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  • 1
    Keywords: EXPRESSION ; DEATH ; CD95 ligand ; chemotherapy ; INVOLVEMENT ; LEUKEMIA-CELLS ; CYTOKINE ; MEDIATED APOPTOSIS ; LYMPHOCYTE ; TNF FAMILY MEMBER
    Abstract: Doxorubicin induces apoptosis in a variety of cells. We investigated the expression and function of various tumor necrosis factor (TNF)alpha-homologues and their receptors. CEM cells did not differentially express any one of the TNFalpha-homologous receptors investigated nor TNF-related apoptosis-inducing ligand or TNF-related weakly apoptosis-inducing ligand (TWEAK) in the presence of doxorubicin. In addition to CD95 ligand, however, receptor activator of nuclear factor kappaB ligand (RANKL) was strongly up-regulated. Doxorubicin-induced apoptosis was greatly suppressed in the presence of either neutralizing antibody or RANK-Fc fusion protein. Moreover, neutralizing RANKL also prevented cytochrome c release from mitochondria. RANKL alone was unable to induce significant levels of apoptosis in CEM cells. However, doxorubicin-induced apoptosis was increased 〉2-fold when exogenous RANKL was added. Therefore, RANKL is necessary but not sufficient to account for early doxorubicin-induced apoptosis in CEM cells. This finding suggests improved chemotherapeutic efficiency of the anthracyclin against susceptible malignant cells in the presence with RANKL.
    Type of Publication: Journal article published
    PubMed ID: 12702561
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  • 2
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    German Medical Science; Düsseldorf, Köln
    In:  122. Kongress der Deutschen Gesellschaft für Chirurgie; 20050405-20050408; München; DOC05dgch2968 /20050615/
    Publication Date: 2005-06-16
    Keywords: ddc: 610
    Language: German
    Type: conferenceObject
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  • 3
    ISSN: 0378-4347
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Description / Table of Contents: Zusammenfassung Es wird über die klinischen und cytogenetischen Befunde bei 3 nichtverwandten Patienten mit Partialtrisomie 4q berichtet. In 2 Fällen ist die Chromosomen-aberration durch eine balancierte elterliche Translokation entstanden (t(3p+;4q-) und t(4q-;18q+)) während im 3. Fall eine spontane invertierte Insertion von 4q22→q34 in 4q34 angenommen wird. Ein Vergleich der Symptomatik dieser Patienten mit 7 Fällen aus der Literatur läßt keinen einheitlichen Phänotyp erkennen.
    Notes: Summary The clinical and cytogenetic data of 3 non-related patients who have a partial trisomy 4q in common are reported. The chromosome aberration originated from a parental balanced translocation in 2 cases (t(3p+;4-) and t(4q-;18q+)); in the 3rd case an inverted insertion of 4q22→q34 into 4q34 occured spontaneously. A comparison of the symptoms exhibited by these probands and 7 cases from the literature gives no indication of an uniform phaenotype of this aberration.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1432-1076
    Keywords: Cyclophosphamide ; Cardiomyopathy ; Bone marrow transplantation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A 12-year-old boy with aplastic anemia developed severe but reversible cardiac failure after treatment with 200 mg/kg cyclophosphamide (4×50 mg/kg on four consecutive days) given as preparation for bone marrow grafting. This and previously reported cases demonstrate the possibility of cardiotoxicity after high doses of the drug.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1432-1076
    Keywords: Cellular immunodeficiency ; Graft-versus-host reaction ; Blood transfusion ; HLA-typing
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A patient with an inborn cellular immunodeficiency syndrome developed a graft-versus-host reaction after a transfusion with packed red cells. This diagnosis was confirmed by skin biopsy and finally proved by tissue typing.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1432-1076
    Keywords: Neutropenic children ; Granulocyte transfusions
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Fifteen children with haematological diseases received an average of 10 granulocyte transfusions each, with 4.7×1010 granulocytes per m2 body surface area (BSA) per transfusion. All patients except one had less than 100 granulocytes per μl blood combined with aplasia or hypoplasia of granulopoiesis. Thirteen patients were transfused therapeutically because of fever and/or severe local lesions unresponsive to antibiotic therapy. Two patients, who were transfused prophylactically after bone-marrow transplantation (BMT), were in excellent clinical condition during the entire period of granulocyte transfusions in spite of severe granulocytopenia. All patients except one showed definite clinical benefit from granulocyte transfusions. The non-responding patient had leukocyte antibodies.
