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  • 1
    Keywords: CANCER ; PROSTATE ; DISEASE ; DISEASES ; incidence ; POPULATION ; SAMPLE ; METABOLISM ; SERA ; hormone ; HEALTH ; DESIGN ; DIFFERENCE ; AGE ; MEN ; smoking ; prostate cancer ; PROSTATE-CANCER ; cancer risk ; UNITED-STATES ; ALCOHOL ; BODY ; nutrition ; IMMUNOASSAYS ; ESTRADIOL ; SERUM ; BODIES ; ENDOCRINE ; WEIGHT ; ESTROGEN ; LEVEL ; SIZE ; USA ; CANCER INCIDENCE ; HORMONE LEVELS ; TESTOSTERONE ; STEROID-HORMONES ; prostate-specific antigen ; GENERAL-POPULATION ; BONE-MINERAL DENSITY ; AFRICAN-AMERICAN ; ANDROGEN CONCENTRATIONS ; BODY-COMPOSITION ; ENDOGENOUS SEX-HORMONES ; HORMONE-BINDING GLOBULIN
    Abstract: Context: Higher testosterone in black compared with white men has been postulated to explain their higher prostate cancer incidence. Previous studies comparing hormone levels by race might have been limited by size, restricted age variation, or lack of representation of the general population. Objective: Our objective was to compare serum testosterone, estradiol, and SHBG concentrations among non-Hispanic black, non-Hispanic white, and Mexican-American men. Participants, Design, and Setting: A total of 1413 men aged 20 + yr and who attended the morning examination session of the Third National Health and Nutrition Examination Survey (NHANES III) in 1988-1991 were included in this cross-sectional study. Measurement: Serum hormone concentrations were measured by electrochemiluminescence immunoassays. Results: After applying sampling weights and adjusting for age, percent body fat, alcohol, smoking, and activity, testosterone concentrations were not different between non-Hispanic blacks (n = 363; eometric mean, 5.29 ng/ml) and non-Hispanic whites (n = 674; 5.11 ng/ml; P 〉 0.05) but were higher in Mexican-Americans (n = 376; 5.48 ng/ml; P 〈 0.05). Non- Hispanic blacks ( 40.80 pg/ml) had a higher estradiol concentration than non-Hispanic whites (35.46 pg/ml; P 〈 0.01) and Mexican-Americans (34.11 pg/ml; P 〈 0.01). Non-hispanic blacks (36.49 nmol/liter) had a higher SHBG concentration than non-Hispanic whites (34.91 nmol/liter; P 〈 0.05) and Mexican-Americans (35.04 nmol/liter; P 〈 0.05). Conclusions: Contrary to the postulated racial difference, testosterone concentrations did not differ notably between black and white men. However, blacks had higher estradiol levels. Mexican-Americans had higher testosterone than whites but similar estradiol and SHBG concentrations. Given these findings, it may be equally if not more important to investigate estradiol as testosterone in relation to diseases with racial disparity
    Type of Publication: Journal article published
    PubMed ID: 17456570
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  • 2
    Keywords: MODEL ; MODELS ; PROSTATE ; VOLUME ; NEW-YORK ; RISK ; SURGERY ; SERA ; RISK-FACTORS ; BINDING ; ASSOCIATION ; NO ; hormone ; HEALTH ; AGE ; CIGARETTE-SMOKING ; MEN ; smoking ; MULTIVARIATE ; ALCOHOL ; ALCOHOL-CONSUMPTION ; CONSUMPTION ; nutrition ; ESTRADIOL ; REGRESSION-MODELS ; METABOLITE ; physical activity ; albumin ; SERUM ; REGRESSION ; ASSOCIATIONS ; WEIGHT ; PHYSICAL-ACTIVITY ; BENIGN PROSTATIC HYPERPLASIA ; ESTROGEN ; INTERVAL ; methods ; PHASE ; USA ; HORMONES ; TESTOSTERONE ; NHANES III ; lower urinary tract symptoms ; STEROID-HORMONES ; EVALUATE ; INCREASED RISK ; odds ratio ; AMERICAN MEN ; LOGISTIC-REGRESSION ; HORMONE-BINDING-GLOBULIN ; SHBG ; sex ; ANDROSTANEDIOL GLUCURONIDE ; DIHYDROTESTOSTERONE ; FINASTERIDE ; FREE TESTOSTERONE
    Abstract: OBJECTIVES To evaluate the association of circulating sex steroid hormones and sex hormone binding globulin (SHBG) with lower urinary tract symptoms (LUTS). METHODS We included 260 men, 60 years old or older, who participated in Phase 1 (1988 to 1991) of the Third National Health and Nutrition Examination Survey and for whom surplus serum was available. We measured the serum concentrations of testosterone, androstanediol glucuronide (AAG), estradiol, and SHBG. Free testosterone was calculated from the circulating testosterone, SHBG, and albumin. The cases (n = 128) were men with two to four symptoms (nocturia, hesitancy, incomplete emptying, and weak stream), but who had never undergone noncancer prostate surgery. The controls (n = 132) were men who neither had symptoms nor had undergone noncancer prostate surgery. We adjusted for age, race/ethnicity, waist circumference, cigarette smoking, alcohol consumption, and physical activity in logistic regression models and used sampling weights. RESULTS The cases had statistically significantly greater AAG and estradiol concentrations than did the controls. After multivariate adjustment, the men in the top tertile of AAG (odds ratio 2.62, 95% confidence interval 1.12 to 6.14) had a greater risk of LUTS compared with men in the bottom two tertiles. Also, men with a greater estradiol concentration (odds ratio 1.78, 95% confidence interval 0.91 to 3.49) and a greater estradiol/SHBG molar ratio (odds ratio 2.41, 95% confidence interval 1.39 to 4.17) had a greater risk of LUTS than did men with lower concentrations. No consistent associations were seen for circulating testosterone, free testosterone, or SHBG. CONCLUSIONS In this cross-sectional study representative of older U.S. men, circulating AAG, a metabolite of dihydrotestosterone, and estradiol were associated with an increased risk of having LUTS
