte Lineage Cells -- Recent Advances in Live Imaging of Cells of the Oligodendrocyte Lineage -- The DTA Mouse Model for Oligodentrocyte Ablation and CNS Demyelination -- Human Glial Chimeric Mice to Define the Role of Glial Pathology in Human Disease -- A Method to Detect Cytochrome c Oxidase Activity and Mitochondrial Proteins in Oligodencrocytes -- Transmission Electron Microscopy of Oligodendrocytes and Myelin -- Toxin-Based Models to Investigate Demyelination and Remyelination -- Magnetic Resonance techniques for Imaging White Matter
    Abstract: This volume looks at the study of oligodendrocytes through in vitro and in vivo techniques, multiple model organisms, using approaches that bridge scales from molecular through system. Chapters in this book cover topics such as fundamental molecular analyses of oligodendrocytes and myelin; in vitro, ex vivo, and in vivo molecular-cellular-electrophysiology-based techniques; oligodendrocyte formation, homeostasis, and disruption in zebrafish and Xenopus; and parallel system-level imaging of animal and human models. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.

 Authoritative and thorough, Oligodendrocytes: Methods and Protocols is a valuable reference guide that highlights the expansive and fast-paced nature of research into oligodendrocyte biology underlying health and function
    Pages: XII, 411 p. 65 illus., 55 illus. in color. : online resource.
    ISBN: 9781493990726
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  • 2
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 344 (1990), S. 10-10 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] SIR—Hoyle and Wickramasinghe1 describe an association between sunspot maxima and pandemics of influenza, claiming that the relationship may be causal and that it holds over 17 cycles. In a causal relationship, it is conventional that the cause precedes the effect it produces, but in four of ...
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 378 (1995), S. 125-125 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] SIR - The gold standard for demonstrating efficacy in modern therapeutics is the placebo-controlled, double-blind (masked) clinical trial. Beatrice Golumb1 makes the point that it is difficult to exclude small systematic effects caused by the placebo, particularly when used over a long period. In ...
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] We have investigated the effect of cysteine to serine substitutions in human basic fibroblast growth factor (bFGF) on the formation of inclusion bodies in Escherichia coli. Using a temperature–sensitive expression system, about 30% of human bFGF, which contains four cysteines at positions 26, ...
    Type of Medium: Electronic Resource
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