CaRLO — Cancer Research Library Online

1

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Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia

Berndt, S.I. ; Skibola, C.F. ; Joseph, V. ; [et al.]

Nature Genetics 45 (8), 868-876

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DOI: 10.1038/ng.2652

Type of Publication: Journal article published

PubMed ID: 23770605

Deep Link: http://www.dkfz.de/cgi-bin/sel?http://www.dkfz.de/PublicationManager/Show/ShowJournal.aspx%3fpublishedId=44840

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2

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Hepatitis C and non-Hodgkin lymphoma among 4784 cases and 6269 controls from the international lymphoma epidemiology consortium

De Sanjose,S. ; Benavente,Y. ; Vajdic,C.M. ; [et al.]

Clinical Gastroenterology and Hepatology 6 (4), 451-458

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Keywords: human ; neoplasms ; CLASSIFICATION ; EPIDEMIOLOGY ; NEW-YORK ; RISK ; SAMPLE ; SAMPLES ; INFECTION ; ASSOCIATION ; antibodies ; antibody ; virus ; LYMPHOMA ; ASSAY ; AGE ; LYMPHOCYTES ; case-control studies ; PREVALENCE ; EUROPE ; B-CELL LYMPHOMA ; HUMAN-IMMUNODEFICIENCY-VIRUS ; SERUM ; ADULT ; case-control study ; MALIGNANT-LYMPHOMA ; MIXED CRYOGLOBULINEMIA ; RECIPIENTS ; non-Hodgkin lymphoma ; analysis ; methods ; SUBTYPES ; ASSAYS ; USA ; B-CELL ; MALIGNANT-LYMPHOMAS ; LOW-GRADE ; non Hodgkin lymphoma ; VIRUS CORE PROTEIN ; CONSORTIUM ; red ; INTERLYMPH

Abstract: Background & Aims: increasing evidence points towards a role of hepatitis C virus (HCV) infection in causing malignant lymphomas. We pooled case-control study data to provide robust estimates of the risk of non-Hodgkin's lymphoma (NHL) subtypes after HCV infection. Methods: The analysis included 7 member studies from the International Lymphoma Epidemiology Consortium (InterLymph) based in Europe, North America, and Australia. Adult cases of NHL (n = 4784) were diagnosed between 1988 and 2004 and controls (n = 6269) were matched by age, sex, and study center. All studies used third-generation enzyme-linked immunosorbent assays to test for antibodies against HCV in serum samples. Participants who were human immunodeficiency virus positive or were organ-transplant recipients were excluded. Results: HCV infection was detected in 172 NHL cases (3.60%) and in 169 (2.70%) controls (odds ratio [OR], 1.78; 95% confidence interval [CI], 1.40 -2.25). In subtype-specific analyses, HCV prevalence was associated with marginal zone lymphoma (OR, 2.47; 95% CI, 1.44-4.23), diffuse large B-cell lymphoma (OR, 2.24; 95% CI, 1.682.99), and lymphoplasmacytic lymphoma (OR, 2.57; 95% CI, 1.14-5.79). Notably, risk estimates were not increased for follicular lymphoma (OR, 1.02; 95% CI, 0.65-1.60). Conclusions: These results confirm the association between HCV infection and NHL and specific B-NHL subtypes (diffuse large B-cell lymphoma, marginal zone lymphoma, and lymphoplasmacytic lymphoma)

Type of Publication: Journal article published

PubMed ID: 18387498

Deep Link: http://www.dkfz.de/cgi-bin/sel?http://www.dkfz.de/PublicationManager/Show/ShowJournal.aspx%3fpublishedId=5746

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3

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Personal use of hair dye and the risk of certain subtypes of non-Hodgkin lymphoma

Zhang,Y. ; De Sanjose,S. ; Bracci,P.M. ; [et al.]

American Journal of Epidemiology 167 (11), 1321-1331

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Keywords: CANCER ; CELLS ; neoplasms ; CT ; INFORMATION ; EPIDEMIOLOGY ; POPULATION ; RISK ; RISKS ; SAMPLE ; SAMPLES ; IDENTIFICATION ; LYMPHOMA ; HEALTH ; WOMEN ; hair dyes ; UNITED-STATES ; case-control studies ; non-Hodgkin lymphoma ; SUBTYPES ; USA ; N-ACETYLTRANSFERASE-1 ; non Hodgkin lymphoma ; non-Hodgkin ; CONSORTIUM ; N-ACETYLATION ; PHENYLENEDIAMINE

Abstract: Personal use of hair dye has been inconsistently linked to risk of non-Hodgkin lymphoma (NHL), perhaps because of small samples or a lack of detailed information on personal hair-dye use in previous studies. This study included 4,461 NHL cases and 5,799 controls from the International Lymphoma Epidemiology Consortium 1988-2003. Increased risk of NHL (odds ratio (OR) = 1.3, 95% confidence interval (CI): 1.1, 1.4) associated with hair-dye use was observed among women who began using hair dye before 1980. Analyses by NHL subtype showed increased risk for follicular lymphoma (FL) and chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) but not for other NHL subtypes. The increased risks of FL (OR = 1.4, 95% CI: 1.1, 1.9) and CLL/SLL (OR = 1.5, 95% CI: 1.1, 2.0) were mainly observed among women who started using hair dyes before 1980. For women who began using hair dye in 1980 or afterward, increased FL risk was limited to users of dark-colored dyes (OR = 1.5, 95% CI: 1.1, 2.0). These results indicate that personal hair-dye use may play a role in risks of FL and CLL/SLL in women who started use before 1980 and that increased risk of FL among women who started use during or after 1980 cannot be excluded

Type of Publication: Journal article published

PubMed ID: 18408225

Deep Link: http://www.dkfz.de/cgi-bin/sel?http://www.dkfz.de/PublicationManager/Show/ShowJournal.aspx%3fpublishedId=7382

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4

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Genome-wide association study of follicular lymphoma identifies a risk locus at 6p21.32

Conde,L. ; Halperin,E. ; Akers,N.K. ; [et al.]

