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  • 1
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    Rosa, R. G., Falavigna, M., Robinson, C. C., da Silva, D. B., Kochhann, R., de Moura, R. M., Santos, M. M. S., Sganzerla, D., Giordani, N. E., Eugenio, C., Ribeiro, T., Cavalcanti, A. B., Bozza, F., Azevedo, L. C. P., Machado, F. R., Salluh, J. I. F., Pellegrini, J. A. S., Moraes, R. B., Hochegger, T., Amaral, A., Teles, J. M. M., da Luz, L. G., Barbosa, M. G., Birriel, D. C., Ferraz, I. d. L., Nobre, V., Valentim, H. M., Correa e Castro, L., Duarte, P. A. D., Tregnago, R., Barilli, S. L. S., Brandao, N., Giannini, A., Teixeira, C., The ICU Visits Study Group Investigators and the BRICNet, Albuquerque, Vasconcelos, Monteiro, Ticianeli, Leite, Barbosa, Horstmann, Paulo, Barreto, Ferreira, Couto, Oliveira, Freitas, Oliveira, Sampaio, Casaes, Cordeiro, Guimaraes, Silva, Pissinate, Lima, Araujo, Muniz, Klemz, Neves, Ferraz, E silva, Ferreira, Soares, Menezes, Pedroso, Silva, Padua, Castilho, Martins, Oliveira, Oliveira, Carvalho, Pereira, Souza, Ataide, Paranhos, Meireles, Silva, Santos, Assuncao, Monteiro, Silva, Ferreira, Silva, Vasconcelos, E silva, Siva, Mendes, Luz, Albuquerque, Nobre, Germano, Nascimento, Lucena, Costa, Bezerra, Nascimento, Leite, Barros, Vasconcelos, Gallindo, Silva, Manzi, Nogueira, Oliveira, Xavier, Ribeiro, Vlieger junior, Prestes, Vieira, Santos, Lima, Moura, Schmidt, Becker, Ayres, Hoshino, Jorge, Sodre, Oliveira, Entrago, Barcellos, Vilela, Silva, Dantas, Monteiro, Brito, Magalhaes, Silva, Miguel, Karnopp, Bonatto, Rosa, Rutzen, Bastos, Teixeira, Nedel, Dalpra, Lazzari, Specht, Lincho, Pilau, Foscarini, Fraporti, Tallamini, Forni, Santos, Silva, Ferreira, Santos, Carvalho, Schmitz,, Prieb, Filho, Mello, Hohenreuther, Susin, Beck, Martins, Hoff, Silveira, Prestes, Pizzato, Rosa, Cremonese, Santos, Leivas, Pettine, Dobrinsky, Foernges, Carvalho, Souza, Cardoso, Torelly, Hadrich, Marins, Baldisserotto, Santos, Bettega, Barcellos, Silveira, Flores, Giacomazzi, Costa, Souza, Silva, Silva, Xis, Vargas, Filho, Mohr, Souza, Aguiar, Arruda, Lovato, Carvalho, Sprioli, Cerantola, Gomes, Perez, Werneck, Vasconcelos, Neves, Dassi
    BMJ Publishing
    Publication Date: 2018-04-14
    Description: Introduction Flexible intensive care unit (ICU) visiting hours have been proposed as a means to improve patient-centred and family-centred care. However, randomised trials evaluating the effects of flexible family visitation models (FFVMs) are scarce. This study aims to compare the effectiveness and safety of an FFVM versus a restrictive family visitation model (RFVM) on delirium prevention among ICU patients, as well as to analyse its potential effects on family members and ICU professionals. Methods and analysis A cluster-randomised crossover trial involving adult ICU patients, family members and ICU professionals will be conducted. Forty medical-surgical Brazilian ICUs with RFVMs (〈4.5 hours/day) will be randomly assigned to either an RFVM (visits according to local policies) or an FFVM (visitation during 12 consecutive hours per day) group at a 1:1 ratio. After enrolment and follow-up of 25 patients, each ICU will be switched over to the other visitation model, until 25 more patients per site are enrolled and followed. The primary outcome will be the cumulative incidence of delirium among ICU patients, measured twice a day using the Confusion Assessment Method for the ICU. Secondary outcome measures will include daily hazard of delirium, ventilator-free days, any ICU-acquired infections, ICU length of stay and hospital mortality among the patients; symptoms of anxiety and depression and satisfaction among the family members; and prevalence of burnout symptoms among the ICU professionals. Tertiary outcomes will include need for antipsychotic agents and/or mechanical restraints, coma-free days, unplanned loss of invasive devices and ICU-acquired pneumonia, urinary tract infection or bloodstream infection among the patients; self-perception of involvement in patient care among the family members; and satisfaction among the ICU professionals. Ethics and dissemination The study protocol has been approved by the research ethics committee of all participant institutions. We aim to disseminate the findings through conferences and peer-reviewed journals. Trial registration NCT02932358 .
