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  • 1
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    German Medical Science GMS Publishing House; Düsseldorf
    In:  59. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie e.V. (DGNC), 3. Joint Meeting mit der Italienischen Gesellschaft für Neurochirurgie (SINch); 20080601-20080604; Würzburg; DOCMO.06.10 /20080530/
    Publication Date: 2008-05-30
    Keywords: Focal cortical dysplasia ; epilepsy surgery ; outcome ; Fokale Kortikale Dysplasie ; Epilepsiechirurgie ; Outcome ; ddc: 610
    Language: English
    Type: conferenceObject
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  • 2
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    German Medical Science GMS Publishing House; Düsseldorf
    In:  58. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie e.V. (DGNC); 20070426-20070429; Leipzig; DOCP 106 /20070411/
    Publication Date: 2007-04-04
    Keywords: Ganglioglioma ; malignant ; follow-up ; Gangliogliom ; maligne ; Verlauf ; ddc: 610
    Language: English
    Type: conferenceObject
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  • 3
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    German Medical Science GMS Publishing House; Düsseldorf
    In:  65. Kongress der Nordrhein-Westfälischen Gesellschaft für Urologie; 20190328-20190329; Münster; DOCP 2.8 /20190225/
    Publication Date: 2019-02-26
    Keywords: ddc: 610
    Language: German
    Type: conferenceObject
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  • 4
    Keywords: brain ; CELLS ; tumor ; Germany ; PATHWAY ; PATHWAYS ; CLASSIFICATION ; SYSTEM ; SYSTEMS ; GENE ; GENES ; TUMORS ; PATIENT ; MECHANISM ; CONTRAST ; mechanisms ; FREQUENCY ; polymorphism ; POLYMORPHISMS ; VARIANTS ; IDENTIFICATION ; LESIONS ; WHITE-MATTER ; SERIES ; pathology ; NEOPLASTIC TRANSFORMATION ; molecular ; VARIANT ; MUTATIONAL ANALYSIS ; ALLELES ; DYSPLASIA ; epilepsy ; focal cortical dysplasia ; FOCAL EPILEPSIES ; GANGLIOGLIOMAS ; glio-neuronal lesion ; GLIONEURONAL TUMORS ; tuberous sclerosis ; TUBEROUS SCLEROSIS COMPLEX
    Abstract: Epilepsy-associated malformations of cortical development (MCDs) comprise a variety of dysplastic and neoplastic lesions of yet undetermined molecular pathology. Histopathologic similarities between MCDs and dysplastic brain lesions in the autosomal inherited neurocutaneous phacomatosis tuberous sclerosis (TSC), which affects the TSC1 and/or TSC2 genes, suggest common pathogenetic mechanisms. Previous studies revealed different alterations of TSC1 and TSC2 in epilepsy-associated malformations and glio-neuronal tumors despite histopathologic similarities. In order to examine current clinico-pathologic classification systems of cortical malformations on the molecular level, we carried out a mutational analysis of TSC1 and TSC2 in a series of surgical specimens obtained from patients with FCD without Taylor type balloon cells (FCDIIa; n = 20), architectural dysplasias (FCDI; n = 15), nodular cortical heterotopias (NCH; It = 4), and heterotopic white matter neurons (WMNH; It = 19). In FCDIIa, abundant genomic polymorphisms were detected in TSC2 (intron 4) but no allelic variants observed in exon 17 of TSCL This allelic distribution pattern is in contrast to findings in FCDI and WMNH but also to those previously reported in FCDIIb (Taylor's balloon cell type). The latter revealed increased frequencies of specific alleles only in TSCL The determination of characteristic molecular genetic alterations in specific epilepsy-associated malformations will support a comprehensive clinico-pathologic classification system and help to identify molecular pathways with potential pathogenetic relevance. Our work is supported by DFG (SFB TRB [AJB], DFG B1 42 1/1-1 [113]), BONFOR, and Deutsche Krebshilfe
    Type of Publication: Journal article published
    PubMed ID: 16042315
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  • 5