Nature Genetics 42 (8), 661-664

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Keywords: RISK ; COMPLEX ; COMPLEXES ; ASSOCIATION ; POLYMORPHISMS ; SUSCEPTIBILITY ; VARIANTS ; LYMPHOMA ; genetics ; HLA ; FOLLICULAR LYMPHOMA ; VARIANT ; HIGH-RESOLUTION ; non-Hodgkin lymphoma ; SUBTYPES ; HAPLOTYPE ; LOCUS ; LOCI ; susceptibility loci ; NON-HODGKIN-LYMPHOMA ; GENOME-WIDE ASSOCIATION ; GENETIC-VARIATION ; non-Hodgkin ; Genetic ; NECROSIS-FACTOR TNF

Abstract: To identify susceptibility loci for non-Hodgkin lymphoma subtypes, we conducted a three-stage genome-wide association study. We identified two variants associated with follicular lymphoma at 6p21.32 (rs10484561, combined P = 1.12 x 10(-29) and rs7755224, combined P = 2.00 x 10(-19); r(2) = 1.0), supporting the idea that major histocompatibility complex genetic variation influences follicular lymphoma susceptibility. We also found confirmatory evidence of a previously reported association between chronic lymphocytic leukemia/small lymphocytic lymphoma and rs735665 (combined P = 4.24 x 10(-9))

Type of Publication: Journal article published

PubMed ID: 20639881

Deep Link: http://www.dkfz.de/cgi-bin/sel?http://www.dkfz.de/PublicationManager/Show/ShowJournal.aspx%3fpublishedId=14470

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5

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Non-Hodgkin lymphoma and obesity: A pooled analysis from the InterLymph consortium

Willett,E.V. ; Morton,L.M. ; Hartge,P. ; [et al.]

International Journal of Cancer 122 (9), 2062-2070

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Keywords: CANCER ; MODEL ; SUPPORT ; EPIDEMIOLOGY ; LONG-TERM ; RISK ; COMPONENTS ; ASSOCIATION ; NO ; LYMPHOMA ; WOMEN ; MEN ; OBESITY ; UNITED-STATES ; case-control studies ; ALCOHOL-CONSUMPTION ; nutrition ; B-CELL LYMPHOMA ; ONCOLOGY ; case-control study ; REGRESSION ; MALIGNANT-LYMPHOMA ; WEIGHT ; PHYSICAL-ACTIVITY ; HEIGHT ; non-Hodgkin lymphoma ; analysis ; diffuse large B-cell lymphoma ; SUBTYPES ; BODY-MASS INDEX ; pooled analysis ; OVERWEIGHT ; USA ; BMI ; RISK-FACTOR ; CANCER-RISK ; B-CELL ; ENGLAND ; RATIO ; non Hodgkin lymphoma ; EXCESS ; POOLED-ANALYSIS ; NO EVIDENCE ; non-Hodgkin ; CONSORTIUM ; nutritional status ; INTERLYMPH ; body mass index weight ; FORMER COLLEGE-STUDENTS ; LYMPHOHEMATOPOIETIC MALIGNANCIES ; SCANDINAVIAN MEN

Abstract: Nutritional status is known to alter immune function, a suspected risk factor for non-Hodgkin lymphoma (NHL). To investigate whether long-term over, or under, nutrition is associated with NHL, self-reported anthropometric data on weight and height from over 10,000 cases of NHL and 16,000 controls were pooled across 18 case-control studies identified through the International Lymphoma Epidemiology Consortium. Study-specific odds ratios (OR) were estimated using logistic regression and combined using a random-effects model. Severe obesity, defined as BMI of 40 kg m(-2) or more, was not associated with NHL overall (pooled OR = 1.00, 95% confidence interval (CI) 0.70-1.41) or the majority of NHL subtypes. An excess was however observed for diffuse large B-cell lymphoma (pooled OR = 1.80, 95% CI 1.24-2.62), although not all study-specific ORs were raised. Among the overweight (BMI 25-29.9 kg m(-2)) and obese (BMI 30-39.9 kg m(-2)), associations were elevated in some studies and decreased in others, while no association was observed among the underweight (BMI 〈 18.5 kg m(-2)). There was little suggestion of increasing ORs for NHL or its subtypes with every 5 kg m(-2) rise in BMI above 18.5 kg m(-2). BMI components height and weight were also examined, and the tallest men, but not women, were at marginally increased risk (pooled OR = 1.19, 95% CI 1.06-1.34). In summary, whilst we conclude that there is no evidence to support the hypothesis that obesity is a determinant of all types of NHL combined, the association between severe obesity and diffuse large B-cell lymphoma may warrant further investigation. (C) 2007 Wiley-Liss, Inc

Type of Publication: Journal article published

PubMed ID: 18167059

Deep Link: http://www.dkfz.de/cgi-bin/sel?http://www.dkfz.de/PublicationManager/Show/ShowJournal.aspx%3fpublishedId=7309

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