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  • 1
    Keywords: Medical Microbiology ; Molecular Biology ; Medical Microbiology ; Molecular Medicine ; Springer eBooks
    Description / Table of Contents: Part I: Bacteriophages as antibacterialagents -- Chapter 1:Production of PhageTherapeutics and Formulations – InnovativeApproaches -- Chapter 2:Phagepharmacokinetics: relationship with administrationroute -- Chapter 3:BacterialResistance to Phage and itsImpact on Clinical Therapy -- Part II: Bacteriophages and the immune system -- Chapter 4:Phageinteraction with the mammalianimmune system -- Chapter 5:Humoralimmuneresponse to phage-basedtherapeutics -- Part III:Use of bacteriophages to combat bacterial infections -- Chapter 6:How to achieve a goodphage therapy clinical trial? -- Chapter 7: Perspectives on the RenewedInterest in the United States -- Chapter 8:Phage Therapy in Orthopaedic Implant-associated Infections -- Chapter 9:The use of bacteriophages in animalhealth and food protection -- Chapter 10:Combiningbacteriophages with otherantibacterialagents to combatbacteria -- Chapter 11: Phage therapy of infectious biofilms: Challenges and strategies -- Part IV:Phage therapy – regulatory and ethical aspects -- Chapter 12:Regulatory Considerations for Bacteriophage Therapy Products -- Chapter 13:Developing phagesintomedicines for Europe -- Chapter 14: Phagetherapy in Europe: Regulatory and intellectualpropertyprotectionissues -- Chapter 15:Ethics of phagetherapy -- Part V: Bacteriophage-derived antibacterial agents -- Chapter 16: NovelAlternative to Antibiotics
    Abstract: This book gives a detailed yet clear insight into the current state of the art of the therapeutic application of bacteriophages in different conditions. The authors bring in their practical expertise within their respective fields of expertise and provide an excellent overview of the potential and actual use of phage therapy. Topics like economic feasibility compared to traditional antibiotics and also regulatory issues are discussed in far detail. This new volume is therefore a valuable resource for individuals engaged in the medical application of novel phage therapies
    Pages: XIII, 385 p. 26 illus., 24 illus. in color. : online resource.
    Edition: 1st ed. 2019.
    ISBN: 9783030267360
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  • 2
    ISSN: 1574-695X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: The covalent conjugate of oligosaccharide core of Escherichia coli type R4 with tetanus toxoid was prepared using reaction of reductive amination. The neoglycoconjugate was a good immunogen in rabbits yielding a high level of anti-lipopolysaccharide (LPS) antibodies of the IgG class. It was found that antiserum was able to react with the smooth LPS molecules of identical (R4) or related (R1) core type. The reactions were shown in the enzyme-linked immunosorbent assay and the immunoblotting test. Flow cytometry showed that anti-core antibodies reacted with LPS present on intact, live, smooth bacteria labelling more than 90% of cells. The anti-OS R4-TT serum used for in vitro studies showed high endotoxin neutralization activity. The serum inhibited endotoxin-induced tumor necrosis factor α and nitric oxide synthesis by the J-774A.1 cell line and attenuated pulmonary retention of YAC-1 cells.
    Type of Medium: Electronic Resource
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