Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Keywords: CDNA ; CLONES ; BIOLOGY ; alternative splicing ; CDNAS ; ASSEMBLIES ; assembly ; ANNOTATION ; COMPLETE GENOM
    Abstract: The human genome sequence defines our inherent biological potential; the realization of the biology encoded therein requires knowledge of the function of each gene. Currently, our knowledge in this area is still limited. Several lines of investigation have been used to elucidate the structure and function of the genes in the human genome. Even so, gene prediction remains a difficult task, as the varieties of transcripts of a gene may vary to a great extent. We thus performed an exhaustive integrative characterization of 41,118 full-length cDNAs that capture the gene transcripts as complete functional cassettes, providing an unequivocal report of structural and functional diversity at the gene level. Our international collaboration has validated 21,037 human gene candidates by analysis of high-quality full-length cDNA clones through curation using unified criteria. This led to the identification of 5,155 new gene candidates. It also manifested the most reliable way to control the quality of the cDNA clones. We have developed a human gene database, called the H-Invitational Database (H-InvDB; http://www.h-invitational.jp/). It provides the following: integrative annotation of human genes, description of gene structures, details of novel alternative splicing isoforms, non-protein-coding RNAs, functional domains, subcellular localizations, metabolic pathways, predictions of protein three-dimensional structure, mapping of known single nucleotide polymorphisms (SNPs), identification of polymorphic microsatellite repeats within human genes, and comparative results with mouse full-length cDNAs. The H-InvDB analysis has shown that up to 4% of the human genome sequence (National Center for Biotechnology Information build 34 assembly) may contain misassembled or missing regions. We found that 6.5% of the human gene candidates (1,377 loci) did not have a good protein-coding open reading frame, of which 296 loci are strong candidates for nonprotein-coding RNA genes. In addition, among 72,027 uniquely mapped SNPs and insertions/deletions localized within human genes, 13,215 nonsynonymous SNPs, 315 nonsense SNPs, and 452 indels occurred in coding regions. Together with 25 polymorphic microsatellite repeats present in coding regions, they may alter protein structure, causing phenotypic effects or resulting in disease. The H-InvDB platform represents a substantial contribution to resources needed for the exploration of human biology and pathology
    Type of Publication: Journal article published
    PubMed ID: 15103394
    Signatur Availability
    BibTip Others were also interested in ...
  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Journal of low temperature physics 105 (1996), S. 495-501 
    ISSN: 1573-7357
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract Single crystals untwinned optimally doped YBa2Cu3O9.65 show a large degree of anisotropy in a-b plane properties such as resistivity, infrared conductivity and value of zero temperature penetration depth. This source of orthorhombicity must ultimately reside in the CuO chains. Using a three plane model; 2 CuO2 and one CuO (chain plane), we study solutions of three coupled BCS equations which include inter- as well as intra-plane coupling. The gaps are found to contain s- as well as d-wave symmetries. From our solutions, we calculate the penetration depth and compare with experiments.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Journal of superconductivity 8 (1995), S. 673-674 
    ISSN: 1572-9605
    Keywords: Josephson ; penetration ; orthorhombic ; d-wave
    Source: Springer Online Journal Archives 1860-2000
    Topics: Electrical Engineering, Measurement and Control Technology , Physics
    Notes: Abstract There should be no Josephson current between a CuO2 plane with a gap of d-wave symmetry and a conventional s-wave superconductor. Nevertheless such a current is observed to exist between YBCO and Pb although with a reduced magnitude. Penetration depth measurements have revealed a large anisotropy between a- and b-directions presumably due to the existence of the CuO chains. Using a simple anisotropic tight binding model in qualitative agreement with the measured penetration depths and a standard model for the spin susceptibility we obtain, on solution of the BCS gap equations, a gap function with a mainly d-wave symmetry but with a minor extended s-wave component. The resultant Josephson current for YBCO-Pb junctions is in good agreement with experiment.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 4
    ISSN: 1572-9605
    Keywords: dx2y2 ; tunnelling ; antiferromagnetic fluctuations
    Source: Springer Online Journal Archives 1860-2000
    Topics: Electrical Engineering, Measurement and Control Technology , Physics
    Notes: Abstract Self consistent calculations, based on the 2 dimensional Hubbard model, indicate that the nearly antiferromagnetic Fermi liquid may be a superconductor with dx2-y2 symmetry. The recent observation of a large anisotropy of the in plane penetration depth has been widely interpreted as evidence that a significant part of the condensate in YBa2Cu3O7−gd resides in the chains. This introduces orthorhombic symmetry. Calculations, which remain within a single tight binding band model but with different nearest neighbour hopping in a- and b-directions, can account for the penetration depth anisotropy and also explain the observed size of the D.C. Josephson current between YBa2Cu3O7−gd and Pb in c-axis tunnelling.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...