Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Keywords: CANCER ; radiotherapy ; carcinoma ; human ; neoplasms ; DIAGNOSIS ; RISK ; PATIENT ; kidney ; RISK-FACTORS ; CARCINOGENESIS ; colon ; ASSOCIATION ; BREAST ; LYMPHOMA ; AGE ; OVARIAN-CANCER ; risk factors ; CERVICAL-CANCER ; RATES ; cancer risk ; REGISTRATION ; CANCER-PATIENTS ; adenocarcinoma ; TOBACCO ; pancreatic cancer ; LONG-TERM SURVIVORS ; YOUNG ; REGISTRY ; REPRODUCTIVE FACTORS ; ASSOCIATIONS ; ENDOMETRIAL ; PANCREATIC-CANCER ; cancer registries ; TESTICULAR CANCER ; LYMPHOMAS ; cancer registry ; pooled analysis ; RISK-FACTOR ; CANCERS ; REGISTRIES ; CANCER-DIAGNOSIS ; pancreatic neoplasms ; MALIGNANT NEOPLASMS ; neoplasms,second primary
    Abstract: Studies of pancreatic cancer in the setting of second primary malignant neoplasms can provide etiologic clues. An international multicenter study was carried out using data from 13 cancer registries with a registration period up to year 2000. Cancer patients were followed up from the initial cancer diagnosis, and the occurrence of second primary malignant neoplasms was compared with expected values derived from local rates, adjusting for age, sex, and period of diagnosis. Results from individual registries were pooled by use of a fixed-effects model. People were at higher risk of developing pancreatic cancer within 10 years of a diagnosis of cancers of the pharynx, stomach, gallbladder, larynx, lung, cervix, corpus uteri, bladder, and eye and 10 years or later following a diagnosis of cancers of the stomach, colon, gallbladder, breast, cervix, placenta, corpus uteri, ovary, testis, bladder, kidney, and eye, as well as Hodgkin's and non-Hodgkin's lymphomas. Pancreatic cancer was connected with smoking-related cancers, confirming the etiologic role of tobacco. The associations with uterine and ovarian cancers suggest that reproductive factors might be implicated in pancreatic carcinogenesis. The elevated pancreatic cancer risk in young patients observed among several types of cancer implies a role of genetic factors. Radiotherapy is also suggested as a risk factor
    Type of Publication: Journal article published
    PubMed ID: 16421239
    Signatur Availability
    BibTip Others were also interested in ...
  • 2
    Keywords: CANCER ; carcinoma ; neoplasms ; DIAGNOSIS ; FOLLOW-UP ; COHORT ; EPIDEMIOLOGY ; incidence ; POPULATION ; RISK ; RISKS ; SITE ; PATIENT ; prognosis ; RISK-FACTORS ; treatment ; LINKAGE ; DESIGN ; NUMBER ; AGE ; risk factors ; CANCER-PATIENTS ; CANCER PATIENTS ; TRENDS ; REGISTRY ; cancer registries ; PRIMARY TUMORS ; SWITZERLAND ; INTERVAL ; PRIMARY NEOPLASMS ; second primary cancers ; cancer registry ; pooled analysis ; RISK-FACTOR ; CANCERS ; REGISTRIES ; population-based ; PRIMARY MALIGNANCIES ; second primary cancer
    Abstract: Context: Increasing incidence and improved prognosis of thyroid cancer have led to concern about the development of second primary cancers, especially after radioiodine treatment. Thyroid cancer can also arise as a second primary neoplasm after other cancers. Objective: The objective of the study was to assess the risk of second primary cancer after thyroid cancer and vice versa. Design: This was a multinational record linkage study. Setting: The study was conducted at 13 population-based cancer registries in Europe, Canada, Australia, and Singapore. Patients or Other Participants: A cohort of 39,002 people (356,035 person-yr of follow-up) with primary thyroid cancer were followed up for SPN for up to 25 yr, and 1,990 cases of thyroid cancer were diagnosed after another primary cancer. Main Outcome Measures: To assess any possible excess of second primary neoplasms after thyroid cancer, the observed numbers of neoplasms were compared with expected numbers derived from age-, the cancer registries, yielding standardized incidence ratios (SIRs). The SIR of second primary thyroid cancer after various types of cancer was also calculated. Results: During the observation period, there were 2821 second primary cancers (all sites combined) after initial diagnosis of thyroid cancer, SIR of 