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  • 1
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    German Medical Science GMS Publishing House; Düsseldorf
    In:  Mainz//2011; 56. Jahrestagung der Deutschen Gesellschaft für Medizinische Informatik, Biometrie und Epidemiologie (gmds), 6. Jahrestagung der Deutschen Gesellschaft für Epidemiologie (DGEpi); 20110926-20110929; Mainz; DOC11gmds115 /20110920/
    Publication Date: 2011-09-20
    Keywords: Dieselmotoremissionen ; Lungenkrebs ; Kohortenstudie ; Fall-Kontroll-Studie ; Cox-Modell ; ddc: 610
    Language: German
    Type: conferenceObject
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  • 2
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    German Medical Science GMS Publishing House; Düsseldorf
    In:  Kongress Medizin und Gesellschaft 2007; 20070917-20070921; Augsburg; DOC07gmds922 /20070906/
    Publication Date: 2007-10-11
    Keywords: Wismut-Workshop ; ddc: 610
    Language: German
    Type: conferenceObject
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  • 3
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    German Medical Science GMS Publishing House; Düsseldorf
    In:  Kongress Medizin und Gesellschaft 2007; 20070917-20070921; Augsburg; DOC07gmds875 /20070906/
    Publication Date: 2007-09-07
    Keywords: Fall-Kontroll-Studie ; Wismut ; Quarz-A-Staub ; Asbestfasern ; Arsen ; ionisierende Strahlung ; Silikose ; Asbestose ; Lungenkrebsrisiko ; ILO-Kriterien ; Röntgen-Thorax ; Synkanzerogenese ; ddc: 610
    Language: German
    Type: conferenceObject
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  • 4
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    German Medical Science; Düsseldorf, Köln
    In:  50. Jahrestagung der Deutschen Gesellschaft für Medizinische Informatik, Biometrie und Epidemiologie (gmds), 12. Jahrestagung der Deutschen Arbeitsgemeinschaft für Epidemiologie; 20050912-20050915; Freiburg im Breisgau; DOC05gmds432 /20050908/
    Publication Date: 2005-09-09
    Keywords: ddc: 610
    Language: German
    Type: conferenceObject
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  • 5
    Keywords: Germany ; DIAGNOSIS ; SUPPORT ; EXPOSURE ; HISTORY ; POPULATION ; RISK ; PATIENT ; ASSOCIATION ; CARBON ; LYMPHOMA ; HEALTH ; AGE ; smoking ; REGION ; REGIONS ; SAFETY ; case-control studies ; ALCOHOL ; ALCOHOL-CONSUMPTION ; CONSUMPTION ; FOLLICULAR LYMPHOMA ; AROMATIC-HYDROCARBONS ; case control study ; case-control study ; REGRESSION ; INCREASE ; case control studies ; INTERVAL ; analysis ; methods ; POWER ; female ; Male ; odds ratio ; population-based ; E ; case control ; LOGISTIC-REGRESSION ; POINT ; case-control ; CLICK ; PERSONAL INTERVIEW
    Abstract: To analyze the relationship between exposure to chlorinated and aromatic organic solvents and malignant lymphoma in a multi-centre, population-based case-control study. METHODS: Male and female patients with malignant lymphoma (n = 710) between 18 and 80 years of age were prospectively recruited in six study regions in Germany (Ludwigshafen/Upper Palatinate, Heidelberg/Rhine-Neckar-County, Würzburg/Lower Frankonia, Hamburg, Bielefeld/Gütersloh, and Munich). For each newly recruited lymphoma case, a gender, region and age-matched (+/- 1 year of birth) population control was drawn from the population registers. In a structured personal interview, we elicited a complete occupational history, including every occupational period that lasted at least one year. On the basis of job task-specific supplementary questionnaires, a trained occupational physician assessed the exposure to chlorinated hydrocarbons (trichloroethylene, tetrachloroethylene, dichloromethane, carbon tetrachloride) and aromatic hydrocarbons (benzene, toluene, xylene, styrene). Odds ratios (OR) and 95% confidence intervals (CI) were calculated using conditional logistic regression analysis, adjusted for smoking (in pack years) and alcohol consumption. To increase the statistical power, patients with specific lymphoma subentities were additionally compared with the entire control group using unconditional logistic regression analysis. RESULTS: We observed a statistically significant association between high exposure to chlorinated hydrocarbons and malignant lymphoma (Odds ratio = 2.1; 95% confidence interval 1.1-4.3). In the analysis of lymphoma subentities, a pronounced risk elevation was found for follicular lymphoma and marginal zone lymphoma. When specific substances were considered, the association between trichloroethylene and malignant lymphoma was of borderline statistical significance. Aromatic hydrocarbons were not significantly associated with the lymphoma diagnosis. CONCLUSION: In accordance with the literature, this data point to a potential etiologic role of chlorinated hydrocarbons (particularly trichloroethylene) and malignant lymphoma. Chlorinated hydrocarbons might affect specific lymphoma subentities differentially. Our study does not support a strong association between aromatic hydrocarbons (benzene, toluene, xylene, or styrene) and the diagnosis of a malignant lymphoma.