    Abstract: BACKGROUND: Lung cancer is one of the most common malignant neoplasms worldwide and has a high mortality rate. To enable individualized therapy regimens, a better understanding of the molecular tumor biology has still to be elucidated. The expression of the cell surface protein CD24 has already been claimed to be associated with shorter patient survival in non-small cell lung cancer (NSCLC), however, the prognostic value and applicability of CD24 immunostaining in paraffin embedded tissue specimens has been questioned due to the recent acknowledgement of restricted epitope specificity of the commonly used antibody SN3b. METHODS: A cohort of 137 primary NSCLC cases was immunostained with a novel CD24 antibody (clone SWA11), which specifically recognizes the CD24 protein core and the resulting expression data were compared with expression profiles based on the monoclonal antibody SN3b. Furthermore, expression data were correlated to clinico-pathological parameters. Univariate and multivariate survival analyses were conducted with Kaplan Meier estimates and Cox regression, respectively. RESULTS: CD24 positivity was found in 34 % resp. 21 % (SN3b) of NSCLC with a membranous and/or cytoplasmic staining pattern. Kaplan-Meier analyses revealed that membranous, but not cytoplasmic CD24 expression (clone SWA11) was associated with lympho-nodular spread and shorter overall survival times (both p 〈 0.05). CD24 expression established by SN3b antibodies did not reveal significant clinicopathological correlations with overall survival, neither for cytoplasmic nor membranous CD24 staining. CONCLUSIONS: Membranous CD24 immunoreactivity, as detected with antibody clone SWA11 may serve as a prognostic factor for lymphonodular spread and poorer overall survival. Furthermore, these results corroborate the importance of a careful distinction between membranous and cytoplasmic localisation, if CD24 is to be considered as a potential prognostic biomarker.
    Type of Publication: Journal article published
    PubMed ID: 26578846
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  • 6
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    German Medical Science; Düsseldorf, Köln
    In:  57. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie e.V. (DGNC), Joint Meeting mit der Japanischen Gesellschaft für Neurochirurgie; 20060511-20060514; Essen; DOCP 05.73 /20060508/
    Publication Date: 2006-07-31
    Keywords: epilepsy ; focal cortical dysplasia ; ganglioglioma ; Epilepsie ; Fokale Kortikale Dysplasie ; Gangliogliom ; ddc: 610
    Language: English
    Type: conferenceObject
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  • 7
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    German Medical Science GMS Publishing House; Düsseldorf
    In:  130. Kongress der Deutschen Gesellschaft für Chirurgie; 20130430-20130503; München; DOC13dgch030 /20130426/
    Publication Date: 2013-04-27
    Keywords: ddc: 610
    Language: German
    Type: conferenceObject
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  • 8
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    German Medical Science GMS Publishing House; Düsseldorf
    In:  28. Wissenschaftliche Jahrestagung der Deutschen Gesellschaft für Phoniatrie und Pädaudiologie (DGPP), 2. Dreiländertagung D-A-CH; 20110909-20110911; Zürich; DOC11dgppP07 /20110818/
    Publication Date: 2011-08-18
    Description: Hintergrund: Der Schluckvorgang zeichnet sich durch eine hohe Komplexität aus. Die Ursachen einer Dysphagie sind vielfältig. So können entzündliche und nichtentzündliche Veränderungen im Bereich der Speisewege ebenso zu Beschwerden führen wie Systemerkrankungen, tumoröse Raumforderungen, Traumata, neuromuskuläre Erkrankungen und vertebragene Veränderungen. Ebenso spielen Störungen im psychosomatisch-psychiatrischen Bereich mitunter eine Rolle.Fallbericht: Wir berichten über einen 61-jährigen Patienten, der sich mit seit zwei Monaten bestehendem intermittierendem Fremdkörpergefühl beim Schlucken in unserer Abteilung vorstellte. Die lupenlaryngoskopische Untersuchung zeigte eine flächige gestielte Raumforderung, die sich im Zuge der Phonation aus der Hypopharynxregion bis in Höhe der Glottis vorwölbte und diese teilweise verlegte. Die laryngealen Schleimhautverhältnisse waren unauffällig; es zeigte sich eine seitengleiche respiratorische Stimmlippenbeweglichkeit, die Randkantenverschieblichkeit erschien unauffällig. Der Stimmklang war etwas belegt, jedoch bestand eine gute Tragfähigkeit und ein normaler Tonumfang; im Elektroglottogramm (EGG) zeigten sich keinerlei Auffälligkeiten.Verlauf: Im Rahmen einer Mikrolaryngoskopie wurde die gestielte polypöse Raumforderung laserchirurgisch abgetragen. Die histologische Begutachtung zeigte einen entzündlich veränderten plattenepithelial ausgekleideten Polypen des Sinus piriformis linksseitig. Differentialdiagnostisch konnte ein mesenchymaler Tumor durch eine immunhistochemische Untersuchung ausgeschlossen werden.Schlussfolgerung: Eine oropharyngeale Dysphagie mit Funktionsstörungen im Bereich des pharyngo-ösophagealen Überganges kann vielfältige Ursachen haben. Daher sind eine umfassende klinische Untersuchung, sowie eine endoskopische Inspektion und ggf. weiterführende radiologische Verfahren für die weitere Abklärung unerlässlich.