1.31 ( 95% confidence interval 1.26 - 1.36) with significantly elevated risks for many specific cancers. Significantly elevated risks of second primary thyroid cancer were also seen after many types of cancer. Conclusion: Pooled data from 13 cancer registries show a 30% increased risk of second primary cancer after thyroid cancer and increased risks of thyroid cancer after various primary cancers. Although bias (detection, surveillance, misclassification) and chance may contribute to some of these observations, it seems likely that shared risk factors and treatment effects are implicated in many. When following up patients who have been treated for primary thyroid cancer, clinicians should maintain a high index of suspicion for second primary cancers
    Type of Publication: Journal article published
    PubMed ID: 16478820
    Signatur Availability
    BibTip Others were also interested in ...
  • 3
    Keywords: CANCER ; carcinoma ; CELL ; LUNG ; PROSTATE ; COHORT ; EXPOSURE ; incidence ; liver ; RISK ; PATIENT ; kidney ; primary ; SKIN ; BREAST ; BREAST-CANCER ; LYMPHOMA ; DIFFERENCE ; DECREASE ; NUMBER ; AGE ; COUNTRIES ; PROSTATE-CANCER ; RATES ; skin cancer ; MELANOMA ; SWEDEN ; COLON-CANCER ; STOMACH ; SIR ; UNITED-STATES ; AUSTRALIA ; second cancer ; SKIN-CANCER ; basal cell carcinoma ; NON-HODGKINS-LYMPHOMA ; CELL CARCINOMA ; ONCOLOGY ; REGISTRY ; pancreas ; cancer registries ; non-Hodgkin lymphoma ; methods ; cancer registry ; CANCER INCIDENCE ; female ; CANCERS ; REGISTRIES ; E ; colorectal ; BASAL-CELL CARCINOMA ; second primary cancer ; SUN EXPOSURE ; vitamin D ; VITAMIN-D ; ULTRAVIOLET-RADIATION ; SUBSEQUENT RISK ; D METABOLITES
    Abstract: Background: Skin cancers are known to be associated with sun exposure, whereas sunlight through the production of vitamin D may protect against some cancers. The aim of this study was to assess whether patients with skin cancer have an altered risk of developing other cancers. Methods: The study cohort consisted of 416,134 cases of skin cancer and 3,776,501 cases of non-skin cancer as a first cancer extracted from 13 cancer registries. 10,886 melanoma and 35,620 non-melanoma skin cancer cases had second cancers. The observed numbers (0) of 46 types of second primary cancer after skin melanoma, basal cell carcinoma or non-basal cell carcinoma, and of skin cancers following non-skin cancers were compared to the expected numbers (E) derived from the age, sex and calendar period specific cancer incidence rates in each of the cancer registries (O/E = SIR, standardised incidence ratios). Rates from cancer registries classified to sunny countries (Australia, Singapore and Spain) and less sunny countries (Canada, Denmark, Finland, Iceland, Norway, Scotland, Slovenia and Sweden) were compared to each other. Results: SIR of all second solid primary cancers (except skin and lip) after skin melanoma were significantly lower for the sunny countries (SIR(S) = 1.03; 95% CI 0.99-1.08) than in the less sunny countries (SIR(L) = 1.14; 95%CI 1.11-1.17). The difference was more obvious after non-melanoma skin cancers: after basal cell carcinoma SIR(S)/SIR(L) = 0.65 (9S%CI = 0.58-0.72); after non-basal cell carcinoma SIR(S)/SIR(L) = 0.58 (95%CI = 0.50-0.67). In sunny countries, the risk of second primary cancer after non-melanoma skin cancers was lower for most of the cancers except for lip, mouth and non-Hodgkin lymphoma. Conclusions: Vitamin D production in the skin seems to decrease the risk of several solid cancers (especially stomach, colorectal, liver and gallbladder, pancreas, lung, female breast, prostate, bladder and kidney cancers). The apparently protective effect of sun exposure against second primary cancer is more pronounced after non-melanoma skin cancers than melanoma, which is consistent with earlier reports that non-melanoma skin cancers reflect cumulative sun exposure, whereas melanoma is more related to sunburn. (c) 2007 Elsevier Ltd. All rights reserved
    Type of Publication: Journal article published
    PubMed ID: 17540555
    Signatur Availability
    BibTip Others were also interested in ...
