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Chemistry of ion coordination and hydration revealed by a K + channel–Fab complex at 2.0 Å resolution (2001)

Zhou, Yufeng ; Morais-Cabral, João H. ; Kaufman, Amelia ; [et al.]

[s.l.] : Macmillian Magazines Ltd.

Nature 414 (2001), S. 43-48

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ISSN: 1476-4687

Source: Nature Archives 1869 - 2009

Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics

Notes: [Auszug] Ion transport proteins must remove an ion's hydration shell to coordinate the ion selectively on the basis of its size and charge. To discover how the K+ channel solves this fundamental aspect of ion conduction, we solved the structure of the KcsA K+ channel ...

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1038/35102009

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Energetic optimization of ion conduction rate by the K + selectivity filter (2001)

Morais-Cabral, João H. ; Zhou, Yufeng ; MacKinnon, Roderick

[s.l.] : Macmillian Magazines Ltd.

Nature 414 (2001), S. 37-42

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ISSN: 1476-4687

Source: Nature Archives 1869 - 2009

Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics

Notes: [Auszug] The K+ selectivity filter catalyses the dehydration, transfer and rehydration of a K+ ion in about ten nanoseconds. This physical process is central to the production of electrical signals in biology. Here we show how nearly diffusion-limited rates are ...

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1038/35102000

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Potassium channel receptor site for the inactivation gate and quaternary amine inhibitors (2001)

Zhou, Ming ; Morais-Cabral, João H. ; Mann, Sabine ; [et al.]

[s.l.] : Macmillian Magazines Ltd.

Nature 411 (2001), S. 657-661

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ISSN: 1476-4687

Source: Nature Archives 1869 - 2009

Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics

Notes: [Auszug] Many voltage-dependent K+ channels open when the membrane is depolarized and then rapidly close by a process called inactivation. Neurons use inactivating K+ channels to modulate their firing frequency. In Shaker-type K+ channels, the ...

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1038/35079500

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