    Type of Publication: Journal article published
    PubMed ID: 17445656
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  • 3
    Keywords: CANCER ; neoplasms ; FOLLOW-UP ; COHORT ; cohort study ; DEATH ; DISEASE ; MORTALITY ; RISK ; MECHANISM ; ASSOCIATION ; HEALTH ; MEN ; PROSPECTIVE COHORT ; nutrition ; HEART-DISEASE ; ESTRADIOL ; CARDIOVASCULAR-DISEASE ; ELDERLY-MEN ; PHASE ; HORMONES ; HORMONE LEVELS ; TESTOSTERONE ; prospective ; older men ; cardiovascular diseases ; androgens ; sex hormone-binding globulin ; journals ; ADULT MEN ; ALL-CAUSE ; CRITICAL ILLNESS ; LOW SERUM TESTOSTERONE ; NHANES-III
    Abstract: The association of sex hormone levels with mortality over a median of 16 years of follow-up was evaluated in a prospective cohort study. The study included 1,114 US men who participated in phase 1 (1988-1991) of the Third National Health and Nutrition Examination Survey Mortality Study and had no history of cardiovascular disease or cancer at baseline. Multivariable adjusted hazard ratios for all-cause mortality associated with a decrease in hormone concentration equal to the difference between the 90th and 10th percentiles of the sex hormone distributions were estimated by using proportional hazards regression. The hazard ratios associated with low free testosterone and low bioavailable testosterone levels were 1.43 (95% confidence interval (CI): 1.09, 1.87) and 1.52 (95% CI: 1.15, 2.02), respectively, for follow-up between baseline and year 9; they were 0.94 (95% CI: 0.51, 1.72) and 0.98 (95% CI: 0.56, 1.72), respectively, for follow-up between year 9 and year 18. Men with low free and bioavailable testosterone levels may have a higher risk of mortality within 9 years of hormone measurement. Future studies should be conducted to fully characterize the association of low free and bioavailable testosterone concentrations and mortality in men and to describe the mechanism underlying the association
    Type of Publication: Journal article published
    PubMed ID: 20083549
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  • 4
    Keywords: BLOOD ; human ; PROSTATE ; NEW-YORK ; POPULATION ; SAMPLE ; SAMPLES ; INFECTION ; papillomavirus ; TYPE-1 ; ASSOCIATION ; antibodies ; antibody ; virus ; NO ; HEALTH ; AGE ; MEN ; human papillomavirus ; TYPE-16 ; HUMAN-PAPILLOMAVIRUS ; UNITED-STATES ; FUTURE ; INFECTIONS ; nutrition ; TYPE-2 ; HUMAN-IMMUNODEFICIENCY-VIRUS ; inflammation ; VIRAL-INFECTION ; ASSOCIATIONS ; VIRUS-INFECTION ; hepatitis C ; methods ; USA ; lower urinary tract symptoms ; C VIRUS-INFECTION ; IMMUNODEFICIENCY VIRUS ; HERPES-SIMPLEX ; cytomegalovirus ; viral ; prostatic hyperplasia ; SEROPREVALENCE ; United States ; YOUNGER ; hepatitis ; SEROPOSITIVITY ; prostatism ; sexually transmitted diseases ; viral diseases
    Abstract: Purpose: Previous epidemiological studies described suggestive positive associations between sexually transmitted infections, particularly gonorrhea and human immunodeficiency virus infection, and lower urinary tract symptoms. To our knowledge no groups have investigated other infections, such as human papillomavirus type 16, herpes simplex virus type 2, cytomegalovirus, human herpesvirus type 8, herpes simplex type 1, and hepatitis B and C virus infection, in relation to lower urinary tract symptoms. Therefore, we examined each of these associations in the Third National Health and Nutrition Examination Survey. Materials and Methods: The Third National Health and Nutrition Examination Survey is a representative, cross-sectional survey of the population in the United States that was done between 1988 and 1994. Each participant provided a blood sample and completed a computer assisted interview including questions on lower urinary tract symptoms (nocturia, incomplete emptying, hesitancy and weak stream). Blood samples were tested for IgG antibodies against each virus. Results: In younger men (ages 30 to 49 years) positive associations were observed between cytomegalovirus, human herpesvirus type 8, herpes simplex virus type 1, and hepatitis B and C virus antibody seropositivity, and lower urinary tract symptoms. In 50 to 59-year-old men positive associations were observed between human papillomavirus type 16, herpes simplex virus type 2, cytomegalovirus, human herpesvirus type 8 and hepatitis C virus antibody seropositivity and lower urinary tract symptoms. In men 60 years or older only a slight, nonsignificant positive association was observed between cytomegalovirus antibody seropositivity and lower urinary tract symptoms. Conclusions: In this cross-sectional survey of American men suggestive positive associations were observed between several viral infections and lower urinary tract symptoms, primarily in 30 to 59-year-old men. These findings provide interesting hypotheses and preliminary evidence for future etiological studies of infections and lower urinary tract symptoms
