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  • 1
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    German Medical Science; Düsseldorf, Köln
    In:  Thoracic Surgical Science; VOL: 1; DOC03 /20041001/
    Publication Date: 2004-10-02
    Description: Pyothorax-associated lymphoma (PAL) is a rare haematological malignancy often associated with artificial pneumothorax due to the treatment of pulmonary tuberculosis. A 76 year old man with chronic tube-drained pyothorax and a history of artificial pneumothorax for pulmonary tuberculosis was admitted to our hospital because of progressive right thoracic pain, weight loss, and pyrexia. After clinical examination and imaging processes a chest wall tumour anterior on the right side was diagnosed as well as a persisting pyothorax. Surgery was performed to resect the tumour and drain the pleural cavity. A diagnosis of a high grade B-cell lymphoma was established after histological examination of the surgical biopsy. Epstein-Barr virus (EBV) was identified in the tumour by immunocytochemical and molecular methods. Additional gastric involvement of B-cell lymphoma could be diagnosed by gastroscopy because of postoperative gastrointestinal bleeding. The patient received chemotherapy with 2 courses of cyclophosphamide, doxorubicin, vincristine and prednisolone (CHOP). The response was favourable initially, but 2 months later the patient died because of lymphoma progression.Most cases of PAL have been described by Japanese investigators and only a few cases are reported in Western countries. To the best of our knowledge this case of PAL is the first to be documented in Germany.Awareness of this rare entity, together with diligent histological examination, in patients with chronic pyothorax are essential for a correct diagnosis and correct early treatment.
    Description: Das Pyothorax-assoziierte Lymphom (PAL) stellt eine seltene maligne Erkrankung dar, die sich häufig auf der Basis einer Pneumothoraxbehandlung nach Tuberkulose entwickelt. Ein 76 jähriger Mann mit einem chronischen Pleuraempyem auf der Basis einer artifiziellen Pneumothoraxtherapie nach stattgehabter Tuberkulose wurde mit zunehmenden rechts-thorakalen Schmerzen, Gewichtsabnahme und Fieber stationär aufgenommen. Nach klinischer Untersuchung und bildgebenden Verfahren wurde die Diagnose eines Tumors der rechten Thoraxwand bei weiterhin bestehendem Pyothorax gestellt. Nach chirurgischer Resektion des Tumors und Debridement des Pyothorax ergab sich die Diagnose eines hoch malignen Epstein-Barr-Virus (EBV) positiven B-Zell-Lymphoms. Zusätzlich gelang der gastroskopische Nachweis des B-Zell-Lymphoms im Magen bei postoperativ aufgetretener oberer gastrointestinaler Blutung. Der Patient erhielt postoperativ 2 Zyklen Chemotherapie nach dem CHOP-Schema (Cyclophosphamid, Doxorubicin, Vincristin und Prednisolon). Nach primärem Erfolg der Chemotherapie starb der Patient 2 Monate später an einer Progression des Tumorleidens.PAL stellt eine vor allem von japanischen Autoren berichtete Entität dar. Nur wenige europäische Fälle sind bisher beschrieben worden. Nach unserem Kenntnisstand ist dies der erste in Deutschland dokumentierte Fall. Die Differentialdiagnose des PAL verbunden mit einer genauen histologischen Untersuchung sollte bei Patienten mit chronischem Pyothorax immer in Erwägung gezogen werden, um durch eine frühzeitige Diagnosestellung die Patienten der adäquaten Therapie zuführen zu können.