    Type of Publication: Journal article published
    PubMed ID: 17407545
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  • 6
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    German Medical Science GMS Publishing House; Düsseldorf
    In:  Mainz//2011; 56. Jahrestagung der Deutschen Gesellschaft für Medizinische Informatik, Biometrie und Epidemiologie (gmds), 6. Jahrestagung der Deutschen Gesellschaft für Epidemiologie (DGEpi); 20110926-20110929; Mainz; DOC11gmds113 /20110920/
    Publication Date: 2011-09-20
    Keywords: case-cohort study ; dinitrololuene ; urothelial cancer ; renal cancer ; copper mining-industry ; ddc: 610
    Language: English
    Type: conferenceObject
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  • 7
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    German Medical Science GMS Publishing House; Düsseldorf
    In:  Kongress Medizin und Gesellschaft 2007; 20070917-20070921; Augsburg; DOC07gmds876 /20070906/
    Publication Date: 2007-09-07
    Keywords: Fall-Kontroll-Studie ; ionisierende Strahlung ; Risiko ; Totgeburt ; ddc: 610
    Language: German
    Type: conferenceObject
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  • 8
    ISSN: 1573-7217
    Keywords: c-erbB-2 protein ; histologic grade ; oral contraceptive use ; PCNA ; prognostic factors
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The prognostic value of c-erbB-2 protein overexpression has been evaluated in 463 patients with operable breast cancer after a median follow-up of 66 months. Overexpression was observed in 99/463 (21%) of the breast tumors. It showed significant positive correlation to histological grade (p 〈 0.0001) and tumor size (p 〈 0.02). A relationship of borderline significance was observed between c-erbB-2 protein overexpression and negative or low estrogen receptor (ER) content. No significant correlation was found to lymph node involvement or proliferating tumor cell fraction as determined by the proliferating cell nuclear antigen (PCNA). After a median follow-up of 66 months (range 6 to 109 months), the overall survival of all patients amounted to 63%. Multivariate analysis revealed lymph node involvement, tumor size, histological grade, histological type, c-erbB-2 protein overexpression, progesterone receptor (PR) content, and oral contraceptive use as independent prognostic factors. In an univariate analysis, the overall survival amounted to 72% and 38% of tumor patients with negative and positive c-erbB-2 protein overexpression, respectively. The most significant finding is that c-erbB-2 overexpression has been recognized as an independent predictive factor in subsets of tumor patients who would be expected to have a generally poor prognosis, such as those indicating axillary lymph node involvement, large tumor size (〉 2 cm), and PR negativity.