  • 4
    Keywords: brain ; EXPOSURE ; LONG-TERM ; POPULATION ; RISK ; meningioma ; HEALTH ; NUMBER ; COUNTRIES ; HEAD ; case-control study ; GLIOMA ; methods ; pooled analysis ; INCREASED RISK ; CANCER-RISK ; INTERNATIONAL CASE-CONTROL ; brain tumours ; CORDLESS TELEPHONES ; mobile phones ; SELECTION BIAS ; PHONE USE ; CELLULAR TELEPHONES ; NONDIFFERENTIAL MISCLASSIFICATION ; radiofrequency fields
    Abstract: Methods An interview-based case-control study with 2708 glioma and 2409 meningioma cases and matched controls was conducted in 13 countries using a common protocol. Results A reduced odds ratio (OR) related to ever having been a regular mobile phone user was seen for glioma [OR 0.81; 95% confidence interval (CI) 0.70-0.94] and meningioma (OR 0.79; 95% CI 0.68-0.91), possibly reflecting participation bias or other methodological limitations. No elevated OR was observed 〉= 10 years after first phone use (glioma: OR 0.98; 95% CI 0.76-1.26; meningioma: OR 0.83; 95% CI 0.61-1.14). ORs were 〈 1.0 for all deciles of lifetime number of phone calls and nine deciles of cumulative call time. In the 10th decile of recalled cumulative call time, 〉= 1640 h, the OR was 1.40 (95% CI 1.03-1.89) for glioma, and 1.15 (95% CI 0.81-1.62) for meningioma; but there are implausible values of reported use in this group. ORs for glioma tended to be greater in the temporal lobe than in other lobes of the brain, but the CIs around the lobe-specific estimates were wide. ORs for glioma tended to be greater in subjects who reported usual phone use on the same side of the head as their tumour than on the opposite side. Conclusions Overall, no increase in risk of glioma or meningioma was observed with use of mobile phones. There were suggestions of an increased risk of glioma at the highest exposure levels, but biases and error prevent a causal interpretation. The possible effects of long-term heavy use of mobile phones require further investigation
    Type of Publication: Journal article published
    PubMed ID: 20483835
    Signatur Availability
    BibTip Others were also interested in ...