    Keywords: pyothorax-associated lymphoma ; empyema ; tuberculosis ; B cell lymphoma ; artificial pneumothorax ; Pyothorax-assoziiertes Lymphom (PAL) ; Empyem ; Tuberkulose ; B-Zell-Lymphom ; artifizielle Pneumothorax ; ddc: 610
    Language: English
    Type: article
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  • 2
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    German Medical Science; Düsseldorf, Köln
    In:  122. Kongress der Deutschen Gesellschaft für Chirurgie; 20050405-20050408; München; DOC05dgch3551 /20050615/
    Publication Date: 2005-06-16
    Keywords: ddc: 610
    Language: German
    Type: conferenceObject
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  • 3
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    German Medical Science; Düsseldorf, Köln
    In:  123. Kongress der Deutschen Gesellschaft für Chirurgie; 20060502-20060505; Berlin; DOC06dgch5780 /20060502/
    Publication Date: 2006-05-09
    Keywords: ddc: 610
    Language: German
    Type: conferenceObject
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  • 4
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    German Medical Science; Düsseldorf, Köln
    In:  122. Kongress der Deutschen Gesellschaft für Chirurgie; 20050405-20050408; München; DOC05dgch3537 /20050615/
    Publication Date: 2005-06-16
    Keywords: ddc: 610
    Language: German
    Type: conferenceObject
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  • 5
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    German Medical Science; Düsseldorf, Köln
    In:  123. Kongress der Deutschen Gesellschaft für Chirurgie; 20060502-20060505; Berlin; DOC06dgch5062 /20060502/
    Publication Date: 2006-05-09
    Keywords: ddc: 610
    Language: German
    Type: conferenceObject
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  • 6
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    German Medical Science; Düsseldorf, Köln
    In:  123. Kongress der Deutschen Gesellschaft für Chirurgie; 20060502-20060505; Berlin; DOC06dgch5783 /20060502/
    Publication Date: 2006-05-09
    Keywords: ddc: 610
    Language: German
    Type: conferenceObject
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  • 7
    ISSN: 1434-4726
    Keywords: Hearing disorders ; Inner ear microcirculation ; Thromboxane A2 synthetase inhibitor ; Thromboxane A2 receptor antagonist disorder
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Since thromboxane (TX) A2 causes vasoconstriction and platelet aggregation, we evaluation the effect of a TXA2 receptor antagonist (vapiprost) and a TXAZ synthetase inhibitor (Y-20811) on a microcirculation disorder in the rat inner ear that was induced by a photochemical reaction between an intravenous injection of rose bengal (RB) and green light. A gradual decrease of the cochlear action potential (CAP) to an 8 kHz sound stimulus was measured with an electrocochleogram and occurred after the RB injection. The CAP then disappeared 5 min after the injection of RB. Both vapiprost and Y-20811 significantly prolonged the time required to complete suppression of the CAP as compared with saline as control. These findings indicate that TXAZ may play an important role in microcirculation disorders in the rat inner ear.
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1573-0530
    Keywords: 81S10 ; 81S40 ; 53C80 ; 43A77
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics , Physics
    Notes: Abstract This is a continuation of the work begun by Cadavid and Nakashima inLett. Math. Phys. 23, 111–115 (1991). An expression for the Weyl Character Formula is obtained in terms of the star-product path integral; and the relationship between the star-product path integral and the path integral developed on coadjoint orbits is established.
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 1573-0530
    Keywords: 83-XX ; consistency formulation ; consistency condition ; Gupta program
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics , Physics
    Notes: Abstract Using a generalized consistency condition (gcc), we construct couplings between massless scalar fields and the spin 2 gravitational field. Specifically, we consider all possible third-order interaction terms for scalar fields ϕ and a μν and use the gcc to single out one. We also find three generalized current identities associated with the massless gauge fields.
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 1434-4726
    Keywords: Inner ear microcirculation ; Photochemically induced vascular thrombosis ; Rose bengal ; Hearing loss
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A new photochemical method was employed to cause disorders in the inner ear's microcirculation, using the rat as an animal model. Hearing loss was used as a measure for establishing the altered microcirculation. Under pentobarbital anesthesia, the middle ear was opened by a ventral approach. The lateral wall of the cochlea was then illuminated with a filtered xenon lamp (wavelength 540 nm) while rose bengal was infused intravenously. Photoactivated rose bengal produces oxygen radicals and oxygen singlets, which subsequently damage the vascular epithelium to cause the adhesion and aggregation of platelets in the small vessels. Disintegration of the inner ear hair cells at the irradiated site became evident 24 h after the illumination. These findings further suggest that the photochemical occlusion in the inner ear's microcirculation led to ischemic damage of the stria vascularis and the hair cells in the inner ear. When the action potential (AP) of the cochlea was measured with an electrocochleogram a gradual decrease occurred after the illumination. When acetylsalicylic acid was injected intravenously before treatment, the time required to completely suppress the AP was prolonged in a dose-dependent manner. Findings indicate that our method causes a photochemically induced occlusion in the inner ear's microcirculation and is therefore potentially useful for evaluating the various effects of drugs on the ear.
    Type of Medium: Electronic Resource
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