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  • 1
    Keywords: RECEPTOR ; CANCER ; EXPRESSION ; GROWTH ; GROWTH-FACTOR ; IN-VITRO ; proliferation ; tumor ; carcinoma ; Germany ; human ; THERAPY ; tumor growth ; INFORMATION ; PROTEIN ; TISSUE ; TUMORS ; radiation ; primary ; TISSUES ; CONTRAST ; CELL-LINES ; PROGRESSION ; MALIGNANCIES ; TUMOR PROGRESSION ; chemotherapy ; MARKERS ; PHENOTYPE ; NETHERLANDS ; RECEPTORS ; CANCER-THERAPY ; VASCULARIZATION ; protein expression ; COLONY-STIMULATING FACTOR ; growth factors ; GM-CSF ; POTENT ; FACTOR RECEPTORS ; BRAIN-TUMORS ; TUMOR-GROWTH ; AUTOCRINE GROWTH-STIMULATION ; CRANIOSPINAL IRRADIATION ; G-CSF,GM-CSF,Ki-67,meningiomas,proliferation,tumor progression ; HUMAN-MELANOMA
    Abstract: The hematopoietic growth factors granulocyte- and granulocyte- macrophage colony stimulating factor (G-CSF and GM-CSF) are nowadays widely used in routine cancer therapies as potent factors to control radiation and chemotherapy induced neutropenia, a side effect that frequently endangers the success of tumor therapies. However, there is little information about the role of G-CSF and GM-CSF for tumor growth or progression. We were interested in the expression and potential role of both factors in human meningiomas, tumors of arachnoidal origin that account for about 20% of all primary intracranial tumors. Therefore, we analyzed immunohistochemically the protein expression of G-CSF, GM-CSF and their respective receptors in 30 meningioma tissues of different malignancy and histopathological type. Both factors and receptors were not expressed in the corresponding normal tissue. In contrast, G-CSF, GM-CSF and their receptors were expressed to a varying degree in human meningiomas. Increasing expression of both factors and receptors correlated significantly with enhanced proliferation in the tumor and thus with higher malignancy. In addition, a strong perivascular expression of G-CSF was associated with a highly vascularized tumor type. Thus, expression of both G-CSF and GM-CSF is associated with the expression of proliferation vascularization, two markers of an increasingly malignant tumor phenotype, suggesting a contribution of both factors to tumor progression
    Type of Publication: Journal article published
    PubMed ID: 15218949
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  • 2
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    German Medical Science GMS Publishing House; Düsseldorf
    In:  125. Kongress der Deutschen Gesellschaft für Chirurgie; 20080422-20080425; Berlin; DOC08dgch9002 /20080416/
    Publication Date: 2008-04-14
    Keywords: ddc: 610
    Language: German
    Type: conferenceObject
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  • 3
    ISSN: 0942-0940
    Keywords: Spinal abscess ; epidural ; subdural ; surgical treatment ; antibiotics ; risk factors ; diagnostic procedures ; MRI
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Bacterial abscesses involving the spinal canal are associated with a high morbidity and mortality. Most frequently, these lesions are found in the epidural, rarely in the subdural space. In this report, our clinical material consists of a series of 16 patients treated during the last seven years. The clinical presentation included local neurological signs (back pain, para-/tetraparesis, bladder dysfunction), disturbances of consciousness (ranging from drowsiness to deep coma) and general inflammatory signs (meningism, fever). All patients presented with risk factors (septic foci, chronic diseases, and iatrogenic causes). Laboratory investigations revealed typically pathological blood sedimentation rate, leucocytosis and CSF-pleocytosis. Radiologically, the diagnosis was confirmed by myelography, CT and preferably MRI. The abscesses were located epidurally in 14 and subdurally in 2 cases. The surgical treatment included laminectomy, or multiple flavectomies in extensive lesions. Drainage systems (either simple silicon outflow drains or suction-/irrigation systems) were installed in all cases, as well as antibiotic treatment. Results of treatment: Following an observation period of 0,5–6 years, we found complete recovery in six (38%) cases, six (38%) others were mildly disabled and four (25%) patients died. Focussing on the results of the two different drainage systems, we found a statistically significant superiority of the inflow-/outflow system. Complications included mandatory re-exploration, post-inflammatory hydrocephalus, syringomyelia, spinal instability, surgical treatment of peripheral septic foci and therapy resistant septicaemia. In conclusion, we propose that spinal epi-or subdural abscesses require surgical evacuation, using a suction-/irrigation drainage system, as well as antibiotic and intensive care treatment.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 0942-0940
    Keywords: Sellar tumours ; MRI ; high resolution CT
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary 41 patients with various sellar and parasellar lesions (pituitary adenomas, meningiomas, optic gliomas, craniopharyngeomas and granulomas), who underwent surgery consecutively, were studied by MRI investigations. In 10 patients post-operative MRI controls were performed. The information obtained by the MRI were compared with the other radiological investigations (especially coronar and axial high resolution CT), and the intra-operative findings. The advantages of MRI in the diagnosis of sellar lesion are demonstrated by exemplary cases.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Acta neurochirurgica 87 (1987), S. 99-104 
    ISSN: 0942-0940
    Keywords: Arachnoidal cyst ; shunting system ; CT ; craniotomy ; infectious complications ; subdural effusions
