Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Keywords: Medicine ; Medical virology ; Biochemistry ; Mechanics ; Biomedicine ; Biomedicine general ; Protein Structure ; Virology ; Mechanics ; Springer eBooks
    Description / Table of Contents: Introduction: the structural basis of virus function -- The basic architecture of viruses -- Conventional electron microscopy, cryo-electron microscopy and cryo-electron tomography of viruses -- X-ray crystallography of viruses.-℗ Nuclear magnetic resonance spectroscopy to study virus structure -- Fluorescence, circular dichroism and mass spectrometry as tools to study virus structure -- Combined approaches to study virus structure -- Atomic force microscopy of viruses -- Optical tweezers to study viruses -- Assembly of simple icosahedral viruses -- Structure and assembly of complex viruses -- Nucleic acid packaging in viruses -- Virus maturation -- Virus morphogenesis in the cell: methods and observations -- Virus-receptor interactions and receptor-mediated virus entry into host cells -- Entry of enveloped viruses into host cells: membrane fusion -- Bacteriophage receptor recognition and nucleic acid transfer.-℗ Mechanical properties of viruses -- Theoretical studies on assembly, physical stability and dynamics of viruses -- Antiviral agents: Structural basis of action and rational design -- Design of novel vaccines based on virus-like particles or chimeric virions -- Nanoscale science and technology with plant viruses and bacteriophages
    Abstract: Structural Virology is today an all-important scientific discipline that permeates most other virological disciplines. The application of physical and physicochemical techniques has led to the determination of the high-resolution molecular structures of many viruses. The interplay of this approach with biochemical and biological approaches has allowed the elucidation of the structural basis of viral function in unprecedented detail. In addition, in the last years theoretical and experimental physicists have begun to tackle a fundamental physics-based approach to study different aspects of the architecture, self-assembly and material properties of virus particles. A new term, Physical Virology, has recently been coined to encompass these and related studies. This approach is beginning to merge with long-standing structural virology approaches to provide a renewed and richer view on viruses, as well as further advances in the fight against viral disease and the applications of viruses in biotechnology and nanotechnology. Structure and Physics of Viruses is an interdisciplinary textbook in which the rapidly expanding fields of structural and physical virology are dealt with in an integrated way. The authors have attempted to write a book basic enough to be useful to students, as well as advanced and current enough to be useful to senior scientists. This book is aimed first at M.Sc. students, Ph.D. students and postdoctoral researchers with a university degree in biology, chemistry, physics or related sciences who share an interest or are actually working on viruses. It is aimed also at providing an updated account of many important concepts, techniques, studies and applications in structural and physical virology for established scientists working on viruses, irrespective of their physical, chemical or biological background and their field of expertise.℗
    Pages: XIX, 728 p. 177 illus., 122 illus. in color. : digital.
    ISBN: 9789400765528
    Signatur Availability
    BibTip Others were also interested in ...
  • 2
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] A major antigenic site (site A) of foot-and-mouth disease virus includes multiple overlapping epitopes located within the flexible G-H loop of capsid protein VP1. We have studied the antigenicity of several recombinant E. coli β-galactosidases displaying the site A from a serotype C virus in ...
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 3
    ISSN: 0887-3585
    Keywords: Fab structures ; viral epitopes ; foot-and-mouth disease virus ; Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: The Fab fragment of the neutralizing monoclonal antibody SD6 elicited against foot-and-mouth disease virus (FMDV) C-SBcl and its complex with a peptide, corresponding to the major antigenic site of FMDV (VPl residues 136-150, YTASARGDLAHLTTT), have been crystallized using the hanging drop vapor diffusion techniques. For the isolated Fab, crystals diffracting to 2.5 Å resolution were obtained at room temperature using ammonium sulfate as precipitant. These crystals are monoclinic, space group C2, and unit cell parameters a = 109.53 Å, b = 89.12 Å, c = 64.04 Å, and β = 112.9° and contain one Fab molecule per asymmetric unit. Crystals from the complex diffract, at least, to 2.8 Å resolution and were obtained, at room temperature, using PEG as precipitant. These crystals are monoclinic, space group P2, and unit cell parameters a = 56.11 Å, b = 60.67 Å, c = 143.45 Å, and β = 95.4°, Density packing considerations indicate that there are two Fab molecules in the asymmetric unit. © 1994 John Wiley & Sons, Inc.
    Additional Material: 1 Tab.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 4
    ISSN: 1072-8368
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] We have analyzed the folding pathway of the tetramerization domain of the tumor suppressor protein p53. Structures of transition states were determined from Φ–values for 25 mutations, including leucine to norvaline, and the analysis encompassed nearly every residue in the domain. ...
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 5
    ISSN: 1572-994X
    Keywords: quasi-species ; virus evolution ; foot-and-mouth disease virus ; antigenic specificity ; antigen-antibody complex
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Aphthoviruses are an important group of animal pathogens. A combination of genetic and structural studies has revealed one of the main principles governing their evolution: severe limitations to variation imposed by functional and structural constraints, in conjunction with high mutation and recombination rates operating during genome replication. Evolution occurs by positive selection and random drift acting on complex quasispecies distributions. The mutant composition of a quasi-species (or mutant spectrum) is largely dictated by tolerance to nucleotide and amino acid substitutions in viral RNAs and proteins, which must remain functionally competent. We review recent evidence to support this proposal, and we suggest that similar concepts may apply to other RNA viruses as well.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...