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 1432-1335
    Keywords: PCNA ; c-erbB-2 ; Histopathology ; Prognosis ; Breast cancer
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Expression of proliferating cell nuclear antigen (PCNA) and c-erbB-2 oncoprotein has been assessed in 471 women with breast cancer to evaluate their prognostic value as compared to conventional histopathological factors. In univariate analysis, high PCNA expression (≥20%) predicted a significantly worse survival in lymph-node-negative tumors (univariateP=0.031). However, the effect disappeared in multivariate analysis and the histological grade remained the only independent factor for this group. Despite its close correlation to histological grade (P〈0.001), PCNA expression discriminated subsets with different survival within the heterogeneous group of moderately differentiated tumors (univariateP=0.073, multivariateP=0.075). PCNA expression was not found to be a significant prognostic factor in lymph-node-positive tumors, thus it was of limited value for breast cancer patients as a whole. c-erbB-2 protein overexpression was associated with a worse survival (univariateP=0.019, multivariateP=0.057) for the entire group of patients. The effect was mainly attributed to the significance of c-erbB-2 as an independent factor in lymph-node-positive (up to three nodes, multivariateP=0.04; four or more nodes: multivariateP=0.017) and large tumors (〉2 cm: multivariateP=0.002). c-erbB-2 was without significance in lymph-node-negative patients. Though both factors might amplify the prognostic information for distinct patient subsets they do not achieve the strong prognostic value of conventional histopathological features in breast cancer.
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 1432-1963
    Keywords: Schlüsselwörter Mammakarzinom ; Orale Kontrazeptiva ; PCNA („proliferating cell nuclear antigen“) ; c-erbB-2 ; Histomorphologische Faktoren ; Key words Breast cancer ; Oral contraceptives ; PCNA (proliferating cell nuclear antigen) ; c-erbB-2 ; Histomorphological factors
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary The influence of oral contraceptives (OC) on histomorphological and molecular biological prognostic factors was studied in 471 breast cancer patients. Differences in histological tumor type, histological grade, tumor size, lymph node status, hormonal receptor status, PCNA expression and c-erbB-2 protein overexpression were investigated in relation to the duration of OC use ( 〈 5 years/ ≥ 5 years) and the time since last use. A total of 297 (63 %) patients had used oral contraceptives at some time in their life; 186 patients (39.5 %) had used OC's for 5 years or more. There were no significant differences in the tumor characteristics investigated with respect to OC use in general. Neither long-term use at some time in their life nor long-term use until breast cancer diagnosis had an effect on histomorphological and molecular biological factors. Thus, steroid hormones contained in OC's had no direct effect on prognostic factors in breast cancer.
    Notes: Zusammenfassung Bei 471 Mammakarzinompatientinnen wurde der Einfluß oraler Kontrazeptiva (OK) auf histomorphologische und tumorbiologische Prognosefaktoren untersucht. Die Häufigkeitsverteilungen von histologischem Tumortyp, -grading, Tumorgröße, Lymphknoten-(LK-)Status, Hormonrezeptorstatus, PCNA-Expression und c-erbB-2-Proteinüberexpression wurden in Abhängigkeit von der Einnahmedauer oraler Kontrazeptiva ( 〈 5 Jahre/ ≥ 5 Jahre) sowie dem Zeitraum der Einnahme in Beziehung zur Diagnose untersucht. 297 (63,0 %) der Patientinnen hatten zu irgendeinem Zeitpunkt vor der Diagnose des Mammakarzinoms orale Kontrazeptiva verwendet und 186 Patientinnen (39,5 %) nahmen orale Kontrazeptiva über einen Zeitraum von 5 Jahren und länger ein. Es zeigten sich keine statistisch signifikanten Differenzen für die erfaßten Tumorcharakteristika in Abhängigkeit von der Einnahme oraler Kontrazeptiva. Auch Langzeiteinnahme generell und Langzeiteinnahme bis unmittelbar zur Diagnose des Mammakarzinoms hatten keinen Einfluß auf die untersuchten Prognosefaktoren. Es konnte somit kein direkter Einfluß exogener Steroidhormone bei Einnahme oraler Kontrazeptiva auf etablierte histomorphologische und tumorbiologische Faktoren beim Mammakarzinom nachgewiesen werden.
    Type of Medium: Electronic Resource
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