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  • 1
    Keywords: Medicine ; Toxicology ; Biomedicine ; Pharmacology/Toxicology ; Springer eBooks
    Description / Table of Contents: Design of Phage-Displayed Cystine-Stabilized Mini-Protein Libraries for Proteinaceous Binder Engineering -- Construction of a Filamentous Phage Display Peptide Library -- Engineering Bio-Active Peptide-Based Therapeutic Molecules -- T7 Lytic Phage-Displayed Peptide Libraries: Construction and Diversity Characterization -- Affinity Selection Using Filamentous Phage Display -- Bioprospecting Open Reading Frames for Peptide Effectors -- Identification of Ideal Peptides for Heterovalent Ligands -- Substrate Phage Display for Protease Substrate Sequence Characterization: Bovine Factor Xa as a Model System -- Engineering Peptide Therapeutics Using MIMETIBODY™ Technology -- Evaluation of Peptides as Protease Inhibitors and Stimulators -- Assessment of Antimicrobial (Host Defense) Peptides as Anti-Cancer Agents -- Peptide Labelling Strategies for Imaging Agents -- Peptide Optimization and Conjugation Strategies in the Development of Molecularly Targeted Magnetic Resonance Imaging Contrast Agents -- Evaluation of Prenylated Peptides for Use in Cellular Imaging and Biochemical Analysis -- Ultraviolet Absorption Spectroscopy of Peptides -- Fluorescence Spectroscopy of Peptides -- Circular Dichroism of Peptides -- Fourier Transform Infrared Spectroscopy of Peptides
    Abstract: Therapeutic Peptides: Methods and Protocols features biological methods for the preparation of peptide phage display libraries using both filamentous and lytic phage.℗ With contributions from renowned authors in the field, the book also explores selection and screening of the prepared peptide libraries for peptides with the desired function and the subsequent characterization of the identified peptides.℗ Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. ℗ Practical and dependable,℗ Therapeutic Peptides: Methods and Protocols is an ideal guide for researchers from all backgrounds seeking methods for the identification of therapeutic peptide candidates
    Pages: XI, 279 p. 53 illus., 8 illus. in color. : online resource.
    ISBN: 9781627036733
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  • 2
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    Philadelphia : Saunders
    Associated volumes
    Call number: QZ200Z:237/5,1
    Pages: viii, 194 p. : ill.
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    QZ200Z:237/5,1 available
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  • 3
    Unknown
    New York, NY : Springer Science+Business Media, LLC
    Keywords: Medicine ; Neurosciences ; Biomedicine ; Neurosciences ; Springer eBooks
    Pages: : digital
    ISBN: 9781441967879
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  • 4
    Unknown
    Menlo Park, Calif. : Addison-Wesley, Medical/Nursing Division
    Call number: QZ200:251
    Keywords: Cancer ; Neoplasms / diagnosis ; Neoplasms / therapy ; Tumor / Diagnose ; Tumor / Therapie
    Pages: xvi, 304 p. : ill.
    ISBN: 0201043688
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    QZ200:251 available
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  • 5
    Keywords: Outcome assessment (Medical care)
    Notes: Electronic reproduction. Ann Arbor, MI : ProQuest, 2016. Available via World Wide Web. Access may be limited to ProQuest affiliated libraries.
    Pages: 1 online resource (43 pages) : illustrations
    Edition: First edition.
    ISBN: 9788897419600
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  • 6
    Unknown
    Beijing : O'Reilly Media, Inc.
    Call number: G200:5
    Keywords: PHP (Computer program language) ; JavaScript (Computer program language) ; Cascading style sheets ; HTML (Document markup language) ; Web sites / Design ; Web site development ; Internet programming ; Relational databases ; MySQL (Electronic resource)
    Description / Table of Contents: Introduction to dynamic web content -- Setting up a development server -- Introduction to PHP -- Expressions and control flow in PHP -- PHP functions and objects -- PHP arrays -- Practical PHP -- Introduction to MySQL -- Mastering MySQL -- Accessing MySQL using PHP -- Using the mysqli extension -- Form handling -- Cookies, sessions, and authentication -- Exploring JavaScript -- Expressions and control flow in JavaScript -- JavaScript functions, objects, and arrays -- JavaScript and PHP validation and error handling -- Using Ajax -- Introduction to CSS -- Advanced CSS with CSS3 -- Accessing CSS from JavaScript -- Introduction to HTML5 -- The HTML5 canvas -- HTML5 audio and video -- Other HTML5 features -- Bringing it all together
    Abstract: Provides information on creating interactive Web sites using a combination of PHP, MySQL, JavaScript, CSS, and HTML5
    Notes: "A step-by-step guide to creating dynamic websites"--Cover.
