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  • 1
    Abstract: The risk of Borrelia burgdorferi infection and the value of antibiotic prophylaxis after tick bite are controversial. In this study, performed in two areas of southwestern Germany, ticks were collected from 730 patients and examined by the polymerase chain reaction (PCR) for B. burgdorferi. To assess whether transmission of B. burgdorferi occurred, the patients were clinically and serologically examined after tick removal and during follow-up examinations. Data from all tick bites gave a total transmission rate of 2.6% (19 patients). Eighty-four ticks (11.3%) were PCR positive. Transmission occurred to 16 (26.7%) of 60 patients who were initially seronegative and could be followed up after the bite of an infected tick. These results indicate that the transmission rate from infected ticks in Europe is higher than previously assumed. Examination of ticks and antibiotic prophylaxis in the case of positivity appears to be indicated.
    Type of Publication: Journal article published
    PubMed ID: 9747761
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  • 2
    Keywords: tumor ; BLOOD ; IN-VIVO ; THERAPY ; CLASSIFICATION ; SITE ; PATIENT ; ACTIVATION ; INDUCTION ; ANTIGEN ; ANTIGENS ; T-CELL ; ASSOCIATION ; antibodies ; antibody ; TARGET ; TRIAL ; LESIONS ; LYMPHOMA ; genetics ; IMMUNOTHERAPY ; TARGETS ; PERIPHERAL-BLOOD ; B-CELL LYMPHOMA ; PHASE-II ; MYCOSIS-FUNGOIDES ; DISORDERS ; REGRESSION ; monitoring ; SEZARY-SYNDROME ; PHASE ; LYMPHOMAS ; tumor antigen ; B-CELL LYMPHOMAS ; prospective ; RECOMMENDATIONS ; CLINICAL-RESPONSE ; B-CELL ; EORTC ; Genetic ; IMMUNE ; PROPOSAL ; Type ; CLINICAL-RESPONSES ; Cutaneous ; LYMPHOPROLIFERATIVE DISORDER ; TASK-FORCE ; TREATMENT-OF-CANCER
    Abstract: Cutaneous lymphomas (CLs) are a heterogeneous group of lymphoproliferative disorders that are manageable by immunotherapy. Twenty-one patients were enrolled in a prospective open-label, dose-escalation multi-center study evaluating the effects of repeated TG1042 [adenovirus-interferon (IFN)-gamma] intralesional injections in patients with primary CLs, of which 18 were of T-cell and 3 of B-cell type. Repeated intralesional therapy using TG1042 consistently results in local tumor regressions in about half of treated patients and one-third of patients also in regressions in noninjected distant lesions, likely reflecting the systemic immune activation after intralesional therapy. Treatment was well tolerated with few adverse events including injection site reactions, chills, lymphopenia, and fever. Immune monitoring in the peripheral blood demonstrated systemic immune activation and the induction of antibodies against tumor antigens in some patients without clear association with clinical responses. CLs, in particular B-cell lymphomas with high objective response rates, seem to be excellent targets for this type of immunotherapy
    Type of Publication: Journal article published
    PubMed ID: 20372104
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  • 3
    ISSN: 0890-8508
    Keywords: Legionella, polymerase chain reaction (PCR), Taq polymerase, DNA
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1432-2307
    Keywords: Whipple's disease ; Tropheryma whippelii ; SPC cells ; Pathology ; Endoscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Whipple's disease is an infectious disorder with intestinal and extra-intestinal manifestations. We reinvestigated the intestinal histology in a series of 48 patients (10 females, 38 males; mean age 56.5 years, standard deviation of the mean ± 11.2 years). A total of 126 biopsy samples, obtained prior to, during, and after therapy, were evaluated by light microscopy. In 43 patients (90%), histology was consistent with common descriptions, while it was uncommon in 3 patients (6%), and non-diagnostic in 2 patients (4%). During treatment, several alterations occurred. Apart from a continuous decrease in PAS-positive macrophages, the pattern of mucosal infiltration changed from diffuse to patchy. Moreover, the cytological aspects of PAS-positive macrophages changed substantially, and this change was used to propose four different subtypes. Initially, subtype 1 macrophages predominated (74%), but showed a gradual decrease within a few months of therapy. After 15 months, subtype 3 and subtype 4 macrophages predominated (〈80%). In 7 of 9 patients followed over long periods some subtype 3 or subtype 4 macrophages persisted. It is concluded that at diagnosis and during treatment the intestinal histology of Whipple's disease is heterogeneous. A few PAS-positive macrophages commonly persist at long-term follow-up. This and other features suggest the presence of a persistent immune defect.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Applied physics 63 (1996), S. 331-337 
    ISSN: 1432-0649
    Keywords: 76.30.Fc ; 76.70.Hb ; 78.20.Ls
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract The analysis of EPR spectra obtained from iron doped KTaO3 crystals in the as-grown state revealed three dominant iron centers: Fe3+-OI, axial Fe-centers with spinS = 3/2 and rhombic Fe3+. By comparison with data from literature possible assignments for the center withS = 3/2 are discussed. For the rhombic species the temperature dependence of the main parameters of the Spin- Hamiltonian was measured. The result makes it most plausible that only one rhombic iron center exists in KTaO3, in contrast with literature. The understanding of the EPR spectra allows us to assign transitions, observed at very low magnetic fields by optically detected magnetic resonance (ODMR), to this rhombic Fe center. On this basis, the magnetic circular dichroism (MCD) of this defect could be identified using the method of tagged-MCD. This spectrum is compared to the tagged-MCD of Fe3+-O1 and of axial Fe4+ centers, which may be generated metastably by optical charge transfer. Considerably different structures in the MCD spectra of both Fe3+ centers indicate different local surroundings and electronic states.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1432-0649