    Keywords: Open access, Intensive care
    Electronic ISSN: 2044-6055
    Topics: Medicine
    Published by BMJ Publishing
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  • 2
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    Cham : Springer International Publishing
    Keywords: Medicine ; Pharmacology ; Medicinal Chemistry ; Medical Biochemistry ; Oxidative Stress ; Biomedicine ; Pharmacology/Toxicology ; Medicinal Chemistry ; Medical Biochemistry ; Oxidative Stress ; Springer eBooks
    Description / Table of Contents: Target Mitochondria -- SECTION I-Mitochondrial Biology -- Introduction: Mitochondria: the cell furnace -- MItochondria: Where are They Coming From? -- Mitochondrial Dynamics: A journey from Mitochondrial Morphology to MItochondrial Function and Quality -- Mitochondrial ROS, Oxidative Stress.and Aging- The Mitochondrial Permeability Transition Pore -- Mitochondrial Regulation of Cell Death -- MItochondria in Liver Diseases -- Mitochondria in Liver Regeneration,Energy Metabolism, and Posthepatectomy Liver Dysfunction -- MItochondrial Remodeling in Cancer -- Mitochondria in Kidney Disease -- CNS diseases and disruption of Mitochondria -- Mitochondrial disruption in cardiovascular diseases -- .Drug-inducing Mitochondrial Toxicity -- MItochondrial DNA: Functions and Role in Acquired Diseases -- SECTION II-MItochondrial Therapeutics: From the Bench to Industry and Patient -- The Evolution of Mitochondrial Toxicity Assessment in Industry -- Designing Mitochondrial-Active Molecules: The Road to MitoQ and Beyond -- Recovering Mitochondrial Function in Patients' Fibroblasts -- Targeting Mitochondria with Sweat: Improving Mitochondrial Function with Physical Activity -- Modulation of Cell Fate by Tauroursodexycholic Acid: All Paths Lead to Mitochondria -- Pharmacological Targeting of the Mitchondrial Permeability Transition Pore -- Strategies to Preserve/Improve Mitochondrial Function in Organ Preservation Solutions -- MItochondrial Targeted Redox Active Compounds and the Astrocytemotoneuron Axis: relevance for the Treatment of Amyotrophic Lateral Sclerosis -- Targeting the Mitochondrial Genome Through a Nanocarrier and the Regulation of the Mitochondrial Gene Experssion -- Mitochoncrial Dysfunction and Chronic Disease: Treatment with Membrane Lipid Replacement and other Natural Supplements -- Development of Mitochondrial-Directed Plastoquinones -- Targeted Mitochondrial Genome Editing -- Targeting Therpeutic Nucleic Acids into Mitochondria: A Long Challenge -- Cell Permeable Peptides Targeting Mitochondria -- MItochondrial -Directed Cancer Therapy -- SkQ1: The Road from the Bench to the Market -- MItochondrial Follies: Comic
    Abstract: This book addresses the therapeutic strategies to target mitochondrial metabolism in diseases where the function of that organelle is compromised, and it discusses the effective strategies used to create mitochondrial-targeted agents that can become commercially available drug delivery platforms. The consistent growth of research focused in understanding the multifaceted role of mitochondria in cellular metabolism, controlling pathways related with cell death, and ionic/redox regulation has extended the research of mitochondrial chemical-biological interactions to include various pharmacological and toxicological applications. Not only does the book extensively cover basic mitochondrial physiology, but it also links the molecular interactions within these pathways to a variety of diseases. It is one of the first books to combine state-of-the-art reviews regarding basic mitochondrial biology, the role of mitochondrial alterations in different diseases, and the importance of that organelle as a target for pharmacological and non-pharmacological interventions to improve human health. The different chapters highlight the chemical-biological linkages of the mitochondria in context with drug development and clinical applications
    Pages: IX, 708 p. 127 illus., 106 illus. in color. : online resource.