    Keywords: ddc: 610
    Language: German
    Type: conferenceObject
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  • 9
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    German Medical Science; Düsseldorf, Köln
    In:  56. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie e.V. (DGNC), 3èmes journées françaises de Neurochirurgie (SFNC); 20050507-20050511; Strasbourg; DOCP010 /20050504/
    Publication Date: 2005-05-05
    Keywords: ddc: 610
    Language: English
    Type: conferenceObject
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  • 10
    Keywords: brain ; EXPRESSION ; Germany ; human ; MODEL ; MODELS ; SYSTEM ; TOOL ; DISEASE ; DISEASES ; POPULATION ; GENE ; GENE-EXPRESSION ; GENES ; GENOME ; microarray ; SAMPLE ; SAMPLES ; DRUG ; TISSUE ; PATIENT ; COMPLEX ; COMPLEXES ; MECHANISM ; RATS ; TISSUES ; mechanisms ; NERVOUS-SYSTEM ; NO ; STAGE ; gene expression ; HUMANS ; microarrays ; PATHOGENESIS ; DAMAGE ; REORGANIZATION ; STRATEGIES ; NETHERLANDS ; CENTRAL-NERVOUS-SYSTEM ; FREQUENT ; INSIGHTS ; DYNAMIC PROCESSES ; FUNCTIONAL GENOMICS ; TEMPORAL-LOBE ; ORIGIN ; LOBE EPILEPSY ; COMPLEXITY ; MOLECULAR-MECHANISM ; WORLDWIDE ; EPILEPTOGENESIS ; HIPPOCAMPAL ; KAINATE ; PILOCARPINE ; SEIZURES ; species comparison ; temporal lobe epilepsy
    Abstract: The advent of gene chip technology and the era of functional genomics have initially been accompanied by huge anticipations to quickly unravel the molecular pathogenesis of multifactorial diseases. Expectations have, today, given way to some concerns about this non-hypothesis driven approach. However, the careful and controlled application of expression microarrays in concert with refined bioinformatic tools may provide novel insights in major disorders particularly of highly complex organs such as the central nervous system (CNS). Epilepsies are among the most frequent CNS disorders affecting approximately 1.5% of the population worldwide. In temporal lobe epilepsy (TLE), the seizure origin typically involves the hippocampal formation, a structure located in the mesial temporal lobe. Many TLE patients develop pharmacoresistance, i.e. seizures can no more be controlled by antiepileptic drugs. In order to achieve seizure control, surgical removal of the epileptogenic focus has been established as successful therapeutic strategy. Hippocampal biopsy tissue of pharmacoresistant TLE patients represents an excellent substrate to analyze molecular mechanisms related to structural and cellular reorganization in epilepsy. The complexity of alterations in TLE hippocampi suggests numerous genes and signaling cascades to be involved in the pathogenesis. By microarrays, genome wide expression profiles can be constituted from TLE tissues. However, hippocampi of pharmacoresistant TLE patients represent an advanced stage of the disease. Early stages of epilepsy development are not available for functional genome analysis in humans. Animal models of TLE appear particularly helpful to study molecular mechanisms of highly dynamic processes such as the development of hyperexcitability and pharmacoresistance. In this review, we summarize recent data of gene expression profiles in human and experimental TILE and discuss the relevance of novel tools for bioinformatic analysis and data mining. (C) 2004 Elsevier B.V All rights reserved
    Type of Publication: Journal article published
    PubMed ID: 15380561
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