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  • 1
    Call number: 08-Med
    Keywords: Brain / Atlases
    Notes: Based on the classic Talairach-Tournoux and Schaltenbrand brain atlases.
    Pages: 1 CD-ROM
    ISBN: 0-86577-671-7
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    08-Med departmental collection or stack – please contact the library
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  • 2
    Keywords: Monoclonal antibodies ; Biochemistry ; Toxicology ; Antibodies ; Protein Science ; Pharmacology/Toxicology ; Springer eBooks
    Description / Table of Contents: Site-Specific Conjugation of Thiol-Reactive Cytotoxic Agents to Non-Native Cysteines of Engineered Monoclonal Antibodies -- Application of Next Generation Maleimides (NGMs) to Site-Selective Antibody Conjugation -- Lysine Bioconjugation on Native Albumin with a Sulfonyl Acrylate Reagent -- Engineering Dual-Variable-Domains for the Generation of Site-Specific Antibody-Drug Conjugates -- Efficient Production of Homogeneous Lysine-Based Antibody Conjugates Using Microbial Transglutaminase -- Engineering Antibodies with C-Terminal Sortase-Mediated Modification for Targeted Nanomedicine -- CRISPR/Cas9-Mediated Genetic Engineering of Hybridomas for Creation of Antibodies that Allow Site-Specific Conjugation -- Site-Specific Modification of Proteins via Trypsiligase -- Site-Selective Functionalization of Nanobodies Using Intein-Mediated Protein Ligation for Innovative Bioconjugation -- Site-Specific Bioconjugation Using SMARTagâ Technology: A Practical and Effective Chemoenzymatic Approach to Generate Antibody-Drug Conjugates -- Protein Labeling and Bioconjugation Using N-Myristoyltransferase -- One-Step Fluorescent Protein Labeling by Tubulin Tyrosine Ligase -- Enzymatically Catalyzed Radiofluorination of Biomolecules -- Site-Selective Enzymatic Labeling of Designed Ankyrin Repeat Proteins Using Protein Farnesyltransferase -- Homogeneous Antibody-Drug Conjugates via Glyco-Engineering -- Labeling Proteins at Site-Specifically Incorporated 5-Hydroxytryptophan Residues Using a Chemoselective Rapid Azo-Coupling Reaction -- Facile Site-Specific Multi-Conjugation Strategies in Recombinant Proteins Produced in Bacteria -- Site-Specific Photocrosslinking to Immunoglobulin G Using Photoreactive Antibody-Binding Domains -- SpyTag-SpyCatcher Chemistry for Protein Bioconjugation In Vitro and Protein Topology Engineering In Vivo -- FN3 Protein Conjugates for Cancer Diagnosis and Imaging Studies
    Abstract: This book explores well-established and emerging conjugation strategies that are relevant for proteins used in the field of precision medicine, focusing on techniques that are suitable for antibodies, antibody-fragments such as Fabs, scFvs, or nanobodies, scaffold proteins such as FN3 or DARPin, peptides, or model proteins. Although centered on the development of bioconjugates rather than their application, most protocols also show the conjugation of the targeting vehicle to a diagnostic or therapeutic entity, with the end-product most often being an antibody-drug conjugate, an optical probe, a nanomedicine, or a radiopharmaceutical. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Bioconjugation: Methods and Protocols is an ideal guide for researchers looking toward precision medicine in order to expand the vital field of drug discovery
    Pages: XI, 317 p. 84 illus., 47 illus. in color. : online resource.
    Edition: 1st ed. 2019.
