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  • 1
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    German Medical Science; Düsseldorf, Köln
    In:  27. Deutscher Krebskongress; 20060322-20060326; Berlin; DOCPO250 /20060320/
    Publication Date: 2006-04-21
    Keywords: ddc: 610
    Language: English
    Type: conferenceObject
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  • 2
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    German Medical Science GMS Publishing House; Düsseldorf
    In:  31. Wissenschaftliche Jahrestagung der Deutschen Gesellschaft für Phoniatrie und Pädaudiologie (DGPP) zusammen mit dem 5. Pädakustiker-Symposium der Akademie für Hörgeräte-Akustik; 20140918-20140921; Lübeck; DOCP12 /20140902/
    Publication Date: 2014-09-03
    Description: Hintergrund: Psychogene Stimmstörungen stellen noch immer eine Herausforderung für den Phoniater dar. Bislang herrscht Uneinigkeit nicht nur im Hinblick auf die Terminologie und auf das therapeutische Vorgehen, sondern auch im Hinblick auf die Diagnostik bei diesen Patienten.Material und Methoden: Analysiert wurden alle Patienten, die sich wegen einer Aphonie in der phoniatrischen Abteilung vorstellten und bei denen eine organische Ursache ausgeschlossen wurde. Neben der phoniatrischen Untersuchung erfolgte eine objektive Stimmbeurteilung durch das Göttinger Heiserkeitsdiagramm, das Stimmfeld sowie eine Evaluierung mit Hilfe des VHI (Voice Handicap Index) und des BSI (Brief Symptom Inventory des SCL-90) sowie eine neurologische und psychiatrische Untersuchung.Ergebnisse: Bei allen 12 Patienten ließ sich bereits während der phoniatrischen Erstuntersuchung die Diagnose einer psychogenen Stimmstörung stellen. Bei der Hälfte der Patienten kam es im Verlauf kurzfristig wieder zu einer Normalisierung der Stimme, während bei 6 Patienten die Stimmstörung langfristig persistierte. Bei drei Patienten ließ sich durch den Psychiater aufgrund des psychopathologischen Befundes eine primär nicht bekannte depressive Störung diagnostizieren. Der Einsatz von Fragebögen (VDI, BSI, WHO-QoL, CGI, GAF) war sowohl im Hinblick auf die Diagnosestellung als auch auf die Prognose als alleiniges Messinstrument wenig hilfreich.Fazit: Ein Konsens der Fachgesellschaft in enger Absprache mit den Psychiatern/Psychosomatikern wäre wünschenswert. Möglicherweise könnte eine engere Zusammenarbeit mit den Nachbardisziplinen vor Ort nicht nur zu einer verbesserten Versorgung, sondern auch zu der Suche nach Prognosefaktoren beitragen.
    Keywords: ddc: 610
    Language: German
    Type: conferenceObject
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  • 3
    ISSN: 1615-6102
    Keywords: Acetabularia ; Actin ; Cytoskeleton ; Microtubules ; Organelle motility ; Nucleus ; Pharmacology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary Migrating secondary nuclei inAcetabularia are tightly associated with actin bundles and possess a comet-like tail composed of microtubules. When secondary nuclei begin to settle in preparation for cyst morphogenesis, the tails expand into radially symmetrical arrays of microtubules. Concomitantly, nuclei become gradually dissociated from the actin bundles and eventually stop moving, even though the actin bundles remain intact and persist through this stage. If, however, the radial perinuclear microtubule arrays are destroyed by inhibitors, the nuclei reassociate with the actin bundles and regain their motile activity. Because this movement is sensitive to Cytochalasin D, we propose that actin is required for nuclear movements, whereas microtubules most likely function as a trailing anchor that begins to act as a braking device above a certain threshold in the number and length of perinuclear microtubules.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1434-6079
    Keywords: 36.40. + d ; 35.20.Wg ; 33.80.Eh
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract A reflecting time of flight mass spectrometer (RETOF) is used to study unimolecular and collision induced fragmentation of ammonia cluster ions. Synchrotron radiation from the BESSY electron storage ring is used in a range of photon energies from 9.08 up to 17.7 eV for single photon ionisation of neutral clusters in a supersonic beam. The threshold photoelectron photoion coincidence technique (TPEPICO) is used to define the energy initially deposited into the cluster ions. Metastable unimolecular decay (µs range) is studied using the RETOF's capacity for energy analysis. Under collision free conditions the by far most prominent metastable process is the evaporation of one neutral NH3 monomer from protonated clusters (NH3) n − 2NH 4 + . Abundance of homogeneous vs. protonated cluster ions and of metastable fragments are reported as a function of photon energy and cluster size up ton=10.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1434-6079