    ISBN: 9783319733449
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  • 3
    Keywords: Life sciences ; Biomedical Engineering ; Regenerative Medicine ; Tissue Engineering ; Biomaterials ; Life sciences ; Regenerative Medicine/Tissue Engineering ; Biomedical Engineering/Biotechnology ; Biomaterials ; Biomedical Engineering ; Springer eBooks
    Description / Table of Contents: Part I: Biomaterials advances in Osteochondral Tissue -- Natural Origin Materials for Osteochondral Tissue Engineering -- Synthetic Materials for Osteochondral Tissue Engineering -- Bioceramics for Osteochondral Tissue Engineering and Regeneration -- Part II: Nanotechnology approaches for Osteochondral Tissue Engineering -- Nanomaterials/nanocomposites for Osteochondral Tissue -- Nano- and Micro-Fibers for Osteochondral Tissue Engineering -- Micro/Nano Scaffolds for Osteochondral Tissue Engineering -- Part III: Osteochondral Tissue Scaffolding -- Mimetic Hierarchical Approaches for Osteochondral Tissue Engineering -- Porous scaffolds for regeneration of cartilage, bone and osteochondral tissue -- Layered Scaffolds for Osteochondral Tissue Engineering -- Part IV: Advanced Processing Methodology -- Preparation of polymeric and composite scaffolds by 3D Bioprinting -- The Use of Electrospinning Technique on OsteoChondral Tissue Engineering -- Supercritical Fluid Technology as a Tool to Prepare Gradient Multifunctional Architectures towards Regeneration of Osteochondral Injuries -- Part V: Hydrogels Systems for Osteochondral Tissue Applications -- Gellan Gum-based Hydrogels for Osteochondral Repair -- Silk Fibroin-Based Hydrogels and Scaffolds for Osteochondral Repair and Regeneration -- In Situ Crosslinkable Polymer Systems and Composites for Osteochondral Regeneration -- Part VI: Translation of Osteochondral Tissue Products -- Stem Cells in Osteochondral Tissue Engineering -- Osteochondral Tissue Engineering: Translational Research and Turning Research into Products -- Clinical trials and Management of Osteochondral Lesions -- Commercial Products for Osteochondral Tissue Repair and Regeneration -- Index
    Abstract: This book reviews the most recent developments in the field of osteochondral tissue engineering (OCTE) and presents challenges and strategies being developed that face not only bone and cartilage regeneration, but also establish osteochondral interface formation in order to translate it into a clinical setting. Topics include nanotechnology approaches and biomaterials advances in osteochondral engineering, advanced processing methodology, as well as scaffolding and surface engineering strategies in OCTE. Hydrogel systems for osteochondral applications are also detailed thoroughly. Osteochondral Tissue Engineering: Nanotechnology, Scaffolding-Related Developments and Translation is an ideal book for biomedical engineering students and a wide range of established researchers and professionals working in the orthopedic field
    Pages: IX, 438 p. 101 illus., 79 illus. in color. : online resource.
