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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Der Hautarzt 51 (2000), S. 617-618 
    ISSN: 1432-1173
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-1246
    Keywords: Key words Occupational UV radiation ; Lifeguard ; Mountain guide ; Ski instructor ; Occupational disease
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Objective: Ultraviolet (UV) radiation is noted to be one of the most important risk factors for non-melanoma and melanoma skin cancers. The recent development of a spore film test chamber containing spores of Bacillus subtilis resulted in a new method of UV measurement with a spectral sensitivity profile similar to erythema-weighted data calculated from spectroradiometric measurements. Methods: The practical application of dosimeters was tested on 11 persons for 43 days, under different conditions of UV exposure in five different geographical regions. Four professional lifeguards at a public swimming pool carried dosimeters attached to their shoulders or to their caps, for 11 days. Three mountain guides attached dosimeters laterally to their heads on 27 different occasions of mountaineering activity in different mountain regions. Four ski instructors carried lateral head dosimeters during eight days of skiing in the Alps. Results: The life guards received daily UV exposures ranging from 3.6 to 9.5 minimal erythema doses (MED) (mean 5.9, SD ± 1.9). The mountain guides had personal daily UV exposures of from 4.4 to 17.1 MED (11.9 ± 3.9) and ski instructors from 2.8 to 8.8 MED (6.1 ± 1.8). Conclusions: Bacillus subtilis spore film dosimeters can be applied effectively for personal solar UV measurements of occupationally exposed persons, such as lifeguards, mountain guides and ski instructors. UV levels in these occupations exceed international limits of exposure.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Monatsschrift Kinderheilkunde 148 (2000), S. 23-25 
    ISSN: 1433-0474
    Keywords: Schlüsselwörter ; Gianotti-Crosti-Syndrom ; Infantiles akrolokalisiertes Syndrom ; Epstein-Barr-Virus ; Key words ; Gianotti-Crosti-Syndrome ; Infantile papular acrodermatits ; Epstein-Barr-Virus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Gianotti-Crosti-Syndrome is a cutaneous reaction associated with a wide range of infectious diseases. We report on an 8-year-old girl who presented with a symmetrical papular and papulovesicular acral eruption. The rash occurred during an otherwise asymptomatic Epstein-Barr-Virus (EBV) primary infection, serology for Hepatitis B virus was negative. Discussion: Besides Hepatitis B Virus, especially EBV and other viruses should be considered as causative agents in acral papulovesicular eruptions. The differential diagnoses atopic dermatitis and drug eruptions have to be ruled out.
    Notes: Zusammenfassung Das infantile akrolokalisierte Syndrom (Gianotti-Crosti-Syndrom) wird im Zusammenhang mit verschiedenen Infektionskrankheiten beschrieben. Bei einem 8jährigen Mädchen traten eruptiv symmetrisch an den Extremitäten Papeln und Papulovesikel auf. Die Virusserologie wies auf eine frische Epstein-Barr-Virus(EBV)-Primärinfektion hin, demgegenüber war die Serologie auf Hepatitis-B-Virus negativ. Diskussion: Bei akralen papulovesikulösen Dermatosen sollte deshalb neben der weithin bekannten Infektion mit dem Hepatitis-B-Virus gerade an EBV und andere Viren als Auslöser gedacht werden. Differentialdiagnostisch sind bei akralen papulovesikulösen Dermatosen eine atopischen Dermatitis oder ein Arzneimittelexanthem auszuschließen.
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  • 4
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background Tyrosinase reverse transcription–polymerase chain reaction (RT–PCR) has been shown to be highly sensitive in detecting tumour cells in melanoma patients. Objective To assess whether the detection of minimal residual disease by RT–PCR is improved by concomitant analysis of sentinel lymph nodes (SLNs), bone marrow (BM) and peripheral blood (PB) in patients with primary melanoma. Methods Thirty-five SLNs, 41 BM samples and 26 PB specimens from 26 patients with primary cutaneous melanoma (tumour thickness ≥ 0·75 mm) were examined by nested RT–PCR for tyrosinase and Melan-A. SLNs and BM samples were also analysed by histopathology. RT–PCR findings were related to tumour thickness of the primary melanoma. Results Overall, melanoma cells were detected by RT–PCR in 13 of 26 patients (50%). Seven patients had positive RT–PCR results in their SLNs (27%), including all patients (n = 4) with histologically positive SLNs, two patients had positive findings in their BM exclusively detected by RT–PCR (8%) and six patients in PB (23%). The presence of tumour cells detected by RT–PCR in SLNs was not related to the presence of melanoma cells in BM and/or PB. The incidence of RT–PCR-positive SLNs was significantly associated with greater tumour thickness (P = 0·004). Both patients with positive RT–PCR findings in their BM had a large tumour thickness (≥ 2 mm). No association between positive RT–PCR findings in PB and greater tumour thickness was observed. Conclusions RT–PCR-positive SLNs were strongly associated with greater tumour thickness, underlining the prognostic significance of SLN positivity. Similar to certain epithelial malignancies, molecular investigation of the BM might provide complementary prognostic information in the early stages of melanoma. In contrast, no association between positive RT–PCR results in PB and increasing tumour thickness was found, implying that RT–PCR findings in PB are of doubtful clinical relevance in primary melanoma.
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  • 5
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background  True local recurrence (LR) means clinically detectable regrowth of parts of the tumour which were not completely excised. In the literature the term ‘LR’ has been used in a vague and inconsistent manner that may include satellite and in-transit metastasis.Objective  The aim of this study was to establish clinical, histological and surgical risk factors for the manifestation of LR and to evaluate the prognostic significance of LR.Study design  Data from 3960 Stage I and II melanoma patients who visited the melanoma clinic of the Department of Dermatology at the University of Tuebingen from 1980 to 1999 were documented in a prospective manner. A retrospective comparative analysis of patients with and without LR was performed.Results  Of all patients 1·4% had a LR as a first recurrence and 1·7% had a LR in the course of the follow-up period. LR were most frequent after previous clinical or histological misdiagnosis and inadequate therapy. In the univariate analysis significant risk factors for LR-free survival were age, tumour surface area, locality, tumour thickness, level of invasion, histological type, associated naevus, surgery (one step vs. multiple steps) and compliance with recommended excision margins. In the multivarate analysis the factors locality (P 〈 0·0001), tumour thickness (P = 0·0086) and compliance with recommendations on excision margins (P = 0·014) were significant independent risk factors for the manifestation of LR. The overall survival of patients with LR as first progression did not significantly differ from the overall survival of the other patients with melanoma (P = 0·60).Conclusion  True LR is a rare event for which tumour locality, tumour thickness and surgery are independent risk factors. The occurrence of LR might not impair the prognosis of melanoma patients. However, in the published literature numerous definitions of ‘LR’, including lymphogenic metastasis, complicate comparison.
    Type of Medium: Electronic Resource
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