neural visinin-like Ca2+-binding protein (NVP)
Springer Online Journal Archives 1860-2000
Summary Phencyclidine (PCP) induces a psychotomimetic state that closely resembles schizophrenia, and PCP-treated animals can serve as a model for schizophrenia. The effects of PCP on the gene expression of NVP-1, a novel Ca2+-binding protein, were studied in rats. After 24 hours, the NVP-1 mRNA level in the nucleus accumbens showed a significant decrease of 42%. This result suggests that alterations in Ca2+-binding protein may be involved in the pathology of PCP-induced psychosis and, presumably, schizophrenia.
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