    ISBN: 9783319767116
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  • 4
    Keywords: Life sciences ; Cell Biology ; Life sciences ; Cell Biology ; Springer eBooks
    Description / Table of Contents: Establishment of Primary Culture of Sertoli Cells -- Evaluation of the Purity of Sertoli Cell Primary Cultures -- Preparation of Testicular Samples for Histology and Immunohistochemistry -- Rabbit Sertoli Cells: Immunohistochemical Profile from Neonatal to Adult Age -- Identification of Proliferative and Apoptotic Sertoli Cells Using Fluorescence and Confocal Microscopy -- Sertoli Cells Preparation for Co-Immunoprecipitation -- Profiling Signaling Proteins in Sertoli Cells by Co-Immunoprecipitation -- Phagocytosis by Sertoli Cells: Analysis of Main Phagocytosis Steps by Confocal and Electron Microscopy -- A Method for In Vivo Induction and Ultrastructural Detection of Mitophagy in Sertoli Cells -- Assessing Autophagy in Sertoli Cells -- Molecular Mechanisms and Signaling Pathways Involved in the Nutritional Support of Spermatogenesis by Sertoli Cells -- Assessing Sertoli Cells Metabolic Activity -- Proteome Profiling of Sertoli Cells Using a GeLC-MS/MS Strategy -- Gene Silencing of Human Sertoli Cells Utilizing Small Interfering RNAs -- Testicular Cell Selective Ablation Using Diphtheria Toxin Receptor Transgenic Mice -- Regulation of Blood-Testis Barrier (BTB) Dynamics, Role of the Actin, and Microtubule-Based Cytoskeletons -- Monitoring the Integrity of the Blood-Testis Barrier (BTB): An In Vivo Assay -- Computational Methods Involved in Evaluating the Toxicity of the Reproductive Roxicants in Sertoli Cell -- A Stopped-Flow Light Scattering Methodology for Assessing the Osmotic Water Permeability of Whole Sertoli Cells -- Cryopreservation of Human Testicular Tissue by Isopropyl-Controlled Slow Freezing
    Abstract: This detailed volume explores the use of Sertoli cells as models in male reproductive biology or as supporters for other cell types, and it answers the need for standardized protocols for their in vitro culture. Prepared for non-specialists as well as experienced researchers that may be interested in a multidisciplinary approach to study these cells, the book examines these remarkable cells that present some unique features that go far beyond the physical and nutritional support of spermatogenesis. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Sertoli Cells: Methods and Protocols serves as a valuable resource for experienced researchers in reproductive biology, particularly andrologists, but also for future investigators and young students starting to study these extraordinary cells
    Pages: XIII, 297 p. 49 illus., 37 illus. in color. : online resource.
    ISBN: 9781493976980
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  • 5
    Keywords: Medicine ; Cell Culture ; Biomedicine ; Biomedicine general ; Cell Culture ; Springer eBooks
    Description / Table of Contents: 1 Introductory remarks -- 2 The Sertoli cell at a glance -- 3 Spermatogenesis -- 4 Sertoli cell and germ cell differentiation -- 5 Testicular Metabolic Cooperation -- 6 Modulation of Sertoli cell metabolism -- 7 Concluding remarks -- 8 Acknowledgments -- 9 References
    Abstract: This book is focused on Sertoli cell physiology and its role in the spermatogenic event. These cells, known as “nurse cells”, are essential for the normal development of germ cells by offering not only physical support and creating an immune-privileged environment, but also for providing nutritional support. The presence of Sertoli cells promotes the establishment of the appropriate microenvironment so that spermatogenesis may occur. Spermatogenesis maintenance in vivo is highly dependent on the metabolic cooperation established between Sertoli cells and developing germ cells. For many years this metabolic cooperation between testicular cells has been disregarded, but recent advances have highlighted the relevance of these processes for male fertility. Thus, the understanding of the functioning and regulation of these metabolic processes is a crucial step to identify key mechanisms associated with Sertoli cell (dys)function and to enlighten their influence on male fertility
    Pages: VIII, 98 p. 14 illus. : online resource.
    Edition: 1st ed. 2015.
