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  • 1
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    German Medical Science GMS Publishing House; Düsseldorf
    In:  Bad Honnef-Symposium 2016; 20160321-20160322; Bonn; DOC16bhs06 /20160316/
    Publication Date: 2016-03-17
    Keywords: ddc: 610
    Language: German
    Type: conferenceObject
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  • 2
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    German Medical Science GMS Publishing House; Düsseldorf
    In:  GMS Zeitschrift für Medizinische Ausbildung; VOL: 24; DOC156 /20071114/
    Publication Date: 2007-11-14
    Keywords: ddc: 610
    Language: German
    Type: article
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  • 3
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    German Medical Science GMS Publishing House; Düsseldorf
    In:  63. Kongress der Nordrhein-Westfälischen Gesellschaft für Urologie; 20170608-20170609; Essen; DOCP 2.11 /20170419/
    Publication Date: 2017-04-19
    Keywords: ddc: 610
    Language: German
    Type: conferenceObject
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  • 4
    ISSN: 1432-1041
    Keywords: Sisomicin ; pharmacokinetics of aminoglycoside antibiotics ; pyelonephritis ; dialysis ; impaired renal function
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Serum concentration, biological half-life, distribution space and serum clearance of sisomicin, a new aminoglycoside antibiotic, have been studied in twenty-three patients in comparison with the pharmacokinetics of125I-labelled iothalamate, a compound only filtered by the kidney. 10 patients had normal or borderline abnormal serum creatinine (〈1,5 mg/100 ml), 8 had various degrees of renal insufficiency (serum creatinine 1.7 – 9.6 mg/100 ml) and 6 were being treated by intermittent haemodialysis. After intravenous injection of sisomicin 1 mg/kg body weight in patients with normal or borderline renal function its half-life was 3.5 h, very similar to that of iothalamate, 3.2 h. The mean distribution space was 20.1 % per cent of body weight; iothalamate, 23.7 %. In patients with renal insufficiency there was a positive correlation between serum creatinine level and the half-life of sisomicin, and an even stronger correlation between the clearances of iothalamate and sisomicin. In patients dependent on haemodialysis, the mean serum half-life between dialysis was 40 h, compared to approximately 100 hours for iothalamate, which implies additional extrarenal clearance or tubular secretion of sisomicin. The results of pharmacokinetic studies indicated that a regime of sisomicin 1 mg/kg every 8 to 12 hours in patients with normal renal function would result in serum and urine levels sufficiently high to treat most urinary tract infections. In patients with impaired renal function the dosage interval should be increased according to the serum creatinine level, and in patients dependent on haemodialysis one standard dose at the end of each dialysis period should suffice. 9 patients with a chronic urinary tract infection severely complicated by an underlying disease were treated according to this dosage regimen with a satisfactory bacteriological and clinical result. No adverse reactions or signs of accumulation were observed.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1434-0879
    Keywords: Irrigating fluid ; absorption ; transurethal prostatic resection
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A review is presented of all methods, nonquantitative as well as quantitative, applied in the determination of absorption of irrigating fluids used during transurethral resection of the prostate. The nonquantitative methods are clinical observations of pulmonary edema, cerebral edema, cardiac failure, mental agitation, hypertension, hemolysis, large postoperative diuresis, unexplained decrease in hematocrit, transient bacteremia, osteomyelitis, hyperglycemia, and extravasation of contrast medium. To determine total absorption in clinical practice the volumetric or gravimetric methods are the most reliable. The use of radioindicators added to the irrigation fluid is recommended for discrimination between intravascular and extravascular absorption. For this purpose 131 I-macroaggregated human serum albumin has the most advantages: low radiation hazard with good sensitivity, possibility of quantitative external monitoring of intravascular absorption, short time delay of the activity accumulation, and additional quantitative measurement of extravascular absorption.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1434-0879
    Keywords: Renal function ; chronic hydronephrosis ; renal lymphatics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Renal function, rate of urine turnover in the renal pelvis, and the role of the renal lymphatics were studied in dogs during total ureteral occlusion lasting from 6 to 34 days with and without induced infection. — Glomerular filtration rate, effective renal plasma flow, concentration ability, and tubular reabsorption of sodium and potassium were followed. The concentrations of 2 radiolabelled clearance substances, iothalamate and o-iodohippurate, as well as those of sodium, potassium, and total protein were determined in hilar and/or subcapsular lymph obtained by cannulization of the lymphatics. — In uninfected hydronephrosis, concentration ability as well as sodium and potassium reabsorption were impaired as compared with control kidneys. In infected hydronephrosis, these partial functions were not maintained. Turnover in the occluded renal pelvis, ranged from 0.04 to 0.16 ml per minute. Following ureteral occlusion of 1 week, pyelolymphatic reabsorption into hilar, but not subcapsular lymph could be demonstrated.