    Type of Publication: Journal article published
    PubMed ID: 17870113
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  • 5
    Keywords: MODEL ; MODELS ; POPULATION ; RISK ; TIME ; RISK-FACTORS ; ASSOCIATION ; HEALTH ; DESIGN ; PLASMA ; AGE ; MEN ; nutrition ; MELLITUS ; albumin ; SERUM ; ASSOCIATIONS ; development ; LEVEL ; PHASE ; TESTOSTERONE ; odds ratio ; RISK-FACTOR ; ANDROGEN ; PREDICT ; MIDDLE-AGED MEN ; HORMONE-BINDING-GLOBULIN ; CORONARY-ARTERY-DISEASE ; ENDOGENOUS SEX-HORMONES ; FREE TESTOSTERONE
    Abstract: OBJECTIVE-Low levels of androgens in men may play a role in the development of diabetes; however, few studies have examined the association between androgen concentration and diabetes in men in the general population. The objective of this study is to test the hypothesis that low normal levels of total, free, and bioavailable testosterone are associated with prevalent diabetes in men. RESEARCH DESIGN AND METHODS-The study sample included 1,413 adult men aged 〉= 20 years who participated in the morning session of the first phase of the Third National Health and Nutrition Examination Survey, a cross-sectional survey of the civilian, noninstitutionalized population of the U.S. Bioavailable and free testosterone levels were calculated from serum total testosterone, sex hormone-binding globulin, and albumin concentrations. RESULTS-in multivariable models adjusted for age, race/ethnicity, and adiposity, men in the first tertile (lowest) of free testosterone level were four times more likely to have prevalent diabetes compared with men in the third tertile (odds ratio 4.12 [95% CI 1.25-13.55]). Similarly, men in the first tertile of bioavailable testosterone also were approximately four times as likely to have prevalent diabetes compared wth men in the third tertile (3.93 [1.39-11.13]). These associations persisted even after excluding men with clinically abnormal testosterone concentrations defined as total testosterone 〈 3.25 ng/ml or free testosterone 〈 0.07 ng/ml. No clear association was observed for total testosterone after multivariable adjustment (P for trend across tertiles = 0.27). CONCLUSIONS-Low free and bioavailable testosterone concentrations in the normal range were associated with diabetes, independent of adiposity. These data suggest that low androgen levels may be a risk factor for diabetes in men
    Type of Publication: Journal article published
    PubMed ID: 17259487
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  • 6
    Keywords: EXPRESSION ; EXPOSURE ; POPULATION ; SAMPLE ; ASSOCIATION ; HEALTH ; PLASMA ; AGE ; MEN ; smoking ; MASS-SPECTROMETRY ; nutrition ; ESTRADIOL ; NATIONAL-HEALTH ; SERUM ; ADULT ; LEVEL ; methods ; PHASE ; USA ; ENGLAND ; FREE TESTOSTERONE ; REPRODUCTIVE ENDOCRINE FUNCTION ; SEMEN QUALITY ; ZEEMAN BACKGROUND CORRECTION
    Abstract: Background: Studies investigating the association of cadmium and sex steroid hormones in men have been inconsistent, but previous studies were relatively small. Methods: In a nationally representative sample of 1,262 men participating in the morning examination session of phase 1 (1998-1991) of the third National Health and Nutrition Examination Survey, creatinine corrected urinary cadmium and serum concentrations of sex steroid hormones were measured following a standardized protocol. Results: After adjustment for age and race-ethnicity, higher cadmium levels were associated with higher levels of total testosterone, total estradiol, sex hormone-binding globulin, estimated free testosterone, and estimated free estradiol ( each p-trend 〈 0.05). After additionally adjusting for smoking status and serum cotinine, none of the hormones maintained an association with urinary cadmium ( each p-trend 〉 0.05). Conclusion: Urinary cadmium levels were not associated with sex steroid hormone concentrations in a large nationally representative sample of US men
    Type of Publication: Journal article published
    PubMed ID: 18294394
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  • 7
    ISSN: 0302-3524
    Keywords: Florida ; algae ; ecology ; fish ; gobies ; population dynamics ; predator control ; sea grasses
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Geography , Geosciences
    Type of Medium: Electronic Resource
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