    ISBN: 9783319197913
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  • 6
    Keywords: Life sciences ; Biomedical Engineering ; Regenerative Medicine ; Tissue Engineering ; Biomaterials ; Life sciences ; Regenerative Medicine/Tissue Engineering ; Biomedical Engineering/Biotechnology ; Biomaterials ; Biomedical Engineering ; Springer eBooks
    Description / Table of Contents: Part I: Current Challenges in Osteochondral Repair and Regeneration: Trauma vs Disease -- Advances for treatment of knee OC defects -- Emerging Concepts in Treating Cartilage, Osteochondral Defects and Osteoarthritis of the Knee and Ankle -- Osteoarthritis: Trauma Vs Disease -- Surgical Treatment Paradigms of Ankle Lateral Instability, Osteochondral Defects and Impingement -- Part II: Viscosupplementation -- Clinical management in early OA -- Hyaluronic Acid -- Semi-IPNs and IPNs Based Hydrogels -- Promising biomolecules -- Part III: Technological Advances in Osteochondral Tissue Engineering -- Nanoparticles-based systems for Osteochondral Tissue Engineering -- Stem cells for osteochondral regeneration -- PRP Therapy -- Enhancing biological and biomechanical fixation of osteochondral scaffold: a grand challenge -- Part IV: Osteochondral Tissue Engineering approaches -- Combination of polymeric supports and drug delivery systems for ostechondral regeneration -- Osteochondral Angiogenesis and Promoted Vascularization: New Therapeutic Target -- Models Of Disease -- Part V: In vitro models for Osteochondral Regeneration -- Tissue Engineering Strategies for Osteochondral Repair -- In vitro mimetic models for the bone-cartilage interface regeneration -- Bioreactors and microfluidics for osteochondral interface maturation -- Part VI: In vivo models for Osteochondral Regeneratio -- nSmall Animal Models -- Large animal models for Osteochondral Regeneration -- Index
    Abstract: This book covers the most recent developments in the field of osteochondral tissue engineering (OCTE) and covers in detail the concepts and current challenges for bone and cartilage repair and regeneration. Specific topics include viscosupplementation, biologicals, tissue engineering approaches, in vitro and in vivo models, and technological advances with stem cells, bioreactors, and microfluidics. Osteochondral Tissue Engineering: Challenges, Current Strategies, and Technological Advances presents challenges and strategies in the field of osteochondral regeneration and serves as a core reference for biomedical engineering students and a wide range of established researchers and professionals working in orthopedics
    Pages: IX, 511 p. 86 illus., 79 illus. in color. : online resource.
    ISBN: 9783319767352
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  • 7
    Keywords: Life sciences ; Agriculture ; Ecology ; Plant breeding ; Plant physiology ; Life sciences ; Plant Genetics & Genomics ; Agriculture ; Plant physiology ; Plant Breeding/Biotechnology ; Terrestial Ecology ; Springer eBooks
    Pages: : digital
    ISBN: 9783540855460
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  • 8
    Keywords: Plant Ecology ; Plant physiology ; Plant anatomy ; Plant development ; Ecosystems ; Plant Ecology ; Plant physiology ; Plant Anatomy/Development ; Ecosystems ; Springer eBooks
    Description / Table of Contents: 1. Assumptions and approaches -- 2. Photosynthesis, respiration, and long-distance transport -- 2a. Photosynthesis -- 2b. Respiration -- 2c. Long‑distance transport of assimilates -- 3. Plant water relations -- 4. Plant energy budgets: environmental effects -- 4a. The plant’s energy balance -- 4b. Effects of radiation and temperature level -- 5. Scaling-up gas exchange and energy balance from the leaf to the canopy level -- 6. Mineral nutrition -- 7. Growth and allocation -- 8. Life cycles: environmental influences and adaptations -- 9. Biotic influences -- 9a. Symbiotic associations -- 9b. Ecological biochemistry: allelopathy and defense against herbivores -- 9c. Effects of microbial pathogens -- 9d. Parasitic associations -- 9e. Interactions among plants -- 9f. Carnivory -- 10. Role in ecosystem and global processes -- 10a. Decomposition -- 10b. Ecosystem and global processes: ecophysiological controls