    Keywords: PACS:76.30.Fc; 76.70.Hb; 78.20.Ls
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract. The analysis of EPR spectra obtained from iron doped KTaO $_3$ crystals in the as-grown state revealed three dominant iron centers: Fe $^{3+}$ -O $_{\rm I}$ , axial Fe-centers with spin $S=\frac{3}{2}$ and rhombic Fe $^{3+}$ . By comparison with data from literature possible assignments for the center with $S=\frac{3}{2}$ are discussed. For the rhombic species the temperature dependence of the main parameters of the Spin- Hamiltonian was measured. The result makes it most plausible that only one rhombic iron center exists in KTaO $_3$ , in contrast with literature. The understanding of the EPR spectra allows us to assign transitions, observed at very low magnetic fields by optically detected magnetic resonance (ODMR), to this rhombic Fe center. On this basis, the magnetic circular dichroism (MCD) of this defect could be identified using the method of tagged-MCD. This spectrum is compared to the tagged-MCD of Fe $^{3+}$ -O $_{\rm I}$ and of axial Fe $^{4+}$ centers, which may be generated metastably by optical charge transfer. Considerably different structures in the MCD spectra of both Fe $^{3+}$ centers indicate different local surroundings and electronic states.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1432-0584
    Keywords: Hemolytic disease ; Infection ; Childhood ; Microbial antigens ; Erythrocyte membrane alteration
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The majority of acute infection-associated hemolytic diseases of infancy and childhood have been suggested to be caused by exogenic alterations of the erythrocyte surface, though laboratory methods for their further evaluation were not yet available. Investigating 96 children, the present study characterizes 72% of cases as corresponding to this type of acute acquired hemolytic anemia, which cannot be clearly related to autoantibodies against unmodified components of the host's own red cells. Using a new immunofluorescence test, the erythrocyte membrane of 80% of these children was found to be altered in vivo by nonspecific adsorption of foreign material released from the infectious micro-organisms. In 24% of cases additive binding of complement was detectable by an antiglobulin test. Thus, the adsorption of microbial antigens to the red cell surface is suggested to be one of the causes for the removal of altered erythrocytes due to phagocytosis or a complement-dependent destruction during the course of infection-associated hemolytic anemia. Especially in childhood, the immunofluorescent detection of an erythrocyte sensitization in vivo provides a further characterization of this type of mostly transient hemolytic disease, which probably can be treated without any immunosuppressive drug, merely by elimination of the underlying infection.
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Cellular and molecular life sciences 26 (1970), S. 1343-1344 
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Half-desmosome like structures binding the cell to the theca have been found in the phytoflagellatePlatymonas. The tonofilaments are parts of the flagellar root system.
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 1432-1289
    Keywords: Schlüsselwörter Humane Brucellose ; Chronische Brucellose ; Undulierendes Fieber ; Brucella melitensis ; Abdominale Schmerzen
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Zusammenfassung Eine seit Jahren in Deutschland lebende, 43jährige türkische Patientin stellte sich nach Auslandsaufenthalt in der Türkei mit wiederholt aufgetretenen Episoden von undulierendem Fieber, Arthralgien, Durchfällen und krampfartigen Abdominalbeschwerden zur weiteren Abklärung vor. Klinisch imponierten der reduzierte Allgemeinzustand und eine Leukopenie mit relativer Lymphozytose. Eine generalisierte Lymphknotenschwellung oder Hepatosplenomegalie traten nicht auf. In der Blutkultur war Brucella melitensis Biotyp 3 als ursächlicher Erreger nachweisbar. Die Serologie für Brucella abortus und Brucella melitenis war positiv. Auch wenn in Deutschland die Rinderbestände Brucellose-frei sind und die Brucellose insgesamt in Deutschland sehr selten ist, sollte durch die hohe Mobilität der Bevölkerung eine solche Diagnose im klinischen Alltag mit in Betracht gezogen werden. In den Mittelmeerländern ist die Inzidenz durch Kontakt sowie Übertragung von infizierten Milch- oder Fleischprodukten erhöht. Somit kann ein wochen- oder monatelang anhaltendes, undulierendes Fieber bei Patienten mit anamnestisch bekanntem Auslandsaufenthalt an eine Brucellose denken lassen. Wenn die serologische Diagnose nicht immer zum Ziel führt, ist eine Erregeranzüchtung in der Blutkultur oder eine histologische Aufarbeitung geschwollener Lymphknoten oder betroffener Organe angezeigt. Therapie der ersten Wahl ist die Kombinationstherapie eines Tetrazyklins mit einem Aminoglykosid. Bei rekurrenten oder chronischen Verläufen sollte nach der Auswahl anhand des Antibiogramms eine weitere Kombination zellgängiger Antibiotika konsequent für 6 Wochen eingesetzt werden.
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