  • 5
    Keywords: CANCER ; LUNG ; neoplasms ; DIAGNOSIS ; FOLLOW-UP ; lung cancer ; LUNG-CANCER ; COHORT ; DISEASE ; RISK ; TIME ; PATIENT ; treatment ; BREAST ; breast cancer ; BREAST-CANCER ; MALIGNANCIES ; AGE ; BRCA1 ; OVARIAN-CANCER ; colorectal cancer ; smoking ; COLORECTAL-CANCER ; chemotherapy ; leukemia ; BLADDER-CANCER ; MUTATIONS ; paclitaxel ; MALIGNANCY ; ONCOLOGY ; REGRESSION ; FAMILIES ; INCREASE ; leukaemia ; female ; CANCERS ; RARE ; colorectal ; INCREASES ; multi-centre cohort study ; second primary cancer ; primary fallopian tube cancer ; PRIMARY-CARCINOMA
    Abstract: Primary fallopian tube cancer (PFTC) is a rare disease, and its aetiological factors are poorly understood. Studies on PFTC in the setting of 2nd primary malignant neoplasms can provide clues on aetiology and also define the possible side effects of different treatment modalities for PFTC. A cohort of 2,084 cases with first PFTC was extracted from the data from 13 cancer registries from Europe, Canada, Australia and Singapore and followed for second primary cancers within the period 1943-2000. Standardized incidence ratios (SIRs) were calculated and Poisson regression analyses were done to find out the RRs related to age at, period or and time since the PFTC diagnosis. There were 118 cancer cases observed after first PFTC (SIR 1.4, 95%CI 1.1-1.6). Elevated SIRs were seen for colorectal cancer (1.7, 95%CI 1.0-2.6), for breast cancer (1.5, 95%CI 1.1-2.2), for bladder cancer (2.8, 95%CI 1.0-6.0), for lung cancer (1.8, 95% CI 0.9-3.2) and for nonlymphoid leukaemia (3.7, 95%CI 1.0-9.4). Significant risk increases were detected for colorectal cancer during the 2nd to 5th year after the first PFTC diagnosis, for breast cancer in follow-up 10+ and for nonlymphoid leukaemia during the 2nd to 10th year. The clustering of cancers of the lung and bladder in PFTC patients may suggest shared smoking aetiology. The excess of colorectal and breast cancers after PFTC may indicate a genetic aetiology. (c) 2007 Wiley-Liss, Inc
    Type of Publication: Journal article published
    PubMed ID: 17266029
    Signatur Availability
    BibTip Others were also interested in ...
  • 6
    Keywords: CANCER ; carcinoma ; PATHWAY ; PATHWAYS ; RISK ; GENE ; TUMORS ; TIME ; DNA ; kidney ; MECHANISM ; RISK-FACTORS ; colon ; mechanisms ; SKIN ; ASSOCIATION ; LYMPHOMA ; NUMBER ; AGE ; DNA-REPAIR ; REPAIR ; DIETARY ; ADENOCARCINOMAS ; INDIVIDUALS ; SMALL-INTESTINE ; NONPOLYPOSIS COLORECTAL-CANCER ; 2ND PRIMARY NEOPLASMS ; DNA repair ; CLUSTER ; REGISTRY ; pancreas ; ASSOCIATIONS ; cancer registries ; INCREASE ; GLAND ; SMALL-BOWEL ; INTERVAL ; GENDER ; second primary cancers ; rectum ; cancer registry ; pooled analysis ; CANCER INCIDENCE ; registry-based study ; small intestine cancer
    Abstract: Cancer of the small intestine is a rare neoplasm, and its etiology remains poorly understood. Analysis of other primary cancers in individuals with small intestine cancer may help elucidate the causes of this neoplasm and the underlying mechanisms. We included 10,946 cases of first primary small intestine cancer from 13 cancer registries in a pooled analysis. The observed numbers of 44 types of second primary cancer were compared to the expected numbers derived from the age-, gender- and calendar period-specific cancer incidence rates in each registry. We also calculated the standardized incidence ratios (SIR) for small intestine cancer as a second primary after other cancers. There was a 68% overall increase in the risk of a new primary cancer after small intestine carcinoma (SIR = 1.68, 95% confidence interval [CI] = 1.47-1.71), that remained constant over time. The overall SIR was 1.18 (95% CI = 1.05-1.32) after carcinoid, 1.29 (1.01-1.63) after sarcoma, and 1.27 (0.78-1.94) after lymphoma. Significant (p 〈 0.05) increases were observed for cancers of the oropharynx, colon, rectum, ampulla of Vater, pancreas, corpus uteri, ovary, prostate, kidney, thyroid gland, skin and soft (issue sarcomas. Small intestine cancer as a second primary was increased significantly after all these cancers, except after oropharyngeal and kidney cancers. Although some of the excess may be attributable to overdiagnosis, it is plausible that most additional cases of second primary cancers were clinically relevant and were due to common genetic (e.g., defects in mismatch or other DNA repair pathways) and environmental (e.g., dietary) factors. (c) 2005 Wiley-Liss, Inc
    Type of Publication: Journal article published
    PubMed ID: 16003748
    Signatur Availability
    BibTip Others were also interested in ...