    Pages: xxv, 700 pages : illustrations
    Edition: 3rd edition 2014, 2nd release.
    ISBN: 9781491918661
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    G200:5 departmental collection or stack – please contact the library
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  • 7
    Publication Date: 2014-05-24
    Description: Novel vaccines are urgently needed to reduce the burden of severe malaria. Using a differential whole-proteome screening method, we identified Plasmodium falciparum schizont egress antigen-1 (PfSEA-1), a 244-kilodalton parasite antigen expressed in schizont-infected red blood cells (RBCs). Antibodies to PfSEA-1 decreased parasite replication by arresting schizont rupture, and conditional disruption of PfSEA-1 resulted in a profound parasite replication defect. Vaccination of mice with recombinant Plasmodium berghei PbSEA-1 significantly reduced parasitemia and delayed mortality after lethal challenge with the Plasmodium berghei strain ANKA. Tanzanian children with antibodies to recombinant PfSEA-1A (rPfSEA-1A) did not experience severe malaria, and Kenyan adolescents and adults with antibodies to rPfSEA-1A had significantly lower parasite densities than individuals without these antibodies. By blocking schizont egress, PfSEA-1 may synergize with other vaccines targeting hepatocyte and RBC invasion.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4184151/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4184151/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Raj, Dipak K -- Nixon, Christian P -- Nixon, Christina E -- Dvorin, Jeffrey D -- DiPetrillo, Christen G -- Pond-Tor, Sunthorn -- Wu, Hai-Wei -- Jolly, Grant -- Pischel, Lauren -- Lu, Ailin -- Michelow, Ian C -- Cheng, Ling -- Conteh, Solomon -- McDonald, Emily A -- Absalon, Sabrina -- Holte, Sarah E -- Friedman, Jennifer F -- Fried, Michal -- Duffy, Patrick E -- Kurtis, Jonathan D -- 1K08AI100997-01A1/AI/NIAID NIH HHS/ -- DP2 AI112219/AI/NIAID NIH HHS/ -- DP2-AI112219/AI/NIAID NIH HHS/ -- K08 AI100997/AI/NIAID NIH HHS/ -- P20GM103421/GM/NIGMS NIH HHS/ -- P30 AI042853/AI/NIAID NIH HHS/ -- P30AI042853/AI/NIAID NIH HHS/ -- R01 AI102907/AI/NIAID NIH HHS/ -- R01-AI076353/AI/NIAID NIH HHS/ -- R01-AI102907/AI/NIAID NIH HHS/ -- R01-AI52059/AI/NIAID NIH HHS/ -- T32-DA013911/DA/NIDA NIH HHS/ -- Intramural NIH HHS/ -- New York, N.Y. -- Science. 2014 May 23;344(6186):871-7. doi: 10.1126/science.1254417.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Center for International Health Research, Rhode Island Hospital, The Warren Alpert Medical School of Brown University, Providence, RI 02903, USA. ; Division of Infectious Diseases, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, USA. ; Center for International Health Research, Rhode Island Hospital, The Warren Alpert Medical School of Brown University, Providence, RI 02903, USA. Department of Pediatrics, Rhode Island Hospital, The Warren Alpert Medical School of Brown University, Providence, RI 02903, USA. ; Department of Pathology and Laboratory Medicine, Rhode Island Hospital, The Warren Alpert Medical School of Brown University, Providence, RI 02906, USA. ; Laboratory of Malaria Immunology and Vaccinology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20892, USA. ; Fred Hutchinson Cancer Research Center Program in Biostatistics and Biomathematics, Department of Biostatistics and Global Health, University of Washington, Seattle, WA 98109, USA. ; Center for International Health Research, Rhode Island Hospital, The Warren Alpert Medical School of Brown University, Providence, RI 02903, USA. Department of Pathology and Laboratory Medicine, Rhode Island Hospital, The Warren Alpert Medical School of Brown University, Providence, RI 02906, USA. jonathan_kurtis@brown.edu.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24855263" target="_blank"〉PubMed〈/a〉
    Keywords: Adolescent ; Adult ; Animals ; Antibodies, Protozoan/blood/*immunology ; Antigens, Protozoan/*immunology ; Child ; Erythrocytes/*parasitology ; Hepatocytes/immunology/parasitology ; Humans ; Immunoglobulin G/blood/immunology ; Kenya ; Malaria/prevention & control ; Malaria Vaccines/*immunology ; Malaria, Falciparum/*prevention & control ; Mice ; Plasmodium berghei/immunology ; Plasmodium falciparum/*growth & development/immunology ; Protozoan Proteins/*immunology ; Recombinant Proteins/immunology ; Schizonts/*growth & development ; Young Adult
