Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
Filter
Collection
  • 1
    Unknown
    New York : Springer
    Associated volumes
    Call number: QZ350:380
    Keywords: Hematological oncology
    Pages: x, 432 p. : ill. (some col.)
    ISBN: 038773743X
    Signatur Availability
    QZ350:380 available
    BibTip Others were also interested in ...
  • 2
    Call number: QH506:60/99
    Keywords: Stress / physiopathology ; Molecular Biology ; Signal Transduction ; Heat Shock Proteins ; Gene Expression
    Pages: xvi, 488 p.
    ISBN: 0896036111
    Signatur Availability
    QH506:60/99 available
    BibTip Others were also interested in ...
  • 3
    Unknown
    Totowa, NJ : Springer Science+Business Media, LLC
    Keywords: Medicine ; Metabolic Diseases ; Sports Medicine ; Medicine & Public Health ; Sports Medicine ; Metabolic Diseases ; Molecular Medicine ; Springer eBooks
    Pages: : digital
    ISBN: 9781607613558
    Signatur Availability
    BibTip Others were also interested in ...
  • 4
    Keywords: Life sciences ; Neurosciences ; Animal behavior ; Consciousness ; Life sciences ; Behavioural Sciences ; Neurosciences ; Cognitive Psychology ; Springer eBooks
    Description / Table of Contents: Metacognitive neuroscience: an introduction -- Quantifying human metacognition for the neurosciences -- Signal detection theory analysis of type 1 and type 2 data: meta-d’, response-specific meta-d’ and the unequal variance SDT model -- The highs and lows of theoretical interpretation in animal-metacognition research -- A computational framework for the study of confidence across species -- Shared mechanisms for confidence judgments and error detection in human decision making -- Metacognition and confidence in value-based choice -- What failure in collective decision-making tells us about metacognition -- Studying metacognitive processes at the single-neuron level -- The neural basis of metacognitive accuracy -- The cognitive neuroscience of metamemory monitoring: understanding metamemory processes, subjective levels expressed and metacognitive accuracy -- Metacognitive facilitation of spontaneous thought processes: When metacognition helps the wandering mind find its way -- What is the human sense of agency and is it metacognitive? Failures of metacognition and lack of insight in neuropsychiatric disorders -- Judgments of agency in schizophrenia: An impairment in autonoetic metacognition -- Metacognition in Alzheimer’s disease
    Abstract: Metacognition is the capacity to reflect upon and evaluate cognition and behaviour. Long of interest to philosophers and psychologists, metacognition has recently become the target of research in the cognitive neurosciences. By combining brain imaging, computational modeling, neuropsychology and insights from psychiatry, the present book offers a picture of the metacognitive functions of the brain. Chapters cover the definition and measurement of metacognition in humans and non-human animals, the computational underpinnings of metacognitive judgments, the cognitive neuroscience of self-monitoring ranging from confidence to error-monitoring, and neuropsychiatric studies of disorders of metacognition. This book provides an invaluable overview of a rapidly emerging and important field within cognitive neuroscience
    Pages: VIII, 407 p. 63 illus., 30 illus. in color. : online resource.
    ISBN: 9783642451904
    Signatur Availability
    BibTip Others were also interested in ...
  • 5
    Keywords: Life sciences ; Pharmacology ; Apoptosis ; Oxidative Stress ; Environmental Health ; Life sciences ; Oxidative Stress ; Pharmacology/Toxicology ; Apoptosis ; Environmental Health ; Springer eBooks
    Description / Table of Contents: Part I. Toxicological Mechanisms and Evaluation of Oxidative Stress -- A historical perspective on oxidative stress and intracellular redox control -- An overview of free radicals as causes and consequences of toxicity -- Oxidants, radicals, free radicals, and other bad stuff in mechanisms of toxicity -- Lipid oxidation -- Protein oxidation and toxicology -- Oxidative stress and DNA damage association with carcinogenesis: A truth or a myth? -- Glutathione and thiols -- Reactive oxygen species as initiators and mediators of cellular signaling processes -- Role of oxidative stress in the process of carcinogenesis -- Part II. Agents that produce toxicity – mechanisms and therapeutic interventions -- Isolation of murine adult bone marrow and fetal liver cells for mechanistic assessment of hematotoxicity caused by organic solvents -- Oxidative stress and ethanol toxicity -- Pharmaceutical agents -- Insecticides and herbicides -- Health effects of indoor air pollution due to cooking with biomass fuel -- Outdoor pollutants -- Oxidative Stress and the Inorganic Carcinogens -- UV-induced signaling: Role of reactive oxygen species -- Nanomaterials -- Chemical warfare agents -- Part III. Special topics -- On the biochemistry of antioxidants — current aspects.-Prevention of age-related diseases — Effects of antioxidant supplements -- The neural progenitor cell (NPC) niche in the adult brain provides a target for neurotoxicity — a potential Adverse Outcome Pathway for ROS-induced NPC dysfunction with higher sensitivity during aging. -- Oxygen toxicity: From cough to convulsion -- Oxidative stress in reproductive toxicology -- Toxicogenomics-based assessment of xenobiotic-induced oxidative stress -- Aquatic and marine biology
    Abstract: This book focuses on data describing the roles of free radicals and related reactive species, and antioxidants, in the causes and treatments of diseases, examining both clinical and pre-clinical trials, as well as basic research. The book is divided into sub-sections with chapters on toxicological mechanisms, agents that produce toxicity, and special topics including areas such as antioxidant supplements, oxygen toxicity, toxicogenomics, and marine biology. Studies on Experimental Toxicology and Pharmacology promotes the concept of using biomarkers of free radical- and reactive species-induced injury as adjuncts to classical laboratory testing and the ability of antioxidants to provide cellular protection. There is increasing evidence that free radicals and other reactive species are causative, or at least supporting factors, that impact organisms and cause numerous tissue disorders. With contributions from international experts in the field, this volume is a valuable resource for researchers and postgraduate students in toxicology and related fields, as well as clinicians and clinical researchers
    Pages: XVI, 498 p. 96 illus., 53 illus. in color. : online resource.
