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  • 1
    Electronic Resource
    Electronic Resource
    Treatment of pitressin sensitive diabetes insipidus in children with clofibrate and carbamazepine (1973)
    Springer
    European journal of pediatrics 115 (1973), S. 83-88 
    Details
    ISSN: 1432-1076
    Keywords: Diabetes insipidus ; Clofibrate in diabetes insipidus ; Carbamazepine in diabetes insipidus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Vier Kinder mit zentralem Diabetes insipidus wurden mit Clofibrat und mit Carbamazepin behandelt. Beide Medikamente verringerten signifikant die täglichen Urinvolumina; Clofibrat um 40–83%, Carbamazepin um 50–70%. Die Kombination beider Medikamente führte zu einer noch weitergehenden Einschränkung der Diurese; der Unterschied zu der Wirkung der einzelnen Medikamente ist hoch signifikant. Mit Clofibrat 25–30 mg/kg/Tag bei zwei Kindern und mit Clofibrat 45 mg/kg/Tag und Carbamazepin 6 mg/kg/Tag in einem Fall konnte der Diabetes insipidus über längere Zeiträume erfolgreich behandelt werden. Bei gesunden erwachsenen Versuchspersonen bewirkte Clofibrat eine sehr deutliche Hemmung der Diurese nach akuter Wasserbelastung.
    Notes: Abstract Four children with pitressin sensitive diabetes insipidus were treated with clofibrate and carbamazepine. Both substances significantly reduced daily urine volumes, clofibrate by 40–83%, carbamazepine by 50–70%. The combination of both substances led to a significant further reduction. Long term clinical control of diabetes insipidus was achieved with clofibrate 25–30 mg/kg/day in 2 cases, and by clofibrate 45 mg/kg/day and carbamazepine 6 mg/kg/day in one child. No side effects of the treatment were observed. In healthy adult volunteers, clofibrate inhibited diuresis effectively after acute hydration.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00438994
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  • 2
    Electronic Resource
    Electronic Resource
    Growth hormone and cortisol in neonates during phototherapy (1975)
    Springer
    European journal of pediatrics 119 (1975), S. 53-58 
    Details
    ISSN: 1432-1076
    Keywords: Phototherapy and growth hormone ; Phototherapy and cortisol ; Growth hormone in neonates ; Cortisol in neonates
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Bei 22 Neugeborenen, die wegen Hyperbilirubinämie eine Phototherapie erhielten, wurden Wachstumshormon (GH) und Cortisol im Plasma bestimmt. Die gemessenen Werte wurden verglichen mit den Hormonkonzentrationen vor und nach der Behandlung und mit Werten gesunder Neugeborener. GH stieg während der Therapie auf 195%±108 (SD) (Kontrollgruppe=100%) an. Der Unterschied ist hoch signifikant. Die Cortisolwerte waren nicht erhöht. Es bestand keine Korrelation zwischen GH und Cortisol oder zwischen Bilirubin und GH oder Cortisol. Die Gründe für den GH-Anstieg sind nicht offensichtlich. Das Abdecken der Augen, die Aufhebung des Tag-Nacht-Rhythmus oder Veränderungen im Zusammenhang mit der Inkubatorpflege könnten diese Wirkung erklären.
    Notes: Abstract In 22 neonates plasma growth hormone (GH) and cortisol concentrations were measured during phototherapy which was administered because of hyperbilirubinemia. These values were compared to the hormone levels before and after therapy and to control values taken from healthy nursery infants. Phototherapy significantly increased GH concentrations to 195%±108 (SD) (healthy control group=100%). Cortisol was not found to be augmented. There was no correlation between GH and cortisol, nor between bilirubin and GH or cortisol. The mechanisms by which phototherapy induces GH increase are not evident. However, this may be due to constant covering of the eyes, deprivation of the day-night rhythm, or other environmental alterations that are brought about by incubator care.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00464696
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  • 3
    Electronic Resource
    Electronic Resource
    Glucocorticosteroids and growth hormone secretion under physiological conditions and in states of steroid excess (1978)
    Springer
    European journal of pediatrics 128 (1978), S. 113-121 
    Details
    ISSN: 1432-1076
    Keywords: Growth hormone ; Cortisol ; Glucocorticoid therapy ; Cushing's disease
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Cortisol and growth hormone (GH) secretion (spontaneous variations at night and the release induced by insulin hypoglycaemia) were investigated in 69 children and adolescents. Statistical analysis of approximately 600 pairs of cortisol and GH values in this study demonstrated that physiological fluctuations of cortisol do not alter GH secretion. A review of the literature shows that GH secretion is consistently depressed in Cushing's disease of central origin and in Cushing's syndrome due to adrenal carcinoma. When acutely administered, doses higher than 100 mg of cortisol (or equivalent amounts of other steroids) per adult are necessary to block GH secretion and the hormones have to be given several hours previously. In long-term steroid treatment, suppression of GH is observed in only 1 out of 3 patients. The effect apparently does not persist beyond elimination of the last dose, i.e. generally not longer than 12 to 24 h. These data can be taken as a rationale for intermittent or alternating dosage schedules, and for the use of short acting derivatives if long-term, high-dose steroid treatment is necessary in children. It remains to be established whether growth deficiency in exogenous hypercortisolism is due to suppression of GH secretion, decreased production of somatomedins, direct antagonism of the action of somatomedins on growing cartilage, or a combination of these mechanisms.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00496996
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