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  • 1
    Abstract: Since acute myeloid leukemia (AML) is characterized by the blockade of hematopoietic differentiation and cell death, we interrogated RIPK3 signaling in AML development. Genetic loss of Ripk3 converted murine FLT3-ITD-driven myeloproliferation into an overt AML by enhancing the accumulation of leukemia-initiating cells (LIC). Failed inflammasome activation and cell death mediated by tumor necrosis factor receptor caused this accumulation of LIC exemplified by accelerated leukemia onset in Il1r1(-/-), Pycard(-/-), and Tnfr1/2(-/-) mice. RIPK3 signaling was partly mediated by mixed lineage kinase domain-like. This link between suppression of RIPK3, failed interleukin-1beta release, and blocked cell death was supported by significantly reduced RIPK3 in primary AML patient cohorts. Our data identify RIPK3 and the inflammasome as key tumor suppressors in AML.
    Type of Publication: Journal article published
    PubMed ID: 27411587
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  • 2
    ISSN: 1432-1041
    Keywords: nalorphine ; hormonal changes ; cortisol ; PRL ; GH ; TSH ; LH ; FSH
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The effects of nalorphine 5 mg i. m., a partial opiate antagonist, on circulating levels of PRL, GH, TSH, LH, FSH and cortisol were studied in six healthy men. Nalorphine produced a prompt and sharp increase in serum PRL and a small, delayed rise in serum GH. Serum LH and cortisol decreased after drug administration and no change in serum FSH and TSH was observed. These findings are discussed and a possible site of action of nalorphine is suggested.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1432-1041
    Keywords: naloxone ; haloperidol ; thyrotropin releasing hormone ; adenohypophyseal ; GH ; LH ; FSH ; PRL ; TSH ; cortisol
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Naloxone 0.8 mg im administered to eight healthy subjects did not affect the serum levels of GH, LH, FSH, PRL, TSH and cortisol. Pretreatment with naloxone 0.8 mg increased TRH-induced TSH and PRL release in six healthy subjects. The same pretreatment caused an enhancement of haloperidol-induced PRL secretion in further other group of six subjects.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1432-1041
    Keywords: nalorphine ; bromocriptine ; sulpiride ; prolactin release
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Nalorphine 5 mg im caused a significant increase in serum PRL in 8 healthy volunteers. Pretreatment with bromocriptine 5 mg inhibited the nalorphine-induced release of PRL, whereas sulpiride administration enhanced it.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1590-3478
    Keywords: migrant sensory neuritis ; sensory neuropathy ; AIDS
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Sommario La “Neurite Sensitiva Migrante di Wartenberg” è una rara sindrome caratterizzata dal coinvolgimento successivo e transitorio di diversi tronchi nervosi sensitivi. Descriviamo il caso di una giovane donna affetta da AIDS che ha presentato un quadro clinico compatibile con questa neuropatia sensitiva. Tra le diverse sindromi neurologiche associate ad AIDS segnaliamo la possibilità di osservare anche la Neurite Sensitiva Migrante.
    Notes: Abstract We studied an AIDS patient who suffered from numbness, paresthesias and pain in the territories of different non-contiguous cutaneous nerves at different times. A transitory partial loss of touch and pinprick sensibility was also present in the same cutaneous areas. Sensory conduction velocities and SAP amplitudes were normal. The clinical picture was consistent with the Migrant Sensory Neuritis of Wartenberg. This rare neuropathy has never previously been described in patients affected by AIDS.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1590-3478
    Keywords: Multiple sclerosis ; EEG ; Coherence Movement-related potentials ; Reaction time ; Cognitive impairment
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Sommario Il coinvolgimento cognitivo è una frequente complicanza della sclerosi multipla (SM), generalmente come demenza sottocorticale. Al fine di valutare le connessioni funzionali cortico-corticali nella SM, abbiamo studiato la coerenza dell'elettroencefalogramma (EEG) in un gruppo di 21 pazienti con SM clinicamente deftnita. I pazienti sono stati inoltre sottoposti a risonanza magnetica (RM) e valutazione neuropsicologica. I pazienti con deficit cognitivi presentavano, rispetto ai pazienti senza deficit, una riduzione della coerenza di banda alfa e theta, nelle derivazioni a breve e a lunga distanza. La coerenza anteroposteriore ed interemisferica era significativamente correlata col cortco lesionale RM immediatamente sottostante la corteccia e non con le lesioni periventricolari. Questi dati supportano l'ipotesi the il coinvolgimento cognitivo nella sclerosi multipla sia principalmente correlato a demielinizzazione o perdita assonale delle connessioni cortico-corticali. In un altro studio abbiamo valutato i correaaai neuropsicologici dei deficit frontali. I lobi frontali hanno un ruolo fondamentale nella programmazione ed esecuzione del movimento. Abbiamo valutato il potenziale movimento-correlato (MRP) in pazienti SM con e senza deficit frontali. Il tempo di reazione manuale al test di Stroop, the valuta le funzioni esecutive, e le componenti del MRP erano ritardate in entrambi i gruppi di pazienti rispetto ai soggetti normali e nei pazienti frontali rispetto ai non frontali. Questi dati suggeriscono the il coinvolgimento cognitivo frontale nella SM corrisponde a un'alterazione dell'attività bioelettrica anche durante un compito motorio semplice.
