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  • 1
    Keywords: Life sciences ; Genetic Engineering ; Microbiology ; Bacteriology ; Life sciences ; Microbiology ; Bacteriology ; Genetic Engineering ; Springer eBooks
    Description / Table of Contents: Pulsed Field Gel Electrophoresis and Genome Size Estimates -- Comparative Analyses of Extrachromosomal Bacterial Replicons, Identification of Chromids and Experimental Evaluation of their Indispensability -- Choice of Next Generation Sequencin Pipelines -- The Pyrosequencing Protocol for Bacterial Genomes -- Bacterial Metabarcoding by 16S rRNA Gene Ion Torrent Amplicon Sequencing -- The Ilumina-Solexa Sequencing Protocol for Bacterial Genomes -- High-Throughput Phenomics -- Comparative Analysis of Gene Expression: Uncovering Expression Conservation and Divergence between Salmonella enterica serovar Typhimurium strains LT2 and 14028S -- Raw Sequence Data and Quality Control -- Methods for Assembling Reads and Producing Contigs -- Mapping Contigs Using CONTIGuator -- Gene Calling and Bacterial Genome Annotation with BG7 -- Defining Orthologs and Pangenome Size Metrics -- Robust Identification of Orthologues and Paralogues for Microbial Pan-Genomics Using GET_HOMOLOGUES: A Case Study of pIncA/C Plasmids -- Genome-Scale Metabolic Networks Reconstruction -- From Pangenome to Phanphenome and Back -- Genome-Wide Detection of Selection and Other Evolutionary Forces -- The Integrated Microbial Genome Resource of Analysis
    Abstract: Bacterial genomics is a mature research interdisciplinary field, which is approached by ecologists, geneticists, bacteriologists, molecular biologists and evolutionary biologists working in medical, industrial and basic science.℗ Thanks to the large diffusion of bacterial genome analysis , Bacterial Pangenomics: Methods and Protocols is able to provide the most recent methodologies about the study of bacterial pangenomes by covering the three major areas: the experimental methods for approaching bacterial pangenomics, the bioinformatic pipelines for analysis and annotation of sequence data, and finally the methods for inferring functional and evolutionary features from the pangenome. Written in the successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. ℗ Authoritative and easily accessible, Bacterial Pangenomics: Methods and Protocols will serve as a field guide for both qualified bacterial genomics investigators who want to update their technical knowledge, for less experienced researchers who want to start working with bacterial genomics and pangenomics, as well as serving as a manual and supplemental textbook for graduate students of genomics and bioinformatics
    Pages: X, 298 p. 59 illus., 42 illus. in color. : online resource.
    ISBN: 9781493917204
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  • 2
    Call number: QZ200Z:237/24,4
    Keywords: Blood Coagulation Disorders ; Blood Coagulation Factors ; Anticoagulants (Medicine)
    Pages: xivp., p. 670-791
    ISBN: 9781437725292
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    QZ200Z:237/24,4 available
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  • 3
    Unknown
    Berlin : Springer
    Call number: WN440:13
    Keywords: Radiobiologie ; Mikrodosimetrie ; Radiotherapie / Arbeitsmethodik
    Pages: xii, 321 p.
