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  • 1
    ISSN: 1573-904X
    Keywords: drug delivery ; ion exchange ; micromembrane ; dopamine hydrochloride
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract The exchange of pharmaceutically significant amounts of dopamine across a micromembrane is reported, establishing the practical basis for such a drug delivery system. Drug release was accomplished with a commercially available device initially intended for use as a postcolumn reactor in ion chromatography. Release of other ionic drugs (e.g., methyldopate and piperacillin) was also achieved but with a lesser efficiency than was dopamine, presumably because of a size effect. The effect of releasing ion identification and concentration, the flow rate of the delivery solution and concentration of drug in the device reservoir on the drug release efficiency was examined. Under optimal conditions the efficiency approaches 80%, and 1 mg of drug is released/ml of delivery solution. Alternatively, operating conditions can be changed so that magnitude of release is optimized but absolute efficiency is sacrificed. Under such conditions the magnitude of dopamine release approaches 2 mg/ml but exchange efficiency is approximately 25%.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1573-904X
    Keywords: dopamine hydrochloride ; oxygen-sensitive drugs ; premixed products ; product stabilization ; antioxidants
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract The ability to stabilize dopamine hydrochloride formulations via the utilization of a secondary bag containing an antioxidant has been established. By physically separating the drug formulation from the stabilization solution, the chemistry of both solutions can be optimized independently so as to ensure product efficacy. Factors controlling the effectiveness of the proposed stabilization strategy are discussed in the context of actual experimental results. Such a strategy is effective in terms of protecting the formulation during processing/storage only if the product is stored in an oxygen barrier overpouch.
    Type of Medium: Electronic Resource
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