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 8
    Keywords: CELLS ; EXPRESSION ; GROWTH ; GENE ; GENES ; PROTEIN ; PROTEINS ; transcription ; DIFFERENTIATION ; FAMILY ; DOMAIN ; SEQUENCES ; IN-SITU ; PATTERNS ; gene expression ; AMINO-ACID-SEQUENCE ; human hair follicle ; FOLLICLE ; HUMAN TYPE-I ; INNER-ROOT-SHEATH ; MATRIX ; FEATURES ; SHEEP ; PATTERN ; HAIR FOLLICLE ; CYSTEINE-RICH PROTEINS ; CELL BIOLOGY ; Determination ; GROWTH CYCLE ; Brush-end ; CORTICAL-CELLS ; EVOLUTIONARY CONSERVATION ; Fibre curvature ; INDUCED GROWTH-CYCLE
    Abstract: The catalogue of hair keratin intermediate. laments (KIFs) and keratin-associated proteins (KAPs) present in wool follicles is incomplete. The full coding sequences for three novel sheep KIFs (KRT27, KRT35 and KRT38) and one KAP (KRTAP4-3) were established in this study. Spatial expression patterns of these and other genes (KRT31, KRT85, KRTAP6-1 and trichohyalin) were determined by in situ hybridisation in wool follicles at synchronised stages of growth. Transcription proceeded in the order: trichohyalin, KRT27, KRT85, KRT35, KRT31, KRT38, KRTAP6-1 and KRTAP4-3, as determined by increasing distance of their expression zones from the germinal matrix in anagen follicles. Expression became gradually more restricted to the lower follicle during follicle regression (catagen), and ceased during dormancy (telogen). Some genes (KRT27, KRT31, KRT85 and KRTAP6-1), but not others, were expressed in cortical cells forming the brush-end, indicating specific requirements for the formation of this anchoring structure. The resumption of keratin expression was observed only in later stages of follicle reactivation (proanagen). KIF expression patterns in primary wool follicles showed general resemblance to their human homologues but with some unique features. Consistent differences in localisation between primary and secondary wool follicles were observed. Asymmetrical expression of KRT27, KRT31, KRT35, KRT85 and trichohyalin genes in secondary follicles were associated with bulb deflection and follicle curvature, suggesting a role in the determination of follicle and fibre morphology.
    Type of Publication: Journal article published
    PubMed ID: 19272529
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  • 9
    Abstract: Background: Of the 4 medulloblastoma subgroups, Group 3 is the most aggressive but the importance of angiogenesis is unknown. This study sought to determine the role of angiogenesis and identify clinically relevant biomarkers of tumor vascularity and survival in Group 3 medulloblastoma. Methods: VEGFA mRNA expression and survival from several patient cohorts were analyzed. Group 3 xenografts were implanted intracranially in nude rats. Dynamic susceptibility weighted (DSC) MRI and susceptibility weighted imaging (SWI) were obtained. DSC MRI was used to calculate relative cerebral blood volume (rCBV) and flow (rCBF). Tumor vessel density and rat vascular endothelial growth factor alpha (VEGFA) expression were determined. Results: Patient VEGFA mRNA levels were significantly elevated in Group 3 compared with the other subgroups (P 〈 0.001) and associated with survival. Xenografts D283, D341, and D425 were identified as Group 3 by RNA hierarchical clustering and MYC amplification. The D283 group had the lowest rCBV and rCBF, followed by D341 and D425 (P 〈 0.05). These values corresponded to histological vessel density (P 〈 0.05), rat VEGFA expression (P 〈 0.05), and survival (P = 0.002). Gene set enrichment analysis identified 5 putative genes with expression profiles corresponding with these findings: RNH1, SCG2, VEGFA, AGGF1, and PROK2. SWI identified 3 xenograft-independent categories of intratumoral vascular architecture with distinct survival (P = 0.004): organized, diffuse microvascular, and heterogeneous. Conclusions: Angiogenesis plays an important role in Group 3 medulloblastoma pathogenesis and survival. DSC MRI and SWI are clinically relevant biomarkers for tumor vascularity and overall survival and can be used to direct the use of antivascular therapies for patients with Group 3 medulloblastoma.
    Type of Publication: Journal article published
    PubMed ID: 28379574
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  • 10
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