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  • 1
    Publication Date: 2018-08-28
    Description: XCMS-MRM and METLIN-MRM: a cloud library and public resource for targeted analysis of small molecules XCMS-MRM and METLIN-MRM: a cloud library and public resource for targeted analysis of small molecules, Published online: 27 August 2018; doi:10.1038/s41592-018-0110-3 A resource of multiple reaction monitoring–mass spectrometry transitions for quantitative analysis of biological small molecules is provided in METLIN-MRM, along with automated tools for analyzing such data in XCMS-MRM.
    Print ISSN: 1548-7091
    Electronic ISSN: 1548-7105
    Topics: Biology , Medicine
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  • 2
    ISSN: 1573-5079
    Keywords: mathematical model ; oscillations ; photosynthesis ; regulation of metabolism
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract The metabolic pathways in photosynthesis are modelled as an interconnected series of chemical reactions representing the electron transfer system, the carbon reduction cycle and starch and sucrose synthesis according to the model of Laisk and Walker [Proc R Soc Lond 227, 281–302 (1986)]. The model is formulated as a set of non-linear differential equations using mass-action kinetics, and stimulated for transient behaviour using an interactive simulation language. The model responses to switched light demonstrate the existence of oscillatory behaviour, similar to that found experimentally in O2 evolution and chlorophyll fluorescence, and explain known transient behaviour. The model is also used to investigate the source of oscillatory behaviour in the phosphate translocator, and other transient phenomena associated with the cyclic electron transfer system.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1573-7225
    Keywords: Case-control study ; childhood brain neoplasms ; neonatal ; perinatal ; prenatal ; Sweden
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Childhood brain tumors (CBT) include a diversity of rare neoplasms of largely unknown etiology. To assess possible maternal and perinatal risk factors for CBT according to subtype, we carried out a nested (within Swedish birth-cohorts, 1973–89) case-control study, utilizing data from the nationwide Birth Registry. We ascertained incident brain tumor cases through linkage of the nationwide Birth and Cancer Registries and randomly selected five living controls from the former, matching each case on gender and birthdate. There were 570CBT cases, including 205 low grade astrocytomas, 58 high grade astrocytomas, 93 medulloblastomas, 54 ependymomas, and 160 ‘others.’ Risks for all brain tumors combined were elevated in relation to: (i) three maternal exposures-oral contraceptives prior to conception (odds ratios [OR]=1.6, 95 percent confidence interval [CI]=1.0–2.8), use of narcotics (OR=1.3, CI=1.0–1.6), or penthrane (OR=1.5, CI=1.1–2.0) during delivery); (ii) characteristics of neonatal distress (a combined variable including low one-minute Apgar score, asphyxia [OR=1.5, CI=1.1–2.0]) or treatments for neonatal distress (use of supplemental oxygen, ventilated on mask, use of incubator, scalp vein infusion, feeding with a jejunal tube [OR=1.6, CI=0.9–2.6]); and (iii) neonatal infections (OR=2.4, CI=1.5–4.0). Higher subtype-specific risks, observed for a few risk factors, did not differ significantly from the risk estimates for all subtypes combined for the corresponding risk factors. Childhood brain tumors were not associated significantly with other maternal reproductive, lifestyle, or disease factors; perinatal pain, anesthetic medications, birth-related complications; or with birthweight, birth defects, or early neonatal diseases. These findings suggest several new leads, but only weak evidence of brain tumor subtype-specific differences.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    New York, NY [u.a.] : Wiley-Blackwell
    Biotechnology and Bioengineering 34 (1989), S. 1331-1336 
    ISSN: 0006-3592
    Keywords: Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    New York, NY [u.a.] : Wiley-Blackwell
    Biotechnology and Bioengineering 35 (1990), S. 252-259 
    ISSN: 0006-3592
    Keywords: Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: This article calculates optimal open-loop temperature trajectories that maximize the average rate of product synthesis of a plant cell culture. It uses a previously published five-state mathematical model which describes the growth and product synthesis of a batch plant cell suspension culture of Catharanthus roseus under temperature control. The optimal open-loop temperatures maximize the final product concentration for predefined fermentation periods. A single switch in temperature is shown by computer simulation to be near optimal, with a 22% increase in final product yield over that obtained at the optimal constant temperature. Examination of the achieved final product yield as a function of fermentation period allows this period also to be chosen optimally. This time is reduced from 16 days in the constant temperature case to 12 days in the switched temperature case.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 233 (1992), S. 538-542 
    ISSN: 0003-276X