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A retrospective study of 35 patients operated upon for arachnoid cysts during the last 10 years was carried out. In 19 patients treated by craniotomy, membrane resection and drainage into the basal cisterns, clinical improvement could be noted in 13 cases. Correspondingly on the CT-controls the cysts were found to have disappeared in two cases and were reduced in size in seven patients. In 11 patients, however, who were initially treated by a shunting procedure, seven patients became free of symptoms. Postoperative CT-controls showed in three cases a significant reduction of the size of the cyst, which remained unchanged in two other cases. In five patients with the combination of a nonspace-occupying arachnoid cyst and subdural effusions, drainage of the latter only was sufficient to relieve the clinical symptoms. The prominent Endings were the high complication rate of the primary or secondary shunting procedures (48%), as well as the close correlation between the clinical outcome and the postoperative CT-controls.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 0942-0940
    Keywords: Hormonactive pituitary tumours ; transsphenoidal surgery ; MRI ; high resolution CT
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The search of reliable imaging methods to detect the substrate for persisting hypersecretion in patients operated on for hormonactive pituitary adenoma prompted us to study the possibilities of the newly available Magnetic Resonance Imaging (MRI) technique in this regard. Pre- and postoperative MRI-studies where performed in 5 patients with persisting GH excess following transsphenoidal surgery as well as in 3 patients with micro- and 2 patients with macroprolactinomas. The MRI-findings were correlated with the results of the endocrinological examinations. Two acromegalic patients and three cases with microprolactinomas, who were sucessfully operated upon as defined by the functional criteria were also included to obtain a baseline for normal postoperative findings. The MRI-study was positive in all of the five patients with persisting GH-overproduction. In prolactinomas, the substrate of hypersecretion could only be detected, when the PRL-value exceeded 2,000 μU/ml. MRI may present an important diagnostic method for evaluating further treatment options in patients with remaining hormonal hypersecretion following transsphenoidal adenomectomy, particularly with regard to a second surgical approach.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1434-4726
    Keywords: Retinoblastoma ; Osteosarcoma ; Irradiation ; Anti-oncogenes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A 24-year-old male patient with hereditary retinoblastoma and a poorly differentiated osteoblastic osteogenic sarcoma was found to carry a mutant RB 1 allele in all cells. This findings was most likely a point mutation or microdeletion because Southern blot analysis of peripheral blood DNA failed to disclose any structural aberration of the RBl gene. A somatic mutation (deletion) affecting the other allele was found in the osteosarcoma cells. Management of tumor by external radiotherapy in early age is questioned because the effect of irradiation is to significantly increase the total incidence of second tumors above the already high incidence in non-irradiated patients.
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1437-2320
    Keywords: Key words Pituitary apoplexy ; Spontaneous hemorrhage ; Fatal course ; Literature
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  A rare fatal course of a spontaneous pituitary apoplexy is described and its histological and pathophysiological causes are discussed. A review of the literature gives an overview of the historical and epidemiological data.
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 0942-0940
    Keywords: Pineal cyst ; enlarged pineal gland ; infratentorial supracerebellar approach ; MRI ; occlusive hydrocephalus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Seven patients with non-neoplastic symptomatic lesions of the pineal gland have been operated on in our department since 1988. Clinical symptoms were slight and there were intermittent signs of a space occupying lesion in the quadrigeminal area, i.e. visual and gait disturbances. In three patients, obstructive hydrocephalus with related symptoms was found. Diagnosis was confirmed by use of MRI in sagittal planes, revealing a cystic lesion in five and a solid tumour in two patients. All patients were operated on without complications using an infratentorial supracerebellar approach. Histological examination showed glial cysts of the pineal gland in five patients. In the two solid specimens, normal pineal tissue was found. These lesions seem to be of special interest, as the only pathological property are their size: Both lesions — “too large pineal glands” — caused obstruction of the outlet of the third ventricle with subsequent hydrocephalus. Surgical treatment was curative in all cases with prompt relief of the symptoms. Clinical symptoms and signs, diagnostic and pathological findings, as well as the surgical results of these cases will be reported.
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 0942-0940
    Keywords: Intrasellar cystic craniopharyngeoma ; trans-sphenoidal approach ; intracavitary irradiation ; 90-Yttrium
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Intracavitary irradiation of intrasellar cystic craniopharyngeomas by stereotactic cyst puncture and injection of radioactive solutions is not yet possible. Therefore we designed a new method sphenoidal approach with only a small bony opening of the sella floor, followed by cyst puncture, exclusion of cyst leakage by Metrizamid injection under x-ray control, injection of Y-90-colloid solution at a dosage wich delivers a radiation of 200 Gy to the cyst wall, and finally tight closure of the puncture site using fibrin glue and gelfoam. This method has been used in three patients with good results (follow-up 12–15 months) and without complications. Even though long-term follow-up is not yet available, our preliminary results suggest that this method will be useful for future
    Type of Medium: Electronic Resource
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