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  • 1
    Unknown
    Stuttgart : Wissenschaftliche Verl.-Ges.
    Call number: C010:L139 ; E080:224 ; M019:23
    Keywords: Toxicology
    Notes: Diese Aufl. basiert teilw. auf "Toxicology", 1999.
    Pages: xxxix, 1348 p.
    Edition: 2., völlig neu bearbeitete Auflage.
    ISBN: 3804717772
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    C010:L139 departmental collection or stack – please contact the library
    E080:224 departmental collection or stack – please contact the library
    M019:23 departmental collection or stack – please contact the library
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  • 2
    Unknown
    Mannheim : BI Wissenschaftsverl.
    Call number: 05-PHA-40:18
    Keywords: Toxicology
    Pages: xviii, 1004 p. : ill.
    ISBN: 3-411-16321-6
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    05-PHA-40:18 departmental collection or stack – please contact the library
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  • 3
    ISSN: 1432-2242
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1432-2242
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary X-ray induced aberrations of the cell nucleus are reviewed and classified as the so-called primary and secondary effects. The primary effects occur when actually dividing nuclei are irradiated and consist of retardation of the nucleus- and cell-divisions; of a change in the surface of chromosomes and chromatidia (stickiness, pyknosis); of anomalies in the chromosome spindles and the chromatidia; and of a change in the staining reaction of the nuclei. The secondary effects occur when resting nuclei are irradiated and are manifested by fragmentation (breaking of chromosomes) and restitution (healing of broken ends). Various types of restitution are discussed in detail. A survey is given concerning the quantitative analysis of fragmentation and restitution. Three different hypotheses of X-ray induced aberrations are briefly mentioned: The original Hit-Hypothesis ofLea, the author's own modified hypothesis of this, and the chemical hypothesis (disturbance of nucleic acid metabolism) ofDarlington.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Chromosoma 8 (1956), S. 617-636 
    ISSN: 1432-0886
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1432-0843
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Doxorubicin-resistant Friend erythroleukemia cells, line F4–6 ADM2R, were selected by exposure of wild-type F4-6 cells to doxorubicin concentrations of up to 1 μg/ml. In these cells, increased expression of multidrug resistance (MDR) genes was demonstrated by Northern blot analysis. The growth-inhibitory effect of doxorubicin, daunorubicin,N,N-dimethyldoxorubicin,N,N-dimethyldaunorubicin, morpholinodoxorubicin, and pyrromycin was comparatively investigated in resistant and wild-type cells. The doxorubicin-resistant F4-6 cells showed approx. 200-fold resistance to doxorubicin and about 100-fold resistance to daunorubicin with respect to the drug-sensitive counterpart. A dramatic decrease in resistance was observed for theN,N-dimethylated derivatives of doxorubicin and daunorubicin as well as for theN,N-dimethylated natural anthracycline pyrromycin and for morpholinodoxorubicin. Uptake studies using [14C]-daunorubicin and [14C]-N,N-dimethyldaunorubicin in resistant F4-6 cells showed a decreased accumulation of daunorubicin but no significant reduction inN,N-dimethyldaunorubicin accumulation as compared with the wild-type cells. Treatment with verapamil led to increased intracellular levels of daunorubicin in resistant cells, whereas an excess ofN,N-dimethyldaunorubicin did not have this effect. Thus, the decreased resistance of the doxorubicin-resistant F4-6 cells to theN-alkylated anthracyclines may at least in part be due to a reduced affinity of these compounds for the efflux pump. The results indicate that the dimethylation of the amino group of the anthracycline sugar moiety and its incorporation within a morpholinyl ring may overcome MDR by similar mechanisms.
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1432-072X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 1432-072X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Description / Table of Contents: Summary 1. During the second division of meiosis of a diploid Saccharomyces cerevisiae var. ellipsoideus yeast foam (Winge, Kopenhagen) the envelope of the nucleus seems to disappear and to be reconstructed in telophase. 2. The newly formed ascospores in the cytoplasm of the ascus are limited by a double membrane. The inner one becomes the plasmalemma of the ascospore cytoplasm. The outer membrane develops by the depositing of material from the cytoplasm of the ascus to the outer coat, the space between the membranes becoming the cortex of the spore. This interpretation appears to be more in agreement with our observations than Hashimotos view of a de nove development of the outer coat. 3. The ascopores contain a densely granulated cytoplasm, a nucleus, endoplasmic reticulum, promitochondria, and lipoidal inclusions. Golgi membrane-complexes and vacuoles—with the exception of occasional small ones—are both lacking. 4. The investigated yeast strain and some other strains contain promitochondria (small mitochondria with few short cristae) only in aerobic cultures. From a cytogenetic point of view, the mitochondria cannot therefore be interpreted as structures sui generis, containing extracaryotic hereditary units. If these units are not located in the cytoplasm, then they can only be located in Saccharomyces on the endoplasmic reticulum. If the reticulum forms mitochondria, then it is possible that hereditary units are also included.
    Notes: Zusammenfassung 1. Bei einer diploiden Saccharomyces cerevisiae var. ellipsoideus yeast foam (Winge, Kopenhagen) kann mindestens bei der zweiten meiotischen Teilung eine Kerneröffnung und eine Neubildung der Kernumhüllung nicht ausgeschlossen werden. 2. Im Raum des Ascusplasmas werden die Ascosporen durch eine Doppelmenbran abgegrenzt. Die innere Membran bleibt Grenzschicht des Ascosporenplasmas, die äußere Membran wird durch Anlagerung aus dem Ascusplasma zur Außenschicht verstärkt. Der Zisternenraum zwischen beiden Membranen wird zur nicht-elektronenstreuenden Mittelschicht. Diese Interpretation wird für wahrscheinlicher gehalten als eine ältere, nach der die Außenschicht de novo entsteht. 3. Die Ascosporen enthalten ein sehr dicht-granuläres Grundplasma, Zellkern, endoplasmatisches Reticulum, Promitochondrien und Lipoidgrana. Golgi-Membrankomplexe fehlen, ebenso in der Regel Vacuolen. 4. Da in verschiedenen Hefestämmen typische Mitochondrien oder einfacher strukturierte Mitochondrien (Promitochondrien) elektronenoptisch nur bei aerober Kultur nachzuweisen sind, können sie unter cytogenetischem Aspekt nicht erbtragende Strukturen sui generis sein. Extrakaryotische Erbeinheiten könnten daher, wenn nicht im Grundplasma, bei Saccharomyces nur auf Membranen des endoplasmatischen Reticulums lokalisiert sein. Sofern diese Mitochondrien bilden, könnten auch sie Erbeinheiten enthalten.
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Rat TGF-I purified from the conditioned medium of Fisher rat embryo fibroblasts transformed by feline sarcoma virus is a single peptide chain containing 50 amino acid residues and 3 disulphide linkages. The primary structure was determined by Edman degradation in a gas-phase microsequencer to be5: ...
    Type of Medium: Electronic Resource
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