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: The cellular localization of uterine oxytocin binding sites in the rat was studied by means of in vitro receptor autoradiography. Using [tyrosyl-3,5-3H]oxytocin as ligand, binding sites were localized in tissue sections from uteri of estrous, mated, and artificially cervically stimulated rats (n = 4 per group), and specificity of binding was investigated by means of simultaneous incubations with oxytocin, [Gly4, Thr7]oxytocin and [Arg]vasopressin. A previously unidentified type of cell was densely labelled by tritiated oxytocin. The labelled cells were preferentially localized near the endomyometrial border and at the interface of the circular and longitudinal muscle layers. In addition, these cells were found in the muscle layers. The dense labelling of these cells, which did not constitute part of the endometrial epithelium or blood vessels, was abolished when oxytocin or [Arg]vasopressin, but not [Gly4, Thr7]oxytocin, was added to the incubation medium. Binding of the radioligand was also found on muscle cells of the circular and longitudinal layers of the myometrium and cells of the endometrial luminal and glandular epithelium. Whereas incubation with oxytocin and [Gly4, Thr7]oxytocin diminished the labelling in both myometrium and endometrium, incubation with [Arg]vasopressin reduced labelling only in the myometrium. Similar results were obtained in tissues from rats in different reproductive states. This study demonstrates the presence of oxytocin binding sites in three different types of cell in the uterus of the rat. While the sites in the myometrium may be associated with the contractile response of this type of tissue to oxytocin, the functional significance of oxytocin binding sites on the endometrial epithelium and in the densely labelled, scattered cell remains to be elucidated. © 1992 Wiley-Liss, Inc.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 0006-3525
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: It was previously shown that the two replacements Gly 77 ↠ Ala (G77A) and Ala 82 ↠ Pro (A82P) increase the thermostability of phage T4 lysozyme at pH 6.5. Such replacements are presumed to restrict the degrees of freedom of the unfolded protein and so decrease the entropy of unfolding [B. W. Matthews, H. Nicholson, and W. J. Becktel (1987) Proceedings of the National Academy of Science USA Vol. 84, pp. 6663-6667].To further test this approach, three additional replacements - G113A, K60P and A93P -  have been constructed. On the basis of model building, each of these three replacements was judged to be less than optimal because it would tend to introduce unfavorable van der Waals contacts with neighboring parts of the protein. The presence of such contacts was verified for G113A and K60P by conformational adjustments seen in the crystal structures of these mutant proteins. In the case of G113A there are backbone conformational changes of 0.5-1.0 Å in the short α-helix, 108-113, that includes the site of substitution. In the case of K60P the pyrrolidine ring shows evidence of strain. The thermal stability of each of the three variants at both pH 2.0 and pH 6.5 was found to be very close to that of wild-type lysozyme. The results suggest that the procedure used to predict sites for both Xaa ↠ Pro and Gly ↠ Ala is, in principle, correct. At the same time, the increase in stability expected from substitutions of this type is modest, and can easily be offset by strain associated with introduction of the alanine or proline. This means that the criteria used to select substitutions that will increase thermostability have to be stringent at least. In the case of T4 lysozyme this severely limits the number of sites. The analysis reveals a significant discrepancy between the conformational energy surface predicted for the residue preceding a proline and the conformations observed in crystal structures. © 1992 John Wiley & Sons, Inc.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 50 (1894), S. 524-524 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] IN the issue of NATURE of September 20, I notice a table of the scientific classes which are to be given in the medical schools of Great Britain during the session 1894–95. In this table I find that the subject of “biology or zoology” is indicated by a cross (x) as being taught in all the ...
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 336 (1988), S. 651-656 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Two different genetically engineered amino-acid substitutions designed to interact with α-helix dipoles in T4 lysozyme are shown to increase the thermal stability of the protein. Crystallographic analyses of the mutant lysozyme structures suggest that the stabilization is due to electrostatic ...
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 3 (1870), S. 86-86 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] I NOTICE in NATURE for Oct. 20, a review by Mr. E. Ray Lankester, of a Manual of Zoology recently published by me, and I crave a small portion of your space to say a few words thereon. Upon Mr. Lankester's zoological strictures on my work I will not enter, partly because the public verdict on ...
    Type of Medium: Electronic Resource
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