    ISBN: 9781493996544
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  • 3
    Keywords: Life sciences ; Biochemistry ; Cytology ; Plant physiology ; Plant breeding ; Life sciences ; Plant Breeding/Biotechnology ; Cell Biology ; Plant physiology ; Plant Biochemistry ; Springer eBooks
    Description / Table of Contents: Prologue: Plant Stem Cells ́€“ Evolution of a Key Concept -- From N♯›mec and Haberlandt to Molecular Cell Biology -- ℗ Part I: Control of Growth And Development -- Why to Spent Tax Money on Plant Microtubules? -- Auxin Biology: Applications and the Mechanisms Behind -- The Biotechnological Potential of Cytokinin Status Manipulation -- Cell Fate Between Life and Death During Somatic Embryogenesis -- Molecular Cell Biology of Pollen Walls -- Part II: Stress Tolerance -- Plant Cell Responses to Cadmium and Zinc -- Applied Cell Biology of Sulfur and Selenium in Plants -- Endocytosis: At the Crossroads of Pattern Recognition Immune Receptors and Pathogen Effectors -- Part III: Plant Metabolism -- Plant Compounds Acting on the Cytoskeleton -- Secondary Metabolites of Traditional Medical Plants ́€“ A Case Study of Ashwagandha (Withania Somnifera) -- Metabolic Engineering of Wood Formation -- Part IV: The Cell Biology Toolbox ́€“ New Approaches -- Flow Cytometry in Plant Research: A Success Story -- Photoconvertible Reporters for Selective Visualization of Subcellular Events and Interactions -- Plant Cell Strains in Fundamental Research and Application
    Abstract: The aim of this volume is to merge classical concepts of plant cell biology with the recent findings of molecular studies and real-world applications in a form attractive not only to specialists in the realm of fundamental research, but also to breeders and plant producers. Four sections deal with the control of development, the control of stress tolerance, the control of metabolic activity, and novel additions to the toolbox of modern plant cell biology in an exemplary and comprehensive manner and are targeted at a broad professional community. It serves as a clear example that a sustainable solution to the problems of food security must be firmly rooted in modern, continuously self re-evaluating cell-biological research. No green biotech without green cell biology. As advances in modern medicine is based on extensive knowledge of animal molecular cell biology, we need to understand the hidden laws of plant cells in order to handle crops, vegetables and forest trees. We need to exploit, not only empirically, their astounding developmental, physiological and metabolic plasticity, which allows plants to cope with environmental challenges and to restore flexible, but robust self-organisation
    Pages: XIV, 481 p. 48 illus., 26 illus. in color. : online resource.
    ISBN: 9783642417870
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  • 4
    Oxford : Oxford University Press
    Call number: QD251:24(2)
    Keywords: Chemistry, Organic
    Notes: Includes index.
    Pages: xxv, 1234 p. : ill. (chiefly col.)
    Edition: 2nd ed.
    ISBN: 978-0-19-927029-3
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    QD251:24(2) available
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  • 5
    Call number: QH447:208(3) ; W450:3
    Keywords: Molecular genetics ; Genes ; Genomes
    Pages: xiv, 386 p. : ill.
    Edition: 3rd ed.
    ISBN: 9780470683859
    Signatur Availability
    QH447:208(3) available
    W450:3 departmental collection or stack – please contact the library
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  • 6
    Call number: QV137:61/14 ; ZZ2003:2/14/Mag
    Keywords: Tobacco Smoke Pollution / adverse effects ; Smoking ; Smoking, Passive ; DKFZ-publications
    Pages: 88 p. : ill.
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    QV137:61/14 available
    ZZ2003:2/14/Mag departmental collection or stack – please contact the library
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  • 7
    Call number: QV137:61/12 ; ZZ2003:2/12/Mag
    Keywords: Law enforcement ; Tobacco manufacture and trade ; DKFZ-publications
    Notes: Der vorliegende Bericht basiert auf freien Übersetzungen von Abschnitten zweier Reporte von Joossens L., Merriman D., Ross H., Raw M. und Johnson P. (2009).
    Pages: 51p. : ill.
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    QV137:61/12 available
    ZZ2003:2/12/Mag departmental collection or stack – please contact the library
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  • 8
    Keywords: Medicine ; Environmental Medicine ; Medicine & Public Health ; Health Promotion and Disease Prevention ; Environmental Health ; Practice Management ; Springer eBooks
    ISBN: 9789400727809
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  • 9
    ISSN: 1572-9559
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract Scalar network analysers measuring the amplitude of the reflection/transmission coefficients of waveguide structures have been realised at Ka- and W-bands. Their accuracy derived by using standard mismatches is excellent at Ka- band and fairly good at W-band. To our knowledge this is the first instance where the accuracy of measurements obtained from a scalar network analyser was checked over full waveguide bands with the aid of standard mismatches. The reported reflectometers are precursors of vector network analysers based on six-port reflectometers. Methods aimed at increasing the signal-to-noise ratio (SNR) of the measurements have been developed, while proposals for improving the dynamic range of these network analysers are put forward.
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 1572-9559
    Keywords: cross-bar mixer ; stripline-to-waveguide transition ; stripline lowpass filter ; matching networks
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract Many receivers operating at millimetre wavelengths utilise a frequency downconverter as their first stage. A rugged, low-conversion loss and simplified cross-bar mixer operating at the atmospheric window centered at 33 GHz was designed, developed and tested as a forerunner to mixers operating at atmospheric windows centred at higher frequencies. The cross-bar mixer exhibits a conversion loss of less than 5 dB over a bandwidth of 2 GHz. Design and optimisation procedures of the mixer are outlined.
    Type of Medium: Electronic Resource
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