  • 7
    Keywords: CANCER ; radiotherapy ; SURVIVAL ; FOLLOW-UP ; RISK ; TUMORS ; kidney ; treatment ; BREAST-CANCER ; chemotherapy ; LONG-TERM SURVIVORS ; ETOPOSIDE ; TESTICULAR CANCER ; COMBINATION CHEMOTHERAPY ; leukaemia ; nonseminoma ; BLEOMYCIN ; NORWEGIAN MALE-PATIENTS ; SECONDARY LEUKEMIA ; seminomas
    Abstract: We investigated the risk of second malignancies among 29,511 survivors of germ-cell testicular cancer recorded in 13 cancer registries. Standardized incidence ratios (SIRs) were estimated comparing the observed numbers of second malignancies with the expected numbers obtained from sex-, age-, period- and population-specific incidence rates. Seminomas and nonseminomas, the 2 main histological groups of testicular cancer, were analyzed separately. During a median follow-up period of 8.3 years (0-35 years), we observed 1,811 second tumors, with a corresponding SIR of 1.65 (95% confidence interval (CI): 1.57-1.73). Statistically significant increased risks were found for fifteen cancer types, including SIRs of 2.0 or higher for cancers of the stomach, gallbladder and bile ducts, pancreas, bladder, kidney, thyroid, and for soft-tissue sarcoma. nonmelanoma skin cancer and myeloid leukemia. The SIR for myeloid leukemia was 2.39 (95% CI: 1.41-3.77) after seminomas. and 6.77 (95% CI: 4.14-10.5) after nonseminomas. It increased to 37.9 (95% CI: 18.9-67.8; based on 11 observed cases of leukemia) among nonseminoma patients diagnosed since 1990. SIRs for most solid cancers increased with follow-up duration, whereas they, did not change with year of testicular cancer diagnosis. Among subjects diagnosed before 1980, 20 year survivors of seminoma had a cumulative risk of solid cancer of 9.6% (95% CI: 8.7-10.5%) vs. 6.5% expected, whereas 20 years survivors of nonseminoma had a risk of 5.0% (95% CI: 4.2-6.0%) vs. 3.1% expected. In conclusion, survivors of testicular cancers have an increased risk of several second primaries, where the effect of the treatment seems to play a major role. (c) 2006 Wiley-Liss, Inc
    Type of Publication: Journal article published
    PubMed ID: 17096341
    Signatur Availability
    BibTip Others were also interested in ...