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1432-2307
    Keywords: Immunodeficiency ; Immunologic disorders ; Immune system ; Thymus ; Lymphatic Tissue ; Congenital disorders
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Histologic, immunohistologic and electron microscopic findings in three children with primary immunodeficiencies are reported. Classical X-linked infantile agammaglobulinemia Bruton was present in case 1 (♂, aged 16 years), selective cellular immunodeficiency with thrombopenia in case 2 (♂, aged 2 1/2 years) and non-lymphopenic severe combined immunodeficiency in case 3 (♂, aged 1 3/4 years). At autopsy, all three cases exhibited unusual types of pneumonia. In case 2 a generalized cytomegalovirus infection was present. Case 3 disclosed panmyelopathia and chronic liver lesions due to severe GvH-reaction subsequent to bone marrow transplantation. A detailed morphologic study of the immune system revealed distinct alterations in the thymus, spleen, and lymph nodes and the lymphatic tissues of the gastrointestinal tract characteristic of an immunodeficiency state, either humoral (case 1), cellular (case 2) or combined (case 3).
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 1433-0474
    Keywords: Schlüsselwörter Coxsackie-B-Virus-Infektion ; Dermatomyositis ; In-situ-Hybridisierung ; Polymerasekettenreaktion ; Key words Coxsackie-B-virus-infection ; Dermatomyositis ; In situ hybridisation ; Polymerase chain reac- tion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Dermatomyositis in a 7 year old girl was diagnosed two months prior to admission to our pediatric rheumatology program. Serological and molecular biology methods were used to investigate the evidence for a recent coxsackie-B-virusinfection. Serum specimens of the patient were analysed for detection of coxsackie-B-virus antibodies in a neutralization test (NT), the complement fixation reaction (CF) and for IgM antibodies in an enzyme-immuno-assay. Muscle biopsy specimens were examined by means of polymerase chain reaction and in situ hybridisation, using RNA-sequences specific for coxsackie-B-virus. The results in all serological tests were positive, indicating a recent coxsackie-B-virus-infection. However, neither polymerase chain reaction nor in situ hybridisation revealed any persistence of coxsackie-B-virus in the muscle. The results of this study are compatible with published reports. There is strong evidence for a role of coxsackie-B-virus-infection in causing dermatomyositis, but virus persistence in muscle tissue, resulting in chronic inflammation, seems unlikely. Possibly, Coxsackie-B-virus infection is implicated in pathogenesis of dermatomyositis by triggering autoimmune processes in sensitive patients, resulting in chronic inflammation.
    Notes: Zusammenfassung Ein 7jähriges Mädchen, bei dem 2 Monate vor der Präsentation in der rheumatologischen Ambulanz der Kinderklinik Tübingen die Diagnose Dermatomyositis gestellt wurde, wurde mit Hilfe von serologischen und molekularbiologischen Untersuchungen auf Zeichen einer Coxsackie-B-Virus-Infektion untersucht. Mit Serumproben der Patientin wurden Antikörper für Coxsackie-B-Virus im Neutralisationstest, in der Komplementbindungsreaktion und für IgM in einem Enzymimmunoassay bestimmt. Ein Muskelbiopsat der Patientin wurde mittels Polymerasekettenreaktion (PCR) sowie In-situ-Hybridisierung auf Viruspersistenz untersucht. Die serologischen Untersuchungen machten eine vor kurzem durchgemachte Coxsackie-B-Virus-Infektion wahrscheinlich. Allerdings konnte weder mit der PCR noch mit der In-situ-Hybridisierung im Muskelbiopsat Coxsackie-B-Virus-RNA nachgewiesen werden, so daß eine Viruspersistenz in diesem Gewebe ausgeschlossen werden konnte. Die Ergebnisse dieser Untersuchung, bei der nach unserem Wissen erstmals alle oben genannten Nachweismethoden an 1 Fall exemplarisch zur Anwendung kamen, sind mit einer Reihe von Berichten aus der Literatur vereinbar. Während Zusammenhänge zwischen Coxsackie-B-Virus-Infektionen und Dermatomyositis belegt sind, muß eine Viruspersistenz im Muskelgewebe als Ursache für eine andauernde Myositis nicht vorliegen. Möglicherweise kommt der Auslösung von Autoimmunreaktionen durch eine Infektion mit Coxsackie-B-Viren eine Bedeutung bei der Pathogenese der Dermatomyositis zu.
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 1433-0474
    Keywords: Schlüsselwörter Röteln ; Enzephalitis ; Rötelnschutzimpfung ; Key words Rubella ; Encephalitis ; Rubella vaccination
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary A 12/3 year old girl developed fulminant and lethal rubella encephalitis with an unusually early onset of cerebral symptoms. Discussion: As to our opinion, the illness could have been prevented by a rubella vaccination in early childhood as recommended by the vaccination schedule.
    Notes: Zusammenfassung Berichtet wird über den Fall einer fulminanten Rötelnenzephalitis bei einem 12/3 Jahre alten Mädchen. Sowohl das zeitlich frühe Auftreten der Enzephalitis als auch der tödliche Verlauf sind ungewöhnlich. Diskussion: Die Erkrankung hätte durch eine Rötelnschutzimpfung im frühen Kleinkindesalter, wie sie von der Ständigen Impfkommission empfohlen wird, verhindert werden können.
    Type of Medium: Electronic Resource
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