    Keywords: PACS. 36.40.Sx Diffusion and dynamics of clusters - 68.45.Da Adsorption and desorption kinetics; evaporation and condensation - 82.65.Pa Surface-enhanced molecular states and other gas-surface interactions
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract: The photoionization efficiency (PIE) of neutral ammonia clusters is studied as a function of photon energy. From these curves the internal energies of clusters in the incident supersonic beam and of clusters surviving after scattering off a LiF(100) surface are derived. A supersonic expansion of ammonia seeded in He produces small clusters of various size but with uniform kinetic energy of about 285 meV per monomer molecule. The mass distribution of clusters in the jet and of the scattered particles is measured in a reflecting time-of-flight mass spectrometer by single photon photoionization using vacuum ultraviolet (VUV) laser radiation tunable between and . In the incident beam the internal energies of clusters up to n = 15 do not vary significantly and amount to an average of about . After scattering off LiF(100) the internal energy of clusters up to n = 4 increases with fragment size and amounts to about half a monomer binding energy.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 0956-5663
    Keywords: C/V measurements ; EIS-structures ; FIA-system ; enzyme sensor
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Electrical Engineering, Measurement and Control Technology , Physics
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 0009-2614
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Objective  To investigate uterotubal transport by means of hysterosalpingoscintigraphy (HSSG) in women with and without endometriosis.Design  A prospective observational study.Setting  University Hospital, Department of Obstetrics and Gynaecology, Division of Reproductive Medicine and Gynaecologic Endocrinology with 350 in vitro fertilisation (IVF)/intracytoplasmic sperm injection (ICSI) cycles and 400 intrauterine insemination (IUI) cycles/year.Population  Cases included 56 infertile women with laparoscopic proven endometriosis and patent fallopian tubes. Twenty-two women with partners suffering from male factor infertility served as controls.Methods  A diagnostic cycle incorporating HSSG was performed. Subsequently, patients underwent either four cycles of timed intercourse (TI) or IUI in order to achieve pregnancy. If pregnancy did not occur, IVF or ICSI was performed.Main outcome measures  Evaluation of uterotubal transport capacity in women with endometriosis and healthy controls.Results  Patients suffering from endometriosis (group I) showed a significant reduction in physiologic uterotubal transport function: While 20 patients (36%) had ipsi- or bilateral uterotubal transport, there was pathological uterotubal transport contralateral to the dominant follicle or a complete failure of transport capacity (negative HSSG) in 36 patients (64%). In the controls (group II), transport function was significantly different: 15 of 22 patients (68%) revealed ipsi- and bilateral tubal demonstration, while 5 patients (22%) showed contralateral transport and 2 patients (10%) showed negative HSSG (P= 0.01). Twenty-three pregnancies were observed (pregnancy rate: 29%). Eleven out of 14 (79%) women with ipsi- or bilateral tubal transport function fell pregnant by means of TI or IUI. In seven of nine patients (78%) with a failure in tubal transport, pregnancy was achieved by IVF/ICSI, despite acceptable semen parameters (P= 0.01).Conclusions  Endometriosis is significantly associated with a reduction in physiologic uterotubal transport capacity compared with controls. This resulted in diminished pregnancy rates even in women with normozoospermic partners. Therefore, IVF/ICSI may be required even when fallopian tubes are patent or semen quality is normal.
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