  • 8
    Keywords: brain ; CANCER ; neoplasms ; DIAGNOSIS ; FOLLOW-UP ; incidence ; POPULATION ; RISK ; RISKS ; TIME ; PATIENT ; SKIN ; BREAST ; breast cancer ; BREAST-CANCER ; LYMPHOMA ; MALIGNANCIES ; EXPERIENCE ; RATES ; leukemia ; ACUTE LYMPHOBLASTIC-LEUKEMIA ; HIGH-RISK ; POPULATIONS ; CHILDREN ; LONG-TERM SURVIVORS ; NON-HODGKINS-LYMPHOMA ; MALIGNANCY ; ONCOLOGY ; CHILDHOOD ; REGISTRY ; POPULATION-BASED COHORT ; cancer registries ; non-Hodgkin lymphoma ; INTERVAL ; methods ; cancer registry ; USA ; UNIT ; HODGKIN LYMPHOMA ; REGISTRIES ; NORDIC COUNTRIES ; GENERAL-POPULATION ; ACUTE LYMPHOCYTIC-LEUKEMIA ; CANCER SURVIVOR ; CRANIAL IRRADIATION ; THYROID-CANCER
    Abstract: Background Survivors of childhood leukemia and lymphoma experience high risks of second malignant neoplasms. We quantified such risk using a large dataset from 13 population-based cancer registries. Methods The registries provided individual data on cases of leukemia, Hodgkin lymphoma, and non-Hodgkin lymphoma occurring in children aged 0-14 years and on subsequent second malignant neoplasms for different time periods from 1943 to 2000. Risks of second malignant neoplasms were assessed through standardized incidence ratios (SIRs) and corresponding 95% confidence intervals (Cls), using the incidence rates in the general populations covered by the registries as a reference. Cumulative absolute risks were also calculated. Results A total of 133 second malignant neoplasms were observed in 16540 patients (12731 leukemias, 1246 Hodgkin lymphomas, and 2563 non-Hodgkin lymphomas) after an average follow-up of 6.5 years. The most frequent second malignancies after leukemia were brain cancer (19 cases, SIR = 8.52, 95% Cl = 5.13 to 13.3), non-Hodgkin lymphoma (nine cases, SIR = 9.41, 95% Cl = 4.30 to 17.9), and thyroid cancer (nine cases, SIR = 18.8, 95% Cl = 8.60 to 35.7); the most frequent after Hodgkin lymphoma were thyroid cancer (nine cases, SIR = 52.5, 95% Cl = 24.0 to 99.6), breast cancer (six cases, SIR = 20.9, 95% Cl = 7.66 to 45.4), and neoplasms of skin (non-melanoma) (six cases, SIR = 34.0, 95% Cl = 12.5 to 74.0); and the most frequent after non-Hodgkin lymphoma were thyroid cancer (six cases, SIR = 40.4, 95% Cl = 14.8 to 88.0) and brain cancer (four cases, SIR = 6.97, 95% Cl = 1.90 to 17.9). Cumulative incidence of any second malignant neoplasm was 2.43% (95% Cl = 1.09 to 3.78), 12.7% (95% Cl = 8.29 to 17.2), and 2.50% (95% Cl = 1.04 to 3.96) within 30 years from diagnosis of leukemia, Hodgkin lymphoma, and non-Hodgkin lymphoma, respectively. Conclusions This population-based study provides, to our knowledge, the most precise and up-to-date estimates for relative and absolute risks of second malignant neoplasms after childhood leukemia and lymphoma
    Type of Publication: Journal article published
    PubMed ID: 17505074
    Signatur Availability
    BibTip Others were also interested in ...
  • 9
    Keywords: brain ; CANCER ; carcinoma ; LUNG ; lung cancer ; LUNG-CANCER ; POPULATION ; RISK ; PATIENT ; RISK-FACTORS ; CARCINOGENESIS ; colon ; SKIN ; SUPPRESSION ; ASSOCIATION ; LYMPHOMA ; HEALTH ; REPAIR ; risk factors ; skin cancer ; leukemia ; DIETARY ; STOMACH ; EPSTEIN-BARR-VIRUS ; EUROPE ; SKIN-CANCER ; NASOPHARYNGEAL CARCINOMA ; ONCOLOGY ; ASSOCIATIONS ; RE ; XRCC1 ; analysis ; methods ; second primary cancers ; cancer registry ; USA ; RISK-FACTOR ; CANCERS ; second primary cancer ; CALIFORNIA ; HOGG1
    Abstract: Objective To study the risk of second primary cancers in nasopharyngeal carcinoma (NPC) patients and the risk of NPC as second primary cancer. Methods We used data from the cancer registries from Singapore and from 12 low-incidence areas, including a total of 8,947 first occurring NPC cases, and 167 second occurring cases. We calculated standardized incidence ratios (SIRs) by comparing the second cancer incidence in NPC patients to the first primary cancer incidence in non-cancer population. We also calculated SIRs of second NPC after other primaries. Results In Singapore, the risk of cancers of the lung (SIR = 0.42), stomach (SIR = 0.41), and colon (SIR = 0.23) was significantly decreased after NPC, whereas that of cancer of the tongue (SIR = 11.1) was significantly increased. In Australia, Canada, and Europe, the risk of non-Hodgkin's lymphoma (NHL) (SIR = 3.06), tongue cancer (SIR = 5.29), brain cancer (SIR = 3.89), myeloid leukemia (SIR = 3.85), and non-melanoma skin cancer (NMSC) (SIR = 3.47) was significantly increased after NPC. Incidences of second occurring NPCs following various primary cancers were not significantly altered compared to the incidence of first occurring NPCs. Conclusions Immune suppression (NHL, NMSC), shared genetic factors (lung cancer, NHL, myeloid leukemia), and shared environmental risk factors (tongue and brain cancers) might explain the associations. Except for NHL, there was no evidence of association with other Epstein-Barr virus-related cancers
    Type of Publication: Journal article published
    PubMed ID: 17237987
    Signatur Availability
    BibTip Others were also interested in ...
