Blackwell Publishing Journal Backfiles 1879-2005
Three odontogenic myxomas are described immunohistochemically by a panel of poly- and monoclonal antibodies to characterize this tumor type. Three types of odontogenic myxoma cells were discriminated: spindle cells, stellate cells and hyaline cells. Neoplastic cells of myxomas were positively stained for transferrin, ferritin. alpha- 1-antichymotrypsin (α1-ACT), alpha- 1-antitrypsin (α1-AT), S-100 protein and vimentin; however, neuron specific enolase (NSE), S-100 α subunit, S-100 β subunit, Factor VIII-related antigen (FVIII-AG) and cytokeratin (CK1) were negative. Spindle cells were positive for transferrin, ferritin, α1-ACT, α1-AT, S-100 protein and vimentin. Stellate cells were strongly positive for transferrin, α1-AT, S-100 protein and vimentin. Hyaline cells reacted with α1-ACT and α1-AT. Myxomatous matrix showed negative reaction for all the antibodies used. These results have confirmed that odontogenic myxoma is a tumor of a dual fibroblastic-histiocytic origin.
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