    Notes: Abstract Cognitive impairment is a frequent complication of multiple sclerosis (MS), generally reflecting subcortical dementia. In order to explore functional cortico-cortical connections in MS, we studied electroencephalogram (EEG) coherence in a group of 21 clinically defined MS patients. Patients also underwent magnetic resonance imaging (MRI) and neuropsychological examinations. Compared to unimpaired MS patients, cognitively involved patients had reduced short-distance and long-distance theta and alpha band coherencies. Anteroposterior and interhemispheric coherencies were significantly correlated with MRI lesion load immediately underlying cortex but not were exclusively associated with periventricular lesions. These data support the hypothesis that cognitive impairment in MS is mostly related to demyelination or axonal loss of cortico-cortical connections. In a second study, we evaluated the neurophysiological correlates of frontal lobe dysfunction. Frontal lobes are also involved in motor planning and execution. We evaluated the EEG movement-related potential (MRP) in MS patients with and without frontal neuropsychological deficits. Reaction times to the Stroop test, which evaluates frontal functions, and MRP components were delayed in both MS groups compared to normal subjects and in frontal compared to nonfrontal MS patients. These data suggest that frontal cognitive involvement in MS corresponds to abnormal bioelectrical activity also during simple motor tasks.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1432-1440
    Keywords: Liver cirrhosis ; Variceal bleeding ; Octreotide ; Terlypressin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Sixty patients with endoscopically confirmed active variceal bleeding entered a randomized controlled clinical trial aimed at comparing the efficacy of octreotide vs. terlypressin in the control of acute variceal hemorrhage (period I, 24 h) and in the prevention of early rebleeding (period II, 6 days). Of the sixty 30 received octreotide (period I, 100 μg bolus followed by continuous intravenous infusion at 25 μg/h; period IT, 100 μg t.i.d. subcutaneously), and 30 received terlypressin (period I, 2 mg intravenous bolus every 4 h; period II, 2nd day, 2 mg every 6 h; from 3th to 7th days, 1 mg every 6 h). Control of bleeding was achieved in 23 (76.6%) patients receiving octreotide and in 16 (53%) treated with terlypressin (NS); none of these patients suffered rebleeding during treatment. No significant difference in mortality was observed between the two groups during the hospitalization period. Complications due to therapy were lower with octreotide than with terlypressin (P 〈 0.01). Under the same effectiveness conditions the cost/benefit ratio must be taken into account.
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1432-2218
    Keywords: Echogenic gallbladder sludge ; Low-level echoes ; Cholesterol crystals ; Calcium bilirubinate granules ; Biliary sludge ; Cholelithiasis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A total of 743 patients affected by various gastrointestinal disorders were examined by ultrasound. The presence in the gallbladder bile of low-level echoes (LLE) was observed in 56 (7.5%). Twenty-six of these patients had surgery: 24 underwent cholecystectomy for important biliary-like painful symptomatology, and 2 had cephalopancreatectomy for pancreatic head carcinoma. Both macro- and microscopic controls of the bile were carried out in all 26 patients. In 20 cases, only microscopic cholesterol crystals and calcium bilirubinate granules were observed in the bile. The microscopic evidence of these crystals was associated in four cases with macroscopic evidence of so-called “biliary sludge” and in four cases with macroscopic evidence of highly viscous bile. In the other 6 cases these crystals were associated with the presence of cholesterol stones. The authors consider that the observation of LLE in the gallbladder bile is an important index of the presence of cholesterol crystals and/or calcium bilirubinate granules. These LLE can assume polymorphic aspects, described by the authors, which may simulate other pathologies and lead to incorrect echographic diagnosis. The high incidence of LLE in an alithiasic population (5.1%), together with the elevated frequency, according to the authors, of association of these echoes with a painful biliary-like symptomatology (52.6%), underlines the diagnostic importance of an accurate ultrasound investigation in this type of pathology.
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 1573-0409
    Keywords: Simulation ; DAE systems ; friction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract The paper deals with simulation of mechanical systems affected by discontinuous phenomena. These phenomena involve impulsive events and/or models whose structure changes depending on the values of some system variables. The models of three kinds of these discontinuities (joint with static friction, collisions with rigid environment, bifurcation behavior near kinematic singularities) are given, and a simulation environment, based on the DAE solver DASSL is presented, that also allows efficient simulation of sample-data systems. Some simulation results achieved with the proposed environment are finally presented.
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 1439-0973
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Das HBeAg/anti-HBe System wurde bei 460 Hämodialysepatienten im Hinblick auf seine Wertigkeit als Marker für Infektiosität und Entwicklung einer chronisch progredienten Lebererkrankung untersucht. Die Bedeutung von HBeAg als Parameter für Infektioistät wurde durch das gleichzeitige Vorkommen von spezifischer DNS Polymerase (31 Patienten) und von diffus verbreiteten Core-Partikeln in Hepatozytenkernen (bei sechs Patienten bioptisch nachgewiesen) bestätigt. Hingegen bestand keine klinisch verwertbare Beziehung zwischen HBeAg und einem progressiven Verlauf der Leberekrankung, der bei allen Fällen durch biochemische und histologische Untersuchung ausgeschlossen wurde.
    Notes: Summary The HBeAg/anti-HBe system was studied as a marker of infectivity and chronic progressive liver disease in 460 hemodialysis patients. The importance of HBeAg as an index of infectivity was confirmed in that it was present simultaneously with specific DNA polymerase (31 patients) and by the presence of widely diffuse core particles in the hepatocyte nuclei (revealed by biopsy in six patients). In contrast, HBeAg showed no useful correlation with progressive liver disease, the absence of which was confirmed in all cases by biochemical and histological studies.
    Type of Medium: Electronic Resource
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