    Abstract: Growth, reproduction, and geographical distribution of plants are profoundly influenced by their physiological ecology: the interaction with the surrounding physical, chemical, and biological environments. This textbook highlights mechanisms that underlie plant physiological ecology at the levels of physiology, biochemistry, biophysics, and molecular biology. At the same time, the integrative power of physiological ecology is well suited to assess the costs, benefits, and consequences of modifying plants for human needs and to evaluate the role of plants in natural and managed ecosystems. Plant Physiological Ecology, Third Edition is significantly updated, with many full color illustrations, and begins with the primary processes of carbon metabolism and transport, plant water relations, and energy balance. After considering individual leaves and whole plants, these physiological processes are then scaled up to the level of the canopy. Subsequent chapters discuss mineral nutrition and the ways in which plants cope with nutrient‑deficient or toxic soils. The book then looks at patterns of growth and allocation, life‑history traits, and interactions between plants and other organisms. Later chapters deal with traits that affect decomposition of plant material and with the consequences of plant physiological ecology at ecosystem and global levels. Plant Physiological Ecology, Third Edition features several boxed entries that extend the discussions of selected issues, a glossary, and numerous references to the primary and review literature. This significant new text is suitable for use in plant ecology courses, as well as classes ranging from plant physiology to plant molecular biology. From reviews of the previous editions: ". . . the authors cover a wide range of plant physiological aspects which up to now could not be found in one book. . . . The book can be recommended not only to students but also to scientists working in general plant physiology and ecology as well as in applied agriculture and forestry." - Journal of Plant Physiology "This is a remarkable book, which should do much to consolidate the importance of plant physiological ecology as a strongly emerging discipline. The range and depth of the book should also persuade any remaining skeptics that plant physiological ecology can offer much in helping us to understand how plants function in a changing and complex environment." - Forestry "This book must be regarded as the most integrated, informative and accessible account of the complexities of plant physiological ecology. It can be highly recommended to graduate students and researchers working in all fields of plant ecology." - Plant Science ". . . there is a wealth of information and new ideas here, and I strongly recommend that this book be on every plant ecophysiologist's shelf. It certainly represents scholarship of the highest level, and many of us will find it a useful source of new ideas for future research." - Ecology
    Pages: XXVII, 736 p. 354 illus., 237 illus. in color. : online resource.
    Edition: 3rd ed. 2019.
    ISBN: 9783030296391
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  • 9
    Publication Date: 2016-03-26
    Description: Brazil has experienced an unprecedented epidemic of Zika virus (ZIKV), with ~30,000 cases reported to date. ZIKV was first detected in Brazil in May 2015, and cases of microcephaly potentially associated with ZIKV infection were identified in November 2015. We performed next-generation sequencing to generate seven Brazilian ZIKV genomes sampled from four self-limited cases, one blood donor, one fatal adult case, and one newborn with microcephaly and congenital malformations. Results of phylogenetic and molecular clock analyses show a single introduction of ZIKV into the Americas, which we estimated to have occurred between May and December 2013, more than 12 months before the detection of ZIKV in Brazil. The estimated date of origin coincides with an increase in air passengers to Brazil from ZIKV-endemic areas, as well as with reported outbreaks in the Pacific Islands. ZIKV genomes from Brazil are phylogenetically interspersed with those from other South American and Caribbean countries. Mapping mutations onto existing structural models revealed the context of viral amino acid changes present in the outbreak lineage; however, no shared amino acid changes were found among the three currently available virus genomes from microcephaly cases. Municipality-level incidence data indicate that reports of suspected microcephaly in Brazil best correlate with ZIKV incidence around week 17 of pregnancy, although this correlation does not demonstrate causation. Our genetic description and analysis of ZIKV isolates in Brazil provide a baseline for future studies of the evolution and molecular epidemiology of this emerging virus in the Americas.