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Disappearance of hepatitis B virus core deletion mutants and successful combined kidney/liver transplantation in a patient treated with lamivudine (1999)

Meisel, Helga ; Preikschat, Petra ; Reinke, Petra ; [et al.]

Springer

Transplant international 12 (1999), S. 283-287

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ISSN: 1432-2277

Keywords: Key words Kidney transplantation ; Hepatitis B core deletion mutants ; Lamivudine ; Famciclovir ; Combined kidney-liver transplantation

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Abstract Hepatitis B virus (HBV) core deletion variants with enhanced viral replication are associated with rapid deterioration of liver function in renal allograft recipients. Antiviral agents such as famciclovir and lamivudine offer new treatment strategies for these patients. Appearance, accumulation and persistence of HBV core deletion mutants were closely monitored in a kidney transplant recipient with liver cirrhosis before and after initiation of antiviral treatment. Under treatment with famciclovir HBV DNA concentration decreased by 50 %, HBV mutants persisted. After replacement of famciclovir by lamivudine HBV replication was reduced below the detection limit. Lamivudine was well tolerated and liver function improved. After successful combined kidney/liver transplantation the patient became HBsAg and HBV DNA (detected by PCR) negative under continuous hyperimmune globulin and lamivudine treatment. Antiviral therapy with lamivudine may be useful in treatment of progressive liver disease associated with HBV core deletion mutants in renal allograft recipients and may enable successful liver transplantation.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/s001470050225

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Comparison of three different recombinant hepatitis B virus core particles expressed inEscherichia coli (1994)

Maaßen, Anke ; Rehfeldt, Annett ; Kießig, S. ; [et al.]

Springer

Archives of virology 135 (1994), S. 131-142

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ISSN: 1432-8798

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Summary The properties of three different recombinant hepatitis B virus core proteins expressed inEscherichia coli were compared: an N-terminal fusion protein, a C-terminally truncated protein and a sequence-authentic protein. All three proteins assembled into capsid-like particles with typical HBc-antigenicity, sedimentation behavior and distinctive electron microscopical images. Apart from this, however, variant HBc proteins displayed properties different from sequence-authentic HBc protein p21.4. Unlike p21.4, the particles of the N-terminal fusion protein p22.2 were sensitive to proteolytic attack by trypsin at variable sites within its arginine-rich C-terminus but not in its extended N-terminus. We therefore conclude that the C-terminal region is located on the surface of the p22.2 particle. These particles also showed increased HBe-antigenicity, as did the C-terminally truncated core particles p17.6, and to an even greater extent p18* particles which were derived from p22.2 by tryptic digestion. This might be interpreted as evidence for an — albeit minor — structural change. All variant core particles were less stable and contained less RNA. Electron microscopic indication for DNA binding of C-terminal deleted p17.6 particles was obtained using an aqueous spreading technique.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF01309770

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Improved removal of viruslike particles from purified monoclonal antibody IgM preparation via virus filtration (1996)

Maerz, Holger ; Hahn, Sven Oliver ; Maassen, Anke ; [et al.]

[s.l.] : Nature Publishing Company

Nature biotechnology 14 (1996), S. 651-652

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ISSN: 1546-1696

Source: Nature Archives 1869 - 2009

Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology

Notes: [Auszug] More and more, monoclonal antibodies (Mabs) are being used for in vivo applications. In immunological research, they are used to examine finely tuned immunological interactions in animal experiments. For example, monoclonal antibodies directed against TNF-α, lipid A, and lipopolysaccha-ride ...

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1038/nbt0596-651

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Genetic characterization of a new hantavirus detected inMicrotus arvalis from Slovakia (1995)

Sibold, Claus ; Sparr, Sabine ; Schulz, Angela ; [et al.]

Springer

Virus genes 10 (1995), S. 277-281

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ISSN: 1572-994X

Keywords: Bunyaviridae ; hantavirus ; hemorrhagic fever with renal syndrome ; RT-PCR

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Abstract A new hantavirus, called Malacky, has been identified in lung tissue specimens of a vole,Microtus arvalis, by the reverse transcriptase polymerase chain reaction (RT-PCR). The voles were trapped in a geographical area in Slovakia where hemorrhagic fever with renal syndrome (HFRS) is endemic in the human population. Sequence analysis of a major part of the S segment showed this virus to represent a new subtype within Tula, a new hantavirus genetic group defined very recently.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF01701817

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