    Edition: 1st ed. 2015.
    ISBN: 9783319190969
    Signatur Availability
    BibTip Others were also interested in ...
  • 6
    ISSN: 1432-2277
    Keywords: Liver transplantation, pediatric, biliary complications ; Biliary complications, liver transplantation, pediatric ; Pediatric liver transplantation, biliary complications
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Between 1983 and 1992, 112 children underwent liver transplantation. Of 138 grafts, 60 (43.4%) were whole livers, 77 (55.6%) were reduced livers, and 1 (0.7%) was a split liver. Biliary complications (BC) were defined as any abnormality, even minor, related to the biliary tract. Results were analysed with a minimum follow-up of 9 months. Some 36 grafts (26.1%) in 34 patients (30.4%) presented with BC: bile leaks (17 grafts), biliary obstructions or dilatations (16 grafts), and other complications (3 grafts). Management was mainly surgical with biliary reconstruction via a Roux-en-Y loop. Interventional radiology had an increasing role in recent years. BC were associated with a mortality of 1.8% (2/112), a graft loss rate of 4.3% (6/138), and significant morbidity. Among the various factors whose association with BC was studied, the date of transplantation, the use of reduced grafts and the use of gallbladder conduits appeared to be the main determining factors for BC. From multivariate analysis the use of reduced grafts emerged as the most important factor in reducing BC. We therefore conclude that BC are associated with significant morbidity, but general improvements in both surgical and medical management seem to account for better results in recent years.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 7
    ISSN: 1546-1718
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] DNA damage surveillance networks in human cells can activate DNA repair, cell cycle checkpoints and apoptosis in response to fewer than four double-strand breaks (DSBs) per genome. These same networks tolerate telomeres, in part because the protein TRF2 prevents recognition of telomeric ends as ...
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 8
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 9
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    FEMS microbiology letters 107 (1993), S. 0 
    ISSN: 1574-6968
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: Abstract To better define the antigenic structure of the outer cell membranes of Legionellae, a panel of 6 monoclonal antibodies was raised against partially purified outer membranes of Legionella pneumophila serogroup 1, Corby strain. This study describes the purification and characterization of one of these monoclonal antibodies reacting with a 135-kDa protein, which was shown to be common to all 14 serogroups of Legionella pneumophila. It shows no cross-reactivity with 20 other Legionella species, or 9 other Gram-negative species tested by SDS-PAGE and Western blotting procedures. The epitope would appear to be predominantly surface exposed and, from preliminary detergent extraction studies, not peptidoglycan-associated.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 10
    ISSN: 1573-7373
    Keywords: brain tumors ; radiation therapy ; PCNU ; AZQ
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Purpose A two-arm randomized clinical trial was performed to determine the efficacy of PCNU and AZQ in the treatment ofde novo or recurrent primary brain tumors. An additional objective was to gather information on the administration and toxicity of these compounds, supplementing that obtained previously in phase I/II studies. Methods During 1982 and 1983 the Brain Tumor Study Group randomized 152 adult patients with primary brain tumors to receive PCNU 75–100 mg/m2 intravenously (IV) every 8 weeks or AZQ 15 mg/m2 IV once a week for 4 weeks, every 6–8 weeks. All patients who had not received ‘full dose’ radiotherapy before randomization received it concurrently with the first course of protocol chemotherapy. The data were analyzed for the total randomized population (RP), and for 130 patients in the valid study group (VSG) formed by excluding 22 patients for whom the histologic diagnosis was not documented by central review. Results Median survival times were 11.0 months for the PCNU group and 8.4 months for the AZQ group. The difference in survival curves was statistically significant for the RP (p=0.01) and the VSG (p=0.02). Lifetable analysis of the VSG showed estimated 2-year survivals of 34% for PCNU and 11% for AZQ. The advantage of PCNU remained significant (p=0.006) after adjustment for histopathologic category, age, initial performance status, and interval from initial reported surgery. Myelosuppression was the principal toxicity in both groups.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...