    ISBN: 3-540-58541-9
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    WN440:13 available
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  • 4
    Keywords: Life sciences ; Linguistics / Philosophy ; Animal behavior ; Evolution (Biology) ; Applied psychology ; Consciousness ; Life sciences ; Evolutionary Biology ; Philosophy of Language ; Cognitive Psychology ; Behavioural Sciences ; Biological Psychology ; Springer eBooks
    Description / Table of Contents: Introduction -- PART I: Philosophical and Historical Roots of Social Communication Studies -- Lord Monboddó€™s Ourang Outang and the Origin and Progress of Language -- Ferality and Morality; The Politics of the ́€œForbidden Experiment́€ in the Twentieth Century -- PART II: The Elements of Social Communication in Primates and Humans -- Experimental Conversations: Sign Language Studies with Chimpanzees -- How Primate Mothers and Infants Communicate: Characterizing Interaction in Mother-Infant Studies -- On Prototypical Facial Expressions vs. Variation in Facial Behavior: What Have We Learned on the ́€œVisibilitý€ of Emotions from Measuring Facial Actions in Humans and Apes -- The Evolution of Joint Attention: A Review and Critique -- Describing Mental States: From Brain Science to a Science of Mind Reading -- PART III: Evolutionary Transitions from Social Communication Systems to Language -- Bodily Mimesis and the Transition to Speech -- From Grasping to Grooming to Gossip: Innovative Use of Chimpanzee Signals in Novel Environments Supports both Vocal and Gestural Theories of Language Origins -- Reevaluating Chimpanzee Vocal Signals from the Ground Up -- PART IV: Evolutionary Origins of Human Language -- Communication and Human Uniqueness -- How did Humans Become Behaviorally Modern? Revisiting the €˜Árt First́€™ Hypothesis -- Experiments and Simulations Can Inform Evolutionary Theories of the Cultural Evolution of Language -- The Emergence of Modern Communication in Primates: a Computational Approach -- What Can an Extended Synthesis do for Bio linguistics: On the Need and Benefits of the Eco-evo-devo Program
    Abstract: How did social communication evolve in primates? In this volume, primatologists, linguists, anthropologists, cognitive scientists and philosophers of science systematically analyze how their specific disciplines demarcate the research questions and methodologies involved in the study of the evolutionary origins of social communication in primates in general, and in humans in particular. In the first part of the book, historians and philosophers of science address how the epistemological frameworks associated with primate communication and language evolution studies have changed over time, and how these conceptual changes affect our current studies on the subject matter. In the second part, scholars provide cutting-edge insights into the various means through which primates communicate socially in both natural and experimental settings. They examine the behavioral building blocks by which primates communicate, and they analyze what the cognitive requirements are for displaying communicative acts. Chapters highlight cross-fostering and language experiments with primates, primate mother-infant communication, the display of emotions and expressions, manual gestures and vocal signals, joint attention, intentionality and theory of mind. The primary focus of the third part is on how these various types of communicative behavior possibly evolved, and how they can be understood as evolutionary precursors to human language. ℗ Leading scholars analyze how both manual and vocal gestures gave way to mimetic and imitational protolanguage, and how the latter possibly transitioned into human language. In the final part, we turn to the hominin lineage, and anthropologists, archeologists and linguists investigate what the necessary neurocognitive, anatomical and behavioral features are in order for human language to evolve, and how language differs from other forms of primate communication
    Pages: X, 326 p. 18 illus., 11 illus. in color. : online resource.
    ISBN: 9783319026695
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  • 5
    Call number: ZZ2000:1/2004a ; ZZ2000:1/2004/Mag
    Keywords: Microscopy / methods ; Image Processing, Computer-Assisted ; Microscopy, Fluorescence ; Microscopy, Confocal ; Microscopy, Video ; Microscopy, Electron ; DKFZ-publications
    Pages: 200 p. : ill.
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    ZZ2000:1/2004a available
    ZZ2000:1/2004/Mag departmental collection or stack – please contact the library
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  • 6
    Call number: ZZ2000:1/2003a ; ZZ2000:1/2003/Mag
    Keywords: Microscopy / methods ; Image Processing, Computer-Assisted ; Microscopy, Fluorescence ; Microscopy, Confocal ; Microscopy, Video ; Microscopy, Electron ; DKFZ-publications
    Pages: 204 p. : ill.