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Faria, Nuno Rodrigues -- Azevedo, Raimunda do Socorro da Silva -- Kraemer, Moritz U G -- Souza, Renato -- Cunha, Mariana Sequetin -- Hill, Sarah C -- Theze, Julien -- Bonsall, Michael B -- Bowden, Thomas A -- Rissanen, Ilona -- Rocco, Iray Maria -- Nogueira, Juliana Silva -- Maeda, Adriana Yurika -- Vasami, Fernanda Giseli da Silva -- Macedo, Fernando Luiz de Lima -- Suzuki, Akemi -- Rodrigues, Sueli Guerreiro -- Cruz, Ana Cecilia Ribeiro -- Nunes, Bruno Tardeli -- Medeiros, Daniele Barbosa de Almeida -- Rodrigues, Daniela Sueli Guerreiro -- Nunes Queiroz, Alice Louize -- da Silva, Eliana Vieira Pinto -- Henriques, Daniele Freitas -- Travassos da Rosa, Elisabeth Salbe -- de Oliveira, Consuelo Silva -- Martins, Livia Caricio -- Vasconcelos, Helena Baldez -- Casseb, Livia Medeiros Neves -- Simith, Darlene de Brito -- Messina, Jane P -- Abade, Leandro -- Lourenco, Jose -- Carlos Junior Alcantara, Luiz -- de Lima, Maricelia Maia -- Giovanetti, Marta -- Hay, Simon I -- de Oliveira, Rodrigo Santos -- Lemos, Poliana da Silva -- de Oliveira, Layanna Freitas -- de Lima, Clayton Pereira Silva -- da Silva, Sandro Patroca -- de Vasconcelos, Janaina Mota -- Franco, Luciano -- Cardoso, Jedson Ferreira -- Vianez-Junior, Joao Lidio da Silva Goncalves -- Mir, Daiana -- Bello, Gonzalo -- Delatorre, Edson -- Khan, Kamran -- Creatore, Marisa -- Coelho, Giovanini Evelim -- de Oliveira, Wanderson Kleber -- Tesh, Robert -- Pybus, Oliver G -- Nunes, Marcio R T -- Vasconcelos, Pedro F C -- 090532/Z/09/Z/Wellcome Trust/United Kingdom -- 095066/Wellcome Trust/United Kingdom -- 102427/Wellcome Trust/United Kingdom -- MR/L009528/1/Medical Research Council/United Kingdom -- R24 AT 120942/AT/NCCIH NIH HHS/ -- New York, N.Y. -- Science. 2016 Apr 15;352(6283):345-9. doi: 10.1126/science.aaf5036. Epub 2016 Mar 24.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Center for Technological Innovation, Evandro Chagas Institute, Ministry of Health, Ananindeua, PA 67030-000, Brazil. Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3PS, UK. ; Department of Arbovirology and Hemorrhagic Fevers, Evandro Chagas Institute, Ministry of Health, Ananindeua, Para State, Brazil. ; Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3PS, UK. ; Instituto Adolfo Lutz, University of Sao Paulo, Sao Paulo, Brazil. ; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK. ; Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3PS, UK. Metabiota, San Francisco, CA 94104, USA. ; Oswaldo Cruz Foundation (FIOCRUZ), Salvador, Bahia, Brazil. ; Centre of Post Graduation in Collective Health, Department of Health, Universidade Estadual de Feira de Santana, Feira de Santana, Bahia, Brazil. ; Institute for Health Metrics and Evaluation, University of Washington, Seattle, WA 98121, USA. Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK. ; Center for Technological Innovation, Evandro Chagas Institute, Ministry of Health, Ananindeua, PA 67030-000, Brazil. ; Laboratorio de AIDS and Imunologia Molecular, Instituto Oswaldo Cruz, FIOCRUZ, Rio de Janeiro, Brazil. ; Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, Ontario, Canada. Department of Medicine, Division of Infectious Diseases, University of Toronto, Toronto, Ontario, Canada. ; Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada. ; Brazilian Ministry of Health, Brasilia, Brazil. ; Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555, USA. ; Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3PS, UK. Metabiota, San Francisco, CA 94104, USA. oliver.pybus@zoo.ox.ac.uk marcionunesbrasil@yahoo.com.br pedrovasconcelos@iec.pa.gov.br. ; Center for Technological Innovation, Evandro Chagas Institute, Ministry of Health, Ananindeua, PA 67030-000, Brazil. Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555, USA. oliver.pybus@zoo.ox.ac.uk marcionunesbrasil@yahoo.com.br pedrovasconcelos@iec.pa.gov.br. ; Department of Arbovirology and Hemorrhagic Fevers, Evandro Chagas Institute, Ministry of Health, Ananindeua, Para State, Brazil. oliver.pybus@zoo.ox.ac.uk marcionunesbrasil@yahoo.com.br pedrovasconcelos@iec.pa.gov.br.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/27013429" target="_blank"〉PubMed〈/a〉
    Keywords: Aedes/virology ; Americas/epidemiology ; Animals ; *Disease Outbreaks ; Female ; Genome, Viral/genetics ; Humans ; Incidence ; Insect Vectors/virology ; Microcephaly/*epidemiology/virology ; Molecular Epidemiology ; Molecular Sequence Data ; Mutation ; Pacific Islands/epidemiology ; Phylogeny ; Pregnancy ; RNA, Viral/genetics ; Sequence Analysis, RNA ; Travel ; Zika Virus/classification/*genetics/isolation & purification ; Zika Virus Infection/*epidemiology/transmission/*virology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 10
    ISSN: 0167-2738
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Physics
    Type of Medium: Electronic Resource
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