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  • 1
    Keywords: Medicine ; Neurosciences ; Neurology ; Laboratory animals ; Biomedicine ; Neurosciences ; Neurology ; Animal Models ; Springer eBooks
    Description / Table of Contents: Brain Tumor Models to Predict Clinical Outcome: Like the Phoenix? -- Animal Models in Cancer Research: Assessment of Severity and the Application of Humane Endpoints -- The VM Mouse Model of Glioblastoma Multiforme -- Oligodendroglioma Models -- Medulloblastoma Model -- Learning about Retinoblastoma from Mouse Models that Missed -- Ependymoma Models -- Meningioma Models -- Pituitary Models -- Growth Regulation of Nervous System Tumors: Models for Assessment of Angiogenesis in Brain Tumors -- Using Genetically-Engineered Mouse Models to Understand Low-Grade Glioma Development and Growth in Children -- EGFR and Tumor–Suppressor Function in Brain Cancer Development -- Rodent Glioma Models: Intracranial Stereotactic Allografts and Xenografts -- Immunotherapy of High-Grade Gliomas: Preclinical In Vivo Experiments in Animal Models -- Assessing Mechanisms of Glioblastoma Invasion -- Positron Emission Tomography (PET)-Based Molecular Imaging -- In Vivo Magnetic Resonance Spectroscopic Imaging (MRSI) and Ex Vivo Quantitative Neuropathology by High Resolution Magic Angle Spinning Proton Magnetic Resonance Spectroscopy (HRMAS)- Single Photon Emission Computed Tomography (SPECT) in Small Animal CNS Research
    Abstract: Although the available models, whether at the cellular, tissue, or animal level, do not exactly represent the biology of human brain tumors, animal models can offer significant insights into these tumors, providing a better understanding of biological mechanisms underlying tumor generation, growth, angiogenesis, invasion, and metastasis.℗ Animal Models of Brain Tumors brings together developments and discoveries in €œín vivó€ experimental tumor research that have provided advances in our understanding of the cellular and molecular mechanisms involved in the generation, progression, and clinical outcome of brain neoplasms. Broken into convenient sections, this thorough volume includes topics such as animal model insights into human brain neoplasms, the cellular, molecular, and genetic basis of brain tumors, ℗ therapies in the treatment of malignant glioma, as well as imaging technologies in animal tumor models, i.e. measuring brain tumor growth and metabolism.℗ Written for the popular Neuromethods series, chapters include the kind of detailed description and implementation advice that is essential for achieving successful results. ℗ Authoritative and cutting-edge, Animal Models of Brain Tumors provides the key methods needed to validate, compare, and contrast the animal model with its proposed human counterpart and further the understanding of our own serious ailments
    Pages: XIII, 391 p. 66 illus., 43 illus. in color. : digital.
    ISBN: 9781627032094
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  • 2
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    New York : Humana Press
    Call number: QZ380:202
    Keywords: Veterinary Medicine ; Veterinary oncology ; Disease Models, Animal ; Brain Neoplasms
    Pages: xiii, 391 p.
    ISBN: 9781627032087
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    QZ380:202 available
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  • 3
    ISSN: 1524-475X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Polyclonal antibodies directed against human recombinant basic fibroblast growth factor were used in immunohistochemical studies to localize this growth factor in normal and wounded rat skeletal muscles. According to the intensity of the stain, three main classes of fibers could be identified: the strongly, moderately, and weakly stained fibers. Basic fibroblast growth factor immunoreactivity was found mainly in the extracellular matrix, primarily in the endomysium, which includes the heparin-containing basal lamina, and also in the capillary basal membrane of both normal and wounded muscles; however, the signal intensity was much stronger in normal muscles. The distribution of basic fibroblast growth factor in wounded muscles became markedly heterogeneous and sparse. After 4 hours of ischemia, about 40% of skeletal muscle fibers lost their basic fibroblast growth factor immuno-reactivity. Muscles which underwent 4 hours of ischemia and 24 hours of reperfusion had only a diminished basic fibroblast growth factor immunoreactivity. The pathologic results supported the concept of destroyed cell connection and fiber necrosis in ischemic and reperfused muscles. Potential mechanisms involved in this reduced concentration of basic fibroblast growth factor in wounded muscles may include oxygen free radical activation, a generalized effect of the inflammatory response, and reduced secretion of endogenous basic fibroblast growth factor. These results are only partially compatible with the established mitogenic role of this growth factor and suggest that a reduction of endogenous fibroblast growth factor may partly contribute to a delay in wound healing.
    Type of Medium: Electronic Resource
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