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  • 1
    ISSN: 1432-0738
    Keywords: Brain Diseases ; Manganese ; Chronic Intoxication ; Hirnerkrankungen ; Mangan ; Chronische Vergiftung
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Einmalige intratracheale Verabfolgung von Mangandioxid (400 mg) an Kaninchen erzeugte chronische Manganvergiftung mit Lähmung der Hinterextremitäten. 24 Monate später werden die Tiere getötet und die Adenosindeaminase-Aktivität wird in Liquor, Gesamtgehirn und Serum, das Proteinmuster in Serum und Liquor bestimmt. Die Gesamtproteine im Serum sind um 23 % erhöht infolge Globulinvermehrung. Im Liquor ist die Albumin- und Globulin-Konzentration deutlich vermindert bei erniedrigtem Gesamtprotein. Unser Befund einer deutlichen Erhöhung der Adenosindeaminase-Aktivität allein im Liquor deutet an, daß dieser Test als klinisch-diagnostische Probe bei Patienten mit chronischer Manganvergiftung eingesetzt werden könnte.
    Notes: Abstract Chronic manganese toxicity was produced in rabbits by intra-tracheal administration of manganese dioxide (400 mg); resulting in hind limb paralysis. The animals were sacrificed at a period of 24 months. Adenosine deaminase activity was determined in cerebrospinal fluid (CSF), whole brain and serum, whereas protein patterns were studied only in serum and CSF. The total serum proteins increased by 23% due to increase in globulins. In CSF there was marked reduction in the concentration of albumin and globulins, thus, resulting in significant lowering of total proteins. Further our findings of marked elevation in adenosine deaminase only in CSP of experimental animals suggests that this test may be used as a clinical diagnostic index in patients with chronic manganese poisoning.
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  • 2
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effects of theophylline on allergen-induced airway obstruction and bronchial hyperresponsiveness were investigated in allergic rabbits. This allergic rabbit model was developed in our laboratory and stimulates the human model of allergic asthma in several aspects. Four allergic rabbits with hyperreactive airways were challenged with ragweed to elicit early- and late-phase asthmatic responses and subsequent increased airway responsiveness. Two to three weeks later, the rabbits received theophylline (5 mg/ml, nebulized for 3 min) prior to a second allergen challenge. Theophylline significantly inhibited the allergen-induced early- and late-phase asthmatic responses by 38% (P〈0.05) and 49% (P〈0.05), respectively. Further theophylline inhibited the allergen-induced increase in lung resistance by 42% (P〈0.05) during the late-phase responses. Theophylline also inhibited the allergen-induced bronchial hyperresponsiveness by 39% (P〈0.05) at 24h. These data suggest a potential anti-inflammatory effect of theophylline in preventing allergen-induced asthmatic responses and bronchial hyperresponsiveness.
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  • 3
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Recently, there has been an increasing interest in the involvement of adenosine as a mediator of allergic asthma. In the present study, we have employed an allergic rabbit model to study the airway responses to adenosine. The rabbit litter mates were injected i.p., within 24 h of birth, with ragweed pollen extract to preferentially produce ragweed-specific IgE. This allergic rabbit model demonstrates many clinical features of asthma similar to human allergic asthma. Aerosolized adenosine (0.156–10 mg/ml) caused a concentration-dependent bronchoconstriction. The normal rabbits (non-immunized) did not respond to adenosine within that concentration range. Theophylline significantly inhibited the adenosine-induced bronchoconstriction. These early studies suggest that adenosine differentiated asthmatic airways from normal airways and adenosine-induced bronchoconstriction in this model was mediated through specific cell surface receptor(s).
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  • 4
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract— The levels of 5-Hydroxytryptamine (5-HT), dopamine and norepinephrine were estimated in whole brain of rabbits inoculated intratracheally with manganese dioxide (400 mg). Twenty one and 58 per cent lowering in the concentrations of dopamine and norepinephrine, respectively, were observed as compared to that of controls, the concentration of 5-HT was found to be unaltered.
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  • 5
    ISSN: 1435-1803
    Keywords: calcium transport ; coronary arteries ; adenosine ; potassium depolarization ; aminophylline
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The effect of adenosine was studied on the efflux and uptake of45Ca by canine coronary arteries (O.D.〈1 mm) using standard isotope flux techniques. Adenosine (10−4 M) did not reduce the uptale of45Ca by coronary arteries incubated in normal physiological solution and had an insignificant effect on the increased45Ca uptake due to high [K+]0. However, adenosine (10−4 M) significantly (P〈0.001) inhibited the elevated45Ca efflux that was induced by K+ depolarization (150 mM) and abolished the transient rise in efflux rate produced by aminophyllie (10−3 M). Aminophylline had no significant effect on the uptake of45Ca. This study suggest that the vasodilator action of adenosine may be related to a reduction of release or an increased binding of calcium which is superficially stored. It also indicates that the antagonism between adenosine and aminophylline in the coronary blood vessels may not involve calcium influx.
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  • 6
    ISSN: 1435-1803
    Keywords: adenosine ; coronary ; circulation ; adenosine receptor ; theophylline ; vascular smooth muscle
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The efficiency of adenosine to relax the bovine coronary arterial strips increased significantly by lowering the bath pH from 7.4 to 6.8 (CO2 or HCO 3 − ). The large vessels (3–4 mm O.D.) relaxed with greater significance at higher concentrations of adenosine, whereas small vessels (0.5–0.7 mm O.D.) relaxed better at low concentrations of adenosine. Theophylline and 8-phenyltheophylline competitively inhibited the effect of adenosine. 8-phenyltheophylline was found to be a better antagonist than theophylline. Furthermore, binding assays with 2-3H adenosine displayed a single species of binding sites. The Kd was 3×10−6 M and 4×10−6 M, while Bmax was 48 and 19 pmoles/mg protein for small and large vessels, respectively. The antagonistic effect of theophylline and 8-phenyltheophylline was not affected by pH variations. It is concluded that relaxation of coronary arteries by adenosine is affected by pH variations.
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