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    ZZ2000:1/2003a available
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  • 7
    Keywords: Medicine ; Human Genetics ; Biomedicine ; Human Genetics ; Springer eBooks
    Description / Table of Contents: The A-like Faker Assay for Measuring Yeast Chromosome III Stability -- The Chromosome Transmission Fidelity Assay for Measuring Chromosome Loss in Yeast -- Measuring Mutation Rates using the Luria-Delbrück Fluctuation Assay -- Molecular Genetic Characterization of Mutagenesis Using a Highly Sensitized Single-Stranded DNA Reporter System in Budding Yeast -- Analyzing Genome Rearrangements in Saccharomyces cerevisiaen: initial; background-size: initial; background-repeat: initial; background-attachment: initial; background-origin: initial; background-clip: initial;"〉 -- High Resolution Mapping of Modified DNA Nucleobases using Excision Repair Enzymes -- Integrated Microarray-based Tools for Detection of Genomic DNA Damage and Repair Mechanisms -- Study of UV-induced DNA Repair Factor Recruitment: Kinetics and Dynamics -- Inserting Site-specific DNA Lesions into Whole Genomes -- A qPCR-based Protocol to Quantify DSB Resection -- Alkaline Denaturing Southern Blot Analysis to Monitor Double-strand Break Processing -- Single Molecule Analysis of Resection Tracks -- Mapping DNA Breaks by Next-generation Sequencing -- Genome-wide Profiling of DNA Double-strand Breaks by the BLESS and BLISS Methods -- DNA Replication Profiling using Deep Sequencing -- Quantitative Bromodeoxyuridine Immunoprecipitation Analyzed by High-Throughput Sequencing (qBrdU-seq or QBU) -- Strand-specific Analysis of DNA Synthesis and Proteins Association with DNA Replication Forks in Budding Yeast -- Analysis of Replicative Polymerase Usage by Ribonucleotide Incorporation -- Dynamic Architecture of Eukaryotic DNA Replication Forks in vivo, Visualized by Electron Microscopy -- A Molecular Toolbox to Engineer Site-Specific DNA Replication Perturbation -- Single Cell Gel Electrophoresis for the Detection of Genomic Ribonucleotides -- Measuring the Levels of Ribonucleotides Embedded in Genomic DNA -- Mapping Ribonucleotides Incorporated into DNA by Hydrolytic End-Sequencing -- Detection of DNA-RNA Hybrids in vivo -- Analysis of de novo Telomere Addition by Southern Blot -- Assays to Study Repair of Inducible DNA Double Strand Breaks at Telomeres -- Telomerase RNA Imaging in Budding Yeast and Human Cells by Fluorescent in situ Hybridization -- Methods to Study Repeat Fragility and Instability in Saccharomyces cerevisiae -- Quantitative Analysis of the Rates for Repeat-mediated Genome Instability in a Yeast Experimental System -- Measuring Dynamic Behaviour of Trinucleotide Repeat Tracts in vivo in Saccharomyces cerevisiae -- The Detection and Analysis of Chromosome Fragile Sites -- Imaging of DNA Ultrafine Bridges in Budding Yeast -- Detection of Ultra-Fine Anaphase Bridges -- A Chromatin Fiber Analysis Pipeline to Model DNA Synthesis and Structures in Fission Yeast -- Long-term Imaging of DNA Damage and Cell Cycle Progression in Budding Yeast Using Spinning Disk Confocal Microscopy -- The CellClamper: A Convenient Microuidic Device for Time-Lapse Imaging of Yeast -- Characterization of Structural and Configurational Properties of DNA by Atomic Force Microscopy -- Genome-wide Quantitative Fitness Analysis (QFA) of Yeast Cultures -- Rewiring the Budding Yeast Proteome using Synthetic Physical Interactions -- Reporter-based Synthetic Genetic Array Analysis: a Functional Genomics Approach for Investigating Transcript or Protein Abundance Using Fluorescent Proteins in Saccharomyces cerevisiae -- Statistical Analysis and Quality Assessment of ChIP-seq Data with DROMPA -- Quantitative Analysis of DNA Damage Signaling Responses to Chemical and Genetic Perturbations
    Abstract: This volume presents forty-two methods and protocols to analyze diverse aspects of genome instability. Chapters detail mutagenesis and repair, methods to quantify and analyze the properties of DNA double-strand breaks, profile replication, replication proteins strand-specifically, genome instability, fluorescence microscopic techniques, and genomic and proteomic approaches. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Genome Instability: Methods and Protocols aims to provide a comprehensive resource for the discovery and analysis of the proteins and pathways that are critical for stable maintenance of the genome
    Pages: XVI, 663 p. 133 illus., 100 illus. in color. : online resource.