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  • 7
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Conclusion The strong raise in histamine content during the first day of experimental hydronephrosis seemed to induce a slow increase of histamine methyltransferase activity, the only histamine metabolizing enzyme in rabbit kidney [4]. This process of adaptation can be interpreted as a defence mechanism against the formation and the release of high amounts of histamine.
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  • 8
    ISSN: 1432-1440
    Keywords: Urinary proteins ; Methods of urinary concentration ; Urinproteine ; Urinkonzentrationsverfahren
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Zur Untersuchung von Proteinurien ist die Konzentrierung des Urins erforderlich. Uns hat sich hierbei die Ultrafiltration (Druck) mit nachfolgender Dialyse und Lyophilisation bewährt. Im Normalurin fanden wir eine Gesamteiweißkonzentration von 59,6 (18,5–100,6) mg/24 Std. Die Proteineinzelfraktionen wurden durch Immundiffusion bestimmt. Wie die Wiederfindversuche mit verdünntem Normalserum zeigten, ergab unsere Methode eine gute Reproduzierbarkeit (VK 4,4).
    Notes: Summary Investigation of proteinuria requires concentrated urine. Ultrafiltration (pressure) with subsequent dialysis and lyophilisation was proved to be the best method. In normal urine we found a total protein excretion of 59.6 (18.5–100.6) mg per 24 hours. Each protein fraction was determined by immunodiffusion. The recovery of our method using diluted normal serum was excellent (variation coefficient 4.4).
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  • 9
    ISSN: 1618-2650
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 1439-0973
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary The minimal inhibitory concentrations (MIC) of ofloxacin against 400 isolates cultured from the urine of urological patients with complicated urinary tract infections (UTI) resulted in an inhibition of 94% (99%) of the gram-negative strains at a concentration of 1 mg/l (2 mg/l) and an inhibition of 59% (100%) of the gram-positive strains at a concentration of 1 mg/l (4 mg/l). According to the MIC 90% values, the corresponding grade of activity was as follows: ciprofloxacin, ofloxacin, norfloxacin, pefloxacin, enoxacin, pipemidic acid, enoxacin and nalidixic acid. After an oral dose of 400 mg of ofloxacin, the mean peak serum concentration of ten patients was 5.5 mg/l. The mean renal excretion during 24 hours was 41%. In ten patients undergoing transurethral resection of the prostate, the median serum concentration was 1.87 mg/l and the median prostatic adenoma tissue concentration 1.20 mg/kg 14.5 to 19 hours after oral administration of 400 mg ofloxacin. Due to thein vitro activity and the concentrations obtained in serum, urine and tissue, ofloxacin appears to be well suited for treatment of complicated UTI.
    Notes: Zusammenfassung Die Bestimmung der minimalen Hemmkonzentrationen (MHK) von Ofloxacin gegenüber 400 Isolaten, angezüchtet aus dem Urin von urologischen Patienten mit komplizierten Harnwegsinfektionen (HWI), ergab bei einer Konzentration von 1 mg/l (2 mg/l) eine Hemmung von 94% (99%) aller grammegativen Erreger und bei einer Konzentration von 1 mg/l (4 mg/l) eine Hemmung von 59% (100%) aller grampositiven Erreger. Entsprechend der MHK 90%-Werte ergibt sich folgende Aktivitätsabstufung: Ciprofloxacin, Ofloxacin, Norfloxacin, Pefloxacin, Enoxacin, Pipemidsäure, Cinoxacin und Nalidixinsäure. Nach oraler Gabe von 400 mg Ofloxacin lag bei zehn Patienten die mittlere Serumspitzenkonzentration bei 5,5 mg/l. Die mittlere renale Ausscheidung betrug 41%. 14,5 bis 19 Stunden nach oraler Gabe von 400 mg betrug bei zehn Patienten, die sich einer transurethralen Resektion der Prostata unterziehen mußten, die mediane Serumkonzentration 1,87 mg/l und die mediane Prostataadenom-Gewebekonzentration 1,20 mg/kg. Aufgrund derIn vitro-Aktivität und der Serum-, Urin- und Gewebekonzentrationen ist zu erwarten, daß Ofloxacin zur Therapie komplizierter HWI sehr gut geeignet ist.
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