  • 10
    Keywords: CANCER ; DIAGNOSIS ; screening ; EXPOSURE ; incidence ; liver ; POPULATION ; RISK ; RISKS ; PATIENT ; kidney ; SKIN ; ASSOCIATION ; PATTERNS ; etiology ; prostate cancer ; PROSTATE-CANCER ; skin cancer ; MELANOMA ; SURVEILLANCE ; STOMACH ; UNITED-STATES ; MALIGNANT-MELANOMA ; AUSTRALIA ; OCULAR MELANOMA ; SKIN-CANCER ; MULTIPLE-MYELOMA ; ONCOLOGY ; REGISTRY ; ASSOCIATIONS ; RE ; cancer registries ; uveal melanoma ; PRIMARY TUMORS ; CUTANEOUS MELANOMAS ; second primary cancers ; cancer registry ; USA ; CANCER INCIDENCE ; female ; INCREASED RISK ; CANCERS ; REGISTRIES ; RARE ; second primary cancer ; registry-based study ; ULTRAVIOLET-RADIATION ; GENERAL-POPULATION ; UNKNOWN PRIMARY
    Abstract: Ocular melanoma is a rare neoplasm with a poorly understood etiology, especially concerning its link with ultraviolet-light exposure. Studying the risk of second primary cancers may help to formulate causal hypotheses. We used data from 13 cancer registries, including 10,396 first occurring ocular melanoma cases, and 404 second occurring cases. To compare the second cancer incidence in ocular melanoma patients to that in noncancer population, we calculated standardized incidence ratios (SIRs) of 32 types of cancer. We also calculated SIRs of second ocular melanoma after other primaries. Ocular melanoma patients had significantly increased risk of cutaneous melanoma (SIR = 2.38, 95% CI 1.77-3.14), multiple myeloma (SIR = 2.00, 1.29-2.95), and of liver (SIR 3.89, 2.66-5.49), kidney (SIR = 1.70, 1.22-2.31), pancreas (SIR 1.58, 1.16-2.11), prostate (SIR = 1.31, 1.11-1.54), and stomach (SIR = 1.33, 1.03-1.68) cancers. Risks of cutaneous melanoma were highly variable between registries and were mainly increased in females, in younger patients, in first years following diagnosis, and for patients diagnosed after 1980. The risk of ocular melanoma was significantly increased only after prostate cancer (SIR = 1.41, 1.08-1.82). Risk of cutaneous melanoma after ocular melanoma had epidemiological patterns, similar to cutaneous melanoma screening in the general population. The increased risk of cutaneous melanoma would be largely due to greater skin cancer surveillance in ocular melanoma patients, and not to common etiological factors. The high SIR found for liver cancer may be explained by misclassification bias. Common etiological factors may be involved in ocular and prostate cancers. (c) 2006 Wiley-Liss, Inc
    Type of Publication: Journal article published
    PubMed ID: 17036322
    Signatur Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...