    ISBN: 9781493973064
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  • 8
    Keywords: Life sciences ; Biological models ; Developmental Biology ; Plant breeding ; Plant Diseases ; Life sciences ; Developmental Biology ; Plant Genetics & Genomics ; Plant Pathology ; Plant Breeding/Biotechnology ; Systems Biology ; Springer eBooks
    Description / Table of Contents: Fungal Transformation: From Protoplasts to Targeted Recombination Systems -- Protoplast Transformation for Genome Manipulation in Fungi -- Trichoderma Transformation Methods -- Transformation of Mucor circinelloides f. lusitanicus Protoplasts -- Transformation of Saccharomyces cerevisiae: Spheroplast Method -- Electroporation Mediated DNA Transformation of Filamentous Fungi -- Chemical Transformation of Candida albicans -- Electroporation of Pichia pastoris -- Insertional Mutagenesis of the Flavinogenic Yeast Candida famata (Candida flareli) -- Biolistic Transformation for Delivering DNA into the Mitochondria -- Bolistic Transformation of Candida glabrata for Homoplasmic Mitochondrial Genome Transformants -- Use of the Biolistic Particle Delivery System to Transform Fungal Genomes -- Transformation of Zygomycete Mortierella alpina Using Biolistic Particle Bombardment -- Agrobacterium tumefaciens-Mediated Transformation -- Agrobacterium tumefaciens-Mediated Transformation of Pucciniomycotina Red Yeasts -- Glass-bead and Agrobacterium-mediated Genetic Transformation of Fusarium oxysporum -- High Efficiency DNA Transformation of Saccharomyces cerevisiae with the LiAc/SS-DNA/PEG Method -- Transformation of Intact Cells of Saccharomyces cerevisiae: Lithium Methods and Possible Underlying Mechanism -- Transformation of Lithium Acetate-treated Neurospora crassa -- Application of Novel Polymeric Carrier of Plasmid DNA for Transformation of Yeast Cells -- Transformation of Fungi Using Shock Waves -- Pathways and Mechanisms of Yeast Competence: A New Frontier of Yeast Genetics -- Evaluation of Competence Phenomenon of Yeast Saccharomyces cerevisiae by Lipophilic Cations Accumulation and FT-IR Spectroscopy. Relation of Competence to Cell Cycle -- Recombination and Gene Targeting in Neurospora -- Efficient Generation of Aspergillus niger Knock Out strains by Combining NHEJ Mutants and a Split Marker Approach -- REMI in Molecular Fungal Biology -- TALEN-Based Genome Editing in Yeast
    Abstract: Several different transformation techniques have been developed over the years and readily shown to be decisive methods℗ in fungal biotechnology. This book will cover the basics behind the most commonly used transformation methods, as well as associated tools and techniques. Each chapter will provide protocols along with examples℗ used in laboratories worldwide. Not only will this text provide a detailed℗ background on℗ applications in℗ industrial and pharmaceutical relevant microbes, but also the℗ importance of fungal pathogens℗ in agricultural production (Phytophthora and Botrytis)℗ and mammalian infection (Penicillium marneffei and Candida).℗ Genetic Transformation Systems in Fungi, Volume 1 provides in-depth coverage of how the transformation of DNA is used to understand the genetic basis behind these fungal℗ traits
    Pages: XV, 318 p. 69 illus., 17 illus. in color. : online resource.
    ISBN: 9783319101422
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  • 9
    Call number: B070:73
    Keywords: Personnel management
    Pages: 330 p. + 1 CD-ROM
    ISBN: 3-9522712-5-X
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    B070:73 departmental collection or stack – please contact the library
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  • 10
    Call number: YY Diss Nici/Mag
    Keywords: DKFZ-publications / academic dissertations
    Pages: 115 p. : ill.
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    YY Diss Nici/Mag departmental collection or stack – please contact the library
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