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  • 1
    Keywords: ENERGIES ; CANCER ; Germany ; CLASSIFICATION ; DENSITY ; COHORT ; RISK ; MARKER ; ASSOCIATION ; FREQUENCY ; BREAST ; breast cancer ; BREAST-CANCER ; PATTERNS ; ENERGY ; AGE ; WOMEN ; cancer risk ; DIET ; DIETARY ; nutrition ; QUESTIONNAIRE ; HABITS ; FOOD ; DIETARY-INTAKE ; urinary estrogen metabolites ; EPIC-GERMANY ; POSTMENOPAUSAL WOMEN ; RE ; ENERGY-INTAKE ; PHYTO-ESTROGENS ; ADJUSTMENT ; POWER ; PREMENOPAUSAL WOMEN ; dietary intake ; ENTEROLACTONE ; EPIC Heidelberg ; EPIC-Heidelberg ; mammographic density ; PARENCHYMAL PATTERNS ; phytoestrogens ; pilot study ; SOY INTAKE
    Abstract: The influence of dietary phytoestrogens provided by Western diets on mammographic density is not well established. Soy and soy products as source of isoflavones were found to be inversely associated with high mammographic density, a marker for breast cancer risk. Another class of phytoestrogens, the lignans, which are more frequent in Western diets, are rarely investigated. Within the European Prospective Investigation into Cancer and Nutrition cohort in Heidelberg (EPIC-Heidelberg) we explored the feasibility of mammogram collection and measurement of mammographic density in order to investigate the association between dietary, phytoestrogen intake and breast density patterns. Wolfe classification was used to summarize mammographic density Dietary habits were assessed by means of a validated food frequency questionnaire. Out of the 505 randomly selected women, 317 (63%) returned the questionnaire and 310 (61.4%) women provided informed consent to collect mammograms. Dietary intake of seven women with dense patterns (DY) was compared with 47 women without dense patterns. A high dietary intake of fibre (p-value = 0.008) and secoisolariciresinol (p-value = 0.043) is inversely associated with non-dense breast patterns. This is also observed for a high dietary intake of soy-products (pvalue = 0.004) and, in tendency, genistein (p-value = 0.069). After adjustment for energy intake and age the groups of dense and non-dense mammographic patterns were different regarding the intake of carbohydrate (p = 0.032), soy-products (p = 0.020), fibre (p 0.046), and secoisolariciresinol (p = 0.027). Our results suggest an inverse association between dietary lignan intake and breast density, similar to the findings for isoflavones. To our knowledge this is the first report on this association, but due to the risk of chance finding, this has to be confirmed in a study with sufficient statistical power
    Type of Publication: Journal article published
    PubMed ID: 16183551
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  • 2
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    German Medical Science; Düsseldorf, Köln
    In:  50. Jahrestagung der Deutschen Gesellschaft für Medizinische Informatik, Biometrie und Epidemiologie (gmds), 12. Jahrestagung der Deutschen Arbeitsgemeinschaft für Epidemiologie; 20050912-20050915; Freiburg im Breisgau; DOC05gmds334 /20050908/
    Publication Date: 2005-09-09
    Keywords: ddc: 610
    Language: English
    Type: conferenceObject
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  • 3
    Keywords: CANCER ; EXPRESSION ; tumor ; carcinoma ; Germany ; DIAGNOSIS ; imaging ; computed tomography ; NUCLEAR-MEDICINE ; PATIENT ; primary ; CONTRAST ; BREAST ; breast cancer ; BREAST-CANCER ; MALIGNANCIES ; metastases ; BREAST-CARCINOMA ; POSITRON-EMISSION-TOMOGRAPHY ; tomography ; CARCINOMAS ; SCINTIGRAPHY ; SPECT ; COMPUTED-TOMOGRAPHY ; PET ; sensitivity ; nuclear medicine ; BIOPSY ; FLUORODEOXYGLUCOSE ; radiology ; MALIGNANCY ; ONCOLOGY ; INFILTRATION ; FDG PET ; TRANSPORTER ; prospective studies ; analysis ; methods ; NUCLEAR ; breast carcinoma ; pharmacology ; USA ; prospective ; uptake ; prospective study ; LYMPH-NODE ; FDG-PET ; Tc-99m-pertechnetate ; EMISSION-TOMOGRAPHY ; F-18-FDG PET ; BIOPSIES ; MEDICINE ; comparison ; EMISSION ; emission tomography ; GLUT-1 ; I-123 scintigraphy ; pertechnetate ; TCO4- scintigraphy ; [F-18]fluoro-2-doxy-glucose
    Abstract: Purpose: Breast carcinomas express the Na+/I- symporter and may-albeit not a routine procedure-be imaged with (123)iodide (I-123) and (99m)technetium-pertechnetate ((TcO4-)-Tc-99m) scintigraphy. The aim of our prospective study was the comparison of (TcO4-)-Tc-99m -and I-123-single-photon emission computed tomography (SPECT) with F-18-2-fluoro-2-deoxy-D-glucose-positron emission tomography (FDG-PET) inpatients suspicious for breast cancer. Methods: Twenty-nine (29) untreated patients suspected of having breast carcinoma were prospectively examined with thorax SPECT with (TcO4-)-Tc-99m (n = 19) or I-123 (n = 10), respectively, and FDG-PET (n = 29) prior to biopsy. Tumor-to-background ratios (TBRs) were calculated for SPECT findings. Mean and maximum standardized uptake values (SUVs) were calculated for PET findings. Findings were compared in an intra- individual lesion-to-lesion analysis. Results: in 28 of 29 patients, malignancy was verified with histopathology. In imaging the primary tumor, sensitivities of (TCO4-)-T-99m-SPECT, I-123-SPECT, and FDG-PET were 63%, 67%, and 89%, respectively. TBR maximum was 2.6 +/- 1.1 in (TCO4-)-T-99m -SPECT and 2.3 +/- 0.6 in I-123-SPECT. In FDG-PET. mean tumor SUV was 4.1 +/- 4 and maximum tumor SUV was 5.4 +/- 5. L In contrast to FDG-PET (TCO4-)-T-99m -SPECT was inefjective in imaging nodal and distant metastases in the thorax, and I-123-SPECT failed in imaging lymph node infiltrations. Distant metastases were not present in patients of the I-123 group, and the value of I-123- SPECT was not evaluated. Conclusions: In cont rast to FDG-PET, (TCO4-)-T-99m- and I-123-SPECT are ineffective in imaging breast carcinoma in clinical practice
    Type of Publication: Journal article published
    PubMed ID: 18158769
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  • 4
    ISSN: 0304-4165
    Keywords: (Rat liver) ; Carbohydrate moiety ; Ferritin binding ; Ferritin receptor ; Subunit composition
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Medicine , Physics
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 0305-0491
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 0009-8981
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
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